SIMILAR PATTERNS OF AMINO ACIDS FOR 4QYN_B_RTLB201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | ILE A 200GLN A 472THR A 264LEU A 47LEU A 246 | None | 1.47A | 4qynB-1ciyA:0.0 | 4qynB-1ciyA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea6 | PMS1 PROTEIN HOMOLOG2 (Homo sapiens) |
PF01119(DNA_mis_repair)PF13589(HATPase_c_3) | 5 | ILE A 66THR A 155LEU A 42LEU A 83LEU A 111 | NoneADP A1366 ( 4.0A)NoneADP A1366 (-4.9A)ADP A1366 (-3.9A) | 1.45A | 4qynB-1ea6A:0.0 | 4qynB-1ea6A:17.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ggl | PROTEIN (CELLULARRETINOL-BINDINGPROTEIN III) (Homo sapiens) |
PF00061(Lipocalin) | 5 | ILE A 25LYS A 40THR A 53ARG A 58TRP A 106 | None | 0.78A | 4qynB-1gglA:23.8 | 4qynB-1gglA:50.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ggl | PROTEIN (CELLULARRETINOL-BINDINGPROTEIN III) (Homo sapiens) |
PF00061(Lipocalin) | 6 | ILE A 25LYS A 40THR A 53TRP A 106LEU A 117LEU A 119 | None | 0.46A | 4qynB-1gglA:23.8 | 4qynB-1gglA:50.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j9a | OLIGORIBONUCLEASE (Haemophilusinfluenzae) |
PF00929(RNase_T) | 5 | PHE A 130THR A 33LEU A 93LEU A 16LEU A 119 | None | 1.38A | 4qynB-1j9aA:0.4 | 4qynB-1j9aA:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kqx | CELLULARRETINOL-BINDINGPROTEIN (Danio rerio) |
PF00061(Lipocalin) | 7 | ILE A 25GLN A 38LYS A 40THR A 53LEU A 77TRP A 106LEU A 117 | None | 1.08A | 4qynB-1kqxA:25.3 | 4qynB-1kqxA:75.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kqx | CELLULARRETINOL-BINDINGPROTEIN (Danio rerio) |
PF00061(Lipocalin) | 6 | ILE A 25GLN A 38THR A 53ARG A 58LEU A 77TRP A 106 | None | 1.20A | 4qynB-1kqxA:25.3 | 4qynB-1kqxA:75.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kqx | CELLULARRETINOL-BINDINGPROTEIN (Danio rerio) |
PF00061(Lipocalin) | 9 | PHE A 16MET A 20ILE A 25GLN A 38LYS A 40THR A 51THR A 53TRP A 106LEU A 117 | None | 0.64A | 4qynB-1kqxA:25.3 | 4qynB-1kqxA:75.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kqx | CELLULARRETINOL-BINDINGPROTEIN (Danio rerio) |
PF00061(Lipocalin) | 8 | PHE A 16MET A 20ILE A 25GLN A 38THR A 51THR A 53ARG A 58TRP A 106 | None | 0.75A | 4qynB-1kqxA:25.3 | 4qynB-1kqxA:75.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lpj | RETINOL-BINDINGPROTEIN IV, CELLULAR (Homo sapiens) |
PF00061(Lipocalin) | 8 | PHE A 16ILE A 25LYS A 40THR A 53ARG A 58LEU A 77TRP A 106LEU A 117 | None | 0.88A | 4qynB-1lpjA:25.2 | 4qynB-1lpjA:58.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lpj | RETINOL-BINDINGPROTEIN IV, CELLULAR (Homo sapiens) |
PF00061(Lipocalin) | 8 | PHE A 16MET A 20ILE A 25LYS A 40THR A 53LEU A 77TRP A 106LEU A 117 | None | 0.75A | 4qynB-1lpjA:25.2 | 4qynB-1lpjA:58.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9b | HYPOTHETICALSHIKIMATE5-DEHYDROGENASE-LIKEPROTEIN YDIB (Escherichiacoli) |
PF08501(Shikimate_dh_N) | 5 | MET A 127ILE A 151THR A 204LEU A 241LEU A 200 | NoneNoneNAI A 301 (-4.4A)NoneNone | 1.06A | 4qynB-1o9bA:undetectable | 4qynB-1o9bA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ser | PROTEIN (SERYL-TRNASYNTHETASE(E.C.6.1.1.11)) (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | ILE A 409THR A 384LEU A 408LEU A 165LEU A 417 | None | 1.40A | 4qynB-1serA:0.0 | 4qynB-1serA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tye | INTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | PHE B 100ILE B 416LEU B 362LEU B 92LEU B 90 | None | 1.33A | 4qynB-1tyeB:undetectable | 4qynB-1tyeB:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v1p | EXOTOXIN 1 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | ILE A 181THR A 112THR A 114LEU A 145LEU A 173 | None | 1.10A | 4qynB-1v1pA:undetectable | 4qynB-1v1pA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbj | PROSTAGLANDIN FSYNTHASE (Trypanosomabrucei) |
