SIMILAR PATTERNS OF AMINO ACIDS FOR 4QWP_A_GCSA301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 159GLY A 135PRO A 136 | None | 0.46A | 4qwpA-1b3bA:0.0 | 4qwpA-1b3bA:20.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1chk | CHITOSANASE (Streptomycessp. N174) |
PF01374(Glyco_hydro_46) | 3 | TYR A 122GLY A 151PRO A 152 | None | 0.18A | 4qwpA-1chkA:34.3 | 4qwpA-1chkA:60.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 160GLY A 136PRO A 137 | None | 0.52A | 4qwpA-1euzA:0.0 | 4qwpA-1euzA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hdg | HOLO-D-GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE (Thermotogamaritima) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | TYR O 18GLY O 55PRO O 54 | None | 0.69A | 4qwpA-1hdgO:0.0 | 4qwpA-1hdgO:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hrd | GLUTAMATEDEHYDROGENASE ([Clostridium]symbiosum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 180GLY A 156PRO A 157 | None | 0.64A | 4qwpA-1hrdA:0.8 | 4qwpA-1hrdA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji8 | DISSIMILATORYSIROHEME-SULFITEREDUCTASE (Pyrobaculumaerophilum) |
PF04358(DsrC) | 3 | TYR A 87GLY A 93PRO A 94 | None | 0.66A | 4qwpA-1ji8A:undetectable | 4qwpA-1ji8A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1f | GLUTAMATEDEHYDROGENASE 1 (Homo sapiens) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 187GLY A 163PRO A 164 | None | 0.52A | 4qwpA-1l1fA:0.4 | 4qwpA-1l1fA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lns | X-PROLYL DIPEPTIDYLAMINOPEPTIDASE (Lactococcuslactis) |
PF02129(Peptidase_S15)PF08530(PepX_C)PF09168(PepX_N) | 3 | TYR A 477GLY A 615PRO A 616 | None | 0.40A | 4qwpA-1lnsA:0.0 | 4qwpA-1lnsA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q33 | ADP-RIBOSEPYROPHOSPHATASE (Homo sapiens) |
PF00293(NUDIX) | 3 | TYR A 140GLY A 166PRO A 167 | None | 0.40A | 4qwpA-1q33A:0.0 | 4qwpA-1q33A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | TYR A 74GLY A 42PRO A 47 | None | 0.00A | 4qwpA-1q5aA:undetectable | 4qwpA-1q5aA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u05 | ORF, CONSERVEDHYPOTHETICAL PROTEIN (Shigellaflexneri) |
PF02578(Cu-oxidase_4) | 3 | TYR A 195GLY A 158PRO A 159 | None | 0.73A | 4qwpA-1u05A:undetectable | 4qwpA-1u05A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uli | BIPHENYL DIOXYGENASELARGE SUBUNIT (Rhodococcusjostii) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | TYR A 256GLY A 417PRO A 416 | None | 0.58A | 4qwpA-1uliA:undetectable | 4qwpA-1uliA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urd | MALTOSE-BINDINGPROTEIN (Alicyclobacillusacidocaldarius) |
PF01547(SBP_bac_1) | 3 | TYR A 76GLY A 85PRO A 86 | None | 0.67A | 4qwpA-1urdA:undetectable | 4qwpA-1urdA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wac | P2 PROTEIN (Pseudomonasvirus phi6) |
PF00680(RdRP_1) | 3 | TYR A 199GLY A 275PRO A 276 | None | 0.66A | 4qwpA-1wacA:undetectable | 4qwpA-1wacA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wno | CHITINASE (Aspergillusfumigatus) |
PF00704(Glyco_hydro_18) | 3 | TYR A 310GLY A 270PRO A 271 | None | 0.69A | 4qwpA-1wnoA:undetectable | 4qwpA-1wnoA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yx3 | HYPOTHETICAL PROTEINDSRC (Allochromatiumvinosum) |
PF04358(DsrC) | 3 | TYR A 88GLY A 94PRO A 95 | None | 0.64A | 4qwpA-1yx3A:undetectable | 4qwpA-1yx3A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9a | NAD(P)H-DEPENDENTD-XYLOSE REDUCTASE ([Candida]tenuis) |
PF00248(Aldo_ket_red) | 3 | TYR A 197GLY A 221PRO A 222 | None | 0.71A | 4qwpA-1z9aA:undetectable | 4qwpA-1z9aA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bma | GLUTAMATEDEHYDROGENASE(NADP+) (Plasmodiumfalciparum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 180GLY A 156PRO A 157 | None | 0.66A | 4qwpA-2bmaA:0.7 | 4qwpA-2bmaA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btv | PROTEIN (VP3 COREPROTEIN) (Bluetonguevirus) |
