SIMILAR PATTERNS OF AMINO ACIDS FOR 4R1Z_B_AERB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 SER A 304
GLY A 281
ALA A 282
THR A  19
 None
 0.76A 4r1zB-1dc1A:
0.0		 4r1zB-1dc1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		4 SER A   5
GLY A  11
ALA A  10
SER A  33
 None
 0.90A 4r1zB-1dctA:
undetectable		 4r1zB-1dctA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 ALA A 272
GLY A 422
GLU A 425
SER A 430
 HC1  A 580 (-3.6A)
None
None
None
 0.77A 4r1zB-1fehA:
undetectable		 4r1zB-1fehA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 ALA A 108
GLY A  90
ALA A  91
SER A 142
 None
 0.88A 4r1zB-1he3A:
0.0		 4r1zB-1he3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ily RIBOSOMAL PROTEIN
L18

(Thermus
thermophilus) 		PF00861
(Ribosomal_L18p) 		4 ALA A  76
GLY A  69
ALA A 104
GLU A 106
 None
 0.78A 4r1zB-1ilyA:
undetectable		 4r1zB-1ilyA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9m RIBOSOMAL PROTEIN
L10E

(Haloarcula
marismortui) 		PF00252
(Ribosomal_L16) 		4 ALA J 134
ALA J 145
GLU J 144
SER J  75
 None
 0.89A 4r1zB-1k9mJ:
undetectable		 4r1zB-1k9mJ:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ALA A  92
SER A  31
ALA A  77
GLU A  79
 None
 0.75A 4r1zB-1llaA:
0.0		 4r1zB-1llaA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 ALA A  55
GLY A  61
ALA A  60
THR A 116
 None
 0.89A 4r1zB-1p1vA:
undetectable		 4r1zB-1p1vA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		4 SER A 112
GLY A  11
ALA A  12
SER A  24
 None
 0.82A 4r1zB-1qycA:
undetectable		 4r1zB-1qycA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		4 ALA A  99
GLY A  64
ALA A  65
THR A  12
 None
 0.85A 4r1zB-1sh8A:
undetectable		 4r1zB-1sh8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A  51
GLY A  29
ALA A  30
GLU A  28
 None
 0.83A 4r1zB-1ulsA:
undetectable		 4r1zB-1ulsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		4 ALA A 127
GLY A 173
ALA A 172
GLU A 171
 FAD  A 300 (-3.3A)
None
None
None
 0.87A 4r1zB-1v93A:
undetectable		 4r1zB-1v93A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 GLY A  59
ALA A  58
GLU A  32
THR A  35
 None
 0.75A 4r1zB-1vbjA:
undetectable		 4r1zB-1vbjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 ALA A 515
GLY A 294
ALA A 293
SER A 324
 None
 0.76A 4r1zB-1xf1A:
undetectable		 4r1zB-1xf1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		4 ALA A  24
GLY A  38
ALA A  39
THR A 143
 None
K  A1162 (-3.8A)
None
None
 0.77A 4r1zB-2c94A:
undetectable		 4r1zB-2c94A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 ALA A 390
GLY A  50
ALA A 431
THR A 429
 None
GLC  A1769 (-3.6A)
None
None
 0.81A 4r1zB-2cn3A:
undetectable		 4r1zB-2cn3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		4 ALA A  46
GLY A 148
ALA A 149
GLU A 150
 None
 0.80A 4r1zB-2f4nA:
undetectable		 4r1zB-2f4nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		4 ALA B 273
GLY A 248
ALA A 247
SER A 160
 PO4  A 401 (-3.8A)
None
None
None
 0.85A 4r1zB-2fpgB:
undetectable		 4r1zB-2fpgB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ALA A 526
GLY A 550
ALA A 549
GLU A 547
 None
 0.89A 4r1zB-2hnhA:
undetectable		 4r1zB-2hnhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqv AGR_C_4470P

