SIMILAR PATTERNS OF AMINO ACIDS FOR 4QZT_A_ACTA202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 TYR A 127
THR A 112
LEU A 113
GLN A 109
 None
 1.34A 4qztA-1a6dA:
undetectable		 4qztA-1a6dA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 GLU A  40
THR A  52
GLN A  36
TRP A  26
 None
 1.37A 4qztA-1dj0A:
undetectable		 4qztA-1dj0A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		4 GLU A  74
THR A  76
LEU A  77
GLN A  98
 None
 0.99A 4qztA-1ftpA:
19.4		 4qztA-1ftpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		4 TYR A  20
GLU A  74
LEU A  77
GLN A  98
 None
 0.69A 4qztA-1ftpA:
19.4		 4qztA-1ftpA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
GLN A  97
TRP A 106
 None
 0.37A 4qztA-1gglA:
23.8		 4qztA-1gglA:
50.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.88A 4qztA-1jjxA:
18.3		 4qztA-1jjxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 GLU A  72
THR A  74
GLN A  97
TRP A 106
 None
 0.42A 4qztA-1kqxA:
25.7		 4qztA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 THR A  74
LEU A  77
GLN A  97
TRP A 106
 None
 0.70A 4qztA-1kqxA:
25.7		 4qztA-1kqxA:
75.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
GLU A  72
LEU A  77
GLN A  97
TRP A 106
 None
 0.58A 4qztA-1lpjA:
25.5		 4qztA-1lpjA:
58.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		4 TYR A  66
THR A  85
LEU A  86
GLN A  46
 None
 1.24A 4qztA-1nmoA:
undetectable		 4qztA-1nmoA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09201
(SRX)
PF09439
(SRPRB) 		4 TYR A 137
THR B  52
LEU B  55
GLN A  13
 None
MG  B   1 ( 3.0A)
None
None
 1.18A 4qztA-1nrjA:
undetectable		 4qztA-1nrjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A 159
GLU A 199
THR A 196
GLN A 284
 None
 1.24A 4qztA-1o5tA:
undetectable		 4qztA-1o5tA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7d INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 TYR A 189
GLU A 257
THR A 258
LEU A 201
 None
 1.34A 4qztA-1p7dA:
undetectable		 4qztA-1p7dA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.72A 4qztA-1pmpA:
20.3		 4qztA-1pmpA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLU A 693
THR A 690
LEU A 658
TRP A 668
 None
 1.43A 4qztA-1rrhA:
undetectable		 4qztA-1rrhA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A  76
THR A 143
LEU A 144
GLN A 103
 None
 1.30A 4qztA-1smkA:
undetectable		 4qztA-1smkA:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.75A 4qztA-1towA:
20.9		 4qztA-1towA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygm HYPOTHETICAL PROTEIN
BSU31320

