SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		8 ILE A  25
LYS A  40
THR A  53
TYR A  60
VAL A  62
TRP A 106
LEU A 117
LEU A 119
 None
 0.60A 4qztA-1gglA:
23.8		 4qztA-1gglA:
50.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.26A 4qztA-1j05L:
0.0		 4qztA-1j05L:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		9 MET A  20
ILE A  25
GLN A  38
LYS A  40
THR A  53
VAL A  62
TRP A 106
GLN A 108
LEU A 117
 None
 0.64A 4qztA-1kqxA:
25.7		 4qztA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 MET A  20
ILE A  25
TYR A  60
VAL A  62
TRP A 106
 None
 1.42A 4qztA-1kqxA:
25.7		 4qztA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 MET A  20
ILE A  25
LYS A  40
THR A  53
VAL A  62
TRP A 106
LEU A 117
 None
 0.66A 4qztA-1lpjA:
25.5		 4qztA-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 306
VAL A 358
SER A 326
LEU A 338
LEU A 374
 PLP  A1110 (-4.5A)
None
None
None
None
 1.45A 4qztA-1m54A:
0.0		 4qztA-1m54A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB
H57 FAB

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE E  48
GLN E   6
TYR E  86
GLN F  39
LEU F  45
 None
 1.47A 4qztA-1nfdE:
0.0		 4qztA-1nfdE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 MET A 127
ILE A 151
THR A 204
LEU A 241
LEU A 200
 None
None
NAI  A 301 (-4.4A)
None
None
 1.09A 4qztA-1o9bA:
undetectable		 4qztA-1o9bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 TYR A  99
VAL A 200
SER A 138
LEU A 170
LEU A  83
 None
 1.36A 4qztA-1otkA:
undetectable		 4qztA-1otkA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		5 MET A 205
THR A 188
VAL A 160
LEU A 192
LEU A 200
 None
 1.18A 4qztA-1vz8A:
0.4		 4qztA-1vz8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 ILE A 437
LYS A 498
GLN A 500
LEU A 541
LEU A 463
 None
 1.12A 4qztA-1xdvA:
undetectable		 4qztA-1xdvA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		5 ILE A  49
VAL A  10
SER A  42
LEU A  89
LEU A  55
 None
 1.40A 4qztA-1y7iA:
undetectable		 4qztA-1y7iA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A 327
TYR A 155
VAL A 126
LEU A   7
LEU A 159
 None
 1.48A 4qztA-1zapA:
undetectable		 4qztA-1zapA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 GLN A 269
TYR A 374
SER A 351
GLN A 382
LEU A 302
 None
 1.26A 4qztA-2a0uA:
undetectable		 4qztA-2a0uA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 MET A 325
ILE A 330
VAL A 262
LEU A 318
LEU A 320
 None
None
NAD  A1403 (-3.8A)
None
None
 1.20A 4qztA-2dphA:
undetectable		 4qztA-2dphA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 ILE A 407
THR A 346
VAL A 169
LEU A  99
LEU A 275
 None
 1.35A 4qztA-2inpA:
undetectable		 4qztA-2inpA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 697
VAL A 667
GLN A 660
LEU A 659
LEU A 689
 None
 1.44A 4qztA-2iujA:
0.3		 4qztA-2iujA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6r FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 TYR A  47
VAL A  52
GLN A  82
LEU A  79
LEU A  41
 None
 1.50A 4qztA-2m6rA:
undetectable		 4qztA-2m6rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 MET A 361
THR A 355
VAL A 398
SER A 244
LEU A 406
 None
None
None
MG  A 901 (-2.2A)
None
 1.36A 4qztA-2odpA:
undetectable		 4qztA-2odpA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		5 THR A 161
VAL A 168
TRP A 221
LEU A 195
LEU A 206
 None
 1.29A 4qztA-2px5A:
undetectable		 4qztA-2px5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 MET A  64
ILE A  67
VAL A  94
LEU A  33
LEU A  29
 None
HEM  A 143 (-4.9A)
HEM  A 143 ( 4.7A)
None
None
 1.42A 4qztA-2r1hA:
undetectable		 4qztA-2r1hA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		11 MET A  20
ILE A  25
GLN A  38
LYS A  40
THR A  53
VAL A  62
SER A  76
TRP A 106
GLN A 108
LEU A 117
LEU A 119
 None
 0.39A 4qztA-2rcqA:
26.6		 4qztA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ILE A 282
TYR A  70
VAL A 131
LEU A   4
LEU A  49
 None
 1.22A 4qztA-2wskA:
undetectable		 4qztA-2wskA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7l FAB HEAVY CHAIN
FAB LIGHT CHAIN

