SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZU_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		5 ILE A  53
ALA A  74
THR A  21
VAL A  18
LEU A 101
 None
 1.26A 4qzuA-1atjA:
0.0		 4qzuA-1atjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		5 PHE A  77
ILE A  53
ALA A  74
THR A  21
LEU A 101
 None
 1.37A 4qzuA-1atjA:
0.0		 4qzuA-1atjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 ILE A 506
THR A 457
ARG A 442
LEU A 486
LEU A 499
 None
 1.03A 4qzuA-1c4oA:
undetectable		 4qzuA-1c4oA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		5 PHE A 179
ILE A 186
THR A 130
VAL A 231
LEU A 210
 None
 1.38A 4qzuA-1dhsA:
undetectable		 4qzuA-1dhsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 PHE A 297
ALA A 293
VAL A 366
LEU A 377
LEU A 362
 None
 1.08A 4qzuA-1fc9A:
0.0		 4qzuA-1fc9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE A 443
ALA A 431
GLN A 430
THR A 423
LEU A 445
 None
 1.09A 4qzuA-1ftsA:
0.2		 4qzuA-1ftsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 ALA A1100
GLN A1050
THR A1054
VAL A1086
LEU A1104
 None
 1.21A 4qzuA-1fx4A:
0.0		 4qzuA-1fx4A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
TRP A 106
LEU A 119
 None
 0.71A 4qzuA-1gglA:
23.8		 4qzuA-1gglA:
50.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LYS A  40
THR A  53
ARG A  58
VAL A  62
TRP A 106
LEU A 119
 None
 0.71A 4qzuA-1gglA:
23.8		 4qzuA-1gglA:
50.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.22A 4qzuA-1gq8A:
undetectable		 4qzuA-1gq8A:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 GLN A  38
THR A  53
ARG A  58
VAL A  62
LEU A 117
 None
 1.37A 4qzuA-1kqxA:
25.5		 4qzuA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		8 ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  53
VAL A  62
LEU A  77
TRP A 106
 None
 1.09A 4qzuA-1kqxA:
25.5		 4qzuA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
GLN A  38
THR A  53
ARG A  58
VAL A  62
LEU A  77
 None
 1.16A 4qzuA-1kqxA:
25.5		 4qzuA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		9 PHE A  16
ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  51
THR A  53
VAL A  62
TRP A 106
 None
 0.71A 4qzuA-1kqxA:
25.5		 4qzuA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		8 PHE A  16
ILE A  25
ALA A  33
GLN A  38
THR A  51
THR A  53
ARG A  58
VAL A  62
 None
 0.80A 4qzuA-1kqxA:
25.5		 4qzuA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
LEU A  77
TRP A 106
 None
 0.80A 4qzuA-1lpjA:
25.3		 4qzuA-1lpjA:
58.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
ILE A  25
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A  77
TRP A 106
 None
 0.90A 4qzuA-1lpjA:
25.3		 4qzuA-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 PHE A 362
ILE A 410
ALA A 365
VAL A 419
LEU A 349
 None
 1.37A 4qzuA-1nq7A:
undetectable		 4qzuA-1nq7A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 ILE A  53
ALA A  74
THR A  21
VAL A  18
LEU A 101
 None
 1.25A 4qzuA-1qo4A:
undetectable		 4qzuA-1qo4A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu0 LAMININ ALPHA2 CHAIN

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 ALA A2946
THR A3056
VAL A2954
LEU A2974
LEU A3074
 None
 1.32A 4qzuA-1qu0A:
undetectable		 4qzuA-1qu0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqr 3-DEHYDROQUINATE
DEHYDRATASE

(Actinobacillus
pleuropneumoniae) 		PF01220
(DHquinase_II) 		5 ILE A  97
ALA A 139
THR A  68
VAL A  92
LEU A   7
 None
 1.31A 4qzuA-1uqrA:
undetectable		 4qzuA-1uqrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ILE A 181
THR A 112
THR A 114
LEU A 145
LEU A 173
 None
 1.08A 4qzuA-1v1pA:
undetectable		 4qzuA-1v1pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vim HYPOTHETICAL PROTEIN
AF1796

