SIMILAR PATTERNS OF AMINO ACIDS FOR 4QWP_B_GCSB305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		3 GLY A  64
PRO A  65
GLN A 275
 None
 0.57A 4qwpB-1j32A:
0.0		 4qwpB-1j32A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		3 GLY A 342
PRO A 343
GLN A 300
 None
 0.36A 4qwpB-1o9jA:
0.1		 4qwpB-1o9jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqa BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00533
(BRCT) 		3 GLY A  17
PRO A  18
GLN A  58
 None
 0.59A 4qwpB-1oqaA:
0.0		 4qwpB-1oqaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 369
PRO A 370
GLN A 375
 None
 0.24A 4qwpB-1poxA:
0.0		 4qwpB-1poxA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux1 CYTIDINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		3 GLY A  81
PRO A  80
GLN A 109
 None
 0.57A 4qwpB-1ux1A:
0.0		 4qwpB-1ux1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		3 GLY A 337
PRO A 338
GLN A 295
 None
 0.35A 4qwpB-1uxtA:
0.0		 4qwpB-1uxtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		3 GLY A 320
PRO A 321
GLN A 278
 None
 0.32A 4qwpB-1wnbA:
0.0		 4qwpB-1wnbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		3 GLY A 302
PRO A 303
GLN A 359
 None
 0.54A 4qwpB-1zzgA:
0.0		 4qwpB-1zzgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING

(Homo sapiens) 		PF00017
(SH2) 		3 GLY A 115
PRO A 116
GLN A  12
 None
 0.58A 4qwpB-2cs0A:
0.8		 4qwpB-2cs0A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eho GINS COMPLEX SUBUNIT
3

(Homo sapiens) 		PF05916
(Sld5) 		3 GLY D  14
PRO D  15
GLN D 122
 None
 0.59A 4qwpB-2ehoD:
undetectable		 4qwpB-2ehoD:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 GLY A 361
PRO A 362
GLN A 320
 None
 0.32A 4qwpB-2ehqA:
undetectable		 4qwpB-2ehqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		3 GLY A 326
PRO A 327
GLN A 283
 None
 0.30A 4qwpB-2iluA:
undetectable		 4qwpB-2iluA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 343
PRO A 344
GLN A 301
 None
 0.34A 4qwpB-2j6lA:
undetectable		 4qwpB-2j6lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 GLY A 341
PRO A 342
GLN A 299
 None
 0.32A 4qwpB-2jg7A:
undetectable		 4qwpB-2jg7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jo7 GLYCOSYLPHOSPHATIDYL
INOSITOL-ANCHORED
MEROZOITE SURFACE
PROTEIN

(Babesia
divergens) 		PF11641
(Antigen_Bd37) 		3 GLY A  95
PRO A  96
GLN A 101
 None
 0.60A 4qwpB-2jo7A:
undetectable		 4qwpB-2jo7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF08327
(AHSA1) 		3 GLY A  42
PRO A  43
GLN A 153
 None
 0.55A 4qwpB-2ldkA:
undetectable		 4qwpB-2ldkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		3 GLY A  78
PRO A  79
GLN A  75
 None
 0.32A 4qwpB-2p4bA:
undetectable		 4qwpB-2p4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		3 GLY A 145
PRO A 146
GLN A 174
 None
 0.37A 4qwpB-2qnuA:
undetectable		 4qwpB-2qnuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqr JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		no annotation 3 GLY A 955
PRO A 956
GLN A 949
 None
 0.58A 4qwpB-2qqrA:
undetectable		 4qwpB-2qqrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 381
PRO A 382
GLN A 338
 None
 0.28A 4qwpB-2w8qA:
undetectable		 4qwpB-2w8qA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		3 GLY A 326
PRO A 327
GLN A 284
 None
 0.29A 4qwpB-2xdrA:
undetectable		 4qwpB-2xdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		3 GLY A  51
PRO A  52
GLN A 127
 None
 0.33A 4qwpB-2ywbA:
undetectable		 4qwpB-2ywbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		3 GLY A 328
PRO A 329
GLN A 286
 None
 0.30A 4qwpB-3b4wA:
undetectable		 4qwpB-3b4wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bij UNCHARACTERIZED
PROTEIN GSU0716

