SIMILAR PATTERNS OF AMINO ACIDS FOR 4R1Z_A_AERA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Bacillus
subtilis)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
5 ALA A  98
ILE A 217
GLY A  66
ALA A  67
THR A  16
None
0.94A 4r1zA-1ao0A:
undetectable
4r1zA-1ao0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE


(Salmonella
enterica)
PF01739
(CheR)
PF03705
(CheR_N)
5 SER A 132
ILE A 133
GLY A 127
ALA A 163
VAL A 206
None
1.08A 4r1zA-1bc5A:
undetectable
4r1zA-1bc5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE


(Shewanella
oneidensis)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
5 ALA A 515
ILE A 131
GLY A 137
ALA A 136
VAL A 535
None
FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.3A)
None
1.19A 4r1zA-1d4eA:
undetectable
4r1zA-1d4eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK


(Escherichia
coli)
PF00012
(HSP70)
5 ASP D   8
GLY D 374
ALA D 174
THR D 173
VAL D 192
None
1.26A 4r1zA-1dkgD:
undetectable
4r1zA-1dkgD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE


(Bacillus
subtilis)
PF01648
(ACPS)
5 ALA A  59
ILE A  15
ASP A   8
ALA A 111
THR A 104
None
None
None
None
NA  A1255 (-3.8A)
1.27A 4r1zA-1f80A:
undetectable
4r1zA-1f80A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE


(Acinetobacter
calcoaceticus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 209
TYR A  91
GLY A 317
ALA A 181
VAL A 202
None
None
None
None
NAD  A 375 (-3.6A)
1.15A 4r1zA-1f8fA:
undetectable
4r1zA-1f8fA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1


(Streptomyces
coelicolor)
PF00067
(p450)
5 SER A 347
ASP A 324
GLY A 322
ALA A 320
VAL A 316
None
1.07A 4r1zA-1gwiA:
29.9
4r1zA-1gwiA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1


(Streptomyces
coelicolor)
PF00067
(p450)
5 SER A 347
ILE A 346
GLY A 322
ALA A 320
VAL A 316
None
1.07A 4r1zA-1gwiA:
29.9
4r1zA-1gwiA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
5 ALA A 478
ILE A 412
ALA A 474
THR A 398
VAL A 500
ADX  A 575 (-4.5A)
None
None
None
None
1.18A 4r1zA-1i2dA:
0.2
4r1zA-1i2dA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl7 MONOMER HEMOGLOBIN
COMPONENT III


(Glycera
dibranchiata)
PF00042
(Globin)
5 ALA A 113
SER A 138
ILE A 137
GLY A 107
VAL A  62
None
None
None
None
HEM  A 148 ( 4.0A)
1.12A 4r1zA-1jl7A:
1.4
4r1zA-1jl7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA


(Thermotoga
maritima)
PF13365
(Trypsin_2)
5 ALA A 159
SER A 148
GLY A 219
ALA A 236
VAL A 175
None
1.17A 4r1zA-1l1jA:
undetectable
4r1zA-1l1jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.)
PF07859
(Abhydrolase_3)
5 ALA A 296
SER A 255
ILE A 188
GLY A 304
ALA A 305
None
1.15A 4r1zA-1lzkA:
undetectable
4r1zA-1lzkA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus)
PF00067
(p450)
5 ALA A 113
ASP A 290
GLY A 293
ALA A 294
THR A 298
DIF  A 501 (-3.6A)
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
0.95A 4r1zA-1nr6A:
44.1
4r1zA-1nr6A:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE


(Desulfovibrio
vulgaris)
PF03063
(Prismane)
5 ALA A 404
ILE A 372
GLY A 457
ALA A 456
VAL A 453
None
1.26A 4r1zA-1oa1A:
1.2
4r1zA-1oa1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 252
ILE A 293
GLY A 259
ALA A 258
VAL A 281
NAD  A 400 ( 3.8A)
None
None
None
None
1.00A 4r1zA-1pl8A:
undetectable
4r1zA-1pl8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)


(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ILE A 393
GLY A 349
ALA A 348
THR A 329
VAL A 323
None
1.22A 4r1zA-1qgrA:
undetectable
4r1zA-1qgrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE


(Pseudomonas
denitrificans
(nomen
rejiciendum))
PF00590
(TP_methylase)
5 ALA A 241
ILE A 141
GLY A 135
ALA A 131
VAL A 181
None
None
None
SAH  A1501 (-3.4A)
None
1.15A 4r1zA-1s4dA:
undetectable
4r1zA-1s4dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX


(Bacillus
subtilis)
PF02504
(FA_synthesis)
5 ALA A  16
SER A  79
GLY A   9
ALA A  98
VAL A   5
None
1.26A 4r1zA-1vi1A:
undetectable
4r1zA-1vi1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis)
PF00908
(dTDP_sugar_isom)
5 ALA A 153
TYR A  64
ILE A  89
ASP A 151
ALA A 177
None
1.24A 4r1zA-1wa4A:
undetectable
4r1zA-1wa4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00291
(PALP)
5 ALA B 296
SER B 335
GLY B 374
ALA B 343
VAL B 350
None
None
None
PLP  B 400 ( 3.8A)
None
1.19A 4r1zA-1wdwB:
undetectable
4r1zA-1wdwB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983


(Mycobacterium
tuberculosis)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ALA A 119
SER A 108
GLY A 182
ALA A 207
VAL A 135
None
1.23A 4r1zA-1y8tA:
undetectable
4r1zA-1y8tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011


(Haemophilus
influenzae)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ALA A 307
SER A 358
ILE A 359
GLY A 353
ALA A 352
None
1.22A 4r1zA-1yzyA:
undetectable
4r1zA-1yzyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE


(Thermus
thermophilus)
PF05067
(Mn_catalase)
5 ALA A 121
TYR A 291
ASP A 277
GLY A 275
ALA A 274
None
1.17A 4r1zA-2cwlA:
undetectable
4r1zA-2cwlA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES


(Escherichia
coli)
PF02615
(Ldh_2)
5 ALA A 182
TYR A  56
ILE A 268
GLY A 122
VAL A 144
NAD  A1001 (-3.2A)
None
EDO  A1019 ( 4.7A)
NAD  A1001 (-3.9A)
NAD  A1001 (-4.4A)
1.24A 4r1zA-2g8yA:
undetectable
4r1zA-2g8yA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES


(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
1.17A 4r1zA-2gkoA:
undetectable
4r1zA-2gkoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC


(Salmonella
enterica)
PF00291
(PALP)
5 ALA A  87
ILE A 141
GLY A 101
ALA A 122
VAL A 125
None
0.94A 4r1zA-2gn1A:
undetectable
4r1zA-2gn1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471


(Haemophilus
influenzae)
PF01032
(FecCD)
5 SER A 208
GLY A  75
ALA A  77
THR A 286
VAL A  82
None
1.26A 4r1zA-2nq2A:
undetectable
4r1zA-2nq2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE


(Rattus
norvegicus)
PF00171
(Aldedh)
5 TYR A 761
SER A 805
ILE A 809
GLY A 711
ALA A 710
None
1.20A 4r1zA-2o2qA:
undetectable
4r1zA-2o2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  57
SER A 328
ILE A 327
GLY A  43
ALA A  95
None
0.97A 4r1zA-2o56A:
undetectable
4r1zA-2o56A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE


(Deinococcus
radiodurans)
PF07992
(Pyr_redox_2)
5 ALA A 303
ILE A  14
GLY A  20
ALA A  19
VAL A 285
None
None
None
FAD  A 348 (-3.3A)
None
1.24A 4r1zA-2q7vA:
undetectable
4r1zA-2q7vA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE


(Helianthus
annuus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A  55
ILE A  98
GLY A 162
ALA A 398
VAL A 146
None
1.22A 4r1zA-2wuaA:
undetectable
4r1zA-2wuaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE


(Streptococcus
pneumoniae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD)
5 ALA A 453
ILE A 513
GLY A 518
ALA A 562
VAL A 478
None
SO4  A2152 (-4.4A)
None
None
None
1.10A 4r1zA-2ya1A:
undetectable
4r1zA-2ya1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE


(Streptococcus
pneumoniae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 ALA A  -2
ILE A  58
GLY A  63
ALA A 107
VAL A  23
None
1.08A 4r1zA-2ya2A:
undetectable
4r1zA-2ya2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli)
PF00595
(PDZ)
PF13365
(Trypsin_2)
5 ALA A 129
SER A 118
GLY A 178
ALA A 196
VAL A 145
None
1.25A 4r1zA-2zleA:
undetectable
4r1zA-2zleA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti)
PF13407
(Peripla_BP_4)
5 SER A 250
ILE A  63
GLY A  19
ALA A  21
VAL A  34
None
1.23A 4r1zA-3ejwA:
undetectable
4r1zA-3ejwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis)
PF04493
(Endonuclease_5)
5 ALA A  90
GLY A 117
ALA A 127
THR A 138
VAL A 132
None
1.17A 4r1zA-3gocA:
undetectable
4r1zA-3gocA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
5 ALA A 263
ILE A 194
ASP A 262
GLY A 237
ALA A 238
None
None
EOH  A 348 ( 2.5A)
None
None
1.20A 4r1zA-3h4xA:
undetectable
4r1zA-3h4xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
PF03598
(CdhC)
6 ALA M 109
SER A 618
ILE A 623
GLY M  28
ALA M  29
VAL A 228
None
1.20A 4r1zA-3i04M:
1.2
4r1zA-3i04M:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE


(Bacillus
subtilis)
PF01593
(Amino_oxidase)
5 SER A 374
ILE A 375
GLY A 371
ALA A 370
THR A 309
None
1.17A 4r1zA-3i6dA:
undetectable
4r1zA-3i6dA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri)
PF00936
(BMC)
5 ALA A 284
TYR A 249
ILE A 265
GLY A 231
ALA A 225
None
1.21A 4r1zA-3io0A:
undetectable
4r1zA-3io0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipr PTS SYSTEM, IIA
COMPONENT


(Enterococcus
faecalis)
PF03610
(EIIA-man)
5 ALA A   7
ILE A  91
ALA A  51
THR A  50
VAL A  79
None
1.26A 4r1zA-3iprA:
undetectable
4r1zA-3iprA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 193
ILE A 315
GLY A 311
ALA A 310
VAL A 304
None
1.27A 4r1zA-3jv7A:
undetectable
4r1zA-3jv7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k88 CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 1


(Burkholderia
cepacia)
PF01613
(Flavin_Reduct)
5 ALA A1129
GLY A1090
ALA A1089
THR A1173
VAL A1033
None
1.15A 4r1zA-3k88A:
undetectable
4r1zA-3k88A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
5 ALA A 207
SER A 132
GLY A 114
ALA A 113
THR A 192
None
1.24A 4r1zA-3k9dA:
undetectable
4r1zA-3k9dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE


(Streptomyces
avermitilis)
PF00857
(Isochorismatase)
5 ALA A 214
TYR A  50
ILE A  48
ALA A 205
THR A 206
None
1.23A 4r1zA-3kl2A:
undetectable
4r1zA-3kl2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwu SERINE PROTEASE
HTRA1


(Homo sapiens)
PF13365
(Trypsin_2)
5 ALA A 281
SER A 270
GLY A 341
ALA A 354
VAL A 297
None
1.21A 4r1zA-3nwuA:
undetectable
4r1zA-3nwuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 ALA A 542
ILE A 496
ASP A 672
GLY A 414
ALA A 413
None
1.25A 4r1zA-3o8lA:
undetectable
4r1zA-3o8lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 ALA A 542
ILE A 525
ASP A 672
GLY A 414
ALA A 413
None
1.22A 4r1zA-3o8lA:
undetectable
4r1zA-3o8lA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens)
PF00067
(p450)
5 ALA A 133
ASP A 326
GLY A 329
ALA A 330
THR A 334
HEM  A 900 (-3.3A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
HEM  A 900 ( 3.2A)
0.40A 4r1zA-3pm0A:
41.5
4r1zA-3pm0A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli)
PF00860
(Xan_ur_permease)
5 ALA A 140
ILE A 329
GLY A  30
ALA A  31
VAL A  37
None
None
None
URA  A 430 ( 3.8A)
None
1.04A 4r1zA-3qe7A:
undetectable
4r1zA-3qe7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)