PF00248(Aldo_ket_red) | 5 | PHE A 73THR A 185LEU A 108LEU A 7LEU A 9 | None | 1.39A | 4qynB-1vbjA:undetectable | 4qynB-1vbjA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 5 | ILE X 387THR X 163ARG X 166LEU X 194LEU X 190 | None | 1.19A | 4qynB-1z3iX:undetectable | 4qynB-1z3iX:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bm7 | PENTAPEPTIDE REPEATFAMILY PROTEIN (Mycobacteriumtuberculosis) |
PF13599(Pentapeptide_4) | 5 | THR A 134THR A 117ARG A 100LEU A 109LEU A 104 | None | 1.44A | 4qynB-2bm7A:undetectable | 4qynB-2bm7A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwj | ADENYLATE KINASE 5 (Homo sapiens) |
PF00406(ADK) | 5 | PHE A 108THR A 90LEU A 8LEU A 40LEU A 79 | None | 1.43A | 4qynB-2bwjA:undetectable | 4qynB-2bwjA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1l | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
PF13091(PLDc_2) | 5 | ILE A 301THR A 287LEU A 205TRP A 229LEU A 230 | None | 1.30A | 4qynB-2c1lA:undetectable | 4qynB-2c1lA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7d | UVRABC SYSTEMPROTEIN B (Bacillussubtilis) |
PF00271(Helicase_C)PF02151(UVR)PF04851(ResIII)PF12344(UvrB) | 5 | ILE A 511THR A 462ARG A 447LEU A 491LEU A 504 | None | 1.21A | 4qynB-2d7dA:undetectable | 4qynB-2d7dA:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7k | MAGUK P55 SUBFAMILYMEMBER 2 (Homo sapiens) |
PF00595(PDZ) | 5 | PHE A 24ILE A 36LEU A 48LEU A 72LEU A 73 | None | 1.27A | 4qynB-2e7kA:undetectable | 4qynB-2e7kA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehb | CALCINEURIN B-LIKEPROTEIN 4 (Arabidopsisthaliana) |
PF13202(EF-hand_5)PF13499(EF-hand_7) | 5 | ILE A 55THR A 201LEU A 45LEU A 195LEU A 99 | None | 1.38A | 4qynB-2ehbA:undetectable | 4qynB-2ehbA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpq | BOTULINUM NEUROTOXIND LIGHT CHAIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | PHE A 94THR A 272LEU A 192LEU A 106LEU A 110 | None ZN A 500 ( 4.8A)NoneNoneNone | 1.30A | 4qynB-2fpqA:undetectable | 4qynB-2fpqA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igi | OLIGORIBONUCLEASE (Escherichiacoli) |
PF00929(RNase_T) | 5 | PHE A 126THR A 29LEU A 89LEU A 12LEU A 115 | None | 1.45A | 4qynB-2igiA:undetectable | 4qynB-2igiA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o55 | PUTATIVEGLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Galdieriasulphuraria) |
PF03009(GDPD) | 5 | PHE A 101ILE A 54LEU A 56LEU A 111LEU A 113 | None | 1.39A | 4qynB-2o55A:undetectable | 4qynB-2o55A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oq5 | TRANSMEMBRANEPROTEASE, SERINE 11E (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 47GLN A 30THR A 139LEU A 209TRP A 207 | None | 1.45A | 4qynB-2oq5A:undetectable | 4qynB-2oq5A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5x | UNCHARACTERIZEDCONSERVED PROTEIN (Geobacilluskaustophilus) |
