SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_B_ACTB201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		4 TYR A 318
GLU A 316
LEU A  19
GLN A  26
 None
 1.12A 4qztB-1by7A:
0.0		 4qztB-1by7A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 TYR A  53
TYR A 134
GLU A  98
LEU A  49
 None
 1.14A 4qztB-1d02A:
0.0		 4qztB-1d02A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A  83
GLU A  81
LEU A  21
GLN A 241
 None
 1.42A 4qztB-1db3A:
undetectable		 4qztB-1db3A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		4 TYR A  20
GLU A  74
LEU A  77
GLN A  98
 None
 0.87A 4qztB-1ftpA:
19.6		 4qztB-1ftpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
TYR A  60
GLU A  72
GLN A  97
 None
 0.40A 4qztB-1gglA:
23.8		 4qztB-1gglA:
50.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
LEU A  77
GLN A  97
 None
 0.80A 4qztB-1lpjA:
25.3		 4qztB-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		4 TYR A  89
TYR A 260
GLU A 216
GLN A 281
 None
None
CA  A 520 (-2.4A)
CA  A 520 ( 3.2A)
 1.25A 4qztB-1qdbA:
0.0		 4qztB-1qdbA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A  79
GLU A  77
LEU A  22
GLN A 235
 None
 1.43A 4qztB-1rpnA:
0.0		 4qztB-1rpnA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 TYR A 208
GLU A 117
LEU A 253
GLN A 354
 None
 1.37A 4qztB-1uuoA:
0.0		 4qztB-1uuoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whs SERINE
CARBOXYPEPTIDASE II

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		4 TYR A 133
GLU A  36
LEU A  46
GLN A  42
 None
GOL  A 450 (-4.0A)
None
GOL  A 450 (-4.3A)
 1.27A 4qztB-1whsA:
undetectable		 4qztB-1whsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 TYR A 780
GLU A 664
LEU A 578
GLN A 566
 None
 1.48A 4qztB-1ygpA:
undetectable		 4qztB-1ygpA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 TYR A  37
GLU A  46
LEU A  21
GLN A  14
 None
 1.43A 4qztB-1yqeA:
undetectable		 4qztB-1yqeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 TYR A 123
GLU A 253
LEU A 211
GLN A 128
 None
 1.32A 4qztB-2cexA:
undetectable		 4qztB-2cexA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		4 TYR A  56
GLU A  34
LEU A  59
GLN A  66
 None
 1.45A 4qztB-2gfqA:
undetectable		 4qztB-2gfqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 TYR A 186
TYR A 180
GLU A 134
GLN A 132
 None
 1.50A 4qztB-2hqbA:
undetectable		 4qztB-2hqbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		4 TYR A 239
TYR A 231
GLU A 387
GLN A 179
 None
 1.45A 4qztB-2o6iA:
undetectable		 4qztB-2o6iA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 TYR A 234
TYR A 289
GLU A  43
GLN A 269
 None
 1.16A 4qztB-2ojhA:
undetectable		 4qztB-2ojhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 TYR A  62
TYR A  39
GLU A 393
LEU A  72
 None
 1.17A 4qztB-2p3eA:
undetectable		 4qztB-2p3eA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		4 TYR A 369
TYR A 211
GLU A 238
LEU A 214
 None
None
PEG  A 415 (-4.7A)
None
 1.35A 4qztB-2py6A:
undetectable		 4qztB-2py6A:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
LEU A  77
GLN A  97
 None
 0.76A 4qztB-2rcqA:
26.1		 4qztB-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 316
TYR A 288
GLU A 269
LEU A 306
 None
 1.35A 4qztB-2wskA:
undetectable		 4qztB-2wskA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8p CHAIN LENGTH
DETERMINANT PROTEIN

