SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZU_C_RTLC201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		3 LYS A  40
TRP A 106
GLN A 108
 None
 0.52A 4qzuC-1kqxA:
25.8		 4qzuC-1kqxA:
75.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 LYS A 336
TRP A 437
GLN A 325
 None
 1.47A 4qzuC-1lmlA:
0.0		 4qzuC-1lmlA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oai NUCLEAR RNA EXPORT
FACTOR

(Homo sapiens) 		PF03943
(TAP_C) 		3 LYS A 561
TRP A 594
GLN A 586
 None
 1.36A 4qzuC-1oaiA:
undetectable		 4qzuC-1oaiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kro CD2-ASSOCIATED
PROTEIN

(Mus musculus) 		PF00018
(SH3_1) 		3 LYS A   1
TRP A  44
GLN A  62
 None
 1.41A 4qzuC-2kroA:
undetectable		 4qzuC-2kroA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  40
TRP A 106
GLN A 108
 None
 0.23A 4qzuC-2rcqA:
26.6		 4qzuC-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf5 MAJOR VAULT PROTEIN

(Mus musculus) 		PF01505
(Vault) 		3 LYS A 132
TRP A 143
GLN A 154
 None
 1.37A 4qzuC-3gf5A:
0.0		 4qzuC-3gf5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 LYS A 391
TRP A 166
GLN A 194
 FZZ  A 602 ( 2.6A)
None
None
 1.07A 4qzuC-4zaaA:
0.0		 4qzuC-4zaaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 LYS A 404
TRP A 172
GLN A 200
 4LU  A 603 (-2.6A)
None
None
 1.09A 4qzuC-4zadA:
0.0		 4qzuC-4zadA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 LYS A 922
TRP A 915
GLN A 916
 None
 1.10A 4qzuC-5a42A:
0.0		 4qzuC-5a42A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		3 LYS A 302
TRP A 369
GLN A 372
 CL  A 679 (-2.8A)
None
MPG  A 605 (-3.9A)
 1.49A 4qzuC-5f15A:
0.0		 4qzuC-5f15A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LYS A 196
TRP A 249
GLN A 144
 None
SGN  A1522 (-4.2A)
None
 1.27A 4qzuC-5g2vA:
undetectable		 4qzuC-5g2vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1
VP2

(Deformed wing
virus;
Deformed wing
virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 LYS B 152
TRP A 236
GLN B 160
 None
 1.46A 4qzuC-5g52B:
undetectable		 4qzuC-5g52B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5we1 PROTECTION OF
TELOMERES PROTEIN
POZ1,PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 LYS A 204
TRP A  91
GLN A  87
 None
 1.39A 4qzuC-5we1A:
undetectable		 4qzuC-5we1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 3 LYS A 690
TRP A 461
GLN A 450
 None
 1.33A 4qzuC-5xqoA:
0.5		 4qzuC-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A2127
TRP A1961
GLN A1964
 None
 1.36A 4qzuC-6emkA:
undetectable		 4qzuC-6emkA:
undetectable