(Archaeoglobus
fulgidus) 		PF01380
(SIS) 		5 PHE A 149
ILE A  48
THR A  23
VAL A  24
LEU A 157
 None
 1.21A 4qzuA-1vimA:
undetectable		 4qzuA-1vimA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmd METHYLGLYOXAL
SYNTHASE

(Thermotoga
maritima) 		PF02142
(MGS) 		5 ILE A 112
ALA A  80
THR A  52
THR A  49
LEU A 109
 None
None
SO4  A 167 (-4.1A)
SO4  A 167 (-3.4A)
None
 1.37A 4qzuA-1vmdA:
undetectable		 4qzuA-1vmdA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 ILE A  91
THR A  47
THR A  49
VAL A  42
LEU A  14
 None
None
None
GTP  A 700 (-4.1A)
None
 1.40A 4qzuA-1wdtA:
undetectable		 4qzuA-1wdtA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.02A 4qzuA-1wl8A:
undetectable		 4qzuA-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 PHE A  64
ILE A  92
VAL A  14
LEU A  48
LEU A  35
 None
 1.31A 4qzuA-1y89A:
undetectable		 4qzuA-1y89A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		5 PHE A 246
ILE A 172
ALA A 215
THR A 239
LEU A 228
 None
 1.39A 4qzuA-1ybmA:
undetectable		 4qzuA-1ybmA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		5 PHE A 117
ILE A  81
THR A  56
THR A  54
LEU A  78
 None
None
FMN  A1200 (-3.7A)
None
None
 1.25A 4qzuA-1yobA:
undetectable		 4qzuA-1yobA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 180
ALA A 281
THR A 152
THR A 128
VAL A 100
 None
 1.29A 4qzuA-2am2A:
undetectable		 4qzuA-2am2A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		5 ILE A 301
THR A 287
LEU A 205
TRP A 229
LEU A 230
 None
 1.32A 4qzuA-2c1lA:
undetectable		 4qzuA-2c1lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		5 ILE A 511
THR A 462
ARG A 447
LEU A 491
LEU A 504
 None
 1.19A 4qzuA-2d7dA:
2.8		 4qzuA-2d7dA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 PHE A 113
ARG A 162
VAL A 170
LEU A  55
LEU A 136
 None
MLY  A  56 ( 3.9A)
None
MLY  A  56 ( 4.6A)
None
 1.36A 4qzuA-2etvA:
undetectable		 4qzuA-2etvA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		5 ILE A  22
ALA A  72
THR A   2
VAL A   4
LEU A  97
 None
 1.25A 4qzuA-2hb6A:
undetectable		 4qzuA-2hb6A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		5 PHE A 141
ILE A  79
ALA A 139
VAL A 231
LEU A 163
 None
 1.40A 4qzuA-2htbA:
1.5		 4qzuA-2htbA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iii S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Aquifex
aeolicus) 		PF02675
(AdoMet_dc) 		5 ILE A  98
ALA A  11
THR A  70
LEU A 101
LEU A  31
 None
 1.03A 4qzuA-2iiiA:
undetectable		 4qzuA-2iiiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmt GLUTATHIONE
TRANSFERASE