(Bacillus
subtilis) 		PF11458
(Mistic) 		4 GLU A  35
THR A  39
LEU A  16
GLN A  36
 None
 1.43A 4qztA-1ygmA:
undetectable		 4qztA-1ygmA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 1 135
THR 1 250
LEU 1  87
GLN 1 148
 None
 1.46A 4qztA-1z7z1:
undetectable		 4qztA-1z7z1:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 GLU A 250
THR A 251
LEU A  64
GLN A 421
 None
 1.29A 4qztA-2i3oA:
undetectable		 4qztA-2i3oA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 GLU A1221
THR A1225
LEU A1228
GLN A1214
 None
 1.03A 4qztA-2ix8A:
undetectable		 4qztA-2ix8A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 TYR A  89
GLU A 301
THR A 165
LEU A 164
 None
 1.36A 4qztA-2po4A:
undetectable		 4qztA-2po4A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 4 TYR B 117
GLU B 373
LEU B 144
GLN B  93
 None
 1.47A 4qztA-2pvcB:
undetectable		 4qztA-2pvcB:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.81A 4qztA-2q9sA:
20.5		 4qztA-2q9sA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
GLU A  72
THR A  74
LEU A  77
GLN A  97
TRP A 106
 None
 0.40A 4qztA-2rcqA:
26.6		 4qztA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 TYR A 225
THR A 298
LEU A  59
GLN A 189
 COA  A1383 (-4.1A)
None
None
None
 1.23A 4qztA-2vatA:
undetectable		 4qztA-2vatA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		4 TYR A 208
GLU A  28
THR A 103
LEU A 203
 None
 1.45A 4qztA-3c02A:
undetectable		 4qztA-3c02A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 GLU A  47
THR A  26
LEU A  25
GLN A  50
 None
 1.22A 4qztA-3l6cA:
undetectable		 4qztA-3l6cA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLU A  47
THR A  26
LEU A  25
GLN A  50
 None
 1.20A 4qztA-3l6rA:
undetectable		 4qztA-3l6rA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
 0.78A 4qztA-3nr3A:
20.4		 4qztA-3nr3A:
31.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		4 TYR A 277
GLU A 113
LEU A 172
GLN A 191
 None
None
None
P1T  A 702 (-2.9A)
 1.50A 4qztA-3pc3A:
undetectable		 4qztA-3pc3A:
12.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		4 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
 0.61A 4qztA-3pp6A:
21.7		 4qztA-3pp6A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 252
GLU A  20
THR A  23
LEU A 348
 MOH  A 413 ( 4.3A)
None
None
None
 1.37A 4qztA-3u0fA:
undetectable		 4qztA-3u0fA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		4 TYR A 204
THR A 135
LEU A 195
TRP A 141
 None
 1.30A 4qztA-3wauA:
undetectable		 4qztA-3wauA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 2AN  A 201 (-4.8A)
None
None
None
 0.75A 4qztA-3wbgA:
20.9		 4qztA-3wbgA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 TYR A 337
GLU A 421
THR A 417
TRP A 343
 GLC  A 801 ( 4.0A)
None
BGC  A 802 (-3.0A)
GLC  A 801 (-4.4A)
 1.44A 4qztA-3wiqA:
undetectable		 4qztA-3wiqA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 TYR A 163
GLU A 612
THR A 316
LEU A 315
 None
SO4  A1694 ( 4.4A)
None
None
 1.49A 4qztA-3zukA:
undetectable		 4qztA-3zukA:
10.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
None
EDO  A1134 ( 4.9A)
None
 0.80A 4qztA-4a60A:
19.7		 4qztA-4a60A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  22
GLU A  75
THR A  77
GLN A  98
 None
 0.63A 4qztA-4aznA:
20.0		 4qztA-4aznA:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  22
GLU A  75
THR A  77
GLN A  98
 None
 0.64A 4qztA-4azpA:
21.0		 4qztA-4azpA:
31.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e10 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 GLU A 337
THR A 338
LEU A 341
GLN A 322
 None
 1.16A 4qztA-4e10A:
undetectable		 4qztA-4e10A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f41 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 GLU A 337
THR A 338
LEU A 341
GLN A 322
 None
 1.27A 4qztA-4f41A:
undetectable		 4qztA-4f41A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnp LIPOPROTEIN

