SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_C_RTLC201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 PHE A  10
ILE A  96
TYR A  84
LEU A  98
LEU A  42
 None
 1.38A 4qztC-1e4oA:
0.0		 4qztC-1e4oA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 GLN A 980
THR A 992
TYR A 974
SER A 897
LEU A 901
 None
 1.40A 4qztC-1fx4A:
undetectable		 4qztC-1fx4A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ILE A  25
ALA A  33
LYS A  40
TYR A  60
TRP A 106
LEU A 119
 None
 0.64A 4qztC-1gglA:
23.5		 4qztC-1gglA:
50.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ILE A  25
LYS A  40
ARG A  58
TYR A  60
TRP A 106
LEU A 119
 None
 0.67A 4qztC-1gglA:
23.5		 4qztC-1gglA:
50.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LYS A  40
ARG A  58
TYR A  60
SER A  76
TRP A 106
 None
 1.01A 4qztC-1gglA:
23.5		 4qztC-1gglA:
50.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 PHE A  32
ALA A  29
THR A 367
SER A 275
LEU A  34
 None
 1.43A 4qztC-1ihpA:
0.0		 4qztC-1ihpA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A 219
ALA A 203
SER A 240
LEU A 191
LEU A 183
 None
 1.27A 4qztC-1iz1A:
undetectable		 4qztC-1iz1A:
16.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		6 ILE A  25
ALA A  33
GLN A  38
ARG A  58
LEU A  77
TRP A 106
 None
 1.01A 4qztC-1kqxA:
25.7		 4qztC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		6 ILE A  25
ALA A  33
GLN A  38
LYS A  40
LEU A  77
TRP A 106
 None
 0.90A 4qztC-1kqxA:
25.7		 4qztC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		7 PHE A  16
ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  51
TRP A 106
 None
 0.57A 4qztC-1kqxA:
25.7		 4qztC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		7 PHE A  16
ILE A  25
ALA A  33
GLN A  38
THR A  51
ARG A  58
TRP A 106
 None
 0.70A 4qztC-1kqxA:
25.7		 4qztC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
ILE A  25
ALA A  33
LYS A  40
LEU A  77
TRP A 106
 None
 0.80A 4qztC-1lpjA:
25.5		 4qztC-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		5 PHE A 375
ILE A 252
ALA A 380
SER A 137
LEU A 385
 None
 1.37A 4qztC-1m22A:
0.0		 4qztC-1m22A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		5 PHE A  91
ILE A  57
ALA A  34
THR A 110
LEU A  81
 None
 1.36A 4qztC-1nijA:
0.0		 4qztC-1nijA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 ILE A 259
ALA A 341
THR A 305
SER A 356
LEU A 323
 None
 1.15A 4qztC-1p9wA:
undetectable		 4qztC-1p9wA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q87 39 KDA INITIATOR
BINDING PROTEIN

(Trichomonas
vaginalis) 		PF11422
(IBP39) 		5 PHE A 276
ILE A 295
THR A 236
TYR A 307
LEU A 308
 None
 1.47A 4qztC-1q87A:
undetectable		 4qztC-1q87A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		5 PHE A 131
ALA A 152
TYR A  80
SER A 179
LEU A 183
 None
 1.23A 4qztC-1rpwA:
undetectable		 4qztC-1rpwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PHE A 458
ILE A 384
ALA A 455
THR A 569
SER A 159
 None
 1.21A 4qztC-1suvA:
undetectable		 4qztC-1suvA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		5 PHE A  23
ILE A   8
TYR A  60
LEU A  56
LEU A  44
 None
 1.43A 4qztC-1ucpA:
undetectable		 4qztC-1ucpA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.02A 4qztC-1wl8A:
undetectable		 4qztC-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02347
(GDC-P)
PF02347
(GDC-P) 		5 PHE A 375
ALA A 346
ARG A 343
LEU B  35
LEU A 211
 None
 1.47A 4qztC-1wytA:
undetectable		 4qztC-1wytA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd5 ANTIFUNGAL PROTEIN
GAFP-1

(Gastrodia elata) 		PF01453
(B_lectin) 		5 ALA A  73
THR A 108
SER A  43
LEU A  31
LEU A  85
 None
 1.45A 4qztC-1xd5A:
undetectable		 4qztC-1xd5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd6 GASTRODIANIN-4