PF08868(YugN) | 5 | ILE A 71ARG A 29LEU A 18LEU A 107LEU A 8 | None | 1.45A | 4qynB-2r5xA:undetectable | 4qynB-2r5xA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc5 | FERREDOXIN-NADPREDUCTASE (Leptospirainterrogans) |
PF00175(NAD_binding_1) | 5 | ILE A 193ARG A 268LEU A 159LEU A 220LEU A 188 | None | 1.40A | 4qynB-2rc5A:undetectable | 4qynB-2rc5A:16.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rcq | RETINOL-BINDINGPROTEIN II, CELLULAR (Homo sapiens) |
PF00061(Lipocalin) | 11 | PHE A 16MET A 20GLN A 38LYS A 40THR A 51THR A 53ARG A 58LEU A 77TRP A 106LEU A 117LEU A 119 | NoneNoneNoneNoneNoneNoneSO4 A 152 (-3.1A)NoneNoneNoneNone | 0.77A | 4qynB-2rcqA:26.3 | 4qynB-2rcqA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rcq | RETINOL-BINDINGPROTEIN II, CELLULAR (Homo sapiens) |
PF00061(Lipocalin) | 11 | PHE A 16MET A 20ILE A 25GLN A 38LYS A 40THR A 51THR A 53LEU A 77TRP A 106LEU A 117LEU A 119 | None | 0.51A | 4qynB-2rcqA:26.3 | 4qynB-2rcqA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfh | SLIT HOMOLOG 2PROTEIN C-PRODUCT (Homo sapiens) |
PF01462(LRRNT)PF01463(LRRCT)PF13855(LRR_8) | 5 | PHE A 845ILE A 856THR A 820LEU A 832LEU A 824 | None | 1.24A | 4qynB-2wfhA:undetectable | 4qynB-2wfhA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x06 | L-SULFOLACTATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF02615(Ldh_2) | 5 | GLN A 51THR A 42ARG A 181LEU A 185LEU A 324 | None | 1.40A | 4qynB-2x06A:0.4 | 4qynB-2x06A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z65 | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13306(LRR_5)PF13855(LRR_8) | 5 | PHE A 246ILE A 218LEU A 238LEU A 276LEU A 272 | None | 1.18A | 4qynB-2z65A:undetectable | 4qynB-2z65A:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a3i | PENICILLIN-BINDINGPROTEIN 4 (Haemophilusinfluenzae) |
PF02113(Peptidase_S13) | 5 | ILE A 409THR A 70THR A 421LEU A 408LEU A 465 | NoneNoneAIX A 501 (-3.4A)NoneNone | 1.34A | 4qynB-3a3iA:undetectable | 4qynB-3a3iA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | PHE A 441ILE A 434LEU A 457LEU A 471LEU A 465 | None | 1.30A | 4qynB-3b2dA:undetectable | 4qynB-3b2dA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5h | GLUCOCORTICOIDRECEPTOR DNA-BINDINGFACTOR 1 (Homo sapiens) |
PF00071(Ras) | 5 | PHE A 216ILE A 164THR A 191LEU A 162LEU A 223 | None | 1.31A | 4qynB-3c5hA:undetectable | 4qynB-3c5hA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ILE A 249THR A 292THR A 288LEU A 330LEU A 339 | NoneNoneL41 A 501 (-3.0A)L41 A 501 (-4.9A)L41 A 501 (-4.8A) | 1.37A | 4qynB-3d5fA:undetectable | 4qynB-3d5fA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dip | ENOLASE (unidentified) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 91GLN A 344LEU A 300LEU A 317LEU A 292 | None | 1.43A | 4qynB-3dipA:undetectable | 4qynB-3dipA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdw | SIGMA-54 INTERACTIONDOMAIN PROTEIN (Enterococcusfaecalis) |
PF03610(EIIA-man) | 5 | ILE A 657THR A 626LEU A 654LEU A 591LEU A 608 | None | 1.20A | 4qynB-3gdwA:undetectable | 4qynB-3gdwA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4l | DNA MISMATCH REPAIRPROTEIN PMS1 (Saccharomycescerevisiae) |