(Staphylococcus
aureus) 		PF01297
(ZnuA) 		4 TYR A 151
GLU A  93
THR A  38
LEU A  42
 None
 1.48A 4qztA-4nnpA:
undetectable		 4qztA-4nnpA:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.75A 4qztA-4nnsA:
20.6		 4qztA-4nnsA:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		4 TYR A 228
THR A 161
LEU A 158
TRP A 156
 None
 1.48A 4qztA-4ojxA:
undetectable		 4qztA-4ojxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		4 TYR A 148
GLU A  90
THR A  35
LEU A  39
 None
 1.44A 4qztA-4oxrA:
undetectable		 4qztA-4oxrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Aspergillus
fumigatus) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 TYR A 395
GLU A 211
LEU A 492
GLN A 331
 None
 1.47A 4qztA-4qbjA:
undetectable		 4qztA-4qbjA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 TYR A  54
GLU A 286
THR A 289
TRP A  76
 None
 1.37A 4qztA-4r6hA:
undetectable		 4qztA-4r6hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 TYR A 287
GLU A 232
THR A 236
LEU A 239
 None
 1.12A 4qztA-4rpfA:
undetectable		 4qztA-4rpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 TYR A 176
GLU A 156
THR A 153
LEU A  21
 None
 1.42A 4qztA-4rv3A:
undetectable		 4qztA-4rv3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 TYR A 293
THR A 330
LEU A 328
GLN A 289
 None
 1.45A 4qztA-4wjvA:
undetectable		 4qztA-4wjvA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 GLU A 464
THR A 333
LEU A 330
GLN A 206
 None
 1.23A 4qztA-4y9lA:
undetectable		 4qztA-4y9lA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrw MINCLE PROTEIN

(Bos taurus) 		PF00059
(Lectin_C) 		4 TYR A  91
GLU A 121
THR A 119
GLN A  87
 None
 1.38A 4qztA-4zrwA:
undetectable		 4qztA-4zrwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay9 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 TYR A 201
THR A 133
LEU A 192
TRP A 139
 None
 1.38A 4qztA-5ay9A:
undetectable		 4qztA-5ay9A:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.75A 4qztA-5b29A:
20.9		 4qztA-5b29A:
40.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 TYR A  22
GLU A  75
THR A  77
GLN A  99
 None
 0.73A 4qztA-5bvtA:
20.1		 4qztA-5bvtA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 TYR A  19
GLU A  72
THR A  74
LEU A  75
GLN A  95
 None
 0.97A 4qztA-5gkbA:
19.9		 4qztA-5gkbA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  22
GLU A  75
THR A  77
GLN A  98
 65X  A 203 ( 4.7A)
None
None
None
 0.60A 4qztA-5hz5A:
20.9		 4qztA-5hz5A:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		4 TYR A 151
GLU A  93
THR A  38
LEU A  42
 None
 1.39A 4qztA-5i4kA:
undetectable		 4qztA-5i4kA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		4 TYR A  70
GLU A 253
THR A 154
LEU A 156
 None
 1.42A 4qztA-5jb1A:
undetectable		 4qztA-5jb1A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4g L-ASPARAGINASE

(Wolinella
succinogenes) 		PF00710
(Asparaginase) 		4 GLU A  97
THR A 165
LEU A 167
GLN A 304
 None
 1.46A 4qztA-5k4gA:
undetectable		 4qztA-5k4gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1

(Lumbricus
terrestris;
Lumbricus
terrestris) 		PF00042
(Globin)
PF00042
(Globin) 		4 GLU D  13
THR D  12
LEU C  38
GLN C 126
 None
 1.24A 4qztA-5m3lD:
undetectable		 4qztA-5m3lD:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		4 TYR A 234
THR A 286
LEU A  60
GLN A 197
 None
 1.10A 4qztA-5w8oA:
undetectable		 4qztA-5w8oA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		4 TYR A 237
THR A 293
LEU A  63
GLN A 200
 None
 1.14A 4qztA-5w8pA:
undetectable		 4qztA-5w8pA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLU A 374
THR A 162
LEU A 166
GLN A 238
 None
 1.37A 4qztA-5wx3A:
undetectable		 4qztA-5wx3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 4 GLU A 217
THR A 189
LEU A 187
GLN A  74
 None
 1.32A 4qztA-6c9bA:
undetectable		 4qztA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 GLU A 381
THR A 169
LEU A 173
GLN A 245
 None
 1.44A 4qztA-6co0A:
undetectable		 4qztA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 GLU A 254
THR A 217
LEU A 216
GLN A 417
 None
 1.45A 4qztA-6es9A:
undetectable		 4qztA-6es9A:
undetectable