(Gastrodia elata) 		PF01453
(B_lectin) 		5 ALA A  73
THR A 108
SER A  43
LEU A  31
LEU A  85
 None
 1.48A 4qztC-1xd6A:
undetectable		 4qztC-1xd6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 PHE A 456
ILE A 438
ALA A 436
TYR A 369
LEU A 446
 None
 1.32A 4qztC-1xf1A:
undetectable		 4qztC-1xf1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		5 ILE A 113
ALA A  42
THR A 368
TYR A 361
LEU A  57
 None
 1.42A 4qztC-1ytkA:
undetectable		 4qztC-1ytkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 PHE A 599
ILE A 671
THR A 643
TYR A 680
LEU A 601
 None
 1.50A 4qztC-1yvlA:
undetectable		 4qztC-1yvlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 ALA A  11
GLN A  13
TYR A 335
SER A  92
LEU A 281
 None
 1.36A 4qztC-1zbrA:
undetectable		 4qztC-1zbrA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		5 ILE A  30
ALA A  28
SER A  20
LEU A  17
LEU A 105
 None
 1.34A 4qztC-1zlyA:
undetectable		 4qztC-1zlyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		5 ILE A 349
ALA A 290
TYR A 297
LEU A 340
LEU A 307
 None
 1.35A 4qztC-2bw3A:
undetectable		 4qztC-2bw3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		5 THR A  86
ARG A 464
TYR A 128
SER A 129
LEU A 130
 None
 1.48A 4qztC-2ftwA:
undetectable		 4qztC-2ftwA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		5 ILE A 100
ALA A 177
TYR A 117
LEU A 103
LEU A  96
 None
 1.45A 4qztC-2hz6A:
2.1		 4qztC-2hz6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 ALA A 271
ARG A 272
TYR A 247
LEU A 245
LEU A 147
 None
 1.47A 4qztC-2jbwA:
undetectable		 4qztC-2jbwA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd1 DNA
INTEGRATION/RECOMBIN
ATION/INVERTION
PROTEIN

(Bacillus cereus) 		PF14659
(Phage_int_SAM_3) 		5 ILE A  46
TYR A  59
SER A  42
LEU A  43
LEU A  84
 None
 1.48A 4qztC-2kd1A:
undetectable		 4qztC-2kd1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqw CBS DOMAIN PROTEIN

(Porphyromonas
gingivalis) 		PF03471
(CorC_HlyC) 		5 PHE A  36
ALA A  35
TYR A  14
LEU A  29
LEU A  46
 None
 1.31A 4qztC-2nqwA:
undetectable		 4qztC-2nqwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 ALA A 331
TYR A 376
SER A 356
LEU A 359
LEU A 321
 None
 1.42A 4qztC-2o4jA:
undetectable		 4qztC-2o4jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		5 PHE A 128
ARG A 153
TYR A 156
LEU A 258
LEU A  31
 None
 1.38A 4qztC-2p4bA:
2.2		 4qztC-2p4bA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 PHE A  36
ALA A  56
THR A 350
LEU A  49
LEU A 312
 None
 1.22A 4qztC-2quaA:
undetectable		 4qztC-2quaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		5 PHE A 265
ALA A 221
TYR A 234
SER A 229
LEU A 245
 None
 1.43A 4qztC-2rauA:
undetectable		 4qztC-2rauA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		5 PHE A 265
ILE A 217
TYR A 234
SER A 229
LEU A 245
 None
CA  A 354 ( 3.9A)
None
None
None
 1.49A 4qztC-2rauA:
undetectable		 4qztC-2rauA:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
GLN A  38
LYS A  40
THR A  51
ARG A  58
LEU A  77
TRP A 106
LEU A 119
 None
None
None
None
SO4  A 152 (-3.1A)
None
None
None
 0.86A 4qztC-2rcqA:
26.5		 4qztC-2rcqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  16
ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  51
LEU A  77
TRP A 106
LEU A 119
 None
 0.43A 4qztC-2rcqA:
26.5		 4qztC-2rcqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  16
ILE A  25
ALA A  33
GLN A  38
LYS A  40
THR A  51
SER A  76
LEU A  77
LEU A 119
 None
 0.77A 4qztC-2rcqA:
26.5		 4qztC-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus) 		PF09367
(CpeS) 		5 PHE A  11
ILE A  41
ALA A  69
THR A 132
LEU A 128
 PO4  A 201 ( 4.4A)
None
PO4  A 201 ( 4.4A)
None
None
 1.15A 4qztC-3bdrA:
8.2		 4qztC-3bdrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB
F26G19 FAB

