SIMILAR PATTERNS OF AMINO ACIDS FOR 4R21_A_STRA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 260
ILE A 145
SER A 285
VAL A 289
 None
 0.70A 4r21A-1a1sA:
0.3		 4r21A-1a1sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 196
GLY A 176
ILE A 215
VAL A 202
 None
 0.80A 4r21A-1bxzA:
undetectable		 4r21A-1bxzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 387
ILE A 417
GLY A 399
ILE A 470
 None
 0.82A 4r21A-1dxlA:
undetectable		 4r21A-1dxlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA B 239
GLY A 245
ILE B 101
VAL B 230
 None
 0.54A 4r21A-1e3dB:
0.0		 4r21A-1e3dB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ILE A 173
GLY A 175
SER A 274
ILE A  90
 None
 0.82A 4r21A-1ethA:
0.0		 4r21A-1ethA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 195
GLY A 224
ILE A 199
VAL A 239
 None
 0.82A 4r21A-1euzA:
undetectable		 4r21A-1euzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ALA A 256
GLY A 451
ILE A 215
VAL A 192
 None
 0.75A 4r21A-1g8xA:
undetectable		 4r21A-1g8xA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 194
GLY A 224
ILE A 198
VAL A 239
 None
SO4  A 421 ( 4.9A)
None
None
 0.82A 4r21A-1gtmA:
0.0		 4r21A-1gtmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 378
ILE A 428
GLY A 395
ILE A 382
 None
 0.76A 4r21A-1iwaA:
undetectable		 4r21A-1iwaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ALA A 267
GLY A 462
ILE A 226
VAL A 203
 None
 0.81A 4r21A-1jx2A:
1.5		 4r21A-1jx2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k44 NUCLEOSIDE
DIPHOSPHATE KINASE

(Mycobacterium
tuberculosis) 		PF00334
(NDK) 		4 ILE A  22
GLY A  13
ILE A  66
VAL A  72
 None
 0.83A 4r21A-1k44A:
undetectable		 4r21A-1k44A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 ALA A 431
ILE A 353
GLY A 398
ILE A 281
 None
 0.71A 4r21A-1lw3A:
undetectable		 4r21A-1lw3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 ALA A 165
ILE A 143
GLY A 138
ILE A 550
 FAD  A3000 (-3.3A)
None
None
FAD  A3000 (-4.2A)
 0.78A 4r21A-1m64A:
undetectable		 4r21A-1m64A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 ALA A 184
ILE A  52
GLY A  93
ILE A 200
 None
 0.82A 4r21A-1mc3A:
undetectable		 4r21A-1mc3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		4 ILE A  27
GLY A  19
ILE A  84
VAL A  38
 None
 0.73A 4r21A-1mxfA:
undetectable		 4r21A-1mxfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ALA A  33
GLY D 607
ILE B 311
VAL B 299
 ATP  A 700 (-3.8A)
None
None
None
 0.83A 4r21A-1qhhA:
undetectable		 4r21A-1qhhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		4 ALA A 274
GLY A 314
ILE A 390
VAL A 343
 None
 0.82A 4r21A-1vmeA:
undetectable		 4r21A-1vmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w98 G1/S-SPECIFIC CYCLIN
E1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 ALA B 288
GLY B 282
ILE B 263
VAL B 237
 None
 0.76A 4r21A-1w98B:
undetectable		 4r21A-1w98B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 ALA A 431
ILE A 353
GLY A 398
ILE A 281
 None
 0.74A 4r21A-1zsqA:
undetectable		 4r21A-1zsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 ALA A 157
ILE A  65
ILE A 101
VAL B 396
 None
 0.71A 4r21A-2e0xA:
undetectable		 4r21A-2e0xA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 ALA A 273
GLY A 248
ILE A  86
VAL A  89
 None
 0.79A 4r21A-2f9rA:
undetectable		 4r21A-2f9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 158
ILE A 312
GLY A 152
ILE A 243
 None
 0.59A 4r21A-2h6eA:
undetectable		 4r21A-2h6eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 ALA A  93
ILE A 104
GLY A  77
ILE A 131
VAL A 134
 None
MG  A 502 (-4.8A)
None
None
None
 1.31A 4r21A-2hmcA:
undetectable		 4r21A-2hmcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ALA A 498
GLY A 635
ILE A 487
VAL A 662
 None
 0.77A 4r21A-2jjdA:
undetectable		 4r21A-2jjdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ALA A  43
GLY A 258
ILE A 164
VAL A 218
 None
 0.72A 4r21A-2nwhA:
undetectable		 4r21A-2nwhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ALA A  20
ILE A  32
GLY A 210
SER A 189
 None
LLP  A  33 ( 4.3A)
LLP  A  33 ( 3.2A)