(Geobacter
sulfurreducens) 		PF00656
(Peptidase_C14) 		3 GLY A 207
PRO A 257
GLN A 212
 None
 0.59A 4qwpB-3bijA:
undetectable		 4qwpB-3bijA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 GLY A 209
PRO A 210
GLN A 401
 None
 0.37A 4qwpB-3byvA:
undetectable		 4qwpB-3byvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 GLY A 209
PRO A 210
GLN A 405
 None
 0.52A 4qwpB-3byvA:
undetectable		 4qwpB-3byvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 GLY A 264
PRO A 265
GLN A 233
 None
 0.56A 4qwpB-3c4qA:
undetectable		 4qwpB-3c4qA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		3 GLY A 308
PRO A 309
GLN A 266
 None
 0.21A 4qwpB-3efvA:
undetectable		 4qwpB-3efvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		3 GLY A 330
PRO A 331
GLN A 288
 None
 0.21A 4qwpB-3ek1A:
undetectable		 4qwpB-3ek1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 GLY A 334
PRO A 335
GLN A 384
 None
 0.53A 4qwpB-3eqqA:
undetectable		 4qwpB-3eqqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 GLY C 365
PRO C 366
GLN C 369
 None
 0.46A 4qwpB-3gzdC:
undetectable		 4qwpB-3gzdC:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		3 GLY A 322
PRO A 323
GLN A 280
 None
 0.20A 4qwpB-3i44A:
undetectable		 4qwpB-3i44A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 GLY A 334
PRO A 335
GLN A 292
 None
 0.45A 4qwpB-3iwjA:
undetectable		 4qwpB-3iwjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 GLY A 334
PRO A 335
GLN A 292
 None
 0.40A 4qwpB-3iwkA:
0.7		 4qwpB-3iwkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		3 GLY A 328
PRO A 329
GLN A 286
 None
 0.14A 4qwpB-3jz4A:
undetectable		 4qwpB-3jz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2i ACYL-COENZYME A
THIOESTERASE 4

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		3 GLY A 153
PRO A 154
GLN A 220
 None
 0.51A 4qwpB-3k2iA:
undetectable		 4qwpB-3k2iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		3 GLY A 329
PRO A 330
GLN A 287
 None
 0.33A 4qwpB-3k2wA:
undetectable		 4qwpB-3k2wA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLY B 707
PRO B 708
GLN B 748
 EDO  B 908 ( 3.4A)
EDO  B 908 ( 4.0A)
EDO  B 909 ( 3.9A)
 0.55A 4qwpB-3l91B:
undetectable		 4qwpB-3l91B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nh9 ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
6, MITOCHONDRIAL

(Homo sapiens) 		PF00005
(ABC_tran) 		3 GLY A 581
PRO A 582
GLN A 652
 None
 0.60A 4qwpB-3nh9A:
undetectable		 4qwpB-3nh9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		3 GLY A 149
PRO A 150
GLN A 146
 None
 0.54A 4qwpB-3p41A:
1.2		 4qwpB-3p41A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 GLY A 360
PRO A 361
GLN A 318
 None
 0.25A 4qwpB-3qanA:
undetectable		 4qwpB-3qanA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 GLY A 328
PRO A 329
GLN A 286
 None
 0.36A 4qwpB-3rh9A:
undetectable		 4qwpB-3rh9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		3 GLY A 315
PRO A 316
GLN A 273
 None
 0.28A 4qwpB-3rhdA:
0.9		 4qwpB-3rhdA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		3 GLY A 361
PRO A 362
GLN A 319
 None
 0.26A 4qwpB-3rjlA:
undetectable		 4qwpB-3rjlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		3 GLY A 262
PRO A 263
GLN A 255
 None
 0.46A 4qwpB-3thcA:
undetectable		 4qwpB-3thcA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		3 GLY A 319
PRO A 320
GLN A 277
 None
 0.34A 4qwpB-3ty7A:
0.7		 4qwpB-3ty7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		3 GLY A 304
PRO A 305
GLN A 262
 None
 0.56A 4qwpB-3vz0A:
undetectable		 4qwpB-3vz0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 3 GLY A 215
PRO A 216
GLN A 211
 None
 0.59A 4qwpB-3wlaA:
undetectable		 4qwpB-3wlaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 3 GLY A 231
PRO A 232
GLN A 227
 None
 0.58A 4qwpB-3wweA:
undetectable		 4qwpB-3wweA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 GLY A 252
PRO A 253
GLN A 265
 None
 0.46A 4qwpB-3zpcA:
undetectable		 4qwpB-3zpcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		3 GLY A 331
PRO A 332
GLN A 289
 None
 0.55A 4qwpB-4a0mA:
undetectable		 4qwpB-4a0mA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9f CD209 ANTIGEN-LIKE
PROTEIN B