(Shewanella sp.
W3-18-1)
PF01717
(Meth_synt_2)
6 ALA A 140
TYR A 245
ILE A 260
ASP A 188
ALA A  20
THR A 320
None
1.44A 4r1zA-3rpdA:
undetectable
4r1zA-3rpdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ALA A 143
SER A 132
GLY A 200
ALA A 218
VAL A 159
None
1.20A 4r1zA-3stjA:
undetectable
4r1zA-3stjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Thermotoga
maritima)
PF13458
(Peripla_BP_6)
5 ALA A 292
ASP A 244
GLY A 242
THR A 118
VAL A  93
EDO  A 403 (-3.5A)
EDO  A 403 ( 2.8A)
PHE  A 400 ( 4.2A)
PHE  A 400 (-2.8A)
PHE  A 400 (-4.7A)
1.12A 4r1zA-3td9A:
undetectable
4r1zA-3td9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1


(Brucella
melitensis)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ALA A  93
ILE A 281
GLY A  78
ALA A  79
THR A  81
None
1.02A 4r1zA-3vabA:
undetectable
4r1zA-3vabA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593)
PF00245
(Alk_phosphatase)
5 TYR A 435
ASP A 269
GLY A 272
ALA A 271
THR A 279
None
ZN  A 504 ( 2.1A)
None
None
None
1.27A 4r1zA-3wbhA:
undetectable
4r1zA-3wbhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE


(Bifidobacterium
longum)
PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C)
5 ALA A 347
TYR A 471
GLY A 340
ALA A 388
VAL A 484
None
1.22A 4r1zA-3wfzA:
undetectable
4r1zA-3wfzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ww3 L-RIBOSE ISOMERASE

(Cellulomonas
parahominis)
no annotation 5 ALA A  18
TYR A  47
ILE A   6
GLY A  39
ALA A  38
None
1.19A 4r1zA-3ww3A:
undetectable
4r1zA-3ww3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 5 ALA A 230
SER A 110
ILE A 178
GLY A 181
VAL A 187
None
F1P  A 702 (-2.6A)
None
F1P  A 702 (-3.6A)
None
1.06A 4r1zA-4bb9A:
undetectable
4r1zA-4bb9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4biz SENSOR PROTEIN CPXA

(Escherichia
coli)
PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c)
5 ILE A 357
GLY A 420
ALA A 422
THR A 426
VAL A 435
None
ADP  A 501 (-3.6A)
None
None
None
1.18A 4r1zA-4bizA:
undetectable
4r1zA-4bizA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
mazei)
PF01458
(UPF0051)
5 SER A 107
ILE A 162
ASP A 128
ALA A 127
THR A 122
None
1.26A 4r1zA-4dn7A:
undetectable
4r1zA-4dn7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 5 ALA P  62
ILE P 215
GLY P 174
ALA P 173
VAL P 107
None
1.17A 4r1zA-4dvyP:
undetectable
4r1zA-4dvyP:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irv CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 5 ALA A  62
ILE A 215
GLY A 174
ALA A 173
VAL A 107
None
1.27A 4r1zA-4irvA:
undetectable
4r1zA-4irvA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmd PUTATIVE
UNCHARACTERIZED
PROTEIN MPPR


(Streptomyces
hygroscopicus)
PF06314
(ADC)
5 ALA A  92
ILE A 248
ASP A  66
GLY A 276
VAL A  62
None
1.14A 4r1zA-4jmdA:
undetectable
4r1zA-4jmdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY
LIPOPROTEIN LPTE