(unidentified;
unidentified) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE B  48
GLN B   6
TYR B  86
GLN A  39
LEU A  45
 None
 1.50A 4qztA-2x7lB:
undetectable		 4qztA-2x7lB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 5 MET C 393
GLN C 119
VAL C  44
LEU C 126
LEU C  55
 None
 1.43A 4qztA-3amjC:
undetectable		 4qztA-3amjC:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB
F26G19 FAB

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.46A 4qztA-3bgfL:
undetectable		 4qztA-3bgfL:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 VAL A 280
SER A  52
GLN A 305
LEU A 308
LEU A  61
 None
 1.27A 4qztA-3f11A:
undetectable		 4qztA-3f11A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		5 ILE A  49
THR A  74
VAL A 123
SER A  95
GLN A 180
 None
 1.47A 4qztA-3fijA:
undetectable		 4qztA-3fijA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		5 ILE A  90
GLN A 145
VAL A  59
LEU A 205
LEU A  84
 None
 1.46A 4qztA-3h90A:
undetectable		 4qztA-3h90A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 MET A 380
THR A 282
TYR A  68
VAL A  58
LEU A 289
 None
EDO  A   2 ( 4.5A)
None
None
None
 1.32A 4qztA-3i4gA:
undetectable		 4qztA-3i4gA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		5 ILE A 481
TYR A 487
VAL A 517
LEU A 435
LEU A 561
 None
 1.20A 4qztA-3jd8A:
undetectable		 4qztA-3jd8A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3s ALTRONATE HYDROLASE

(Shigella
flexneri) 		PF08666
(SAF) 		5 ILE A  69
VAL A  27
GLN A   2
LEU A  19
LEU A  34
 None
 1.44A 4qztA-3k3sA:
undetectable		 4qztA-3k3sA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		5 GLN A 124
THR A 127
TYR A 128
SER A  78
LEU A 164
 ARG  A 600 (-3.6A)
ARG  A 600 (-4.3A)
ARG  A 600 (-4.7A)
ARG  A 600 (-2.6A)
None
 1.41A 4qztA-3qaxA:
undetectable		 4qztA-3qaxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893

(Haemophilus
influenzae) 		PF00440
(TetR_N) 		5 MET A  30
ILE A  44
GLN A 107
LEU A  25
LEU A  28
 None
 1.46A 4qztA-3qkxA:
undetectable		 4qztA-3qkxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893

