SIMILAR PATTERNS OF AMINO ACIDS FOR 4QWP_B_GCSB304_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
3 GLN A 279
SER A 312
ASP A 309
None
0.80A 4qwpA-1clxA:
0.0
4qwpB-1clxA:
0.0
4qwpA-1clxA:
20.74
4qwpB-1clxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER


(Thermochromatium
tepidum)
PF00124
(Photo_RC)
PF02276
(CytoC_RC)
3 GLN C 239
SER L 166
ASP L 163
None
BCL  L 602 ( 4.3A)
None
0.89A 4qwpA-1eysC:
0.0
4qwpB-1eysC:
0.0
4qwpA-1eysC:
22.03
4qwpB-1eysC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus)
PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central)
3 GLN A 323
SER A 307
ASP A 308
None
0.87A 4qwpA-1f5aA:
0.0
4qwpB-1f5aA:
0.0
4qwpA-1f5aA:
18.42
4qwpB-1f5aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN


(Influenza C
virus)
PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
PF08720
(Hema_stalk)
3 GLN A   8
SER B 134
ASP B   5
None
0.95A 4qwpA-1flcA:
0.0
4qwpB-1flcA:
0.0
4qwpA-1flcA:
20.65
4qwpB-1flcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Zea mays)
PF00311
(PEPcase)
3 GLN A 596
SER A 286
ASP A 454
None
0.85A 4qwpA-1jqoA:
0.1
4qwpB-1jqoA:
0.0
4qwpA-1jqoA:
15.71
4qwpB-1jqoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi)
PF13385
(Laminin_G_3)
PF13859
(BNR_3)
3 GLN A 325
SER A 393
ASP A 389
None
0.95A 4qwpA-1ms8A:
0.0
4qwpB-1ms8A:
0.0
4qwpA-1ms8A:
18.31
4qwpB-1ms8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii)
PF00331
(Glyco_hydro_10)
3 GLN A 245
SER A 275
ASP A 272
None
0.68A 4qwpA-1nq6A:
0.0
4qwpB-1nq6A:
0.0
4qwpA-1nq6A:
22.98
4qwpB-1nq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I


(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 GLN A 175
SER A 342
ASP A 259
GLC  A 904 (-3.5A)
None
SGC  A 902 ( 4.7A)
0.67A 4qwpA-1q2eA:
undetectable
4qwpB-1q2eA:
undetectable
4qwpA-1q2eA:
20.84
4qwpB-1q2eA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)
PROTEIN (IMPORTIN
BETA SUBUNIT)


(Homo sapiens)
PF01749
(IBB)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
3 GLN B  46
SER A 715
ASP A 719
None
0.91A 4qwpA-1qgrB:
undetectable
4qwpB-1qgrB:
undetectable
4qwpA-1qgrB:
8.37
4qwpB-1qgrB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli)
PF08282
(Hydrolase_3)
3 GLN A  50
SER A 178
ASP A  11
None
GOL  A 804 (-3.2A)
GOL  A 804 (-4.9A)
0.80A 4qwpA-1rlmA:
undetectable
4qwpB-1rlmA:
undetectable
4qwpA-1rlmA:
20.00
4qwpB-1rlmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Zea mays)
PF00903
(Glyoxalase)
3 GLN A 405
SER A 215
ASP A 307
None
0.86A 4qwpA-1sp8A:
undetectable
4qwpB-1sp8A:
undetectable
4qwpA-1sp8A:
21.31
4qwpB-1sp8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
3 GLN B 177
SER B  21
ASP B  22
None
0.96A 4qwpA-1sxjB:
2.1
4qwpB-1sxjB:
2.1
4qwpA-1sxjB:
22.46
4qwpB-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei)
PF16499
(Melibiase_2)
3 GLN A 207
SER A 178
ASP A 142
None
None
GOL  A 901 (-3.7A)
0.93A 4qwpA-1sznA:
undetectable
4qwpB-1sznA:
undetectable
4qwpA-1sznA:
19.90
4qwpB-1sznA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
3 GLN A 502
SER A 487
ASP A 493
None
0.91A 4qwpA-1thgA:
undetectable
4qwpB-1thgA:
undetectable
4qwpA-1thgA:
19.56
4qwpB-1thgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B