PF01119(DNA_mis_repair)PF13589(HATPase_c_3) | 5 | ILE A 86THR A 174LEU A 62LEU A 103LEU A 131 | NoneANP A 397 (-3.7A)NoneANP A 397 (-4.7A)ANP A 397 (-3.9A) | 1.46A | 4qynB-3h4lA:undetectable | 4qynB-3h4lA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzr | TRYPTOPHANYL-TRNASYNTHETASE (Entamoebahistolytica) |
PF00579(tRNA-synt_1b) | 5 | PHE A 100ILE A 34THR A 78LEU A 65LEU A 224 | None | 1.42A | 4qynB-3hzrA:undetectable | 4qynB-3hzrA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibr | BACTERIOPHYTOCHROME (Pseudomonasaeruginosa) |
PF00360(PHY)PF01590(GAF)PF08446(PAS_2) | 5 | ILE A 481ARG A 321LEU A 349LEU A 492LEU A 489 | None | 1.38A | 4qynB-3ibrA:undetectable | 4qynB-3ibrA:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icq | EXPORTIN-T (Schizosaccharomycespombe) |
PF08389(Xpo1) | 5 | PHE T 836THR T 776LEU T 819LEU T 784LEU T 839 | None | 1.46A | 4qynB-3icqT:undetectable | 4qynB-3icqT:8.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihg | RDME (Streptomycespurpurascens) |
PF01494(FAD_binding_3) | 5 | PHE A 23THR A 53ARG A 58LEU A 15LEU A 126 | NoneNoneNoneFAD A 536 (-4.6A)None | 1.05A | 4qynB-3ihgA:undetectable | 4qynB-3ihgA:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mil | ISOAMYLACETATE-HYDROLYZINGESTERASE (Saccharomycescerevisiae) |
PF13472(Lipase_GDSL_2) | 5 | MET A 44THR A 77ARG A 115LEU A 32LEU A 36 | None | 1.46A | 4qynB-3milA:undetectable | 4qynB-3milA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne8 | N-ACETYLMURAMOYL-L-ALANINE AMIDASE (Bartonellahenselae) |
PF01520(Amidase_3) | 5 | ILE A 201THR A 270ARG A 384LEU A 378LEU A 286 | None | 1.24A | 4qynB-3ne8A:undetectable | 4qynB-3ne8A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 5 | ILE A 524ARG A 533LEU A 523LEU A 585LEU A 553 | None | 0.96A | 4qynB-3nowA:undetectable | 4qynB-3nowA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npg | UNCHARACTERIZEDDUF364 FAMILYPROTEIN (Pyrococcushorikoshii) |
PF04016(DUF364)PF13938(DUF4213) | 5 | ILE A 88THR A 212LEU A 201LEU A 183LEU A 5 | None | 1.47A | 4qynB-3npgA:undetectable | 4qynB-3npgA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6n | APL1 (Anophelesgambiae) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | PHE A 450ILE A 463LEU A 440LEU A 410LEU A 433 | None | 1.39A | 4qynB-3o6nA:undetectable | 4qynB-3o6nA:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oja | ANOPHELESPLASMODIUM-RESPONSIVE LEUCINE-RICHREPEAT PROTEIN 1 (Anophelesgambiae) |
PF13855(LRR_8) | 5 | PHE B 450ILE B 463LEU B 440LEU B 410LEU B 433 | None | 1.38A | 4qynB-3ojaB:undetectable | 4qynB-3ojaB:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3h | HMW1C-LIKEGLYCOSYLTRANSFERASE (Actinobacilluspleuropneumoniae) |
no annotation | 5 | PHE A 12MET A 68ILE A 101LEU A 98LEU A 75 | None | 1.39A | 4qynB-3q3hA:undetectable | 4qynB-3q3hA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4w | FANCONI ANEMIA GROUPD2 PROTEIN HOMOLOG (Mus musculus) |
PF14631(FancD2) | 5 | PHE B 73THR B 102LEU B 143LEU B 57LEU B 50 | None | 1.43A | 4qynB-3s4wB:undetectable | 4qynB-3s4wB:7.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 5 | PHE A 224THR A 232LEU A 188LEU A 250LEU A 242 | GOL A 3 (-4.2A)NoneNoneNoneNone | 1.38A | 4qynB-3t6qA:undetectable | 4qynB-3t6qA:11.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u37 | ACETYL-XYLANESTERASE EST2A (Butyrivibrioproteoclasticus) |
