SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZU_C_RTLC201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ILE A 242
ALA A 254
LEU A 240
LEU A 210
LEU A 198
 None
 1.19A 4qzuC-1d8cA:
0.0		 4qzuC-1d8cA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 PHE A 297
ALA A 293
VAL A 366
LEU A 377
LEU A 362
 None
 1.06A 4qzuC-1fc9A:
0.0		 4qzuC-1fc9A:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
THR A  53
TYR A  60
VAL A  62
LEU A 117
LEU A 119
 None
 0.78A 4qzuC-1gglA:
23.6		 4qzuC-1gglA:
50.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.18A 4qzuC-1gq8A:
undetectable		 4qzuC-1gq8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ILE A  66
ALA A  22
LEU A  90
LEU A   5
LEU A  97
 None
 1.18A 4qzuC-1hvcA:
undetectable		 4qzuC-1hvcA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
GLN A  38
THR A  53
VAL A  62
LEU A  77
LEU A 117
 None
 0.87A 4qzuC-1kqxA:
25.8		 4qzuC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
ILE A  25
ALA A  33
GLN A  38
THR A  51
THR A  53
VAL A  62
LEU A 117
 None
 0.55A 4qzuC-1kqxA:
25.8		 4qzuC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
ILE A  25
ALA A  33
THR A  53
LEU A  77
LEU A 117
 None
 0.69A 4qzuC-1lpjA:
25.4		 4qzuC-1lpjA:
58.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
ILE A  25
ALA A  33
THR A  53
VAL A  62
LEU A 117
 None
 0.58A 4qzuC-1lpjA:
25.4		 4qzuC-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 ILE A 141
TYR A 229
VAL A 227
LEU A 144
LEU A 105
 None
 1.14A 4qzuC-1ni3A:
undetectable		 4qzuC-1ni3A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 MET A 127
ILE A 151
THR A 204
LEU A 241
LEU A 200
 None
None
NAI  A 301 (-4.4A)
None
None
 1.09A 4qzuC-1o9bA:
undetectable		 4qzuC-1o9bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 ILE A 412
ALA A 377
LEU A 409
LEU A 389
LEU A 437
 None
 1.18A 4qzuC-1qasA:
undetectable		 4qzuC-1qasA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		5 ILE A 112
ALA A  17
VAL A 278
LEU A 110
LEU A  96
 FAD  A 400 (-3.7A)
None
None
None
None
 1.19A 4qzuC-1vdcA:
undetectable		 4qzuC-1vdcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 MET A 205
THR A 188
VAL A 160
LEU A 192
LEU A 200
 None
 1.13A 4qzuC-1vz8A:
undetectable		 4qzuC-1vz8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.03A 4qzuC-1wl8A:
undetectable		 4qzuC-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		5 ILE A 255
ALA A 219
THR A 242
LEU A 207
LEU A 229
 None
 1.08A 4qzuC-1wlsA:
undetectable		 4qzuC-1wlsA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ALA A  92
VAL A 128
LEU A  34
LEU A  61
LEU A  65
 ALA  A  92 ( 0.0A)
VAL  A 128 ( 0.6A)
LEU  A  34 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  65 ( 0.6A)
 1.18A 4qzuC-1wqaA:
undetectable		 4qzuC-1wqaA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 THR A1020
THR A1022
TYR A1010
VAL A1012
LEU A 949
 None
 0.92A 4qzuC-1xf1A:
undetectable		 4qzuC-1xf1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A  83
GLN A  81
LEU A  74
LEU A 165
LEU A 166
 None
 0.93A 4qzuC-1xkwA:
4.8		 4qzuC-1xkwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		5 PHE A 117
ILE A  81
THR A  56
THR A  54
LEU A  78
 None
None
FMN  A1200 (-3.7A)
None
None
 1.11A 4qzuC-1yobA:
undetectable		 4qzuC-1yobA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm7 PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF13599
(Pentapeptide_4) 		5 PHE A  74
ALA A  92
THR A  24
LEU A  39
LEU A  59
 None
 1.17A 4qzuC-2bm7A:
undetectable		 4qzuC-2bm7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 238
THR A 201
LEU A 225
LEU A 187
LEU A 191
 None
 1.06A 4qzuC-2cukA:
undetectable		 4qzuC-2cukA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 ILE A 200
ALA A 221
THR A  90
LEU A   6
LEU A  41
 None
 1.01A 4qzuC-2d42A:
undetectable		 4qzuC-2d42A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		5 PHE A  82
ALA A 107
VAL A 336
LEU A 299
LEU A 295
 None
 1.17A 4qzuC-2exaA:
undetectable		 4qzuC-2exaA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 436
ALA A 449
GLN A 364
VAL A 485
LEU A 403
 HEM  A 600 (-4.4A)
HEM  A 600 ( 3.8A)
HEM  A 600 (-4.5A)
None
None
 1.18A 4qzuC-2f9qA:
undetectable		 4qzuC-2f9qA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 ILE C 163
VAL C 257
LEU C 222
LEU C 152
LEU C 155
 None
 1.17A 4qzuC-2fm8C:
undetectable		 4qzuC-2fm8C:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iii S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Aquifex
aeolicus) 		PF02675
(AdoMet_dc) 		5 ALA A  55
VAL A  81
LEU A  31
LEU A  13
LEU A 101
 None
 0.97A 4qzuC-2iiiA:
undetectable		 4qzuC-2iiiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A 102
VAL A  48
LEU A 122
LEU A  82
LEU A 107
 None
 1.10A 4qzuC-2oolA:
undetectable		 4qzuC-2oolA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qco CMER