(Cellulomonas
fimi;
Streptomyces
olivaceoviridis)
PF00331
(Glyco_hydro_10)
3 GLN A 252
SER A 282
ASP A 279
None
0.64A 4qwpA-1v6yA:
undetectable
4qwpB-1v6yA:
undetectable
4qwpA-1v6yA:
21.41
4qwpB-1v6yA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B


(Thermotoga
maritima)
PF00331
(Glyco_hydro_10)
3 GLN A 771
SER A 801
ASP A 798
None
0.71A 4qwpA-1vbrA:
undetectable
4qwpB-1vbrA:
undetectable
4qwpA-1vbrA:
22.39
4qwpB-1vbrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D


(Pyrococcus
abyssi)
PF00710
(Asparaginase)
3 GLN A 205
SER A 146
ASP A 179
None
ASP  A1000 (-2.2A)
ASP  A1000 (-3.6A)
0.75A 4qwpA-1zq1A:
undetectable
4qwpB-1zq1A:
undetectable
4qwpA-1zq1A:
20.05
4qwpB-1zq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0


(Mammalian
rubulavirus 5)
PF00523
(Fusion_gly)
3 GLN A 169
SER A  59
ASP A  58
None
0.76A 4qwpA-2b9bA:
undetectable
4qwpB-2b9bA:
undetectable
4qwpA-2b9bA:
20.55
4qwpB-2b9bA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqu PEROXISOMAL
D3,D2-ENOYL-COA
ISOMERASE


(Homo sapiens)
PF00887
(ACBP)
3 GLN A  86
SER A  23
ASP A  19
None
0.90A 4qwpA-2cquA:
undetectable
4qwpB-2cquA:
undetectable
4qwpA-2cquA:
19.12
4qwpB-2cquA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE


([Clostridium]
stercorarium)
PF00331
(Glyco_hydro_10)
3 GLN A 319
SER A 350
ASP A 347
None
0.71A 4qwpA-2depA:
undetectable
4qwpB-2depA:
undetectable
4qwpA-2depA:
21.02
4qwpB-2depA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
3 GLN A 399
SER A 354
ASP A 367
None
0.64A 4qwpA-2dpyA:
undetectable
4qwpB-2dpyA:
undetectable
4qwpA-2dpyA:
22.15
4qwpB-2dpyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE


(Cellulomonas
fimi)
PF00331
(Glyco_hydro_10)
3 GLN A 250
SER A 280
ASP A 277
None
0.62A 4qwpA-2hisA:
undetectable
4qwpB-2hisA:
undetectable
4qwpA-2hisA:
23.22
4qwpB-2hisA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5r GLUTATHIONE
PEROXIDASE 5


(Populus
trichocarpa x
Populus
deltoides)
PF00255
(GSHPx)
3 GLN A 145
SER A   6
ASP A  14
None
0.83A 4qwpA-2p5rA:
undetectable
4qwpB-2p5rA:
undetectable
4qwpA-2p5rA:
20.47
4qwpB-2p5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
3 GLN A 646
SER A 589
ASP A 199
None
None
MVL  A1865 ( 2.9A)
0.90A 4qwpA-2vmfA:
undetectable
4qwpB-2vmfA:
undetectable
4qwpA-2vmfA:
14.57
4qwpB-2vmfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus)
PF06745
(ATPase)
3 GLN A 166
SER A  40
ASP A 130
None
0.81A 4qwpA-2w0mA:
1.1
4qwpB-2w0mA:
undetectable
4qwpA-2w0mA:
20.23
4qwpB-2w0mA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN


(Saccharophagus
degradans)
PF07632
(DUF1593)
3 GLN A 684
SER A 542
ASP A 539
CA  A1934 ( 4.3A)
None
CA  A1934 (-2.2A)
0.86A 4qwpA-2yhgA:
undetectable
4qwpB-2yhgA:
undetectable
4qwpA-2yhgA:
21.79
4qwpB-2yhgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum)
PF00840
(Glyco_hydro_7)
3 GLN A 188
SER A 355
ASP A 272
None
None
PEG  A1445 (-3.9A)
0.82A 4qwpA-2yokA:
undetectable
4qwpB-2yokA:
undetectable
4qwpA-2yokA:
18.85
4qwpB-2yokA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1y ACIDIC RIBOSOMAL
PROTEIN P0