None
 0.81A 4r21A-2odoA:
undetectable		 4r21A-2odoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 ALA A 319
GLY A 147
ILE A 226
VAL A 154
 None
 0.79A 4r21A-2p82A:
undetectable		 4r21A-2p82A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		4 ALA A 329
ILE A 235
GLY A 296
ILE A 346
 None
YE1  A 997 (-3.3A)
YE1  A 997 (-3.6A)
None
 0.74A 4r21A-2pg8A:
undetectable		 4r21A-2pg8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		4 ALA A 128
GLY A  16
ILE A   4
VAL A 170
 None
 0.75A 4r21A-2pkeA:
undetectable		 4r21A-2pkeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ALA A 292
GLY A 300
ILE A 156
VAL A 321
 None
 0.77A 4r21A-2pxjA:
undetectable		 4r21A-2pxjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		4 ALA A   6
ILE A  86
GLY A  32
ILE A 148
 None
 0.82A 4r21A-2q2lA:
undetectable		 4r21A-2q2lA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		4 ALA A 145
GLY A  74
ILE A 136
VAL A 106
 None
 0.83A 4r21A-2rjbA:
undetectable		 4r21A-2rjbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 ALA A 320
ILE A 455
GLY A 469
ILE A  12
 None
 0.81A 4r21A-2ze4A:
undetectable		 4r21A-2ze4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 ALA A 169
ILE A  69
GLY A  67
VAL A  94
 None
 0.82A 4r21A-2zu0A:
undetectable		 4r21A-2zu0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 ALA A 413
ILE A 480
GLY A 482
ILE A 318
 None
 0.62A 4r21A-3a1iA:
undetectable		 4r21A-3a1iA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		4 ALA A  39
ILE A 192
GLY A 202
ILE A  41
 None
 0.81A 4r21A-3a5fA:
undetectable		 4r21A-3a5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Bacillus
halodurans) 		PF13580
(SIS_2) 		4 ALA A 201
ILE A 114
GLY A 195
ILE A  27
 None
 0.66A 4r21A-3cvjA:
undetectable		 4r21A-3cvjA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d01 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF14588
(YjgF_endoribonc) 		4 ALA A 153
ILE A  84
GLY A  49
ILE A  58
 None
 0.73A 4r21A-3d01A:
undetectable		 4r21A-3d01A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsb PUTATIVE
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00583
(Acetyltransf_1) 		4 ALA A  22
ILE A 119
ILE A  30
VAL A 100
 None
 0.81A 4r21A-3dsbA:
undetectable		 4r21A-3dsbA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 ALA A 225
ILE A 253
ILE A 187
VAL A 335
 None
 0.79A 4r21A-3fmqA:
undetectable		 4r21A-3fmqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA B 641
ILE B 463
GLY B 648
VAL B 651
 None
 0.69A 4r21A-3govB:
undetectable		 4r21A-3govB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 ALA A 143
GLY A 291
ILE A 123
VAL A  88
 None
 0.71A 4r21A-3gybA:
undetectable		 4r21A-3gybA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 ILE A 245
GLY A 292
ILE A  57
VAL A  48
 None
 0.81A 4r21A-3hvyA:
1.2		 4r21A-3hvyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		4 ILE A 245
GLY A 292
ILE A  56
VAL A  47
 None
 0.80A 4r21A-3i16A:
undetectable		 4r21A-3i16A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb8 COAT PROTEIN

(Maize chlorotic
mottle virus) 		PF00729
(Viral_coat) 		4 ALA A  88
ILE A 101
GLY A  73
ILE A 211
 None
 0.83A 4r21A-3jb8A:
undetectable		 4r21A-3jb8A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 ALA A 723
ILE A 611
ILE A 720
VAL A 692
 None
 0.77A 4r21A-3nawA:
undetectable		 4r21A-3nawA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A  78
ILE A 109
SER A 170
ILE A 105
VAL A 161
 None
 1.40A 4r21A-3o04A:
undetectable		 4r21A-3o04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ALA A 927
ILE A 874
SER A 771
ILE A 925
 None
 0.68A 4r21A-3poyA:
undetectable		 4r21A-3poyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ALA A 911
ILE A 858
SER A 755
ILE A 909
 None
 0.72A 4r21A-3qcwA:
undetectable		 4r21A-3qcwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 ALA A 246
GLY A 237
ILE A 233
VAL A 220
 None
 0.79A 4r21A-3re1A:
undetectable		 4r21A-3re1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN

(Treponema
denticola) 		PF00731
(AIRC) 		4 ALA A 120
ILE A  34
SER A  73