(Campylobacter
jejuni) 		PF00440
(TetR_N) 		5 PHE A  62
ILE A 130
GLN A 118
TYR A 116
VAL A 178
 None
 1.16A 4qzuC-2qcoA:
undetectable		 4qzuC-2qcoA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		5 ALA A 214
VAL A 228
LEU A 177
LEU A 281
LEU A 249
 None
 1.06A 4qzuC-2qpxA:
undetectable		 4qzuC-2qpxA:
15.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  16
MET A  20
ILE A  25
ALA A  33
GLN A  38
THR A  51
THR A  53
VAL A  62
LEU A  77
LEU A 117
LEU A 119
 None
 0.38A 4qzuC-2rcqA:
26.6		 4qzuC-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		5 ILE A 146
TYR A  89
VAL A  91
LEU A 119
LEU A  25
 None
 0.93A 4qzuC-2rhdA:
undetectable		 4qzuC-2rhdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 5 PHE A 245
ALA A 145
TYR A 152
LEU A 584
LEU A 342
 None
 1.20A 4qzuC-2vf1A:
undetectable		 4qzuC-2vf1A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		5 PHE A 118
ILE A  82
THR A  57
THR A  55
LEU A  79
 None
None
FMN  A 183 (-3.7A)
None
None
 1.19A 4qzuC-2wc1A:
undetectable		 4qzuC-2wc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A  46
ALA A 242
THR A 283
LEU A  86
LEU A 124
 None
 1.18A 4qzuC-2wd9A:
undetectable		 4qzuC-2wd9A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 454
THR A 470
LEU A 510
LEU A 448
LEU A 512
 None
 1.01A 4qzuC-2wyhA:
1.7		 4qzuC-2wyhA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 MET A 200
ILE A 203
ALA A 269
GLN A 267
LEU A 196
 None
 0.98A 4qzuC-2yabA:
undetectable		 4qzuC-2yabA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PHE A 246
ILE A 218
LEU A 238
LEU A 276
LEU A 272
 None
 1.16A 4qzuC-2z65A:
undetectable		 4qzuC-2z65A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 ILE A 380
ALA A 432
VAL A 400
LEU A 391
LEU A 352
 None
 1.03A 4qzuC-3bc8A:
undetectable		 4qzuC-3bc8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 223
TYR A 312
VAL A 307
LEU A 367
LEU A 370
 None
 1.10A 4qzuC-3cjwA:
undetectable		 4qzuC-3cjwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.91A 4qzuC-3cphA:
undetectable		 4qzuC-3cphA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		5 ILE A 120
ALA A 365
VAL A 129
LEU A 143
LEU A 145
 None
 1.01A 4qzuC-3dtgA:
undetectable		 4qzuC-3dtgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		5 PHE A 263
ALA A 288
THR A 281
LEU A 256
LEU A 225
 None
 1.03A 4qzuC-3iteA:
undetectable		 4qzuC-3iteA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		6 ILE A 282
ALA A 277
THR A 243
VAL A 271
LEU A 289
LEU A 232
 None
 1.45A 4qzuC-3jy6A:
undetectable		 4qzuC-3jy6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o26 SALUTARIDINE
REDUCTASE