(Haemophilus
influenzae) 		PF00440
(TetR_N) 		5 MET A  30
ILE A  44
VAL A  62
LEU A  25
LEU A  28
 None
 1.38A 4qztA-3qkxA:
undetectable		 4qztA-3qkxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 ILE B 183
TYR B 215
VAL B 223
SER B 176
LEU B 193
 None
 1.41A 4qztA-3r7wB:
1.7		 4qztA-3r7wB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		5 ILE A 141
SER A 182
GLN A   7
LEU A   4
LEU A  26
 None
 1.37A 4qztA-3rkrA:
undetectable		 4qztA-3rkrA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 MET A 149
THR A  67
TYR A  35
VAL A  65
SER A   4
 None
 1.41A 4qztA-3u95A:
undetectable		 4qztA-3u95A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		5 ILE B 184
GLN B 138
TYR B 222
GLN B  40
LEU B  46
 None
 1.40A 4qztA-3uzvB:
undetectable		 4qztA-3uzvB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		5 ILE A 196
THR A 100
SER A 240
LEU A 295
LEU A 316
 None
None
None
4A2  A1366 (-4.1A)
None
 1.15A 4qztA-3zcwA:
undetectable		 4qztA-3zcwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		5 MET A 130
THR A  30
GLN A 429
LEU A 347
LEU A 345
 None
 1.45A 4qztA-4b2gA:
undetectable		 4qztA-4b2gA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		5 ILE A 358
TYR A 194
GLN A 215
LEU A 217
LEU A 362
 None
RUJ  A 401 (-4.3A)
ZN  A 402 ( 4.2A)
None
OGA  A 400 (-4.9A)
 1.43A 4qztA-4bhiA:
undetectable		 4qztA-4bhiA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 ILE A 436
GLN A 838
VAL A 788
SER A 429
LEU A 836
 None
 1.44A 4qztA-4ecnA:
undetectable		 4qztA-4ecnA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		5 MET A 317
ILE A 348
SER A 393
LEU A 321
LEU A 353
 None
 1.34A 4qztA-4f9dA:
undetectable		 4qztA-4f9dA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
HEAVY CHAIN
ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  48
GLN L   6
TYR L  86
GLN H  38
LEU H  44
 None
 1.48A 4qztA-4hbcL:
undetectable		 4qztA-4hbcL:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.42A 4qztA-4idjL:
undetectable		 4qztA-4idjL:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		5 ILE A 122
TYR A 139
VAL A 146
LEU A 150
LEU A 128
 GOL  A 503 ( 4.6A)
None
None
None
None
 1.31A 4qztA-4lejA:
undetectable		 4qztA-4lejA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 ILE X 229
VAL X 219
SER X 207
LEU X 240
LEU X 238
 LLP  X  42 ( 4.7A)
None
None
None
None
 1.48A 4qztA-4li3X:
undetectable		 4qztA-4li3X:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ILE B  48
GLN B   6
TYR B  86
GLN A  39
LEU A  45
 None
 1.39A 4qztA-4llvB:
undetectable		 4qztA-4llvB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 VAL A 199
SER A 401
GLN A 211
LEU A 208
LEU A 158
 None
 1.46A 4qztA-4p08A:
undetectable		 4qztA-4p08A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16

(Homo sapiens) 		PF02760
(HIN) 		5 ILE A 386
TYR A 317
GLN A 310
LEU A 307
LEU A 378
 None
 1.19A 4qztA-4qguA:
undetectable		 4qztA-4qguA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ILE P 521
TYR P 585
VAL P 589
SER P 558
LEU P 446
 None
None
None
SO4  P 704 (-4.9A)
None
 1.50A 4qztA-4s2tP:
undetectable		 4qztA-4s2tP:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ILE E 188
GLN E 145
TYR E 226
GLN D  39
LEU D  45
 None
 1.24A 4qztA-4v1dE:
undetectable		 4qztA-4v1dE:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjz SCFV H2526

(Homo sapiens) 		PF07686
(V-set) 		5 ILE L  49
GLN L   6
TYR L  87
GLN L 239
LEU L 245
 None
 1.33A 4qztA-4yjzL:
undetectable		 4qztA-4yjzL:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  51
GLN L   9
TYR L  89
GLN H  42
LEU H  48
 None
 1.39A 4qztA-4yueL:
undetectable		 4qztA-4yueL:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  50
GLN L   6
TYR L  88
GLN H  41
LEU H  47
 None
 1.20A 4qztA-4zs7L:
undetectable		 4qztA-4zs7L:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		5 GLN A 168
VAL A 218
SER A 132
LEU A  21
LEU A 163
 None
None
NAD  A 400 ( 4.0A)
None
None
 1.26A 4qztA-5eksA:
undetectable		 4qztA-5eksA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ILE L  50
GLN L   6
TYR L  88
GLN H  39
LEU H  45
 None
 1.14A 4qztA-5grjL:
undetectable		 4qztA-5grjL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		5 ILE A 451
THR A 516
SER A 479
LEU A 501
LEU A 459
 None
 1.29A 4qztA-5h2vA:
undetectable		 4qztA-5h2vA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hns NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 481
TYR A 487
VAL A 517
LEU A 435
LEU A 561
 None
 1.20A 4qztA-5hnsA:
undetectable		 4qztA-5hnsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB HEAVY CHAIN
HHH1 FAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  50
GLN L   6
TYR L  88
GLN H  39
LEU H  45
 None
 1.40A 4qztA-5i8kL:
undetectable		 4qztA-5i8kL:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 5 TYR A 198
SER A 202
GLN A  47
LEU A  33
LEU A  35
 None
 1.01A 4qztA-5nywA:
undetectable		 4qztA-5nywA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.30A 4qztA-5u3pL:
undetectable		 4qztA-5u3pL:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		5 ILE A 160
GLN A 231
VAL A 101
LEU A 243
LEU A 173
 None
 1.20A 4qztA-5v1mA:
undetectable		 4qztA-5v1mA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		5 ILE A  50
VAL A  71
GLN A  -2
LEU A  -5
LEU A  -8
 None
 1.11A 4qztA-5v88A:
undetectable		 4qztA-5v88A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 ILE A  79
GLN A 141
THR A 254
TRP A 514
LEU A  84
 FAD  A 701 (-4.0A)
None
CL  A 717 ( 4.1A)
None
None
 1.22A 4qztA-5wgxA:
2.6		 4qztA-5wgxA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5


