SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_A_RTLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)

(Murine leukemia
virus) 		PF00078
(RVT_1) 		3 PHE A 156
THR A  96
LEU A  87
 None
 0.78A 4qztA-1d1uA:
0.0		 4qztA-1d1uA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A 220
THR A 383
LEU A 261
 CAA  A 600 (-4.6A)
None
CAA  A 600 (-4.5A)
 0.62A 4qztA-1ee0A:
0.2		 4qztA-1ee0A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 PHE A 496
THR A 225
LEU A 412
 None
 0.79A 4qztA-1ii2A:
0.0		 4qztA-1ii2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 PHE A 361
THR A 380
LEU A 280
 None
 0.75A 4qztA-1lgfA:
0.0		 4qztA-1lgfA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		3 PHE A 190
THR A 239
LEU A 223
 None
 0.79A 4qztA-1o9bA:
undetectable		 4qztA-1o9bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 PHE A 238
THR A  84
LEU A 300
 MAL  A 900 (-4.5A)
NAD  A 500 (-4.7A)
NAD  A 500 ( 4.9A)
 0.68A 4qztA-1obbA:
0.0		 4qztA-1obbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 PHE A 205
THR A 373
LEU A 400
 None
MAP  A 450 (-3.7A)
None
 0.74A 4qztA-1qpgA:
0.0		 4qztA-1qpgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 PHE 1 116
THR 3 227
LEU 3  43
 None
 0.78A 4qztA-1r1a1:
0.0		 4qztA-1r1a1:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida;
Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 PHE C   3
THR B 707
LEU A  69
 None
 0.68A 4qztA-1t3qC:
undetectable		 4qztA-1t3qC:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 PHE A 609
THR A 644
LEU A 686
 None
 0.67A 4qztA-1uusA:
undetectable		 4qztA-1uusA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		3 PHE A 200
THR A 309
LEU A 271
 None
 0.79A 4qztA-1wruA:
undetectable		 4qztA-1wruA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 PHE A 488
THR A 569
LEU A 511
 None
 0.71A 4qztA-1y1uA:
undetectable		 4qztA-1y1uA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		3 PHE A 189
THR A  11
LEU A 183
 None
MNN  A 300 (-2.6A)
None
 0.74A 4qztA-1yb6A:
undetectable		 4qztA-1yb6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 PHE A  24
THR A 270
LEU A  62
 None
 0.78A 4qztA-1ycnA:
undetectable		 4qztA-1ycnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		3 PHE A 511
THR A 246
LEU A 432
 None
ATP  A 541 (-4.8A)
None
 0.72A 4qztA-1ytmA:
undetectable		 4qztA-1ytmA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 PHE A  14
THR A  26
LEU A 163
 None
 0.72A 4qztA-2as9A:
undetectable		 4qztA-2as9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 184
THR A 148
LEU A 172
 None
 0.76A 4qztA-2atcA:
undetectable		 4qztA-2atcA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3w HYPOTHETICAL PROTEIN
YBIA

(Escherichia
coli) 		PF08719
(DUF1768) 		3 PHE A  19
THR A  46
LEU A 145
 None
 0.52A 4qztA-2b3wA:
undetectable		 4qztA-2b3wA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A 228
THR A 394
LEU A 269
 None
 0.77A 4qztA-2d52A:
0.1		 4qztA-2d52A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 PHE A1121
THR A1002
LEU A1006
 None
 0.72A 4qztA-2eyqA:
undetectable		 4qztA-2eyqA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		3 PHE A 384
THR A  83
LEU A  57
 None
 0.78A 4qztA-2hi4A:
undetectable		 4qztA-2hi4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		3 PHE A  90
THR A  72
LEU A 123
 None
 0.70A 4qztA-2k8dA:
undetectable		 4qztA-2k8dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		3 PHE A  59
THR A 145
LEU A 161
 None
 0.77A 4qztA-2lkdA:
undetectable		 4qztA-2lkdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 PHE A 173
THR A 296
LEU A 219
 None
 0.63A 4qztA-2m6kA:
undetectable		 4qztA-2m6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 PHE A 768
THR A 824
LEU A 804
 None
 0.71A 4qztA-2nztA:
undetectable		 4qztA-2nztA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		3 PHE A 190
THR A  95
LEU A 274
 None
None
EDO  A 704 (-3.4A)
 0.73A 4qztA-2p2vA:
undetectable		 4qztA-2p2vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		3 PHE A 239
THR A 284
LEU A 257
 None
 0.59A 4qztA-2pb0A:
undetectable		 4qztA-2pb0A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 PHE B 177
THR B 265
LEU B 362
 None
 0.47A 4qztA-2qgaB:
undetectable		 4qztA-2qgaB:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 PHE A  16
THR A  51
LEU A  77
 None
 0.50A 4qztA-2rcqA:
26.6		 4qztA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 PHE A1712
THR A1654
LEU A1826
 None
NAP  A3001 (-3.0A)
None
 0.67A 4qztA-2vz9A:
undetectable		 4qztA-2vz9A:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 PHE A 581
THR A 537
LEU A 601
 None
 0.74A 4qztA-2z66A:
undetectable		 4qztA-2z66A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		3 PHE B  85
THR B 111
LEU B  75
 None
 0.59A 4qztA-3a0gB:
undetectable		 4qztA-3a0gB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkw DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 PHE A  90
THR A  78
LEU A  16
 None
 0.73A 4qztA-3dkwA:
undetectable		 4qztA-3dkwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		3 PHE A 124
THR A  40
LEU A  62
 None
 0.73A 4qztA-3gveA:
0.6		 4qztA-3gveA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 PHE A 320
THR A 160
LEU A 300
 None
 0.72A 4qztA-3i5tA:
1.4		 4qztA-3i5tA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		3 PHE W1100
THR W 671
LEU W1104
 None
 0.78A 4qztA-3iylW:
undetectable		 4qztA-3iylW:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 185
THR A 149
LEU A 173
 None
 0.78A 4qztA-3lxmA:
undetectable		 4qztA-3lxmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7x CAPSID PROTEIN

(Decapod
penstyldensovirus
1) 		PF16530
(IHHNV_capsid) 		3 PHE A  58
THR A  52
LEU A  74
 None
 0.70A 4qztA-3n7xA:
undetectable		 4qztA-3n7xA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns5 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 PHE A 103
THR A 123
LEU A 149
 None
 0.78A 4qztA-3ns5A:
undetectable		 4qztA-3ns5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		3 PHE A 232
THR A 278
LEU A 250
 None
 0.76A 4qztA-3nx3A:
undetectable		 4qztA-3nx3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		3 PHE A 546
THR A 634
LEU A 624
 None
 0.71A 4qztA-3opbA:
undetectable		 4qztA-3opbA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		3 PHE A 219
THR A  70
LEU A  14
 None
None
NAD  A 901 (-4.6A)
 0.66A 4qztA-3orfA:
undetectable		 4qztA-3orfA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 PHE A  75
THR A  13
LEU A  58
 None
 0.70A 4qztA-3p11A:
undetectable		 4qztA-3p11A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 3 PHE C 376
THR C 252
LEU C 285
 None
 0.72A 4qztA-3r0qC:
undetectable		 4qztA-3r0qC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 PHE A 259
THR A 179
LEU A 188
 None
 0.77A 4qztA-3r5tA:
undetectable		 4qztA-3r5tA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		3 PHE A 190
THR A  11
LEU A 184
 None
 0.76A 4qztA-3rksA:
undetectable		 4qztA-3rksA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 3 PHE A 254
THR A 402
LEU A 427
 None
 0.73A 4qztA-3rylA:
undetectable		 4qztA-3rylA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 PHE A  93
THR A 117
LEU A 157
 None
 0.68A 4qztA-3se5A:
undetectable		 4qztA-3se5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		3 PHE A  82
THR A  75
LEU A  93
 None
 0.71A 4qztA-3slzA:
undetectable		 4qztA-3slzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PHE A 191
THR A 299
LEU A 340
 None
 0.73A 4qztA-3sqiA:
undetectable		 4qztA-3sqiA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		3 PHE A 401
THR A 391
LEU A 193
 None
 0.77A 4qztA-3t2nA:
undetectable		 4qztA-3t2nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 PHE A 179
THR A 185
LEU A 171
 None
 0.63A 4qztA-3t6sA:
undetectable		 4qztA-3t6sA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PHE A 191
THR A 299
LEU A 340
 None
 0.61A 4qztA-3t79A:
undetectable		 4qztA-3t79A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 PHE A  69
THR A   7
LEU A  52
 None
 0.60A 4qztA-3u2pA:
undetectable		 4qztA-3u2pA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 PHE A  69
THR A   7
LEU A  52
 None
 0.61A 4qztA-3u7uA:
undetectable		 4qztA-3u7uA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		3 PHE A 676
THR A 637
LEU A 549
 None
 0.63A 4qztA-3uelA:
undetectable		 4qztA-3uelA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PHE A 535
THR A 406
LEU A 515
 None
 0.70A 4qztA-3vf1A:
undetectable		 4qztA-3vf1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		3 PHE A 815
THR A 775
LEU A 795
 None
 0.73A 4qztA-3welA:
1.6		 4qztA-3welA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		3 PHE A 401
THR A 143
LEU A 397
 None
 0.75A 4qztA-3wqyA:
undetectable		 4qztA-3wqyA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		3 PHE A 189
THR A  11
LEU A 183
 None
EDO  A 302 ( 2.9A)
None
 0.68A 4qztA-3wwpA:
undetectable		 4qztA-3wwpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 PHE A 382
THR A 137
LEU A 121
 None
 0.76A 4qztA-4ak9A:
undetectable		 4qztA-4ak9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		3 PHE A 254
THR A 213
LEU A 242
 None
 0.78A 4qztA-4dj2A:
undetectable		 4qztA-4dj2A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A 225
THR A 123
LEU A 234
 None
 0.79A 4qztA-4e4fA:
undetectable		 4qztA-4e4fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		3 PHE A 673
THR A 634
LEU A 546
 None
 0.47A 4qztA-4fc2A:
0.7		 4qztA-4fc2A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 PHE A  98
THR A 144
LEU A  71
 None
 0.77A 4qztA-4fymA:
undetectable		 4qztA-4fymA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		3 PHE A 557
THR A 551
LEU A 526
 None
 0.71A 4qztA-4gkpA:
1.4		 4qztA-4gkpA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		3 PHE A 741
THR A 722
LEU A 698
 None
 0.78A 4qztA-4i1sA:
undetectable		 4qztA-4i1sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		3 PHE A 234
THR A  63
LEU A 300
 None
 0.73A 4qztA-4kf7A:
undetectable		 4qztA-4kf7A:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 PHE A 312
THR A 384
LEU A 348
 None
 0.68A 4qztA-4kt1A:
undetectable		 4qztA-4kt1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 PHE A 315
THR A 387
LEU A 351
 None
 0.70A 4qztA-4li2A:
undetectable		 4qztA-4li2A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 PHE A 809
THR A 948
LEU A 895
 None
 0.79A 4qztA-4nmeA:
undetectable		 4qztA-4nmeA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		3 PHE A 367
THR A 522
LEU A 464
 None
 0.70A 4qztA-4oe6A:
undetectable		 4qztA-4oe6A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		3 PHE A 562
THR A 625
LEU A 599
 None
 0.62A 4qztA-4ppmA:
undetectable		 4qztA-4ppmA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrk HYPOTHETICAL PROTEIN

(Clostridium
sporogenes) 		PF09922
(DUF2154)
PF17115
(Toast_rack_N) 		3 PHE A 141
THR A  52
LEU A 145
 None
 0.67A 4qztA-4qrkA:
undetectable		 4qztA-4qrkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 3 PHE A 178