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 ALA L  25
GLN L  90
THR H 100
ARG L  66
TYR L  32
 None
 1.47A 4qztC-3bgfL:
undetectable		 4qztC-3bgfL:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.35A 4qztC-3breA:
undetectable		 4qztC-3breA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		5 PHE A 216
ILE A 164
THR A 191
LEU A 162
LEU A 223
 None
 1.33A 4qztC-3c5hA:
undetectable		 4qztC-3c5hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ILE A  95
GLN A  87
SER A 302
LEU A 306
LEU A 103
 None
 1.05A 4qztC-3e0lA:
undetectable		 4qztC-3e0lA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A  66
ALA A  19
SER A  36
LEU A  70
LEU A   3
 None
 1.31A 4qztC-3e7wA:
undetectable		 4qztC-3e7wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		5 PHE A  97
ILE A 183
ALA A 123
LEU A 155
LEU A  99
 None
 1.28A 4qztC-3eeyA:
undetectable		 4qztC-3eeyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		5 ILE A 182
ALA A 186
TYR A  78
LEU A 129
LEU A 120
 None
 1.23A 4qztC-3fijA:
undetectable		 4qztC-3fijA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		5 ILE A  17
ALA A 146
TYR A 143
SER A 141
LEU A  23
 None
 1.15A 4qztC-3h2dA:
undetectable		 4qztC-3h2dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.28A 4qztC-3i5bA:
undetectable		 4qztC-3i5bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN

(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		PF00990
(GGDEF) 		5 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.50A 4qztC-3i5cA:
undetectable		 4qztC-3i5cA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k69 PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF02082
(Rrf2) 		5 ILE A  44
TYR A  19
SER A  36
LEU A  33
LEU A  57
 None
 1.02A 4qztC-3k69A:
undetectable		 4qztC-3k69A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 PHE A 223
ALA A 241
SER A 236
LEU A 233
LEU A 208
 None
 1.23A 4qztC-3nawA:
undetectable		 4qztC-3nawA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp4 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		5 ILE A 156
ALA A  51
SER A  79
LEU A  56
LEU A 178
 None
 1.48A 4qztC-3qp4A:
undetectable		 4qztC-3qp4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		5 ALA A 337
THR A  53
SER A 304
LEU A 301
LEU A 379
 None
 1.27A 4qztC-3vdgA:
undetectable		 4qztC-3vdgA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ILE A 123
ALA A 120
TYR A 329
LEU A 399
LEU A 372
 None
 1.48A 4qztC-3w5nA:
2.6		 4qztC-3w5nA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 335
TYR A 380
SER A 360
LEU A 363
LEU A 325
 None
 1.43A 4qztC-3wgpA:
undetectable		 4qztC-3wgpA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 PHE A 245
ALA A 340
TYR A 233
LEU A 232
LEU A 197
 None
 1.49A 4qztC-4be9A:
undetectable		 4qztC-4be9A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 332
THR A  48
SER A 299
LEU A 296
LEU A 375
 None
 1.37A 4qztC-4dhgA:
undetectable		 4qztC-4dhgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 5 ILE A  86
ALA A 158
SER A  72
LEU A  73
LEU A 103
 None
 1.36A 4qztC-4h5yA:
undetectable		 4qztC-4h5yA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 5 ILE A  86
ALA A 158
THR A  63
SER A  72
LEU A 103
 None
 1.23A 4qztC-4h5yA:
undetectable		 4qztC-4h5yA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10