PF01700(Orbi_VP3) | 3 | TYR A 410GLY A 322PRO A 323 | None | 0.51A | 4qwpA-2btvA:undetectable | 4qwpA-2btvA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkk | CYTOCHROME P450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | TYR A 258GLY A 26PRO A 27 | None | 0.48A | 4qwpA-2dkkA:undetectable | 4qwpA-2dkkA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehq | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 3 | TYR A 502GLY A 196PRO A 197 | None | 0.60A | 4qwpA-2ehqA:undetectable | 4qwpA-2ehqA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fep | CATABOLITE CONTROLPROTEIN A (Bacillussubtilis) |
PF13377(Peripla_BP_3) | 3 | TYR A 222GLY A 186PRO A 187 | SO4 A4397 (-4.2A)NoneNone | 0.69A | 4qwpA-2fepA:undetectable | 4qwpA-2fepA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdr | GLUTATHIONES-TRANSFERASE (Paraburkholderiaxenovorans) |
PF02798(GST_N)PF13410(GST_C_2) | 3 | TYR A 157GLY A 66PRO A 67 | NoneGSH A 224 (-3.9A)None | 0.55A | 4qwpA-2gdrA:undetectable | 4qwpA-2gdrA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iny | HEXON PROTEIN (Fowlaviadenovirus A) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 3 | TYR A 851GLY A 776PRO A 777 | None | 0.53A | 4qwpA-2inyA:undetectable | 4qwpA-2inyA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5v | DNA REPLICATION ANDREPAIR PROTEIN RECF (Deinococcusradiodurans) |
PF02463(SMC_N) | 3 | TYR A 227GLY A 247PRO A 248 | None | 0.68A | 4qwpA-2o5vA:0.6 | 4qwpA-2o5vA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9b | POSSIBLE PROLIDASE (Bifidobacteriumlongum) |
PF01979(Amidohydro_1) | 3 | TYR A 140GLY A 163PRO A 164 | None | 0.67A | 4qwpA-2p9bA:undetectable | 4qwpA-2p9bA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r18 | CAPSID ASSEMBLYPROTEIN VP3 (Infectiousbursal diseasevirus) |
PF01767(Birna_VP3) | 3 | TYR A 195GLY A 202PRO A 203 | None | 0.71A | 4qwpA-2r18A:undetectable | 4qwpA-2r18A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3z | PUTATIVE DEACETYLASE (Streptococcusmutans) |
PF01522(Polysacc_deac_1) | 3 | TYR A 172GLY A 214PRO A 213 | NonePO4 A1313 (-3.6A)PO4 A1313 (-4.6A) | 0.70A | 4qwpA-2w3zA:undetectable | 4qwpA-2w3zA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whk | MANNANENDO-1,4-BETA-MANNOSIDASE (Bacillussubtilis) |
PF02156(Glyco_hydro_26) | 3 | TYR A 278GLY A 268PRO A 269 | None | 0.57A | 4qwpA-2whkA:undetectable | 4qwpA-2whkA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfh | GLUTAMATEDEHYDROGENASE,NAD-SPECIFICGLUTAMATEDEHYDROGENASE,GLUTAMATEDEHYDROGENASE (Escherichiacoli;[Clostridium]symbiosum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 181GLY A 157PRO A 158 | None | 0.65A | 4qwpA-2yfhA:undetectable | 4qwpA-2yfhA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 3 | TYR A 90GLY A 285PRO A 286 | None | 0.68A | 4qwpA-2ylzA:1.7 | 4qwpA-2ylzA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2x | TK-SUBTILISIN (Thermococcuskodakarensis) |
PF00082(Peptidase_S8) | 3 | TYR A 180GLY A 206PRO A 207 | None CA A1005 ( 4.2A)None | 0.55A | 4qwpA-2z2xA:undetectable | 4qwpA-2z2xA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2z | TK-SUBTILISINPRECURSOR (Thermococcuskodakarensis) |
PF00082(Peptidase_S8) | 3 | TYR A 180GLY A 206PRO A 207 | None CA A1003 ( 4.3A)None | 0.47A | 4qwpA-2z2zA:undetectable | 4qwpA-2z2zA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7j | CAPSID ASSEMBLYPROTEIN VP3 (Infectiousbursal diseasevirus) |
PF01767(Birna_VP3) | 3 | TYR A 195GLY A 202PRO A 203 | None | 0.74A | 4qwpA-2z7jA:undetectable | 4qwpA-2z7jA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aoe | GLUTAMATEDEHYDROGENASE (Thermusthermophilus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 169GLY A 145PRO A 146 | None | 0.62A | 4qwpA-3aoeA:undetectable | 4qwpA-3aoeA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aoe | GLUTAMATEDEHYDROGENASE (Thermusthermophilus) |
