SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZU_D_ACTD202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ASP A  70
VAL A  71
TRP A  24
GLU A  69
 None
 1.18A 4qzuA-1b8aA:
0.0
4qzuD-1b8aA:
0.0		 4qzuA-1b8aA:
14.42
4qzuD-1b8aA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2z CD2 ANTIGEN
(CYTOPLASMIC
TAIL)-BINDING
PROTEIN 2

(Homo sapiens) 		PF02213
(GYF) 		4 LYS A  42
ASP A   1
VAL A   2
TRP A   4
 None
 1.28A 4qzuA-1l2zA:
undetectable
4qzuD-1l2zA:
undetectable		 4qzuA-1l2zA:
25.42
4qzuD-1l2zA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00150
(Cellulase) 		4 ASP A  33
VAL A  66
TRP A  68
GLU A 109
 None
 1.48A 4qzuA-3ndyA:
0.0
4qzuD-3ndyA:
0.0		 4qzuA-3ndyA:
18.29
4qzuD-3ndyA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		4 ASP A  49
VAL A  50
TRP A  17
GLU A  20
 None
 1.48A 4qzuA-3q10A:
0.0
4qzuD-3q10A:
0.0		 4qzuA-3q10A:
17.50
4qzuD-3q10A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		4 ASP A 134
VAL A  82
TRP A  85
GLU A 138
 None
 1.48A 4qzuA-3ro8A:
0.0
4qzuD-3ro8A:
0.0		 4qzuA-3ro8A:
17.77
4qzuD-3ro8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 LYS A 106
VAL A 260
TRP A 265
GLU A 108
 None
 1.46A 4qzuA-3s99A:
0.0
4qzuD-3s99A:
0.0		 4qzuA-3s99A:
16.29
4qzuD-3s99A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2a PUTATIVE
ACETYLTRANSFERASE

(Streptococcus
mutans) 		PF13673
(Acetyltransf_10) 		4 ASP A 165
VAL A 132
TRP A 166
GLU A 134
 None
 1.48A 4qzuA-4e2aA:
0.0
4qzuD-4e2aA:
0.0		 4qzuA-4e2aA:
19.71
4qzuD-4e2aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ASP A 517
VAL A 571
TRP A 521
GLU A 520
 None
 1.49A 4qzuA-4madA:
0.0
4qzuD-4madA:
0.0		 4qzuA-4madA:
13.23
4qzuD-4madA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		4 LYS A 437
ASP A 491
VAL A 493
GLU A 392
 None
 1.50A 4qzuA-4r10A:
0.0
4qzuD-4r10A:
undetectable		 4qzuA-4r10A:
12.06
4qzuD-4r10A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		4 ASP A 346
VAL A 345
TRP A 353
GLU A 352
 None
 1.42A 4qzuA-4z4lA:
0.0
4qzuD-4z4lA:
0.0		 4qzuA-4z4lA:
17.31
4qzuD-4z4lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUP54

(Xenopus laevis) 		PF13874
(Nup54) 		4 ASP A 333
VAL A 332
TRP A 337
GLU A 338
 None
 1.26A 4qzuA-5c3lA:
undetectable
4qzuD-5c3lA:
undetectable		 4qzuA-5c3lA:
17.80
4qzuD-5c3lA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 ASP A 234
VAL A 236
TRP A 235
GLU A 432
 None
 1.40A 4qzuA-5ohsA:
0.9
4qzuD-5ohsA:
0.1		 4qzuA-5ohsA:
undetectable
4qzuD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 ASP A 877
VAL A 878
TRP A1060
GLU A 868
 None
 0.88A 4qzuA-6fj4A:
undetectable
4qzuD-6fj4A:
undetectable		 4qzuA-6fj4A:
undetectable
4qzuD-6fj4A:
undetectable