PF13472(Lipase_GDSL_2) | 5 | PHE A 120ILE A 17THR A 54LEU A 84LEU A 100 | None | 1.50A | 4qynB-3u37A:undetectable | 4qynB-3u37A:14.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wbg | FATTY ACID-BINDINGPROTEIN, HEART (Homo sapiens) |
PF00061(Lipocalin) | 5 | PHE A 16MET A 20THR A 53LEU A 115LEU A 117 | 2AN A 201 ( 4.9A)2AN A 201 ( 3.9A)2AN A 201 ( 4.0A)NoneNone | 0.81A | 4qynB-3wbgA:20.6 | 4qynB-3wbgA:37.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyo | LEUCINE-RICHREPEAT-CONTAININGPROTEIN 4B (Mus musculus) |
PF00560(LRR_1)PF07679(I-set)PF13855(LRR_8) | 5 | PHE A 299ILE A 270LEU A 291LEU A 328LEU A 324 | None | 1.19A | 4qynB-3zyoA:undetectable | 4qynB-3zyoA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp6 | CHOLINE BINDINGPROTEIN PCPA (Streptococcuspneumoniae) |
PF13306(LRR_5) | 5 | PHE A 231ILE A 265LEU A 226LEU A 192LEU A 217 | None | 1.35A | 4qynB-4cp6A:undetectable | 4qynB-4cp6A:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkn | AMPHIOXUS GREENFLUORESCENT PROTEIN,GFPA1 (Branchiostomafloridae) |
PF01353(GFP) | 5 | PHE A 102ILE A 9LEU A 57LEU A 98LEU A 117 | NoneNoneCR2 A 60 ( 4.4A)NoneNone | 1.32A | 4qynB-4dknA:undetectable | 4qynB-4dknA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eys | MCCC FAMILY PROTEIN (Streptococcuspneumoniae) |
PF02016(Peptidase_S66) | 5 | MET A 73ILE A 5THR A 83THR A 111LEU A 118 | None | 1.17A | 4qynB-4eysA:undetectable | 4qynB-4eysA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gt6 | CELL SURFACE PROTEIN (Faecalibacteriumprausnitzii) |
PF13306(LRR_5) | 5 | PHE A 227ILE A 215LEU A 193LEU A 188LEU A 210 | NoneNoneEDO A 908 (-4.3A)NoneEDO A 908 ( 4.8A) | 1.33A | 4qynB-4gt6A:undetectable | 4qynB-4gt6A:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i99 | CHROMOSOME PARTITIONPROTEIN SMCPUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus;Pyrococcusfuriosus) |
PF02463(SMC_N)no annotation | 5 | PHE C 168ILE C 198LEU C 188LEU A1157LEU A1155 | None | 1.28A | 4qynB-4i99C:undetectable | 4qynB-4i99C:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv9 | TRYPTOPHAN2-MONOOXYGENASE (Pseudomonassavastanoi) |
PF01593(Amino_oxidase) | 5 | ILE A 312THR A 496THR A 504LEU A 347LEU A 340 | None | 1.18A | 4qynB-4iv9A:undetectable | 4qynB-4iv9A:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kng | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 5 (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | PHE A 370ILE A 386LEU A 364LEU A 333LEU A 357 | None | 1.39A | 4qynB-4kngA:undetectable | 4qynB-4kngA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kng | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 5 (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | PHE A 370ILE A 386LEU A 364LEU A 351LEU A 357 | None | 1.17A | 4qynB-4kngA:undetectable | 4qynB-4kngA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 5 | ILE A 91THR A 219LEU A 164LEU A 202LEU A 181 | None | 1.43A | 4qynB-4pmhA:undetectable | 4qynB-4pmhA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdh | VARIABLE LYMPHOCYTERECEPTOR B,TOLL-LIKE RECEPTOR 9CHIMERA (Eptatretusburgeri;Mus musculus) |
PF01462(LRRNT)PF11921(DUF3439)PF13306(LRR_5)PF13855(LRR_8) | 5 | PHE A 300ILE A 293LEU A 269LEU A 283LEU A 286 | None | 1.27A | 4qynB-4qdhA:undetectable | 4qynB-4qdhA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qik | ROQUIN-1 (Homo sapiens) |