(Salmonella
enterica)
PF04390
(LptE)
5 ALA B  50
ASP B 149
ALA B 151
THR B 120
VAL B  80
None
0.94A 4r1zA-4n4rB:
undetectable
4r1zA-4n4rB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 182
SER A 160
GLY A 120
ALA A 198
VAL A 100
None
1.17A 4r1zA-4na3A:
undetectable
4r1zA-4na3A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
5 ALA A 113
ASP A 298
GLY A 301
ALA A 302
VAL A 483
HEM  A 600 ( 2.9A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 3.0A)
3QZ  A 601 (-2.9A)
3QZ  A 601 (-4.1A)
0.96A 4r1zA-4nkyA:
51.1
4r1zA-4nkyA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
8 ALA A 113
TYR A 201
ILE A 205
ASP A 298
GLY A 301
ALA A 302
THR A 306
VAL A 482
HEM  A 600 ( 2.9A)
None
3QZ  A 601 ( 3.4A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 3.0A)
3QZ  A 601 (-2.9A)
HEM  A 600 ( 3.2A)
3QZ  A 601 (-4.1A)
0.68A 4r1zA-4nkyA:
51.1
4r1zA-4nkyA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Thermococcus
kodakarensis)
PF03009
(GDPD)
5 ALA A 101
ILE A 231
GLY A  14
ALA A  30
VAL A   9
None
1.28A 4r1zA-4oecA:
undetectable
4r1zA-4oecA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy8 PUTATIVE SECRETED
CELLULOSE-BINDING
PROTEIN


(Streptomyces
coelicolor)
PF03067
(LPMO_10)
5 ALA A 104
ILE A 209
ASP A 101
GLY A 100
ALA A  99
None
1.24A 4r1zA-4oy8A:
undetectable
4r1zA-4oy8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA


(Kluyvera
cryocrescens)
PF01804
(Penicil_amidase)
5 ALA B 430
GLY B 343
ALA B 345
THR B 447
VAL B 442
None
1.23A 4r1zA-4pelB:
undetectable
4r1zA-4pelB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C


(Zea mays)
PF00171
(Aldedh)
5 ALA A  93
GLY A 125
ALA A 126
THR A 173
VAL A 100
None
1.22A 4r1zA-4pxlA:
undetectable
4r1zA-4pxlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0s L-RIBOSE ISOMERASE

(Acinetobacter
sp. DL-28)
no annotation 5 ALA A  18
TYR A  47
ILE A   6
GLY A  39
ALA A  38
None
1.21A 4r1zA-4q0sA:
undetectable
4r1zA-4q0sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A2717
SER A2695
GLY A2656
ALA A2733
VAL A2637
None
1.24A 4r1zA-4qyrA:
undetectable
4r1zA-4qyrA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2


(Danio rerio)
PF00067
(p450)
7 ALA A 120
TYR A 208
ILE A 212
GLY A 301
ALA A 302
THR A 306
VAL A 480
AER  A 602 (-3.7A)
None
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
0.74A 4r1zA-4r20A:
24.7
4r1zA-4r20A:
46.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgb CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 SER A 260
ILE A 263
GLY A  33
ALA A  28
VAL A  23
None
0.94A 4r1zA-4rgbA:
undetectable
4r1zA-4rgbA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 310
ILE A   7
GLY A  13
ALA A  12
VAL A 293
None
FAD  A 501 ( 4.9A)
None
FAD  A 501 (-3.8A)
None
1.17A 4r1zA-4ywoA:
undetectable
4r1zA-4ywoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis)
no annotation 5 ALA A 565
SER A 577
ILE A 578
GLY A 554
ALA A 553
None
FMN  A 900 (-2.6A)
None
FMN  A 900 (-3.2A)
FMN  A 900 ( 4.3A)
1.26A 4r1zA-4z38A:
undetectable
4r1zA-4z38A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris)
PF00759
(Glyco_hydro_9)
5 ALA A  87
TYR A  23
SER A  19
ILE A  20
GLY A 425
None
1.17A 4r1zA-4zg8A:
undetectable
4r1zA-4zg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris)
PF00759
(Glyco_hydro_9)
5 TYR A  23
SER A  19
ILE A  20
GLY A 425
ALA A 428
None
1.24A 4r1zA-4zg8A:
undetectable
4r1zA-4zg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN


(Streptococcus
pyogenes)
PF01597
(GCV_H)
5 SER A  63
ILE A  49
ASP A  41
ALA A  68
THR A  97
None
1.09A 4r1zA-5a35A:
undetectable
4r1zA-5a35A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA


(Methanothermobacter
marburgensis)
PF02240
(MCR_gamma)
5 ALA C  99
ILE C  88
ASP C  92
GLY C 152
VAL C 141
None
1.17A 4r1zA-5a8rC:
undetectable
4r1zA-5a8rC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum)
no annotation 5 ALA A 208
ILE A  35
GLY A 198
ALA A 199
THR A 200
None
1.18A 4r1zA-5bk6A:
undetectable
4r1zA-5bk6A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 SER b 462
ILE b 463
ASP b 481
ALA b 480
THR b 478
None
1.17A 4r1zA-5gw5b:
undetectable
4r1zA-5gw5b:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))


(Thermoplasma
acidophilum)
PF00171
(Aldedh)
5 ILE A 201
ASP A  47
ALA A  49
THR A 168
VAL A 143
None
1.00A 4r1zA-5izdA:
undetectable
4r1zA-5izdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 5 ALA A 278
TYR A 322
SER A  10
GLY A  12
ALA A  62
None
1.22A 4r1zA-5mg5A:
undetectable
4r1zA-5mg5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE


(Sulfolobus
solfataricus)
no annotation 5 TYR A 208
ILE A 212
ASP A 222
GLY A 201
THR A 239
None
1.27A 4r1zA-5w3wA:
undetectable
4r1zA-5w3wA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT


(Oryctolagus
cuniculus)
no annotation 5 ALA B 341
ILE B 366
ASP B 261
GLY B 264
ALA B 265
None
1.09A 4r1zA-5w7aB:
undetectable
4r1zA-5w7aB:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3x UNCHARACTERIZED
PROTEIN CBIQ


(Rhodobacter
capsulatus)
PF02361
(CbiQ)
5 ALA Q 112
ILE Q 237
GLY Q  29
ALA Q  32
VAL Q  37
None
1.14A 4r1zA-5x3xQ:
undetectable
4r1zA-5x3xQ:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN


(Clostridium
perfringens)
no annotation 5 ALA A 292
TYR A 255
ILE A 271
GLY A 239
VAL A 259
None
1.24A 4r1zA-5xcbA:
undetectable
4r1zA-5xcbA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN


(Clostridium
perfringens)
no annotation 5 ALA A 292
TYR A 255
ILE A 271
GLY A 239
VAL A 259
None
1.24A 4r1zA-5xccA:
undetectable
4r1zA-5xccA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xum HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE


(Thermotoga
maritima)
no annotation 5 ALA A  55
TYR A 162
ILE A 165
GLY A  86
VAL A  68
None
1.14A 4r1zA-5xumA:
undetectable
4r1zA-5xumA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1


(Danio rerio)
no annotation 7 ALA A 126
TYR A 214
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
0.68A 4r1zA-6b82A:
52.7
4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1


(Danio rerio)
no annotation 6 ALA A 126
TYR A 214
SER A 215
GLY A 312
ALA A 313
VAL A 494
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.4A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
None
0.99A 4r1zA-6b82A:
52.7
4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1


(Danio rerio)
no annotation 7 ALA A 126
TYR A 214
SER A 215
ILE A 218
GLY A 312
ALA A 313
THR A 317
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.4A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
0.44A 4r1zA-6b82A:
52.7
4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis)
no annotation 5 ALA A 190
TYR A 395
ILE A 324
GLY A 162
VAL A 142
None
1.11A 4r1zA-6co7A:
undetectable
4r1zA-6co7A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE


(Acetobacterium
woodii)
no annotation 5 ALA A 344
SER A 354
GLY A 350
ALA A 349
VAL A 371
FAD  A 401 (-3.5A)
None
None
None
None
1.20A 4r1zA-6fahA:
undetectable
4r1zA-6fahA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE


(Acetobacterium
woodii)
no annotation 5 ALA A 344
SER A 354
ILE A 357
GLY A 350
ALA A 349
FAD  A 401 (-3.5A)
None
None
None
None
1.17A 4r1zA-6fahA:
undetectable
4r1zA-6fahA:
10.88