ILE A  85
 None
 0.71A 4r21A-3rggA:
undetectable		 4r21A-3rggA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 ALA A 243
ILE A 235
ILE A 251
VAL A  18
 None
 0.82A 4r21A-3sg1A:
undetectable		 4r21A-3sg1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		4 ALA A 209
ILE A 111
GLY A 140
ILE A 135
 None
None
NAD  A 292 (-3.7A)
None
 0.76A 4r21A-3tnlA:
undetectable		 4r21A-3tnlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		4 ALA A 119
GLY A 336
SER A 196
ILE A 202
 None
 0.80A 4r21A-3tqgA:
undetectable		 4r21A-3tqgA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A 190
GLY A 129
ILE A  96
VAL A  40
 ILE  A 190 ( 0.7A)
GLY  A 129 ( 0.0A)
ILE  A  96 ( 0.7A)
VAL  A  40 ( 0.6A)
 0.83A 4r21A-3ulkA:
undetectable		 4r21A-3ulkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ALA A 356
ILE A 250
ILE A 210
VAL A 192
 None
 0.81A 4r21A-3uszA:
undetectable		 4r21A-3uszA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 ALA A 351
ILE A 438
GLY A 345
ILE A 380
 None
 0.69A 4r21A-4c0tA:
undetectable		 4r21A-4c0tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ALA A 261
GLY A 458
ILE A 220
VAL A 191
 None
 0.70A 4r21A-4db1A:
1.2		 4r21A-4db1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		4 ALA A 246
GLY A 237
ILE A 233
VAL A 220
 None
 0.79A 4r21A-4es6A:
undetectable		 4r21A-4es6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		4 ALA A 274
ILE A 177
SER A 284
ILE A 280
 None
None
UDP  A 402 (-2.7A)
None
 0.77A 4r21A-4fkzA:
undetectable		 4r21A-4fkzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 GLY A 194
SER A 327
ILE A 160
VAL A 295
 None
 0.81A 4r21A-4g3mA:
undetectable		 4r21A-4g3mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		4 ALA A 164
ILE A 273
GLY A 110
SER A  41
 None
None
None
PO4  A 301 (-2.5A)
 0.80A 4r21A-4gd5A:
undetectable		 4r21A-4gd5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ALA A 296
GLY A 304
ILE A 160
VAL A 325
 None
 0.79A 4r21A-4hooA:
undetectable		 4r21A-4hooA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 ILE A 463
GLY A 648
ILE A 606
VAL A 651
 None
 0.77A 4r21A-4igdA:
undetectable		 4r21A-4igdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		4 ILE A 111
GLY A  28
ILE A   5
VAL A  40
 None
 0.73A 4r21A-4jc0A:
undetectable		 4r21A-4jc0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		4 ILE A  84
GLY A  54
ILE A 114
VAL A  70
 IOD  A 302 (-3.9A)
None
None
None
 0.74A 4r21A-4jxjA:
undetectable		 4r21A-4jxjA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		4 ALA A 275
GLY A 287
ILE A 167
VAL A 152
 None
FAD  A 601 (-3.5A)
None
None
 0.82A 4r21A-4k2xA:
undetectable		 4r21A-4k2xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 ALA A 279
GLY A 291
ILE A 178
VAL A 163
 None
FAD  A 601 (-3.5A)
None
None
 0.81A 4r21A-4k5rA:
undetectable		 4r21A-4k5rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ILE A  92
GLY A  75
ILE A  28
VAL A 121
 None
 0.71A 4r21A-4lk5A:
undetectable		 4r21A-4lk5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 349
GLY A 171
ILE A 353
VAL A   5
 None
 0.76A 4r21A-4ls5A:
undetectable		 4r21A-4ls5A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 113
ILE A 205
GLY A 301
ILE A 371
 HEM  A 600 ( 2.9A)
3QZ  A 601 ( 3.4A)
3QZ  A 601 ( 3.0A)
HEM  A 600 (-3.8A)
 0.78A 4r21A-4nkyA:
49.0		 4r21A-4nkyA:
44.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		4 ALA A 161
ILE A 168
SER A 227
ILE A 155
 None
 0.82A 4r21A-4ovsA:
undetectable		 4r21A-4ovsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		4 ALA A 101
ILE A 154
GLY A 147
VAL A 130
 None
 0.64A 4r21A-4pyrA:
undetectable		 4r21A-4pyrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 ALA A 269
GLY A 244
ILE A  86
VAL A  89
 None
 0.68A 4r21A-4q6xA:
undetectable		 4r21A-4q6xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		4 ALA A 134
ILE A 243
GLY A  80
SER A  11
 None
None
None
PO4  A 301 (-2.5A)
 0.77A 4r21A-4q8rA:
undetectable		 4r21A-4q8rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 350
GLY A 173
ILE A 354
VAL A   6
 None
 0.75A 4r21A-4qavA:
undetectable		 4r21A-4qavA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ALA A 126
ILE A 218
SER A 378
ILE A 382
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
HEM  A 600 ( 4.6A)
HEM  A 600 ( 4.1A)
 0.79A 4r21A-4r1zA:
49.0		 4r21A-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		6 ALA A 120
ILE A 212
GLY A 301
SER A 367
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
AER  A 602 (-3.5A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.78A 4r21A-4r20A:
58.8		 4r21A-4r20A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 ALA A 129
GLY A 157
SER A 170
ILE A 146
 None
 0.72A 4r21A-4rv4A:
undetectable		 4r21A-4rv4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 ALA A 323
ILE A 371
ILE A 381
VAL A 417
 None
BU1  A 706 ( 4.8A)
None
None
 0.72A 4r21A-4s28A:
undetectable		 4r21A-4s28A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 ALA A 369
GLY A 357
ILE A 386
VAL A 315
 None
 0.78A 4r21A-4s38A:
undetectable		 4r21A-4s38A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA L 249
GLY S 246
ILE L 111
VAL L 240
 None
 0.49A 4r21A-4u9iL:
undetectable		 4r21A-4u9iL:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 316
GLY A 355
ILE A 245
VAL A  81
 None
P33  A 401 (-3.4A)
None
P33  A 401 (-4.5A)
 0.77A 4r21A-4xvxA:
undetectable		 4r21A-4xvxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ALA A  26
ILE A  44
SER A  72
ILE A  40
 None
 0.83A 4r21A-5bshA:
undetectable		 4r21A-5bshA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A  44
GLY A  17
SER A  72
ILE A  40
 None
 0.65A 4r21A-5bshA:
undetectable		 4r21A-5bshA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 ALA A 452
ILE A 374
GLY A 419
ILE A 302
 None
 0.67A 4r21A-5c16A:
undetectable		 4r21A-5c16A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 ALA A 485
ILE A 393
GLY A 338
ILE A 600
 None
 0.77A 4r21A-5dztA:
undetectable		 4r21A-5dztA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 138
ILE A 347
GLY A  75
VAL A 158
 None
 0.78A 4r21A-5fi5A:
undetectable		 4r21A-5fi5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 ALA A 409
GLY A 100
SER A 438
VAL A 456
 None
 0.75A 4r21A-5fsaA:
32.9		 4r21A-5fsaA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 GLY A 124
SER A  83
ILE A  77
VAL A 112
 None
61P  A 406 (-3.0A)
None
None
 0.82A 4r21A-5hctA:
undetectable		 4r21A-5hctA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		4 ALA A 114
ILE A  26
ILE A  62
VAL B 347
 None
 0.77A 4r21A-5hftA:
undetectable		 4r21A-5hftA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 ALA A 255
ILE A 438
GLY A 359
ILE A 247
VAL A 328
 None
 1.01A 4r21A-5m41A:
undetectable		 4r21A-5m41A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 ILE A 319
GLY A 331
ILE A 423
VAL A 347
 None
 0.81A 4r21A-5od2A:
undetectable		 4r21A-5od2A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 4 ALA A 238
GLY A 215
ILE A 278
VAL A 272
 None
PLP  A 702 (-3.4A)
None
HEM  A 701 (-4.1A)
 0.82A 4r21A-5ohxA:
undetectable		 4r21A-5ohxA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 ALA A 262
GLY A 274
ILE A 162
VAL A 147
 None
FAD  A 501 (-3.5A)
None
None
 0.78A 4r21A-5xgvA:
undetectable		 4r21A-5xgvA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpc DNAATION
FACTOR-RELATED
PROTEIN 4

(Drosophila
melanogaster) 		PF02017
(CIDE-N) 		4 ALA A 117
ILE A  72
ILE A 119
VAL A  52
 None
 0.66A 4r21A-5xpcA:
undetectable		 4r21A-5xpcA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 ALA A 111
GLY A  88
ILE A 107
VAL A  63
 None
 0.75A 4r21A-5yvsA:
undetectable		 4r21A-5yvsA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 4 ALA A 126
ILE A 218
SER A 378
ILE A 382
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 (-3.2A)
None
 0.48A 4r21A-6b82A:
46.5		 4r21A-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 4 ALA A 307
GLY A 325
SER A 354
ILE A 279
 None
FAD  A 401 (-3.3A)
None
None
 0.82A 4r21A-6fahA:
undetectable		 4r21A-6fahA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 4 ALA A 261
GLY A 458
ILE A 220
VAL A 191
 None
 0.72A 4r21A-6fsaA:
1.6		 4r21A-6fsaA:
undetectable