(Proteus
mirabilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  27
THR A  21
ARG A  19
VAL A 153
LEU A  55
 None
 1.28A 4qzuA-2pmtA:
undetectable		 4qzuA-2pmtA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 PHE A  25
ILE A   8
VAL A 248
LEU A  76
LEU A 293
 None
 1.36A 4qzuA-2pn1A:
undetectable		 4qzuA-2pn1A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 315
GLN A 282
THR A 106
VAL A 110
LEU A 311
 None
 1.32A 4qzuA-2ps2A:
undetectable		 4qzuA-2ps2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		5 PHE A 562
ALA A 565
THR A 522
THR A 526
LEU A 540
 None
 1.35A 4qzuA-2qr7A:
undetectable		 4qzuA-2qr7A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 PHE A  36
ALA A  56
THR A 350
LEU A  49
LEU A 312
 None
 1.32A 4qzuA-2quaA:
undetectable		 4qzuA-2quaA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		10 PHE A  16
GLN A  38
LYS A  40
THR A  51
THR A  53
ARG A  58
VAL A  62
LEU A  77
TRP A 106
LEU A 119
 None
None
None
None
None
SO4  A 152 (-3.1A)
None
None
None
None
 0.77A 4qzuA-2rcqA:
26.6		 4qzuA-2rcqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  16
ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  51
THR A  53
VAL A  62
LEU A  77
TRP A 106
LEU A 119
 None
 0.50A 4qzuA-2rcqA:
26.6		 4qzuA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		5 ILE A 290
ALA A 212
GLN A  30
THR A   7
LEU A 256
 None
 1.36A 4qzuA-2vc6A:
undetectable		 4qzuA-2vc6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 558
ALA A 561
THR A 518
THR A 522
LEU A 536
 None
 1.34A 4qzuA-2wntA:
undetectable		 4qzuA-2wntA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8e RAB-PROTEIN 6

(Drosophila
melanogaster) 		PF00071
(Ras) 		5 PHE A  13
ALA A 170
VAL A  91
LEU A 165
LEU A  65
 None
 1.21A 4qzuA-2y8eA:
undetectable		 4qzuA-2y8eA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 THR A  37
ARG A 279
VAL A  77
LEU A 276
LEU A  33
 None
 1.37A 4qzuA-2yb4A:
undetectable		 4qzuA-2yb4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli) 		PF13360
(PQQ_2) 		5 PHE D 259
ALA D 269
ARG D 281
VAL D 305
LEU D 308
 None
 1.29A 4qzuA-2ymsD:
undetectable		 4qzuA-2ymsD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 ILE A 409
THR A  70
THR A 421
LEU A 408
LEU A 465
 None
None
AIX  A 501 (-3.4A)
None
None
 1.34A 4qzuA-3a3iA:
undetectable		 4qzuA-3a3iA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus) 		PF09367
(CpeS) 		5 PHE A  11
ILE A  41
ALA A  69
THR A 132
LEU A 128
 PO4  A 201 ( 4.4A)
None
PO4  A 201 ( 4.4A)
None
None
 1.18A 4qzuA-3bdrA:
8.2		 4qzuA-3bdrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.24A 4qzuA-3czmA:
undetectable		 4qzuA-3czmA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3r CALCYPHOSIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  82
ALA A  85
ARG A  12
LEU A  11
LEU A  33
 None
 1.33A 4qzuA-3e3rA:
undetectable		 4qzuA-3e3rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ILE A 122
ALA A  72
THR A  83
VAL A 348
LEU A 341
 None
 1.25A 4qzuA-3eafA:
undetectable		 4qzuA-3eafA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		5 ALA B 357
THR B 419
THR B 404
VAL B 402
LEU B 324
 None
 1.25A 4qzuA-3fgtB:
undetectable		 4qzuA-3fgtB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		5 ALA A 357
THR A 419
THR A 404
VAL A 402
LEU A 324
 None
 1.29A 4qzuA-3fgwA:
undetectable		 4qzuA-3fgwA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 171
GLN A 169
THR A 253
THR A 251
LEU A 157
 None
 1.27A 4qzuA-3hhdA:
undetectable		 4qzuA-3hhdA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		5 PHE A 100
ILE A  34
THR A  78
LEU A  65
LEU A 224
 None
 1.40A 4qzuA-3hzrA:
undetectable		 4qzuA-3hzrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PHE D 746
ILE D 770
GLN D 831
VAL D 839
LEU D 736
 None
 1.32A 4qzuA-3j9pD:
undetectable		 4qzuA-3j9pD:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		5 ILE A 282
ALA A 277
THR A 243
VAL A 271
LEU A 289
 None
 1.37A 4qzuA-3jy6A:
undetectable		 4qzuA-3jy6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		5 PHE A 187
ILE A  86
VAL A 128
LEU A  92
LEU A  73
 None
 1.34A 4qzuA-3licA:
undetectable		 4qzuA-3licA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		5 ILE B1246
THR B1462
VAL B1222
LEU B1094
LEU B1239
 None
 1.39A 4qzuA-3myrB:
undetectable		 4qzuA-3myrB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.21A 4qzuA-3om9A:
undetectable		 4qzuA-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owv DNA-ENTRY NUCLEASE