(Papaver
somniferum) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 ILE A  37
ALA A 291
THR A  18
LEU A 163
LEU A  92
 None
 1.15A 4qzuC-3o26A:
undetectable		 4qzuC-3o26A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.20A 4qzuC-3om9A:
undetectable		 4qzuC-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		5 PHE A  53
ILE A  73
ALA A  38
LEU A  71
LEU A 124
 None
None
FMN  A 401 (-3.5A)
None
None
 1.04A 4qzuC-3pftA:
undetectable		 4qzuC-3pftA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		5 PHE A  17
MET A  21
ALA A  34
THR A  54
LEU A 117
 None
PAM  A 133 ( 3.9A)
PAM  A 133 ( 3.7A)
PAM  A 133 ( 3.9A)
None
 0.66A 4qzuC-3pp6A:
21.7		 4qzuC-3pp6A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puf RIBONUCLEASE H2
SUBUNIT B

(Homo sapiens) 		PF09468
(RNase_H2-Ydr279) 		5 ALA B 104
THR B 142
TYR B 156
LEU B 113
LEU B  94
 None
 1.08A 4qzuC-3pufB:
undetectable		 4qzuC-3pufB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 MET B 148
ILE B 153
ALA B  80
LEU B 183
LEU B 144
 None
 0.91A 4qzuC-3qkcB:
undetectable		 4qzuC-3qkcB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.17A 4qzuC-3sluA:
undetectable		 4qzuC-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 ILE A 525
THR A 561
LEU A 546
LEU A 641
LEU A 639
 None
 1.17A 4qzuC-3szeA:
undetectable		 4qzuC-3szeA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 ILE A 403
ALA A 436
THR A 354
THR A 316
VAL A 355
 None
 1.09A 4qzuC-3t5tA:
undetectable		 4qzuC-3t5tA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		5 ILE A 122
TYR A 210
VAL A 238
LEU A 104
LEU A 102
 None
EDO  A 301 (-4.2A)
None
None
EDO  A 302 ( 4.9A)
 1.08A 4qzuC-3tztA:
undetectable		 4qzuC-3tztA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 MET A 301
ALA A 230
LEU A 298
LEU A 344
LEU A 307
 None
 1.14A 4qzuC-3upnA:
undetectable		 4qzuC-3upnA:
13.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
MET A  20
ALA A  33
THR A  53
LEU A 115
LEU A 117
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.0A)
None
None
 0.63A 4qzuC-3wbgA:
21.0		 4qzuC-3wbgA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 ILE A  30
ALA A 318
VAL A  45
LEU A  32
LEU A 243
 None
 1.02A 4qzuC-3wx7A:
undetectable		 4qzuC-3wx7A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 ALA A  18
GLN A  11
VAL A  34
LEU A 109
LEU A 113
 None
None
DLZ  A1511 (-4.5A)
None
None
 1.05A 4qzuC-3zxsA:
undetectable		 4qzuC-3zxsA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 ILE A 158
ALA A 156
VAL A 143
LEU A 159
LEU A  60
 None
 1.17A 4qzuC-4azvA:
undetectable		 4qzuC-4azvA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 ILE A 158
ALA A 156
VAL A 143
LEU A 159
LEU A  60
 None
 1.14A 4qzuC-4azwA:
undetectable		 4qzuC-4azwA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ALA A 339
VAL A 350
LEU A 535
LEU A 303
LEU A 314
 None
 1.17A 4qzuC-4byfA:
undetectable		 4qzuC-4byfA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL15

(Sus scrofa) 		PF00828
(Ribosomal_L27A) 		5 PHE P 148
ILE P 105
ALA P 150
VAL P 156
LEU P  98
 None
 1.14A 4qzuC-4ce4P:
undetectable		 4qzuC-4ce4P:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 ALA A 335
VAL A 255
LEU A 285
LEU A 296
LEU A 299
 None
 1.13A 4qzuC-4cp6A:
undetectable		 4qzuC-4cp6A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 ILE A 288
ALA A 323
GLN A 373
THR A 352
LEU A  17
 None
 0.94A 4qzuC-4dimA:
undetectable		 4qzuC-4dimA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.14A 4qzuC-4eysA:
undetectable		 4qzuC-4eysA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 ALA B  98
THR B 129
VAL B 130
LEU B 115
LEU B 112
 None
CYC  B 201 (-4.2A)
None
CYC  B 201 ( 4.9A)
None
 1.16A 4qzuC-4f0uB:
undetectable		 4qzuC-4f0uB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkf CRISPR SYSTEM CMR
SUBUNIT CMR5

