SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZU_B_ACTB202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 TYR A   8
LEU A 262
GLN A 276
ARG A 270
 None
 1.02A 4qzuB-1bf6A:
0.0		 4qzuB-1bf6A:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
TYR A  60
GLN A  97
ARG A 104
TRP A 106
 None
 0.47A 4qzuB-1gglA:
23.6		 4qzuB-1gglA:
50.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 TYR A 110
TYR A 177
LEU A 194
ARG A 192
 None
 1.47A 4qzuB-1jm1A:
0.0		 4qzuB-1jm1A:
16.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LEU A  77
GLN A  97
ARG A 104
TRP A 106
 None
 0.68A 4qzuB-1kqxA:
25.7		 4qzuB-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
LEU A  77
GLN A  97
ARG A 104
TRP A 106
 None
 0.77A 4qzuB-1lpjA:
25.1		 4qzuB-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE

(Homo sapiens) 		PF00764
(Arginosuc_synth) 		4 TYR A 291
LEU A 295
GLN A 311
ARG A 307
 None
 1.40A 4qzuB-2nz2A:
0.0		 4qzuB-2nz2A:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
LEU A  77
GLN A  97
ARG A 104
TRP A 106
 None
 0.66A 4qzuB-2rcqA:
26.1		 4qzuB-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00033
(Cytochrome_B)
PF00032
(Cytochrom_B_C) 		4 TYR A 136
TYR B  82
LEU B  76
TRP B  79
 None
 1.40A 4qzuB-2zt9A:
0.0		 4qzuB-2zt9A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 TYR A 173
TYR A 144
LEU A 112
GLN A 180
 None
 1.39A 4qzuB-3bmaA:
undetectable		 4qzuB-3bmaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 126
LEU A 201
GLN A 110
ARG A 207
 None
 1.10A 4qzuB-4qq1A:
3.4		 4qzuB-4qq1A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 TYR A 440
TYR A 456
LEU A 457
GLN A 452
 None
 1.33A 4qzuB-4wviA:
undetectable		 4qzuB-4wviA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 159
TYR A 171
GLN A  63
ARG A  66
 EDO  A 307 ( 4.9A)
EDO  A 307 (-4.5A)
EDO  A 307 ( 3.5A)
EDO  A 307 (-4.9A)
 1.37A 4qzuB-4zfzA:
1.0		 4qzuB-4zfzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 TYR 1 646
LEU 1 565
GLN 1 557
ARG 1 554
 None
 1.36A 4qzuB-5mz61:
undetectable		 4qzuB-5mz61:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1
VP0

(Hepatovirus A;
Hepatovirus A) 		PF12944
(HAV_VP)
PF00073
(Rhv) 		4 TYR B 177
LEU A 215
GLN A 135
ARG A 261
 None
 1.43A 4qzuB-5wtfB:
undetectable		 4qzuB-5wtfB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 TYR O  49
TYR O 132
LEU O 131
GLN O 652
 None
 1.41A 4qzuB-6eu2O:
undetectable		 4qzuB-6eu2O:
undetectable