(Mus musculus) 		PF00059
(Lectin_C) 		3 GLY A 250
PRO A 251
GLN A 213
 None
GQ2  A1324 ( 4.9A)
None
 0.57A 4qwpB-4c9fA:
undetectable		 4qwpB-4c9fA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4caj CD209 ANTIGEN-LIKE
PROTEIN B

(Mus musculus) 		PF00059
(Lectin_C) 		3 GLY A 250
PRO A 251
GLN A 213
 None
 0.47A 4qwpB-4cajA:
undetectable		 4qwpB-4cajA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 GLY A 320
PRO A 321
GLN A 278
 None
 0.19A 4qwpB-4dalA:
undetectable		 4qwpB-4dalA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 GLY A 700
PRO A 701
GLN A 647
 None
 0.56A 4qwpB-4fgvA:
undetectable		 4qwpB-4fgvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		3 GLY A 321
PRO A 322
GLN A 279
 None
 0.39A 4qwpB-4go4A:
undetectable		 4qwpB-4go4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 GLY A 303
PRO A 304
GLN A 261
 None
 0.31A 4qwpB-4h7nA:
undetectable		 4qwpB-4h7nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		3 GLY A 336
PRO A 337
GLN A 294
 None
 0.39A 4qwpB-4i8pA:
undetectable		 4qwpB-4i8pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		3 GLY A 335
PRO A 336
GLN A 293
 None
 0.28A 4qwpB-4i8qA:
undetectable		 4qwpB-4i8qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		3 GLY A 302
PRO A 303
GLN A 260
 None
 0.37A 4qwpB-4itaA:
undetectable		 4qwpB-4itaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		3 GLY A 152
PRO A 153
GLN A 211
 None
 0.57A 4qwpB-4iviA:
undetectable		 4qwpB-4iviA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		3 GLY A  37
PRO A  38
GLN A   4
 None
 0.42A 4qwpB-4jotA:
undetectable		 4qwpB-4jotA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 GLY A 325
PRO A 326
GLN A 282
 None
 0.08A 4qwpB-4jz6A:
undetectable		 4qwpB-4jz6A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 342
PRO A 343
GLN A 300
 None
 0.32A 4qwpB-4kwgA:
0.6		 4qwpB-4kwgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		3 GLY A  50
PRO A  51
GLN A  53
 None
 0.53A 4qwpB-4mdyA:
undetectable		 4qwpB-4mdyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLY A 349
PRO A 350
GLN A 307
 None
 0.28A 4qwpB-4o5hA:
undetectable		 4qwpB-4o5hA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLY A 321
PRO A 322
GLN A 279
 None
 0.36A 4qwpB-4o6rA:
undetectable		 4qwpB-4o6rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		3 GLY A 400
PRO A 401
GLN A 349
 None
 0.52A 4qwpB-4oe6A:
0.0		 4qwpB-4oe6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		3 GLY A 342
PRO A 343
GLN A 300
 None
 0.28A 4qwpB-4ou2A:
undetectable		 4qwpB-4ou2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		3 GLY A 341
PRO A 342
GLN A 299
 None
 0.33A 4qwpB-4pxnA:
undetectable		 4qwpB-4pxnA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		3 GLY A 303
PRO A 304
GLN A 320
 None
 0.53A 4qwpB-4q6tA:
undetectable		 4qwpB-4q6tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 GLY A 832
PRO A 833
GLN A 790
 None
 0.18A 4qwpB-4q73A:
undetectable		 4qwpB-4q73A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 GLY A 341
PRO A 342
GLN A 299
 None
 0.35A 4qwpB-4qyjA:
undetectable		 4qwpB-4qyjA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLY A 337
PRO A 338
GLN A 295
 None
 0.27A 4qwpB-4u3wA:
undetectable		 4qwpB-4u3wA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		3 GLY A  89
PRO A  88
GLN A  93
 GLY  A  89 ( 0.0A)
PRO  A  88 ( 1.1A)
GLN  A  93 ( 0.6A)
 0.52A 4qwpB-4w65A:
undetectable		 4qwpB-4w65A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		3 GLY A 169