(Streptococcus
pneumoniae) 		PF01223
(Endonuclease_NS) 		5 PHE A 173
ALA A  97
THR A 108
VAL A 109
LEU A 161
 None
 1.41A 4qzuA-3owvA:
undetectable		 4qzuA-3owvA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 369
ALA A 118
THR A 312
THR A 342
LEU A 111
 None
 1.21A 4qzuA-3qn3A:
undetectable		 4qzuA-3qn3A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 ILE A 403
ALA A 436
THR A 354
THR A 316
VAL A 355
 None
 1.20A 4qzuA-3t5tA:
undetectable		 4qzuA-3t5tA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		5 ALA A 334
THR A 247
ARG A   5
VAL A 244
LEU A   2
 None
 1.34A 4qzuA-4bf7A:
undetectable		 4qzuA-4bf7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 ALA A 225
ARG A 210
VAL A  16
LEU A 218
LEU A 100
 None
 1.36A 4qzuA-4eelA:
undetectable		 4qzuA-4eelA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h43 27.5 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03536
(VRP3) 		5 PHE A 179
ARG A 186
VAL A 109
LEU A 121
LEU A 157
 None
 1.36A 4qzuA-4h43A:
undetectable		 4qzuA-4h43A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER

(Saccharomyces
cerevisiae) 		PF01699
(Na_Ca_ex) 		5 ILE A 207
ALA A 330
GLN A 328
LEU A 208
LEU A 215
 None
 1.37A 4qzuA-4k1cA:
undetectable		 4qzuA-4k1cA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4w CYTOCHROME
B(562),SMOOTHENED
HOMOLOG

(Shigella
flexneri;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 ILE A  17
ALA A  75
GLN A  71
THR A  97
LEU A  14
 None
 1.32A 4qzuA-4n4wA:
undetectable		 4qzuA-4n4wA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 185
 None
 1.31A 4qzuA-4r5cA:
undetectable		 4qzuA-4r5cA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1