(;
) 		no annotation
no annotation 		5 ILE D  49
GLN D   6
TYR D  87
GLN C  39
LEU C  45
 None
 1.44A 4qztA-5yy5D:
undetectable		 4qztA-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ILE A  49
GLN A   7
TYR A  87
GLN B  38
LEU B  44
 None
 1.39A 4qztA-6ba5A:
undetectable		 4qztA-6ba5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejm SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 5 ILE H 227
GLN H 180
TYR H 265
GLN H  77
LEU H  83
 None
 1.50A 4qztA-6ejmH:
undetectable		 4qztA-6ejmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 5 ILE A 174
TYR A 256
VAL A 152
LEU A 137
LEU A 132
 None
 1.34A 4qztA-6gebA:
1.3		 4qztA-6gebA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)

(Murine leukemia
virus) 		PF00078
(RVT_1) 		3 PHE A 156
THR A  96
LEU A  87
 None
 0.78A 4qztA-1d1uA:
0.0		 4qztA-1d1uA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A 220
THR A 383
LEU A 261
 CAA  A 600 (-4.6A)
None
CAA  A 600 (-4.5A)
 0.62A 4qztA-1ee0A:
0.2		 4qztA-1ee0A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 PHE A 496
THR A 225
LEU A 412
 None
 0.79A 4qztA-1ii2A:
0.0		 4qztA-1ii2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 PHE A 361
THR A 380
LEU A 280
 None
 0.75A 4qztA-1lgfA:
0.0		 4qztA-1lgfA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		3 PHE A 190
THR A 239
LEU A 223
 None
 0.79A 4qztA-1o9bA:
undetectable		 4qztA-1o9bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 PHE A 238
THR A  84
LEU A 300
 MAL  A 900 (-4.5A)
NAD  A 500 (-4.7A)
NAD  A 500 ( 4.9A)
 0.68A 4qztA-1obbA:
0.0		 4qztA-1obbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 PHE A 205
THR A 373
LEU A 400
 None
MAP  A 450 (-3.7A)
None
 0.74A 4qztA-1qpgA:
0.0		 4qztA-1qpgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 PHE 1 116
THR 3 227
LEU 3  43
 None
 0.78A 4qztA-1r1a1:
0.0		 4qztA-1r1a1:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida;
Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 PHE C   3
THR B 707
LEU A  69
 None
 0.68A 4qztA-1t3qC:
undetectable		 4qztA-1t3qC:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 PHE A 609
THR A 644
LEU A 686
 None
 0.67A 4qztA-1uusA:
undetectable		 4qztA-1uusA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		3 PHE A 200
THR A 309
LEU A 271
 None
 0.79A 4qztA-1wruA:
undetectable		 4qztA-1wruA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 PHE A 488
THR A 569
LEU A 511
 None
 0.71A 4qztA-1y1uA:
undetectable		 4qztA-1y1uA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		3 PHE A 189
THR A  11
LEU A 183
 None
MNN  A 300 (-2.6A)
None
 0.74A 4qztA-1yb6A:
undetectable		 4qztA-1yb6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 PHE A  24
THR A 270
LEU A  62
 None
 0.78A 4qztA-1ycnA:
undetectable		 4qztA-1ycnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		3 PHE A 511
THR A 246
LEU A 432
 None
ATP  A 541 (-4.8A)
None
 0.72A 4qztA-1ytmA:
undetectable		 4qztA-1ytmA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 PHE A  14
THR A  26
LEU A 163
 None
 0.72A 4qztA-2as9A:
undetectable		 4qztA-2as9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 184
THR A 148
LEU A 172
 None
 0.76A 4qztA-2atcA:
undetectable		 4qztA-2atcA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3w HYPOTHETICAL PROTEIN
YBIA