(Pyrococcus
horikoshii)
PF00466
(Ribosomal_L10)
3 GLN G 104
SER G  32
ASP G 190
None
0.90A 4qwpA-3a1yG:
undetectable
4qwpB-3a1yG:
undetectable
4qwpA-3a1yG:
23.08
4qwpB-3a1yG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1


(Saccharomyces
cerevisiae)
PF00128
(Alpha-amylase)
3 GLN A 279
SER A 241
ASP A 242
None
0.88A 4qwpA-3axiA:
undetectable
4qwpB-3axiA:
undetectable
4qwpA-3axiA:
16.98
4qwpB-3axiA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans)
PF00149
(Metallophos)
3 GLN A 232
SER A 262
ASP A 259
None
0.86A 4qwpA-3c9fA:
undetectable
4qwpB-3c9fA:
undetectable
4qwpA-3c9fA:
16.85
4qwpB-3c9fA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 GLN A 375
SER A 170
ASP A 326
None
0.89A 4qwpA-3e7wA:
undetectable
4qwpB-3e7wA:
undetectable
4qwpA-3e7wA:
18.57
4qwpB-3e7wA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
3 GLN A 284
SER A 130
ASP A 128
None
0.93A 4qwpA-3eluA:
undetectable
4qwpB-3eluA:
undetectable
4qwpA-3eluA:
22.68
4qwpB-3eluA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
3 GLN A 433
SER A  64
ASP A 438
None
None
NAG  A 551 (-3.8A)
0.93A 4qwpA-3eqaA:
undetectable
4qwpB-3eqaA:
undetectable
4qwpA-3eqaA:
22.46
4qwpB-3eqaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
3 GLN A  76
SER A 104
ASP A 100
IOD  A 203 (-3.9A)
None
None
0.81A 4qwpA-3g7rA:
undetectable
4qwpB-3g7rA:
undetectable
4qwpA-3g7rA:
24.15
4qwpB-3g7rA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus)
PF01094
(ANF_receptor)
3 GLN A 106
SER A 138
ASP A  98
None
0.73A 4qwpA-3hsyA:
undetectable
4qwpB-3hsyA:
undetectable
4qwpA-3hsyA:
22.75
4qwpB-3hsyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE


(Staphylococcus
aureus)
PF00912
(Transgly)
3 GLN A 251
SER A 124
ASP A 127
None
0.82A 4qwpA-3hzsA:
undetectable
4qwpB-3hzsA:
2.6
4qwpA-3hzsA:
18.47
4qwpB-3hzsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR


(Streptococcus
mutans)
PF00440
(TetR_N)
3 GLN A 138
SER A  69
ASP A  72
None
0.95A 4qwpA-3mvpA:
undetectable
4qwpB-3mvpA:
undetectable
4qwpA-3mvpA:
20.86
4qwpB-3mvpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA


(Escherichia
coli)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
3 GLN D 368
SER D 322
ASP D 335
None
0.90A 4qwpA-3oaaD:
undetectable
4qwpB-3oaaD:
undetectable
4qwpA-3oaaD:
21.75
4qwpB-3oaaD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
3 GLN B 777
SER B 936
ASP B 933
None
0.92A 4qwpA-3opyB:
undetectable
4qwpB-3opyB:
undetectable
4qwpA-3opyB:
13.66
4qwpB-3opyB:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 GLN A 275
SER A 145
ASP A 201
None
None
MG  A 390 (-2.8A)
0.78A 4qwpA-3ozyA:
undetectable
4qwpB-3ozyA:
undetectable
4qwpA-3ozyA:
22.25
4qwpB-3ozyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 GLN A 115
SER A 148
ASP A 149
None
0.87A 4qwpA-3q1yA:
undetectable
4qwpB-3q1yA:
0.4
4qwpA-3q1yA:
23.69
4qwpB-3q1yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2i DEHYDROGENASE