(Agrobacterium
fabrum) 		PF06228
(ChuX_HutX) 		4 ALA A  43
GLY A 155
ALA A 156
SER A 146
 None
 0.83A 4r1zB-2hqvA:
undetectable		 4r1zB-2hqvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		4 SER A  96
ALA A  72
GLU A  62
SER A  59
 None
 0.79A 4r1zB-2it2A:
undetectable		 4r1zB-2it2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2itb TRNA-(MS(2)IO(6)A)-H
YDROXYLASE, PUTATIVE

(Pseudomonas
putida) 		PF06175
(MiaE) 		4 ALA A 162
GLY A 118
ALA A 119
GLU A 122
 None
EDO  A 506 (-3.6A)
None
FE  A 502 ( 2.0A)
 0.87A 4r1zB-2itbA:
undetectable		 4r1zB-2itbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msk NITROGEN REGULATION
PROTEIN NR(I)

(Salmonella
enterica) 		PF00072
(Response_reg) 		4 ALA A  89
GLY A  97
ALA A  98
SER A  53
 None
 0.78A 4r1zB-2mskA:
undetectable		 4r1zB-2mskA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ALA A 312
GLY A 280
ALA A 281
GLU A 284
 None
 0.86A 4r1zB-2ohhA:
undetectable		 4r1zB-2ohhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v76 DOCKING PROTEIN 1

(Homo sapiens) 		PF02174
(IRS) 		4 ALA A  16
GLY A  73
ALA A  72
SER A  69
 None
SO4  A1106 (-3.5A)
None
None
 0.74A 4r1zB-2v76A:
undetectable		 4r1zB-2v76A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		4 ALA A  94
ALA A 254
GLU A 257
THR A 258
 REA  A1445 ( 3.7A)
HEM  A1444 (-3.3A)
None
HEM  A1444 ( 3.3A)
 0.79A 4r1zB-2ve3A:
36.4		 4r1zB-2ve3A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo8 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF12135
(Sialidase_penC) 		4 GLY A1054
ALA A1053
GLU A 972
THR A 971
 None
 0.83A 4r1zB-2vo8A:
undetectable		 4r1zB-2vo8A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 GLY A 131
ALA A 132
THR A 128
SER A 124
 None
 0.87A 4r1zB-2x98A:
undetectable		 4r1zB-2x98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ALA A 243
GLY A 457
ALA A 502
GLU A 458
 None
 0.78A 4r1zB-2xaxA:
undetectable		 4r1zB-2xaxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		4 ALA A 273
GLY A 241
ALA A 242
THR A 246
 None
 0.49A 4r1zB-3b9yA:
undetectable		 4r1zB-3b9yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		4 ALA A 190
ALA A 197
THR A 228
SER A 276
 None
 0.82A 4r1zB-3c3kA:
undetectable		 4r1zB-3c3kA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 ALA B 100
GLY B 128
ALA B 129
THR B 163
 None
 0.71A 4r1zB-3cdkB:
undetectable		 4r1zB-3cdkB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 GLY A 192
ALA A 193
GLU A 196
THR A 197
 None
None
FEO  A 501 (-2.1A)
None
 0.65A 4r1zB-3chiA:
2.0		 4r1zB-3chiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		4 ALA A 206
GLY A 144
ALA A 145
GLU A 143
 None
 0.81A 4r1zB-3czpA:
undetectable		 4r1zB-3czpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		4 GLY A  17
ALA A  18
GLU A  19
SER A 281
 None
 0.78A 4r1zB-3e5zA:
undetectable		 4r1zB-3e5zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ALA A 108
ALA A 411
GLU A 451
THR A 452
 None
 0.89A 4r1zB-3fhhA:
undetectable		 4r1zB-3fhhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 GLY A 354
ALA A 355
GLU A 360
SER A 150
 None
 0.80A 4r1zB-3hpaA:
undetectable		 4r1zB-3hpaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1