(Pyrococcus
furiosus) 		PF09701
(Cas_Cmr5) 		5 ILE A  30
ALA A  34
VAL A  86
LEU A  97
LEU A 106
 None
 1.19A 4qzuC-4gkfA:
undetectable		 4qzuC-4gkfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 632
THR A 625
VAL A 660
LEU A 639
LEU A 605
 None
 1.03A 4qzuC-4iugA:
undetectable		 4qzuC-4iugA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B 148
TYR B  91
VAL B  93
LEU B 121
LEU B  27
 None
 0.97A 4qzuC-4jvsB:
undetectable		 4qzuC-4jvsB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 ILE A  34
ALA A 322
VAL A  49
LEU A  36
LEU A 247
 None
 1.01A 4qzuC-4nz5A:
undetectable		 4qzuC-4nz5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		no annotation 5 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.14A 4qzuC-4uisB:
undetectable		 4qzuC-4uisB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 PHE A 128
ALA A 115
VAL A  82
LEU A 183
LEU A 157
 None
 1.11A 4qzuC-4uovA:
undetectable		 4qzuC-4uovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 TYR A 182
VAL A  77
LEU A 138
LEU A  13
LEU A  17
 None
 1.13A 4qzuC-4wd4A:
undetectable		 4qzuC-4wd4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.20A 4qzuC-4x5tA:
undetectable		 4qzuC-4x5tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF07034
(ORC3_N)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 ALA C 243
VAL E 441
LEU E 321
LEU E 416
LEU E 410
 None
 1.16A 4qzuC-4xgcC:
undetectable		 4qzuC-4xgcC:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A 879
ALA A1002
GLN A1001
THR A 911
LEU A 863
 None
 1.05A 4qzuC-5a42A:
undetectable		 4qzuC-5a42A:
6.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A  20
ALA A  33
THR A  53
LEU A 115
LEU A 117
 PLM  A 200 ( 4.0A)
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.2A)
None
None
 0.75A 4qzuC-5b29A:
21.1		 4qzuC-5b29A:
40.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ILE A 403
ALA A 407
VAL A 432
LEU A 379
LEU A 383
 None
 1.00A 4qzuC-5chcA:
undetectable		 4qzuC-5chcA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czd ACYL-CARRIER-PROTEIN

(Streptomyces
halstedii) 		PF00550
(PP-binding) 		5 ILE B  32
THR B  73
LEU B  29
LEU B  46
LEU B  42
 None
 1.04A 4qzuC-5czdB:
undetectable		 4qzuC-5czdB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF02775
(TPP_enzyme_C) 		5 PHE C 133
ALA C 108
LEU C 118
LEU C 189
LEU C 125
 None
 1.16A 4qzuC-5exeC:
undetectable		 4qzuC-5exeC:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ALA A 285
VAL A 216
LEU A 256
LEU A 223
LEU A 230
 None
 1.08A 4qzuC-5gmhA:
undetectable		 4qzuC-5gmhA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 ILE A 329
THR A 123
VAL A 264
LEU A 113
LEU A 109
 ANP  A 602 ( 4.2A)
None
None
None
None
 1.10A 4qzuC-5h1cA:
undetectable		 4qzuC-5h1cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.01A 4qzuC-5iq6A:
undetectable		 4qzuC-5iq6A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a IMMUNITY PROTEIN
CDII

(Burkholderia
pseudomallei) 		no annotation 5 ALA B   2
THR B  56
VAL B  42
LEU B  94
LEU B  23
 None
 1.05A 4qzuC-5j4aB:
undetectable		 4qzuC-5j4aB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.03A 4qzuC-5k5mA:
undetectable		 4qzuC-5k5mA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh1 INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 ILE A 184
ALA A 206
LEU A 197
LEU A 241
LEU A 221
 None
 1.18A 4qzuC-5kh1A:
undetectable		 4qzuC-5kh1A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 ILE A  38
ALA A 299
THR A  19
LEU A 171
LEU A  96
 None
 1.07A 4qzuC-5l51A:
undetectable		 4qzuC-5l51A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short) 		5 ILE A  30
ALA A 293
THR A  11
LEU A 165
LEU A  87
 None
 1.10A 4qzuC-5lcxA:
undetectable		 4qzuC-5lcxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 PHE C 116
ILE C  74
VAL C  15
LEU C  78
LEU C 144
 HEM  C 201 (-4.0A)
HEM  C 201 (-4.5A)
None
HEM  C 201 ( 4.9A)
None
 1.02A 4qzuC-5m3lC:
undetectable		 4qzuC-5m3lC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 PHE A  36
ALA A  15
TYR A  80
VAL A 107
LEU A  61
 None
 1.15A 4qzuC-5uf2A:
undetectable		 4qzuC-5uf2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A 413
ALA A 380
THR A 238
LEU A 370
LEU A 395
 None
 1.06A 4qzuC-5ujsA:
undetectable		 4qzuC-5ujsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A 413
THR A 238
TYR A 239
LEU A 370
LEU A 395
 None
 0.98A 4qzuC-5ujsA:
undetectable		 4qzuC-5ujsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu3 COMPETENCE
DAMAGE-INDUCIBLE
PROTEIN A