(Escherichia
coli) 		PF08719
(DUF1768) 		3 PHE A  19
THR A  46
LEU A 145
 None
 0.52A 4qztA-2b3wA:
undetectable		 4qztA-2b3wA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 PHE A 228
THR A 394
LEU A 269
 None
 0.77A 4qztA-2d52A:
0.1		 4qztA-2d52A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 PHE A1121
THR A1002
LEU A1006
 None
 0.72A 4qztA-2eyqA:
undetectable		 4qztA-2eyqA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		3 PHE A 384
THR A  83
LEU A  57
 None
 0.78A 4qztA-2hi4A:
undetectable		 4qztA-2hi4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		3 PHE A  90
THR A  72
LEU A 123
 None
 0.70A 4qztA-2k8dA:
undetectable		 4qztA-2k8dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		3 PHE A  59
THR A 145
LEU A 161
 None
 0.77A 4qztA-2lkdA:
undetectable		 4qztA-2lkdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 PHE A 173
THR A 296
LEU A 219
 None
 0.63A 4qztA-2m6kA:
undetectable		 4qztA-2m6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 PHE A 768
THR A 824
LEU A 804
 None
 0.71A 4qztA-2nztA:
undetectable		 4qztA-2nztA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		3 PHE A 190
THR A  95
LEU A 274
 None
None
EDO  A 704 (-3.4A)
 0.73A 4qztA-2p2vA:
undetectable		 4qztA-2p2vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		3 PHE A 239
THR A 284
LEU A 257
 None
 0.59A 4qztA-2pb0A:
undetectable		 4qztA-2pb0A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 PHE B 177
THR B 265
LEU B 362
 None
 0.47A 4qztA-2qgaB:
undetectable		 4qztA-2qgaB:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 PHE A  16
THR A  51
LEU A  77
 None
 0.50A 4qztA-2rcqA:
26.6		 4qztA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 PHE A1712
THR A1654
LEU A1826
 None
NAP  A3001 (-3.0A)
None
 0.67A 4qztA-2vz9A:
undetectable		 4qztA-2vz9A:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 PHE A 581
THR A 537
LEU A 601
 None
 0.74A 4qztA-2z66A:
undetectable		 4qztA-2z66A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		3 PHE B  85
THR B 111
LEU B  75
 None
 0.59A 4qztA-3a0gB:
undetectable		 4qztA-3a0gB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkw DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 PHE A  90
THR A  78
LEU A  16
 None
 0.73A 4qztA-3dkwA:
undetectable		 4qztA-3dkwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		3 PHE A 124
THR A  40
LEU A  62
 None
 0.73A 4qztA-3gveA:
0.6		 4qztA-3gveA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 PHE A 320
THR A 160
LEU A 300
 None
 0.72A 4qztA-3i5tA:
1.4		 4qztA-3i5tA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		3 PHE W1100
THR W 671
LEU W1104
 None
 0.78A 4qztA-3iylW:
undetectable		 4qztA-3iylW:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A 185
THR A 149
LEU A 173
 None
 0.78A 4qztA-3lxmA:
undetectable		 4qztA-3lxmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7x CAPSID PROTEIN