no annotation | 5 | MET A 155ILE A 363LEU A 360LEU A 106LEU A 140 | None | 1.28A | 4qynB-4qikA:undetectable | 4qynB-4qikA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5c | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | PHE A 200ILE A 216LEU A 192LEU A 161LEU A 185 | None | 1.43A | 4qynB-4r5cA:undetectable | 4qynB-4r5cA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Drosophilamelanogaster;Drosophilamelanogaster) |
PF07034(ORC3_N)PF13191(AAA_16)PF14630(ORC5_C) | 5 | PHE E 104ILE E 123THR C 184LEU E 69LEU E 96 | None | 1.36A | 4qynB-4xgcE:undetectable | 4qynB-4xgcE:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z31 | ROQUIN-2 (Homo sapiens) |
no annotation | 5 | MET A 152ILE A 360LEU A 357LEU A 105LEU A 137 | None | 1.30A | 4qynB-4z31A:undetectable | 4qynB-4z31A:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr8 | UROPORPHYRINOGENDECARBOXYLASE (Acinetobacterbaumannii) |
PF01208(URO-D) | 5 | MET A 227ILE A 206THR A 153LEU A 178LEU A 182 | None | 1.26A | 4qynB-4zr8A:undetectable | 4qynB-4zr8A:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aiz | ZINC FINGER MIZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
no annotation | 5 | PHE A 45ARG A 85LEU A 96LEU A 35LEU A 53 | None | 1.49A | 4qynB-5aizA:undetectable | 4qynB-5aizA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amq | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF04196(Bunya_RdRp)PF15518(L_protein_N) | 5 | PHE A 618ILE A 730THR A 637LEU A1257LEU A 747 | None | 1.43A | 4qynB-5amqA:undetectable | 4qynB-5amqA:4.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqn | BOTULINUM NEUROTOXINTYPE D,BOTULINUMNEUROTOXIN TYPE D (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | PHE A 94THR A 272LEU A 192LEU A 106LEU A 110 | None | 1.38A | 4qynB-5bqnA:undetectable | 4qynB-5bqnA:8.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czd | ACYL-CARRIER-PROTEIN (Streptomyceshalstedii) |
PF00550(PP-binding) | 5 | ILE B 32THR B 73LEU B 29LEU B 46LEU B 42 | None | 1.20A | 4qynB-5czdB:undetectable | 4qynB-5czdB:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7e | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 14 (Saccharomycescerevisiae) |
PF03366(YEATS) | 5 | PHE A 51ILE A 101THR A 137LEU A 127LEU A 92 | None | 1.22A | 4qynB-5d7eA:1.3 | 4qynB-5d7eA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dil | NON-STRUCTURALPROTEIN 1 (Influenza Bvirus) |
PF02942(Flu_B_NS1) | 5 | ILE A 239ARG A 246LEU A 243LEU A 274LEU A 265 | None | 1.32A | 4qynB-5dilA:undetectable | 4qynB-5dilA:26.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evi | BETA-LACTAMASE/D-ALANINECARBOXYPEPTIDASE (Pseudomonassyringae groupgenomosp. 3) |
PF00144(Beta-lactamase) | 5 | ILE B 238THR B 67ARG B 255LEU B 61LEU B 230 | NoneNoneNoneMLY B 224 ( 4.9A)None | 1.38A | 4qynB-5eviB:1.0 | 4qynB-5eviB:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8z | PLASMA KALLIKREINLIGHT CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 47GLN A 30THR A 139LEU A 209TRP A 208 | None | 1.43A | 4qynB-5f8zA:undetectable | 4qynB-5f8zA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs0 | TOLL-LIKE RECEPTOR 3 (Homo sapiens) |
PF13516(LRR_6)PF13855(LRR_8) | 5 | PHE A 401ILE A 422LEU A 438LEU A 409LEU A 430 | None | 1.34A | 4qynB-5gs0A:undetectable | 4qynB-5gs0A:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdh | TOLL-LIKE RECEPTOR 8 (Homo sapiens) |