(Salmonella
enterica) 		PF02706
(Wzz) 		4 TYR A 151
GLU A 117
LEU A 106
GLN A 113
 None
 1.04A 4qztB-3b8pA:
undetectable		 4qztB-3b8pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 TYR A 173
TYR A 144
LEU A 112
GLN A 180
 None
 1.38A 4qztB-3bmaA:
undetectable		 4qztB-3bmaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 TYR A 352
TYR A 474
GLU A 272
GLN A  45
 None
 1.31A 4qztB-3c9fA:
undetectable		 4qztB-3c9fA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 TYR A 818
GLU A 873
LEU A 861
GLN A 870
 None
 0.96A 4qztB-3cqcA:
undetectable		 4qztB-3cqcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 TYR A 818
GLU A 873
LEU A 861
GLN A 870
 None
 1.02A 4qztB-3cqgA:
undetectable		 4qztB-3cqgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		4 TYR A 241
GLU A  24
LEU A 245
GLN A  29
 None
 1.42A 4qztB-3m5uA:
undetectable		 4qztB-3m5uA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 203
GLU A 226
LEU A  71
GLN A 243
 None
 1.43A 4qztB-3pieA:
undetectable		 4qztB-3pieA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A 254
TYR A 427
GLU A 152
GLN A 148
 None
 1.41A 4qztB-3u78A:
undetectable		 4qztB-3u78A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		4 TYR A  79
TYR A 235
GLU A 205
GLN A 256
 None
None
CA  A 476 (-2.4A)
CA  A 476 (-3.2A)
 1.22A 4qztB-3ubrA:
undetectable		 4qztB-3ubrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		4 TYR A 235
GLU A 205
LEU A 253
GLN A 256
 None
CA  A 476 (-2.4A)
None
CA  A 476 (-3.2A)
 0.88A 4qztB-3ubrA:
undetectable		 4qztB-3ubrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		4 TYR A  77
GLU A  13
LEU A  17
GLN A  85
 None
 1.49A 4qztB-4au7A:
undetectable		 4qztB-4au7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A  37
TYR A 493
GLU A 111
LEU A  40
 None
 1.15A 4qztB-4bziA:
undetectable		 4qztB-4bziA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		4 TYR A  66
GLU A  27
LEU A  20
GLN A 111
 None
 1.40A 4qztB-4dheA:
undetectable		 4qztB-4dheA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2c CHIMERIC WZZB CHAIN
LENGTH DETERMINANT
PROTEIN

(Shigella
flexneri;
Salmonella
enterica) 		no annotation 4 TYR A 151
GLU A 117
LEU A 106
GLN A 113
 None
 1.04A 4qztB-4e2cA:
undetectable		 4qztB-4e2cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		4 TYR A 129
GLU A 119
LEU A  41
GLN A 115
 None
 1.32A 4qztB-4ekuA:
undetectable		 4qztB-4ekuA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 TYR A  87
GLU A 654
LEU A  90
GLN A 456
 EDO  A 822 (-4.7A)
EDO  A 822 (-3.1A)
EDO  A 822 (-4.2A)
EDO  A 822 ( 3.0A)
 1.34A 4qztB-4fusA:
undetectable		 4qztB-4fusA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		4 TYR E 155
TYR E  99
GLU E   9
GLN E  70
 None
 1.39A 4qztB-4nhuE:
undetectable		 4qztB-4nhuE:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		4 TYR A 172
GLU A  87
LEU A 210
GLN A 312
 None
 1.33A 4qztB-4xq6A:
undetectable		 4qztB-4xq6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 TYR A 212
TYR A 192
GLU A 148
LEU A 199
 None
 1.30A 4qztB-5fohA:
0.5		 4qztB-5fohA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
LEU A  75
GLN A  95
 None
 0.86A 4qztB-5gkbA:
20.0		 4qztB-5gkbA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 TYR A 208
GLU A 117
LEU A 253
GLN A 354
 None
 1.34A 4qztB-5mvdA:
undetectable		 4qztB-5mvdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 TYR A 911
GLU A 526
LEU A1143
GLN A 529
 None
 1.27A 4qztB-5u70A:
undetectable		 4qztB-5u70A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 TYR A 903
TYR A 779
GLU A 684
LEU A 769
 None
 1.44A 4qztB-5ywzA:
undetectable		 4qztB-5ywzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2m -

(-) 		no annotation 4 TYR A  78
GLU A 105
LEU A  14
GLN A  71
 None
 1.25A 4qztB-5z2mA:
undetectable		 4qztB-5z2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TYR A1803
GLU A1537
LEU A1322
GLN A1315
 None
 1.48A 4qztB-6b3rA:
undetectable		 4qztB-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 TYR A 325
TYR A  62
GLU A  68
LEU A  72
 GOL  A 403 (-4.5A)
None
None
GOL  A 403 (-3.1A)
 0.95A 4qztB-6bqcA:
undetectable		 4qztB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 TYR O  49
TYR O 132
LEU O 131
GLN O 652
 None
 1.41A 4qztB-6eu2O:
undetectable		 4qztB-6eu2O:
undetectable