PRO A 170
GLN A 130
 None
 0.50A 4qwpB-4xacA:
undetectable		 4qwpB-4xacA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLY A 321
PRO A 322
GLN A 280
 None
 0.32A 4qwpB-4yweA:
undetectable		 4qwpB-4yweA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		3 GLY A 329
PRO A 330
GLN A 287
 None
 0.35A 4qwpB-4zwlA:
0.8		 4qwpB-4zwlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 GLY A 342
PRO A 343
GLN A 300
 None
 0.39A 4qwpB-5abmA:
undetectable		 4qwpB-5abmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		3 GLY A 328
PRO A 329
GLN A 285
 None
 0.31A 4qwpB-5eebA:
0.8		 4qwpB-5eebA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 GLY A 346
PRO A 345
GLN A 382
 None
 0.55A 4qwpB-5f4oA:
undetectable		 4qwpB-5f4oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 354
PRO A 355
GLN A 312
 None
 0.27A 4qwpB-5fhzA:
undetectable		 4qwpB-5fhzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		3 GLY A 340
PRO A 341
GLN A 298
 None
 0.33A 4qwpB-5gtkA:
undetectable		 4qwpB-5gtkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 GLY A 479
PRO A 480
GLN A 509
 None
 0.46A 4qwpB-5h1kA:
undetectable		 4qwpB-5h1kA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 3 GLY B1145
PRO B1146
GLN B1118
 None
 0.45A 4qwpB-5hb0B:
undetectable		 4qwpB-5hb0B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		3 GLY A 319
PRO A 320
GLN A 279
 None
 0.19A 4qwpB-5izdA:
undetectable		 4qwpB-5izdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		3 GLY A 325
PRO A 326
GLN A 283
 None
 0.20A 4qwpB-5j6bA:
undetectable		 4qwpB-5j6bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 GLY A 325
PRO A 326
GLN A 283
 None
 0.25A 4qwpB-5jryA:
undetectable		 4qwpB-5jryA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 GLY A 884
PRO A 885
GLN A 842
 None
 0.36A 4qwpB-5kf7A:
undetectable		 4qwpB-5kf7A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		3 GLY A 198
PRO A 199
GLN A 177
 None
 0.55A 4qwpB-5kwsA:
undetectable		 4qwpB-5kwsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		3 GLY A 342
PRO A 343
GLN A 300
 None
 0.23A 4qwpB-5mz8A:
undetectable		 4qwpB-5mz8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		3 GLY A 259
PRO A 260
GLN A  70
 None
 0.50A 4qwpB-5nciA:
undetectable		 4qwpB-5nciA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 3 GLY A 174
PRO A 175
GLN A 223
 None
 0.58A 4qwpB-5nitA:
undetectable		 4qwpB-5nitA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 GLY A 818
PRO A 819
GLN A 776
 None
 0.28A 4qwpB-5ur2A:
0.5		 4qwpB-5ur2A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1)
PF09614
(Cas_Csy2) 		3 GLY B 246
PRO B 245
GLN A 324
 None
 0.57A 4qwpB-5uz9B:
undetectable		 4qwpB-5uz9B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		3 GLY A 330
PRO A 331
GLN A 288
 None
 0.32A 4qwpB-5vbfA:
undetectable		 4qwpB-5vbfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		3 GLY A 285
PRO A 284
GLN A 297
 None
 0.52A 4qwpB-5vn5A:
undetectable		 4qwpB-5vn5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 3 GLY A 360
PRO A 361
GLN A 318
 None
 0.20A 4qwpB-6b5iA:
undetectable		 4qwpB-6b5iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 3 GLY A 320
PRO A 321
GLN A 278
 None
 0.26A 4qwpB-6c43A:
undetectable		 4qwpB-6c43A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY

(Mus musculus) 		no annotation 3 GLY D  48
PRO D  47
GLN D 169
 None
 0.57A 4qwpB-6eqcD:
undetectable		 4qwpB-6eqcD:
15.66