(Arabidopsis
thaliana) 		PF02225
(PA) 		5 ILE A 115
ALA A 112
THR A  31
VAL A  30
LEU A 116
 None
 1.40A 4qzuA-4tjvA:
undetectable		 4qzuA-4tjvA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 PHE A  94
ALA A  49
GLN A  45
THR A  35
VAL A  32
 None
 1.16A 4qzuA-4wd9A:
undetectable		 4qzuA-4wd9A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.32A 4qzuA-4x5tA:
0.8		 4qzuA-4x5tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 ILE C 920
ALA C 958
THR C 943
VAL C 931
LEU C 924
 None
 1.40A 4qzuA-4y7mC:
undetectable		 4qzuA-4y7mC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A 879
ALA A1002
GLN A1001
THR A 911
LEU A 863
 None
 1.02A 4qzuA-5a42A:
undetectable		 4qzuA-5a42A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  19
ALA A  26
VAL A   6
LEU A  15
LEU A  79
 None
 1.39A 4qzuA-5cfkA:
2.6		 4qzuA-5cfkA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		5 ILE A 235
ALA A 270
THR A 124
VAL A 126
LEU A 151
 None
 1.28A 4qzuA-5dlbA:
undetectable		 4qzuA-5dlbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 292
ALA A 290
GLN A 275
ARG A 303
LEU A 324
 None
 1.04A 4qzuA-5fi0A:
1.7		 4qzuA-5fi0A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 292
GLN A 275
ARG A 303
LEU A 324
LEU A 253
 None
 1.30A 4qzuA-5fi0A:
1.7		 4qzuA-5fi0A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 PHE A 164
ILE A 133
ALA A 216
LEU A 113
LEU A 141
 None
 1.25A 4qzuA-5gwoA:
1.2		 4qzuA-5gwoA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 PHE A 362
ILE A 306
THR A 443
VAL A 445
TRP A 379
 None
 1.17A 4qzuA-5i5hA:
3.6		 4qzuA-5i5hA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 ALA A2946
THR A3056
VAL A2954
LEU A2974
LEU A3074
 None
 1.31A 4qzuA-5ik8A:
undetectable		 4qzuA-5ik8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 ILE B 124
GLN B 108
LYS B 250
THR B 297
VAL B 299
 None
SO4  B 501 (-3.1A)
SO4  B 501 (-4.1A)
None
None
 1.35A 4qzuA-5ivlB:
undetectable		 4qzuA-5ivlB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 ALA A 129
GLN A 128
LYS A 169
THR A 165
VAL A 117
 None
 1.39A 4qzuA-5kwsA:
undetectable		 4qzuA-5kwsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 PHE C 116
ILE C  74
VAL C  15
LEU C  78
LEU C 144
 HEM  C 201 (-4.0A)
HEM  C 201 (-4.5A)
None
HEM  C 201 ( 4.9A)
None
 1.10A 4qzuA-5m3lC:
undetectable		 4qzuA-5m3lC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m43 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00782
(DSPc) 		5 ALA A 153
VAL A  75
LEU A 118
TRP A 166
LEU A 163
 None
 1.40A 4qzuA-5m43A:
undetectable		 4qzuA-5m43A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ALA B 171
GLN B 169
THR B 253
THR B 251
LEU B 157
 None
 1.31A 4qzuA-5my0B:
undetectable		 4qzuA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A  47
ALA A  93
THR A  54
VAL A  59
LEU A 310
 None
 1.37A 4qzuA-5ncsA:
undetectable		 4qzuA-5ncsA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 ILE A2016
ALA A2074
GLN A2070
THR A2096
LEU A2013
 None
 1.38A 4qzuA-5nj6A:
undetectable		 4qzuA-5nj6A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 PHE A 105
ILE A 127
ALA A  40
VAL A  17
LEU A 129
 None
 1.36A 4qzuA-5osbA:
undetectable		 4qzuA-5osbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 PHE A 267
ILE A 311
ALA A 244
THR A 252
LEU A 264
 None
 1.38A 4qzuA-5u4hA:
undetectable		 4qzuA-5u4hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ALA A 153
THR A 128
THR A 126
VAL A  72
LEU A  49
 None
 1.37A 4qzuA-5ucdA:
undetectable		 4qzuA-5ucdA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ung CHIMERA PROTEIN OF
TYPE-2 ANGIOTENSIN
II RECEPTOR AND
SOLUBLE CYTOCHROME
B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 ILE B1017
ALA B1075
GLN B1071
THR B1097
LEU B1014
 None
 1.37A 4qzuA-5ungB:
undetectable		 4qzuA-5ungB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 PHE A 248
ILE A 259
ALA A 275
THR A 242
LEU A 207
 None
 1.40A 4qzuA-5x2qA:
undetectable		 4qzuA-5x2qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc3 PROBABLE RAB-RELATED
GTPASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 PHE A 161
ILE A   8
VAL A  16
LEU A  10
LEU A 160
 None
None
GDP  A1200 (-4.0A)
None
None
 1.35A 4qzuA-5xc3A:
undetectable		 4qzuA-5xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli) 		no annotation 5 ILE A  44
ALA A 196
VAL A 208
LEU A 251
LEU A 147
 None
 1.19A 4qzuA-5ypzA:
undetectable		 4qzuA-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ILE A1017
ALA A1075
GLN A1071
THR A1097
LEU A1014
 None
 1.37A 4qzuA-6aqfA:
undetectable		 4qzuA-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A2316
ILE A2331
ALA A2455
LYS A2272
VAL A2345
 None
 1.31A 4qzuA-6emkA:
undetectable		 4qzuA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD
ACTD
ACTF

(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		no annotation
no annotation
no annotation 		5 ALA D  74
THR D 124
THR D  82
LEU C 234
LEU F 333
 None
 1.37A 4qzuA-6f0kD:
undetectable		 4qzuA-6f0kD:
undetectable