(Chromobacterium
violaceum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 GLN A 189
SER A  83
ASP A 182
HP7  A 550 (-4.8A)
NAI  A 500 (-2.7A)
None
0.58A 4qwpA-3q2iA:
undetectable
4qwpB-3q2iA:
undetectable
4qwpA-3q2iA:
21.75
4qwpB-3q2iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 GLN A 188
SER A  82
ASP A 181
HP7  A 550 (-3.9A)
NAI  A 500 (-2.7A)
None
0.64A 4qwpA-3q2kA:
undetectable
4qwpB-3q2kA:
undetectable
4qwpA-3q2kA:
21.74
4qwpB-3q2kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
3 GLN A 259
SER A 295
ASP A 296
None
0.93A 4qwpA-3t05A:
undetectable
4qwpB-3t05A:
undetectable
4qwpA-3t05A:
18.70
4qwpB-3t05A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
3 GLN A 216
SER A 158
ASP A 129
None
0.96A 4qwpA-3t57A:
undetectable
4qwpB-3t57A:
undetectable
4qwpA-3t57A:
18.30
4qwpB-3t57A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC


(Mus musculus)
PF00074
(RnaseA)
PF13516
(LRR_6)
3 GLN A  12
SER E 401
ASP E 431
None
0.60A 4qwpA-3tsrA:
undetectable
4qwpB-3tsrA:
undetectable
4qwpA-3tsrA:
17.41
4qwpB-3tsrA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E


(Arabidopsis
thaliana)
PF00069
(Pkinase)
3 GLN A 135
SER A 166
ASP A 140
None
0.92A 4qwpA-3ujgA:
undetectable
4qwpB-3ujgA:
undetectable
4qwpA-3ujgA:
21.51
4qwpB-3ujgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
3 GLN A 268
SER A 299
ASP A 296
None
0.72A 4qwpA-3w25A:
undetectable
4qwpB-3w25A:
undetectable
4qwpA-3w25A:
23.45
4qwpB-3w25A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A


(Streptomyces
sp.)
PF00331
(Glyco_hydro_10)
3 GLN A 288
SER A 318
ASP A 315
None
0.75A 4qwpA-3wufA:
undetectable
4qwpB-3wufA:
undetectable
4qwpA-3wufA:
24.30
4qwpB-3wufA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
3 GLN B 342
SER B  74
ASP B 109
None
0.76A 4qwpA-4cakB:
undetectable
4qwpB-4cakB:
undetectable
4qwpA-4cakB:
16.18
4qwpB-4cakB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dni FUSION PROTEIN OF
RNA-EDITING COMPLEX
PROTEINS MP42 AND
MP18


(Trypanosoma
brucei)
PF00436
(SSB)
3 GLN A 257
SER A  79
ASP A  84
None
0.76A 4qwpA-4dniA:
undetectable
4qwpB-4dniA:
undetectable
4qwpA-4dniA:
20.36
4qwpB-4dniA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE


(Penicillium
canescens)
PF00331
(Glyco_hydro_10)
3 GLN A 289
SER A 320
ASP A 317
None
0.81A 4qwpA-4f8xA:
undetectable
4qwpB-4f8xA:
undetectable
4qwpA-4f8xA:
22.16
4qwpB-4f8xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri)
PF02655
(ATP-grasp_3)
3 GLN A 247
SER A 138
ASP A 194
CO3  A 907 (-4.1A)
ADP  A 902 (-3.2A)
None
0.91A 4qwpA-4fflA:
undetectable
4qwpB-4fflA:
undetectable
4qwpA-4fflA:
21.58
4qwpB-4fflA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2


(Homo sapiens)
PF01746
(tRNA_m1G_MT)
3 GLN A 221
SER A 145
ASP A 106
None
0.65A 4qwpA-4fmwA:
undetectable
4qwpB-4fmwA:
undetectable
4qwpA-4fmwA:
19.25
4qwpB-4fmwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
3 GLN A 316
SER A 264
ASP A 261
None
0.94A 4qwpA-4fzvA:
undetectable
4qwpB-4fzvA:
undetectable
4qwpA-4fzvA:
21.94
4qwpB-4fzvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV


(Borreliella
burgdorferi)
PF00496
(SBP_bac_5)
3 GLN A 181
SER A 429
ASP A 431
None
0.91A 4qwpA-4gl8A:
undetectable
4qwpB-4gl8A:
undetectable
4qwpA-4gl8A:
18.32
4qwpB-4gl8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes)
PF00331
(Glyco_hydro_10)
PF02368
(Big_2)
3 GLN A 406
SER A 437
ASP A 434
None
0.71A 4qwpA-4hu8A:
undetectable
4qwpB-4hu8A:
undetectable
4qwpA-4hu8A:
21.99
4qwpB-4hu8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS


(Streptococcus
mutans)
PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c)
3 GLN A 330
SER A 275
ASP A 263
None
0.93A 4qwpA-4i5sA:
undetectable
4qwpB-4i5sA:
undetectable
4qwpA-4i5sA:
18.10
4qwpB-4i5sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY


(Danio rerio;
Escherichia
coli)
PF00619
(CARD)
PF13416
(SBP_bac_8)
3 GLN A 336
SER A  74
ASP A 380
None
0.78A 4qwpA-4irlA:
undetectable
4qwpB-4irlA:
undetectable
4qwpA-4irlA:
21.41
4qwpB-4irlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus)
PF03051
(Peptidase_C1_2)
3 GLN A 261
SER A 146
ASP A 143
None
0.72A 4qwpA-4k7cA:
0.3
4qwpB-4k7cA:
undetectable
4qwpA-4k7cA:
18.67
4qwpB-4k7cA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Conexibacter
woesei)
PF13407
(Peripla_BP_4)
3 GLN A 286
SER A 111
ASP A 137
GOL  A 502 (-3.4A)
None
GOL  A 502 (-2.8A)
0.81A 4qwpA-4kq9A:
undetectable
4qwpB-4kq9A:
undetectable
4qwpA-4kq9A:
27.24
4qwpB-4kq9A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE


(Plasmodium
falciparum)
PF00082
(Peptidase_S8)
3 GLN A 355
SER A 621
ASP A 450
None
0.88A 4qwpA-4lvoA:
undetectable
4qwpB-4lvoA:
0.8
4qwpA-4lvoA:
20.55
4qwpB-4lvoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8)
3 GLN A 462
SER A 511
ASP A 516
None
0.76A 4qwpA-4lxrA:
undetectable
4qwpB-4lxrA:
undetectable
4qwpA-4lxrA:
14.34
4qwpB-4lxrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE


(Streptomyces
lavendulae)
PF02668
(TauD)
3 GLN A 123
SER A 164
ASP A 157
None
0.91A 4qwpA-4m2gA:
undetectable
4qwpB-4m2gA:
undetectable
4qwpA-4m2gA:
22.59
4qwpB-4m2gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
3 GLN A 377
SER A 332
ASP A 345
None
0.92A 4qwpA-4nphA:
undetectable
4qwpB-4nphA:
undetectable
4qwpA-4nphA:
22.25
4qwpB-4nphA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE


(Mycobacterium
tuberculosis)
PF02558
(ApbA)
PF08546
(ApbA_C)
3 GLN A  77
SER A 246
ASP A 250
NAP  A 301 (-3.1A)
OXM  A 302 ( 2.7A)
NAP  A 301 ( 4.8A)
0.95A 4qwpA-4ol9A:
undetectable
4qwpB-4ol9A:
undetectable
4qwpA-4ol9A:
23.12
4qwpB-4ol9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oud TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
3 GLN B 300
SER B 293
ASP B 290
GLN  B 300 ( 0.6A)
SER  B 293 ( 0.0A)
ASP  B 290 ( 0.6A)
0.96A 4qwpA-4oudB:
undetectable
4qwpB-4oudB:
undetectable
4qwpA-4oudB:
20.15
4qwpB-4oudB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Psychromonas
ingrahamii)
PF00464
(SHMT)
3 GLN A 326
SER A 360
ASP A 322
None
0.94A 4qwpA-4p3mA:
undetectable
4qwpB-4p3mA:
undetectable
4qwpA-4p3mA:
23.96
4qwpB-4p3mA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4


(Homo sapiens)
PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
3 GLN B 322
SER B 234
ASP B 232
None
0.94A 4qwpA-4r7aB:
undetectable
4qwpB-4r7aB:
undetectable
4qwpA-4r7aB:
18.94
4qwpB-4r7aB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1


(Homo sapiens)
PF08774
(VRR_NUC)
3 GLN A 568
SER A 617
ASP A 614
None
0.95A 4qwpA-4ricA:
undetectable
4qwpB-4ricA:
undetectable
4qwpA-4ricA:
16.77
4qwpB-4ricA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE


(Plasmodium
vivax)
PF00082
(Peptidase_S8)
3 GLN A 299
SER A 564
ASP A 394
PO4  A 806 ( 4.2A)
None
None
0.80A 4qwpA-4tr2A:
0.3
4qwpB-4tr2A:
0.4
4qwpA-4tr2A:
17.24
4qwpB-4tr2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus)
PF04055
(Radical_SAM)
3 GLN B 114
SER B 188
ASP B 141
None
0.86A 4qwpA-4u0pB:
undetectable
4qwpB-4u0pB:
undetectable
4qwpA-4u0pB:
24.20
4qwpB-4u0pB:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
3 GLN A 326
SER A 164
ASP A 165
None
0.93A 4qwpA-4wt7A:
undetectable
4qwpB-4wt7A:
undetectable
4qwpA-4wt7A:
22.46
4qwpB-4wt7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus)
PF00001
(7tm_1)
3 GLN A 269
SER A  84
ASP A  80
None
0.96A 4qwpA-4ww3A:
0.6
4qwpB-4ww3A:
undetectable
4qwpA-4ww3A:
20.85
4qwpB-4ww3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xx6 BETA-XYLANASE

(Gloeophyllum
trabeum)
PF00331
(Glyco_hydro_10)
3 GLN A 282
SER A 313
ASP A 310
None
0.75A 4qwpA-4xx6A:
undetectable
4qwpB-4xx6A:
undetectable
4qwpA-4xx6A:
22.51
4qwpB-4xx6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA


(Mus musculus)
PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3)
3 GLN A  53
SER A 176
ASP A 174
None
0.88A 4qwpA-4yh7A:
undetectable
4qwpB-4yh7A:
undetectable
4qwpA-4yh7A:
16.24
4qwpB-4yh7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zet C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C


(Homo sapiens)
PF00059
(Lectin_C)
3 GLN A 158
SER A 112
ASP A 117
None
0.86A 4qwpA-4zetA:
undetectable
4qwpB-4zetA:
undetectable
4qwpA-4zetA:
18.33
4qwpB-4zetA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 GLN A 749
SER A 849
ASP A1051
None
0.96A 4qwpA-4zktA:
0.8
4qwpB-4zktA:
0.7
4qwpA-4zktA:
11.41
4qwpB-4zktA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Dictyostelium
purpureum)
PF00840
(Glyco_hydro_7)
3 GLN A 174
SER A 348
ASP A 258
None
0.75A 4qwpA-4zzpA:
undetectable
4qwpB-4zzpA:
undetectable
4qwpA-4zzpA:
19.46
4qwpB-4zzpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Dictyostelium
discoideum)
PF00840
(Glyco_hydro_7)
3 GLN A 174
SER A 348
ASP A 258
None
0.95A 4qwpA-4zzqA:
undetectable
4qwpB-4zzqA:
undetectable
4qwpA-4zzqA:
19.63
4qwpB-4zzqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE


(Klebsiella
pneumoniae)
PF01228
(Gly_radical)
PF02901
(PFL-like)
3 GLN A 685
SER A1067
ASP A 747
None
0.69A 4qwpA-5a0zA:
undetectable
4qwpB-5a0zA:
undetectable
4qwpA-5a0zA:
16.75
4qwpB-5a0zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffq SHUY-LIKE PROTEIN

(Escherichia
coli)
PF13460
(NAD_binding_10)
3 GLN A 139
SER A 112
ASP A 111
None
0.78A 4qwpA-5ffqA:
undetectable
4qwpB-5ffqA:
undetectable
4qwpA-5ffqA:
24.34
4qwpB-5ffqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens)
PF00240
(ubiquitin)
3 GLN A 131
SER A 220
ASP A 221
None
0.85A 4qwpA-5h07A:
undetectable
4qwpB-5h07A:
undetectable
4qwpA-5h07A:
23.99
4qwpB-5h07A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN


(Lavandula
lanata)
PF01255
(Prenyltransf)
3 GLN A  94
SER A 145
ASP A 141
None
0.70A 4qwpA-5hc8A:
1.6
4qwpB-5hc8A:
1.6
4qwpA-5hc8A:
21.50
4qwpB-5hc8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens)
PF01039
(Carboxyl_trans)
3 GLN A 253
SER A  63
ASP A  60
None
0.95A 4qwpA-5infA:
undetectable
4qwpB-5infA:
undetectable
4qwpA-5infA:
19.05
4qwpB-5infA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena)
no annotation 3 GLN A 238
SER A 272
ASP A 269
None
0.84A 4qwpA-5m0kA:
undetectable
4qwpB-5m0kA:
undetectable
4qwpA-5m0kA:
24.58
4qwpB-5m0kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena)
no annotation 3 GLN A 242
SER A 272
ASP A 269
None
0.84A 4qwpA-5m0kA:
undetectable
4qwpB-5m0kA:
undetectable
4qwpA-5m0kA:
24.58
4qwpB-5m0kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-)
no annotation 3 GLN G 165
SER G 207
ASP G 205
None
0.94A 4qwpA-5mlvG:
undetectable
4qwpB-5mlvG:
undetectable
4qwpA-5mlvG:
undetectable
4qwpB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli)
PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30)
3 GLN A 687
SER A 665
ASP A 667
None
0.89A 4qwpA-5n8oA:
0.5
4qwpB-5n8oA:
undetectable
4qwpA-5n8oA:
10.96
4qwpB-5n8oA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride)
no annotation 3 GLN A 175
SER A 342
ASP A 259
BTB  A 604 (-3.8A)
None
None
0.76A 4qwpA-5o5dA:
undetectable
4qwpB-5o5dA:
undetectable
4qwpA-5o5dA:
15.90
4qwpB-5o5dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-)
no annotation 3 GLN B 324
SER B 253
ASP B 258
None
0.93A 4qwpA-5ochB:
undetectable
4qwpB-5ochB:
undetectable
4qwpA-5ochB:
undetectable
4qwpB-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofk GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
3 GLN A 273
SER A 304
ASP A 301
None
0.73A 4qwpA-5ofkA:
undetectable
4qwpB-5ofkA:
undetectable
4qwpA-5ofkA:
20.90
4qwpB-5ofkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
3 GLN A 976
SER A 903
ASP A 971
None
0.90A 4qwpA-5t8vA:
undetectable
4qwpB-5t8vA:
undetectable
4qwpA-5t8vA:
11.04
4qwpB-5t8vA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs1 HYPERGLYCEMIC
HORMONE-LIKE PEPTIDE


(Scylla olivacea)
no annotation 3 GLN A   1
SER A   6
ASP A   4
None
0.95A 4qwpA-5xs1A:
undetectable
4qwpB-5xs1A:
undetectable
4qwpA-5xs1A:
13.60
4qwpB-5xs1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1)
no annotation 3 GLN A 266
SER A 296
ASP A 293
None
0.82A 4qwpA-5xzuA:
undetectable
4qwpB-5xzuA:
undetectable
4qwpA-5xzuA:
16.19
4qwpB-5xzuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Bacillus
subtilis)
no annotation 3 GLN A 361
SER A 204
ASP A 315
None
0.82A 4qwpA-6cgmA:
undetectable
4qwpB-6cgmA:
undetectable
4qwpA-6cgmA:
17.98
4qwpB-6cgmA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1


(Saccharomyces
cerevisiae)
no annotation 3 GLN A 688
SER A 388
ASP A 390
None
0.85A 4qwpA-6f42A:
undetectable
4qwpB-6f42A:
undetectable
4qwpA-6f42A:
17.89
4qwpB-6f42A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 3 GLN A 433
SER A  64
ASP A 438
None
None
NAG  A 703 (-3.1A)
0.88A 4qwpA-6frvA:
undetectable
4qwpB-6frvA:
undetectable
4qwpA-6frvA:
17.34
4qwpB-6frvA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx6 -

(-)
no annotation 3 GLN A  96
SER A 131
ASP A 127
None
0.80A 4qwpA-6fx6A:
undetectable
4qwpB-6fx6A:
undetectable
4qwpA-6fx6A:
undetectable
4qwpB-6fx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g45 PUTATIVE MAJOR
CAPSID PROTEIN


(Cafeteriavirus-dependent
mavirus)
no annotation 3 GLN A 127
SER A 336
ASP A 347
None
0.88A 4qwpA-6g45A:
undetectable
4qwpB-6g45A:
undetectable
4qwpA-6g45A:
14.68
4qwpB-6g45A:
14.68