(Decapod
penstyldensovirus
1) 		PF16530
(IHHNV_capsid) 		3 PHE A  58
THR A  52
LEU A  74
 None
 0.70A 4qztA-3n7xA:
undetectable		 4qztA-3n7xA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns5 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 PHE A 103
THR A 123
LEU A 149
 None
 0.78A 4qztA-3ns5A:
undetectable		 4qztA-3ns5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		3 PHE A 232
THR A 278
LEU A 250
 None
 0.76A 4qztA-3nx3A:
undetectable		 4qztA-3nx3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		3 PHE A 546
THR A 634
LEU A 624
 None
 0.71A 4qztA-3opbA:
undetectable		 4qztA-3opbA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		3 PHE A 219
THR A  70
LEU A  14
 None
None
NAD  A 901 (-4.6A)
 0.66A 4qztA-3orfA:
undetectable		 4qztA-3orfA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 PHE A  75
THR A  13
LEU A  58
 None
 0.70A 4qztA-3p11A:
undetectable		 4qztA-3p11A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 3 PHE C 376
THR C 252
LEU C 285
 None
 0.72A 4qztA-3r0qC:
undetectable		 4qztA-3r0qC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 PHE A 259
THR A 179
LEU A 188
 None
 0.77A 4qztA-3r5tA:
undetectable		 4qztA-3r5tA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		3 PHE A 190
THR A  11
LEU A 184
 None
 0.76A 4qztA-3rksA:
undetectable		 4qztA-3rksA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 3 PHE A 254
THR A 402
LEU A 427
 None
 0.73A 4qztA-3rylA:
undetectable		 4qztA-3rylA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 PHE A  93
THR A 117
LEU A 157
 None
 0.68A 4qztA-3se5A:
undetectable		 4qztA-3se5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		3 PHE A  82
THR A  75
LEU A  93
 None
 0.71A 4qztA-3slzA:
undetectable		 4qztA-3slzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PHE A 191
THR A 299
LEU A 340
 None
 0.73A 4qztA-3sqiA:
undetectable		 4qztA-3sqiA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		3 PHE A 401
THR A 391
LEU A 193
 None
 0.77A 4qztA-3t2nA:
undetectable		 4qztA-3t2nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 PHE A 179
THR A 185
LEU A 171
 None
 0.63A 4qztA-3t6sA:
undetectable		 4qztA-3t6sA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PHE A 191
THR A 299
LEU A 340
 None
 0.61A 4qztA-3t79A:
undetectable		 4qztA-3t79A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 PHE A  69
THR A   7
LEU A  52
 None
 0.60A 4qztA-3u2pA:
undetectable		 4qztA-3u2pA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 PHE A  69
THR A   7
LEU A  52
 None
 0.61A 4qztA-3u7uA:
undetectable		 4qztA-3u7uA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		3 PHE A 676
THR A 637
LEU A 549
 None
 0.63A 4qztA-3uelA:
undetectable		 4qztA-3uelA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PHE A 535
THR A 406
LEU A 515
 None
 0.70A 4qztA-3vf1A:
undetectable		 4qztA-3vf1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		3 PHE A 815
THR A 775
LEU A 795
 None
 0.73A 4qztA-3welA:
1.6		 4qztA-3welA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		3 PHE A 401
THR A 143
LEU A 397
 None
 0.75A 4qztA-3wqyA:
undetectable		 4qztA-3wqyA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		3 PHE A 189
THR A  11
LEU A 183
 None
EDO  A 302 ( 2.9A)
None
 0.68A 4qztA-3wwpA:
undetectable		 4qztA-3wwpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 PHE A 382
THR A 137
LEU A 121
 None
 0.76A 4qztA-4ak9A:
undetectable		 4qztA-4ak9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		3 PHE A 254
THR A 213
LEU A 242
 None
 0.78A 4qztA-4dj2A:
undetectable		 4qztA-4dj2A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A 225
THR A 123
LEU A 234
 None
 0.79A 4qztA-4e4fA:
undetectable		 4qztA-4e4fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		3 PHE A 673
THR A 634
LEU A 546
 None
 0.47A 4qztA-4fc2A:
0.7		 4qztA-4fc2A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 PHE A  98
THR A 144
LEU A  71
 None
 0.77A 4qztA-4fymA:
undetectable		 4qztA-4fymA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		3 PHE A 557
THR A 551
LEU A 526
 None
 0.71A 4qztA-4gkpA:
1.4		 4qztA-4gkpA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		3 PHE A 741
THR A 722
LEU A 698
 None
 0.78A 4qztA-4i1sA:
undetectable		 4qztA-4i1sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		3 PHE A 234
THR A  63
LEU A 300
 None
 0.73A 4qztA-4kf7A:
undetectable		 4qztA-4kf7A:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 PHE A 312
THR A 384
LEU A 348
 None
 0.68A 4qztA-4kt1A:
undetectable		 4qztA-4kt1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 PHE A 315
THR A 387
LEU A 351
 None
 0.70A 4qztA-4li2A:
undetectable		 4qztA-4li2A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 PHE A 809
THR A 948
LEU A 895
 None
 0.79A 4qztA-4nmeA:
undetectable		 4qztA-4nmeA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		3 PHE A 367
THR A 522
LEU A 464
 None
 0.70A 4qztA-4oe6A:
undetectable		 4qztA-4oe6A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		3 PHE A 562
THR A 625
LEU A 599
 None
 0.62A 4qztA-4ppmA:
undetectable		 4qztA-4ppmA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrk HYPOTHETICAL PROTEIN

