SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_C_ACTC202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLU A  12
THR B 369
GLN B 330
TRP A  13
 None
 1.48A 4qztC-1bplA:
0.0		 4qztC-1bplA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 GLU A  40
THR A  52
GLN A  36
TRP A  26
 None
 1.40A 4qztC-1dj0A:
0.0		 4qztC-1dj0A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 GLU A  72
THR A  74
GLN A  97
TRP A 106
 None
 0.35A 4qztC-1kqxA:
25.7		 4qztC-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 GLU A  72
THR A  74
GLN A  97
TRP A 106
 None
 0.16A 4qztC-2rcqA:
26.5		 4qztC-2rcqA:
100.00