(Vitis vinifera) 		PF05368
(NmrA) 		4 SER A 118
GLY A  17
ALA A  18
SER A  30
 None
 0.83A 4r1zB-3i5mA:
undetectable		 4r1zB-3i5mA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		4 ALA A   5
GLY A 265
ALA A 264
GLU A 263
 None
 0.87A 4r1zB-3im8A:
undetectable		 4r1zB-3im8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j83 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A  77
GLY A 178
ALA A 181
SER A 187
 None
 0.80A 4r1zB-3j83A:
undetectable		 4r1zB-3j83A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 ALA A 273
SER A  31
ALA A 202
THR A 222
 None
 0.86A 4r1zB-3pgyA:
2.1		 4r1zB-3pgyA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 133
GLY A 329
ALA A 330
THR A 334
 HEM  A 900 (-3.3A)
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
HEM  A 900 ( 3.2A)
 0.32A 4r1zB-3pm0A:
41.0		 4r1zB-3pm0A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A 465
SER A 406
GLY A 517
ALA A 518
 None
 0.87A 4r1zB-3pqsA:
undetectable		 4r1zB-3pqsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ALA A 146
GLY A 175
ALA A 176
SER A 222
 None
 0.87A 4r1zB-3q6dA:
undetectable		 4r1zB-3q6dA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6s CHROMOBOX PROTEIN
HOMOLOG 1