PF13855(LRR_8) | 5 | PHE A 332ILE A 327LEU A 323LEU A 292LEU A 316 | None | 1.48A | 4qynB-5hdhA:undetectable | 4qynB-5hdhA:9.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIIICOAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens;Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3)PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 5 | ILE B1852THR A 667LEU B1945LEU B1789LEU B1855 | None | 1.41A | 4qynB-5k8dB:undetectable | 4qynB-5k8dB:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l26 | NUCLEOSIDE PERMEASE (Neisseriawadsworthii) |
PF01773(Nucleos_tra2_N)PF07662(Nucleos_tra2_C)PF07670(Gate) | 5 | ILE A 125THR A 62LEU A 124LEU A 111LEU A 115 | None6ZL A 504 (-3.8A)NoneNoneNone | 1.26A | 4qynB-5l26A:undetectable | 4qynB-5l26A:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqp | CONDENSIN COMPLEXSUBUNIT 3 (Saccharomycescerevisiae) |
no annotation | 5 | PHE A 276ILE A 299LEU A 298LEU A 241LEU A 279 | None | 1.28A | 4qynB-5oqpA:undetectable | 4qynB-5oqpA:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpi | PUTATIVETRANSCRIPTIONALREGULATOR (LYSRFAMILY) (Klebsiellapneumoniae) |
PF03466(LysR_substrate) | 5 | ILE A 279ARG A 286LEU A 282LEU A 122LEU A 93 | None | 1.43A | 4qynB-5tpiA:undetectable | 4qynB-5tpiA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfr | PROTEASOME SUBUNITALPHA TYPE-4 (Homo sapiens) |
no annotation | 5 | ILE I 213LYS I 180LEU I 44LEU I 175LEU I 35 | None | 1.29A | 4qynB-5vfrI:undetectable | 4qynB-5vfrI:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w81 | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Danio rerio) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 5 | ILE A 615THR A 469LEU A 616LEU A 393LEU A 447 | None | 1.35A | 4qynB-5w81A:undetectable | 4qynB-5w81A:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgx | FLAVIN-DEPENDENTHALOGENASE (Malbrancheaaurantiaca) |
PF04820(Trp_halogenase) | 5 | ILE A 79GLN A 141THR A 254TRP A 514LEU A 84 | FAD A 701 (-4.0A)None CL A 717 ( 4.1A)NoneNone | 1.23A | 4qynB-5wgxA:undetectable | 4qynB-5wgxA:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3j | TOLL-LIKE RECEPTOR 9 (Equus caballus) |
no annotation | 5 | PHE A 517ILE A 508LEU A 484LEU A 498LEU A 501 | None | 1.13A | 4qynB-5y3jA:undetectable | 4qynB-5y3jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3j | TOLL-LIKE RECEPTOR 9 (Equus caballus) |
no annotation | 5 | PHE A 720ILE A 713LEU A 689LEU A 703LEU A 706 | None | 1.19A | 4qynB-5y3jA:undetectable | 4qynB-5y3jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 5 | PHE A 894MET A 842LEU A 838LEU A 881LEU A 879 | None | 1.00A | 4qynB-5zalA:undetectable | 4qynB-5zalA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 5 | PHE A 518ILE A 509LEU A 485LEU A 499LEU A 502 | None | 1.12A | 4qynB-5zlnA:undetectable | 4qynB-5zlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zln | TOLL-LIKE RECEPTOR 9 (Mus musculus) |
no annotation | 5 | PHE A 721ILE A 714LEU A 690LEU A 704LEU A 707 | None | 1.22A | 4qynB-5zlnA:undetectable | 4qynB-5zlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eq8 | PERIPLASMICALPHA-GALACTOSIDE-BINDING PROTEIN (Agrobacteriumtumefaciens) |
no annotation | 5 | ILE D 113THR D 88ARG D 646LEU D 661LEU D 285 | NoneNoneNoneP4G D 713 ( 3.6A)None | 1.29A | 4qynB-6eq8D:undetectable | 4qynB-6eq8D:undetectable |