(Enterobacter
cloacae) 		PF02464
(CinA) 		5 ALA A 103
VAL A 164
LEU A  24
LEU A  42
LEU A  46
 None
 1.07A 4qzuC-5vu3A:
undetectable		 4qzuC-5vu3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 5 THR A 167
TYR A 239
LEU A 241
LEU A 227
LEU A 223
 None
 1.17A 4qzuC-5x8hA:
undetectable		 4qzuC-5x8hA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 PHE A 894
MET A 842
LEU A 838
LEU A 881
LEU A 879
 None
 1.01A 4qzuC-5zalA:
undetectable		 4qzuC-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.03A 4qzuC-6c33A:
undetectable		 4qzuC-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 ALA A 275
VAL A 349
LEU A 337
LEU A 294
LEU A 287
 None
 1.04A 4qzuC-6d46A:
undetectable		 4qzuC-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 5 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.19A 4qzuC-6d72A:
undetectable		 4qzuC-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.09A 4qzuC-6dk2A:
undetectable		 4qzuC-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es4 SYNCRIP, ISOFORM K

(Drosophila
melanogaster) 		no annotation 5 PHE A 184
ALA A 221
LEU A 236
LEU A 195
LEU A 180
 None
CME  A 187 ( 3.7A)
None
None
None
 1.18A 4qzuC-6es4A:
undetectable		 4qzuC-6es4A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		3 LYS A  40
TRP A 106
GLN A 108
 None
 0.52A 4qzuC-1kqxA:
25.8		 4qzuC-1kqxA:
75.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 LYS A 336
TRP A 437
GLN A 325
 None
 1.47A 4qzuC-1lmlA:
0.0		 4qzuC-1lmlA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oai NUCLEAR RNA EXPORT
FACTOR

(Homo sapiens) 		PF03943
(TAP_C) 		3 LYS A 561
TRP A 594
GLN A 586
 None
 1.36A 4qzuC-1oaiA:
undetectable		 4qzuC-1oaiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kro CD2-ASSOCIATED
PROTEIN

(Mus musculus) 		PF00018
(SH3_1) 		3 LYS A   1
TRP A  44
GLN A  62
 None
 1.41A 4qzuC-2kroA:
undetectable		 4qzuC-2kroA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  40
TRP A 106
GLN A 108
 None
 0.23A 4qzuC-2rcqA:
26.6		 4qzuC-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf5 MAJOR VAULT PROTEIN

(Mus musculus) 		PF01505
(Vault) 		3 LYS A 132
TRP A 143
GLN A 154
 None
 1.37A 4qzuC-3gf5A:
0.0		 4qzuC-3gf5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 LYS A 391
TRP A 166
GLN A 194
 FZZ  A 602 ( 2.6A)
None
None
 1.07A 4qzuC-4zaaA:
0.0		 4qzuC-4zaaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 LYS A 404
TRP A 172
GLN A 200
 4LU  A 603 (-2.6A)
None
None
 1.09A 4qzuC-4zadA:
0.0		 4qzuC-4zadA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 LYS A 922
TRP A 915
GLN A 916
 None
 1.10A 4qzuC-5a42A:
0.0		 4qzuC-5a42A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		3 LYS A 302
TRP A 369
GLN A 372
 CL  A 679 (-2.8A)
None
MPG  A 605 (-3.9A)
 1.49A 4qzuC-5f15A:
0.0		 4qzuC-5f15A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LYS A 196
TRP A 249
GLN A 144
 None
SGN  A1522 (-4.2A)
None
 1.27A 4qzuC-5g2vA:
undetectable		 4qzuC-5g2vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1
VP2

(Deformed wing
virus;
Deformed wing
virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 LYS B 152
TRP A 236
GLN B 160
 None
 1.46A 4qzuC-5g52B:
undetectable		 4qzuC-5g52B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5we1 PROTECTION OF
TELOMERES PROTEIN
POZ1,PROTECTION OF
TELOMERES PROTEIN
POZ1

(Schizosaccharomyces
pombe) 		no annotation 3 LYS A 204
TRP A  91
GLN A  87
 None
 1.39A 4qzuC-5we1A:
undetectable		 4qzuC-5we1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 3 LYS A 690
TRP A 461
GLN A 450
 None
 1.33A 4qzuC-5xqoA:
0.5		 4qzuC-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A2127
TRP A1961
GLN A1964
 None
 1.36A 4qzuC-6emkA:
undetectable		 4qzuC-6emkA:
undetectable