(Thermus
thermophilus;
Thermus
thermophilus) 		no annotation
no annotation 		5 ILE J  71
ALA J  28
TYR H 134
LEU J  68
LEU H  81
 None
 1.49A 4qztC-4he8J:
undetectable		 4qztC-4he8J:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 PHE N 326
ALA N 295
TYR N 374
SER N 261
LEU N 257
 None
 1.46A 4qztC-4heaN:
undetectable		 4qztC-4heaN:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   6
ALA A 108
THR A  95
LEU A  75
LEU A  11
 None
 1.36A 4qztC-4jhmA:
undetectable		 4qztC-4jhmA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 168
ALA A 330
GLN A 312
SER A 345
LEU A 203
 None
 1.48A 4qztC-4kamA:
undetectable		 4qztC-4kamA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 PHE A 302
ALA A 342
ARG A 339
TYR A 335
LEU A 314
 None
 1.15A 4qztC-4lctA:
undetectable		 4qztC-4lctA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		5 PHE A 232
ALA A 237
GLN A 240
LYS A 291
LEU A 247
 None
None
None
1X8  A 401 (-2.7A)
None
 1.48A 4qztC-4lh7A:
undetectable		 4qztC-4lh7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ARG A 203
TYR A 204
SER A 266
LEU A 267
LEU A  54
 None
 1.27A 4qztC-4llsA:
undetectable		 4qztC-4llsA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 PHE A 321
ALA A 320
TYR A 431
LEU A 308
LEU A 339
 None
 1.34A 4qztC-4m4dA:
2.7		 4qztC-4m4dA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 5 PHE A 141
ILE A 243
THR A 233
SER A 239
LEU A 240
 None
None
PGE  A1003 (-4.0A)
None
None
 1.26A 4qztC-4p8iA:
undetectable		 4qztC-4p8iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ILE A 255
ALA A 337
THR A 301
SER A 352
LEU A 319
 None
 1.23A 4qztC-4phtA:
undetectable		 4qztC-4phtA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A 569
THR A 657
TYR A 626
LEU A 633
LEU A 616
 None
 1.46A 4qztC-4qiwA:
undetectable		 4qztC-4qiwA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		5 ILE A  24
ALA A  71
THR A 127
SER A  97
LEU A  94
 None
 1.44A 4qztC-4rpcA:
undetectable		 4qztC-4rpcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		5 ALA A 173
GLN A 175
ARG A 331
LEU A 308
LEU A 163
 None
 1.32A 4qztC-4wh3A:
undetectable		 4qztC-4wh3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		5 PHE A 152
ALA A 181
GLN A 180
TYR A 174
SER A 227
 None
 1.31A 4qztC-5a5tA:
undetectable		 4qztC-5a5tA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 PHE A  20
ALA A  70
THR A 223
LEU A  39
LEU A  30
 None
 1.48A 4qztC-5aeeA:
undetectable		 4qztC-5aeeA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 ILE A 205
ALA A 228
GLN A 227
TYR A 191
LEU A 163
 None
 1.49A 4qztC-5ereA:
undetectable		 4qztC-5ereA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		5 ILE A 164
ALA A 121
TYR A 134
LEU A 168
LEU A 178
 None
 1.38A 4qztC-5f5vA:
undetectable		 4qztC-5f5vA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 PHE A 164
ILE A 133
ALA A 216
LEU A 113
LEU A 141
 None
 1.27A 4qztC-5gwoA:
1.0		 4qztC-5gwoA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h69 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF06470
(SMC_hinge) 		5 ILE A 549
ALA A 572
TYR A 500
LEU A 511
LEU A 672
 None
 1.41A 4qztC-5h69A:
undetectable		 4qztC-5h69A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		5 PHE A 200
ALA A 175
THR A  91
TYR A 130
LEU A 186
 None
 1.35A 4qztC-5jseA:
undetectable		 4qztC-5jseA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 ALA A 478
TYR A 411
SER A 505
LEU A 481
LEU A 465
 EDO  A1016 (-3.5A)
EDO  A1009 (-4.3A)
EDO  A1011 ( 3.6A)
EDO  A1009 ( 3.5A)
None
 1.47A 4qztC-5kdxA:
undetectable		 4qztC-5kdxA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 PHE B 138
ILE B  74
ALA B 133
LEU B 126
LEU B 113
 None
 1.41A 4qztC-5lb3B:
undetectable		 4qztC-5lb3B:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2d ENDOGLUCANASE-LIKE
PROTEIN

(Acremonium
chrysogenum) 		no annotation 5 PHE A 192
ALA A 194
THR A 177
LEU A 199
LEU A 124
 None
 1.34A 4qztC-5m2dA:
undetectable		 4qztC-5m2dA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 5 ILE A 199
LYS A 243
TYR A 250
SER A 260
LEU A 256
 None
 1.46A 4qztC-5tosA:
undetectable		 4qztC-5tosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 190
ALA A 136
SER A 145
LEU A 148
LEU A 132
 None
 1.40A 4qztC-5uf2A:
undetectable		 4qztC-5uf2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 ILE A 163
GLN A 240
TYR A 238
LEU A 213
LEU A 190
 None
 1.26A 4qztC-5x7nA:
undetectable		 4qztC-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		5 ILE B  64
ALA B  38
GLN A 475
THR A 486
LEU B 197
 None
 1.50A 4qztC-6ch3B:
undetectable		 4qztC-6ch3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cu5 PROTEIN ARGININE
N-METHYLTRANSFERASE

(Naegleria
fowleri) 		no annotation 5 PHE A 125
ILE A 295
ALA A 245
LEU A 211
LEU A 127
 None
 1.49A 4qztC-6cu5A:
undetectable		 4qztC-6cu5A:
undetectable