(Homo sapiens) 		PF01393
(Chromo_shadow) 		4 ALA A 149
GLY A 124
ALA A 125
SER A 129
 None
 0.81A 4r1zB-3q6sA:
undetectable		 4r1zB-3q6sA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		4 ALA A 350
SER A 196
GLY A 401
ALA A 402
 None
 0.82A 4r1zB-3qfhA:
undetectable		 4r1zB-3qfhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		4 ALA A  16
SER A 113
GLY A 280
ALA A 279
 None
None
FAD  A 501 (-3.1A)
None
 0.84A 4r1zB-3r9uA:
undetectable		 4r1zB-3r9uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		4 ALA A 118
SER A 143
GLY A  92
ALA A  91
 None
None
NAP  A 240 (-4.5A)
NAP  A 240 (-3.6A)
 0.87A 4r1zB-3rkrA:
undetectable		 4r1zB-3rkrA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A 117
GLY A 146
ALA A 145
GLU A 143
 None
 0.86A 4r1zB-3u9sA:
undetectable		 4r1zB-3u9sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		4 ALA A  70
GLY A 121
ALA A 120
GLU A 119
 None
None
PGO  A1003 ( 3.8A)
None
 0.87A 4r1zB-3wicA:
undetectable		 4r1zB-3wicA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		4 ALA A  23
GLY A  14
ALA A  15
THR A  45
 None
FAD  A 601 (-3.2A)
None
None
 0.89A 4r1zB-3x0vA:
undetectable		 4r1zB-3x0vA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 4 SER A 144
GLY A 106
ALA A 107
THR A 111
 None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.8A)
None
 0.86A 4r1zB-3zbqA:
undetectable		 4r1zB-3zbqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 GLY A 134
ALA A 135
GLU A 131
SER A 138
 None
 0.80A 4r1zB-3zh4A:
undetectable		 4r1zB-3zh4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ALA A 483
GLY A 557
ALA A 558
SER A 313
 None
 0.76A 4r1zB-4a01A:
undetectable		 4r1zB-4a01A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 ALA A  75
GLY A 112
GLU A 113
SER A 399
 None
 0.79A 4r1zB-4au2A:
undetectable		 4r1zB-4au2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 ALA A 362
SER A 304
ALA A 328
GLU A 306
 None
 0.84A 4r1zB-4c60A:
undetectable		 4r1zB-4c60A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 GLY A 123
ALA A 122
THR A  95
SER A 100
 None
 0.86A 4r1zB-4cczA:
undetectable		 4r1zB-4cczA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ALA A 111
GLY A  87
GLU A  89
THR A 154
 None
 0.75A 4r1zB-4cgrA:
undetectable		 4r1zB-4cgrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 GLY A 324
ALA A 325
GLU A 327
SER A 426
 None
 0.79A 4r1zB-4dxbA:
undetectable		 4r1zB-4dxbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 ALA A  87
GLY A  91
ALA A  93
GLU A  95
 None
 0.85A 4r1zB-4humA:
undetectable		 4r1zB-4humA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 ALA A  87
GLY A  91
ALA A  93
THR A  96
 None
 0.84A 4r1zB-4humA:
undetectable		 4r1zB-4humA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 ALA A 202
GLY A 236
ALA A 235
THR A 251
 None
 0.85A 4r1zB-4icqA:
undetectable		 4r1zB-4icqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 ALA A 148
GLY A 189
ALA A 190
THR A 434
 None
 0.88A 4r1zB-4impA:
undetectable		 4r1zB-4impA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 ALA A 131
SER A 282
GLY A 151
ALA A 152
 None
 0.80A 4r1zB-4kv7A:
undetectable		 4r1zB-4kv7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 122
ALA A 210
GLU A 199
SER A 207
 None
 0.80A 4r1zB-4l1fA:
0.8		 4r1zB-4l1fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 GLY A 150
ALA A 151
GLU A 154
THR A 155
 None
 0.62A 4r1zB-4maaA:
undetectable		 4r1zB-4maaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		4 ALA A  83
GLY A  75
ALA A  74
THR A  34
 None
 0.61A 4r1zB-4n0qA:
undetectable		 4r1zB-4n0qA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 113
GLY A 301
ALA A 302
GLU A 305
THR A 306
 HEM  A 600 ( 2.9A)
3QZ  A 601 ( 3.0A)
3QZ  A 601 (-2.9A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.2A)
 0.64A 4r1zB-4nkyA:
50.5		 4r1zB-4nkyA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 ALA A 120
SER A 232
GLY A 235
ALA A 236
 None
 0.77A 4r1zB-4nn3A:
undetectable		 4r1zB-4nn3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A 472
SER A 412
GLY A 526
ALA A 527
 None
 0.87A 4r1zB-4o4xA:
undetectable		 4r1zB-4o4xA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 ALA A  90
GLY A  59
ALA A  60
GLU A  63
 None
 0.76A 4r1zB-4ookA:
undetectable		 4r1zB-4ookA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 4 ALA B 362
SER B 318
GLY B 322
GLU B 321
 None
 0.82A 4r1zB-4oouB:
undetectable		 4r1zB-4oouB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ALA A 126
ALA A 110
GLU A 112
SER A  88
 None
 0.77A 4r1zB-4ptsA:
undetectable		 4r1zB-4ptsA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		6 ALA A 120
GLY A 301
ALA A 302
GLU A 305
THR A 306
SER A 367
 AER  A 602 (-3.7A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
None
HEM  A 601 ( 3.3A)
AER  A 602 (-3.5A)
 0.50A 4r1zB-4r20A:
50.3		 4r1zB-4r20A:
46.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8

(Homo sapiens) 		PF03540
(TFIID_30kDa)
PF07524
(Bromo_TP) 		4 ALA A 146
GLY B  73
ALA B  76
THR B  96
 None
 0.85A 4r1zB-4wv4A:
undetectable		 4r1zB-4wv4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		4 GLY A 149
ALA A 170
GLU A 169
SER A 211
 None
 0.64A 4r1zB-4yeiA:
undetectable		 4r1zB-4yeiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		4 GLY A 270
ALA A 271
GLU A 267
SER A 312
 None
 0.86A 4r1zB-5ao5A:
undetectable		 4r1zB-5ao5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN

(Porphyromonas
gingivalis) 		no annotation 4 ALA C 153
GLY C 261
ALA C 260
SER C  57
 None
 0.76A 4r1zB-5dhmC:
undetectable		 4r1zB-5dhmC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		4 ALA A 109
GLY A  85
ALA A  84
SER A  25
 None
 0.79A 4r1zB-5e2cA:
undetectable		 4r1zB-5e2cA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 GLY A 300
ALA A 299
GLU A 298
THR A 200
 None
 0.83A 4r1zB-5esyA:
undetectable		 4r1zB-5esyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 ALA A 306
SER A 122
GLY A 354
ALA A 357
 None
 0.90A 4r1zB-5f15A:
undetectable		 4r1zB-5f15A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		4 GLY A 120
ALA A 121
GLU A 122
SER A 127
 None
 0.78A 4r1zB-5f4bA:
undetectable		 4r1zB-5f4bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 ALA I  46
GLY I  15
ALA I  16
SER I 169
 None
 0.89A 4r1zB-5fmgI:
undetectable		 4r1zB-5fmgI:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 ALA I 126
GLY I  45
ALA I  46
SER I 169
 None
 0.86A 4r1zB-5fmgI:
undetectable		 4r1zB-5fmgI:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A

(Bacillus sp.
HIL-Y85/54728;
Staphylococcus
aureus) 		PF02216
(B)
PF02441
(Flavoprotein) 		4 ALA A 185
ALA A 221
GLU A 220
SER A 206
 None
 0.86A 4r1zB-5h75A:
undetectable		 4r1zB-5h75A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i20 UNCHARACTERIZED
PROTEIN

(Starkeya
novella) 		PF00892
(EamA) 		4 ALA A 246
GLY A 277
ALA A 278
THR A 282
 None
None
None
OLC  A 302 ( 4.4A)
 0.81A 4r1zB-5i20A:
undetectable		 4r1zB-5i20A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A  92
SER A 169
GLY A 156
ALA A 155
 None
 0.85A 4r1zB-5i8iA:
undetectable		 4r1zB-5i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens) 		PF00316
(FBPase) 		4 GLY B 340
ALA B 339
THR B 236
SER B 215
 None
 0.82A 4r1zB-5iz3B:
undetectable		 4r1zB-5iz3B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 ALA A 401
SER A 347
GLY A 342
ALA A 341
THR A 194
 None
 1.38A 4r1zB-5lb8A:
undetectable		 4r1zB-5lb8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 SER A 915
GLY A1000
ALA A1001
SER A 974
 None
 0.81A 4r1zB-5n8pA:
undetectable		 4r1zB-5n8pA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 SER A 915
GLY A1000
ALA A1001
SER A 974
 None
 0.82A 4r1zB-5n97A:
undetectable		 4r1zB-5n97A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 318
GLY A 374
ALA A 373
GLU A 320
 None
 0.89A 4r1zB-5na7A:
undetectable		 4r1zB-5na7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 ALA B 925
GLY B 131
ALA B 130
GLU B 140
 None
 0.89A 4r1zB-5nd1B:
undetectable		 4r1zB-5nd1B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile) 		no annotation 4 GLY C 255
ALA C 256
GLU C 259
THR C 260
 None
 0.87A 4r1zB-5ol2C:
undetectable		 4r1zB-5ol2C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 GLY A 108
ALA A 107
GLU A 106
SER A 140
 None
 0.85A 4r1zB-5ufvA:
undetectable		 4r1zB-5ufvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 ALA C 439
ALA C 484
GLU C 485
THR C 481
 None
 0.88A 4r1zB-5wvoC:
undetectable		 4r1zB-5wvoC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ALA A 265
GLY A 294
ALA A 295
SER A 341
 None
 0.73A 4r1zB-5x49A:
undetectable		 4r1zB-5x49A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 7 ALA A 126
SER A 215
GLY A 312
ALA A 313
GLU A 316
THR A 317
SER A 378
 HEM  A 601 (-3.8A)
AER  A 602 (-3.4A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
None
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
 0.58A 4r1zB-6b82A:
52.1		 4r1zB-6b82A:
13.16