(Clostridium
sporogenes) 		PF09922
(DUF2154)
PF17115
(Toast_rack_N) 		3 PHE A 141
THR A  52
LEU A 145
 None
 0.67A 4qztA-4qrkA:
undetectable		 4qztA-4qrkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 3 PHE A 178
THR A 152
LEU A 171
 None
 0.73A 4qztA-4rxxA:
undetectable		 4qztA-4rxxA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		3 PHE A 521
THR A 586
LEU A 655
 None
 0.60A 4qztA-4yj1A:
undetectable		 4qztA-4yj1A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 PHE A 641
THR A 504
LEU A 634
 None
 0.79A 4qztA-5a22A:
undetectable		 4qztA-5a22A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 PHE A 162
THR A 105
LEU A  69
 None
 0.76A 4qztA-5bswA:
undetectable		 4qztA-5bswA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 PHE A  93
THR A 117
LEU A 157
 None
 0.73A 4qztA-5cglA:
undetectable		 4qztA-5cglA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 PHE A 959
THR A 581
LEU A 792
 None
 0.51A 4qztA-5cjuA:
undetectable		 4qztA-5cjuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		3 PHE A 237
THR A  23
LEU A 136
 None
 0.75A 4qztA-5dooA:
undetectable		 4qztA-5dooA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		3 PHE A 200
THR A 207
LEU A 185
 None
 0.77A 4qztA-5griA:
undetectable		 4qztA-5griA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		3 PHE B 259
THR B 397
LEU B 273
 None
 0.65A 4qztA-5j1sB:
undetectable		 4qztA-5j1sB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		3 PHE A  41
THR A 106
LEU A 330
 None
 0.57A 4qztA-5kc9A:
undetectable		 4qztA-5kc9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
PF08641
(Mis14) 		3 PHE N  80
THR D 187
LEU D 175
 None
 0.62A 4qztA-5lskN:
undetectable		 4qztA-5lskN:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 3 PHE B 474
THR B 631
LEU B 538
 None
 0.76A 4qztA-5ochB:
undetectable		 4qztA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 3 PHE B 128
THR B  22
LEU B  57
 None
FMN  B5201 (-2.5A)
FMN  B5201 (-3.7A)
 0.74A 4qztA-5svwB:
undetectable		 4qztA-5svwB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 3 PHE A 189
THR A  11
LEU A 183
 None
GOL  A 300 (-2.9A)
None
 0.67A 4qztA-5tdxA:
undetectable		 4qztA-5tdxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		3 PHE A 474
THR A 523
LEU A 413
 None
 0.78A 4qztA-5tr1A:
undetectable		 4qztA-5tr1A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 PHE A 738
THR A 876
LEU A 823
 None
 0.75A 4qztA-5ux5A:
undetectable		 4qztA-5ux5A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides) 		PF04073
(tRNA_edit) 		3 PHE A 115
THR A 137
LEU A 121
 None
 0.75A 4qztA-5vxbA:
undetectable		 4qztA-5vxbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 PHE A  69
THR A 359
LEU A 348
 None
 0.61A 4qztA-5xapA:
undetectable		 4qztA-5xapA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 PHE A  86
THR A 445
LEU A 423
 None
 0.77A 4qztA-5xblA:
undetectable		 4qztA-5xblA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 3 PHE A 482
THR A 159
LEU A 461
 None
 0.75A 4qztA-5xxiA:
undetectable		 4qztA-5xxiA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 PHE C1028
THR C 996
LEU C1059
 None
 0.72A 4qztA-5y3rC:
undetectable		 4qztA-5y3rC:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 3 PHE A 461
THR A 419
LEU A 436
 None
 0.76A 4qztA-5z24A:
undetectable		 4qztA-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 3 PHE B 641
THR B 618
LEU B 675
 None
 0.73A 4qztA-6b4jB:
undetectable		 4qztA-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 3 PHE E  41
THR E 161
LEU E 114
 None
 0.79A 4qztA-6bm7E:
undetectable		 4qztA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 3 PHE A 563
THR A 557
LEU A 526
 None
 0.78A 4qztA-6c0mA:
undetectable		 4qztA-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f39 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 3 PHE A  43
THR A  27
LEU A  48
 None
 0.62A 4qztA-6f39A:
undetectable		 4qztA-6f39A:
undetectable