THR A 152
LEU A 171
 None
 0.73A 4qztA-4rxxA:
undetectable		 4qztA-4rxxA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		3 PHE A 521
THR A 586
LEU A 655
 None
 0.60A 4qztA-4yj1A:
undetectable		 4qztA-4yj1A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 PHE A 641
THR A 504
LEU A 634
 None
 0.79A 4qztA-5a22A:
undetectable		 4qztA-5a22A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 PHE A 162
THR A 105
LEU A  69
 None
 0.76A 4qztA-5bswA:
undetectable		 4qztA-5bswA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 PHE A  93
THR A 117
LEU A 157
 None
 0.73A 4qztA-5cglA:
undetectable		 4qztA-5cglA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 PHE A 959
THR A 581
LEU A 792
 None
 0.51A 4qztA-5cjuA:
undetectable		 4qztA-5cjuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		3 PHE A 237
THR A  23
LEU A 136
 None
 0.75A 4qztA-5dooA:
undetectable		 4qztA-5dooA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		3 PHE A 200
THR A 207
LEU A 185
 None
 0.77A 4qztA-5griA:
undetectable		 4qztA-5griA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		3 PHE B 259
THR B 397
LEU B 273
 None
 0.65A 4qztA-5j1sB:
undetectable		 4qztA-5j1sB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		3 PHE A  41
THR A 106
LEU A 330
 None
 0.57A 4qztA-5kc9A:
undetectable		 4qztA-5kc9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
PF08641
(Mis14) 		3 PHE N  80
THR D 187
LEU D 175
 None
 0.62A 4qztA-5lskN:
undetectable		 4qztA-5lskN:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 3 PHE B 474
THR B 631
LEU B 538
 None
 0.76A 4qztA-5ochB:
undetectable		 4qztA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 3 PHE B 128
THR B  22
LEU B  57
 None
FMN  B5201 (-2.5A)
FMN  B5201 (-3.7A)
 0.74A 4qztA-5svwB:
undetectable		 4qztA-5svwB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 3 PHE A 189
THR A  11
LEU A 183
 None
GOL  A 300 (-2.9A)
None
 0.67A 4qztA-5tdxA:
undetectable		 4qztA-5tdxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		3 PHE A 474
THR A 523
LEU A 413
 None
 0.78A 4qztA-5tr1A:
undetectable		 4qztA-5tr1A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 PHE A 738
THR A 876
LEU A 823
 None
 0.75A 4qztA-5ux5A:
undetectable		 4qztA-5ux5A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides) 		PF04073
(tRNA_edit) 		3 PHE A 115
THR A 137
LEU A 121
 None
 0.75A 4qztA-5vxbA:
undetectable		 4qztA-5vxbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 PHE A  69
THR A 359
LEU A 348
 None
 0.61A 4qztA-5xapA:
undetectable		 4qztA-5xapA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 PHE A  86
THR A 445
LEU A 423
 None
 0.77A 4qztA-5xblA:
undetectable		 4qztA-5xblA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 3 PHE A 482
THR A 159
LEU A 461
 None
 0.75A 4qztA-5xxiA:
undetectable		 4qztA-5xxiA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 PHE C1028
THR C 996
LEU C1059
 None
 0.72A 4qztA-5y3rC:
undetectable		 4qztA-5y3rC:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 3 PHE A 461
THR A 419
LEU A 436
 None
 0.76A 4qztA-5z24A:
undetectable		 4qztA-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 3 PHE B 641
THR B 618
LEU B 675
 None
 0.73A 4qztA-6b4jB:
undetectable		 4qztA-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 3 PHE E  41
THR E 161
LEU E 114
 None
 0.79A 4qztA-6bm7E:
undetectable		 4qztA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 3 PHE A 563
THR A 557
LEU A 526
 None
 0.78A 4qztA-6c0mA:
undetectable		 4qztA-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 3 PHE A  43
THR A  27
LEU A  48
 None
 0.62A 4qztA-6f39A:
undetectable		 4qztA-6f39A:
undetectable