no annotation | 3 | TYR E 168GLY E 144PRO E 145 | None | 0.59A | 4qwpA-3aoeE:undetectable | 4qwpA-3aoeE:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3be7 | ZN-DEPENDENTARGININECARBOXYPEPTIDASE (unidentified) |
PF01979(Amidohydro_1) | 3 | TYR A 110GLY A 133PRO A 134 | None | 0.70A | 4qwpA-3be7A:undetectable | 4qwpA-3be7A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ct9 | ACETYLORNITHINEDEACETYLASE (Bacteroidesthetaiotaomicron) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | TYR A 346GLY A 320PRO A 321 | None | 0.60A | 4qwpA-3ct9A:undetectable | 4qwpA-3ct9A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqq | BENZENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonasputida) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | TYR A 254GLY A 415PRO A 414 | None | 0.70A | 4qwpA-3eqqA:undetectable | 4qwpA-3eqqA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzg | THYMIDYLATE SYNTHASETHYX (Mycobacteriumtuberculosis) |
PF02511(Thy1) | 3 | TYR A 189GLY A 32PRO A 33 | None | 0.62A | 4qwpA-3hzgA:undetectable | 4qwpA-3hzgA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8z | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 170GLY A 146PRO A 147 | None | 0.68A | 4qwpA-3k8zA:undetectable | 4qwpA-3k8zA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k92 | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 171GLY A 147PRO A 148 | None | 0.66A | 4qwpA-3k92A:undetectable | 4qwpA-3k92A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld8 | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
PF02373(JmjC) | 3 | TYR A 117GLY A 178PRO A 179 | None | 0.66A | 4qwpA-3ld8A:undetectable | 4qwpA-3ld8A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3liu | PUTATIVE CELLADHESION PROTEIN (Parabacteroidesdistasonis) |
PF06321(P_gingi_FimA) | 3 | TYR A 212GLY A 387PRO A 388 | None | 0.62A | 4qwpA-3liuA:undetectable | 4qwpA-3liuA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mst | PUTATIVE NITRATETRANSPORT PROTEIN (Thermoplasmavolcanium) |
PF12916(DUF3834) | 3 | TYR A 181GLY A 9PRO A 10 | NoneACT A 232 ( 4.8A)ACT A 232 (-4.6A) | 0.66A | 4qwpA-3mstA:undetectable | 4qwpA-3mstA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvq | SEMAPHORIN-7A (Homo sapiens) |
PF01403(Sema)PF01437(PSI)PF13895(Ig_2) | 3 | TYR A 406GLY A 51PRO A 52 | None | 0.57A | 4qwpA-3nvqA:undetectable | 4qwpA-3nvqA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3j | GLUTAMATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 244GLY A 220PRO A 221 | None | 0.67A | 4qwpA-3r3jA:undetectable | 4qwpA-3r3jA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro2 | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF13176(TPR_7)PF13424(TPR_12) | 3 | TYR A 206GLY A 156PRO A 157 | None | 0.66A | 4qwpA-3ro2A:0.9 | 4qwpA-3ro2A:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1t | ASPARTOKINASE (Mycobacteriumtuberculosis) |
PF01842(ACT)PF13840(ACT_7) | 3 | TYR A 91GLY A 70PRO A 71 | None | 0.73A | 4qwpA-3s1tA:undetectable | 4qwpA-3s1tA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5t | DUF3298 FAMILYPROTEIN (Bacteroidesfragilis) |
PF11738(DUF3298)PF13739(DUF4163) | 3 | TYR A 169GLY A 257PRO A 258 | None | 0.69A | 4qwpA-3s5tA:undetectable | 4qwpA-3s5tA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stt | METHYLKETONESYNTHASE I (Solanumhabrochaites) |
PF12697(Abhydrolase_6) | 3 | TYR A 202GLY A 116PRO A 117 | None | 0.71A | 4qwpA-3sttA:undetectable | 4qwpA-3sttA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vta | CUCUMISIN (Cucumis melo) |
PF00082(Peptidase_S8) | 3 | TYR A 429GLY A 402PRO A 403 | None | 0.73A | 4qwpA-3vtaA:undetectable | 4qwpA-3vtaA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3waj | TRANSMEMBRANEOLIGOSACCHARYLTRANSFERASE (Archaeoglobusfulgidus) |
PF02516(STT3) | 3 | TYR A 276GLY A 83PRO A 84 | None | 0.65A | 4qwpA-3wajA:undetectable | 4qwpA-3wajA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmt | PROBABLE FERULOYLESTERASE B-1 (Aspergillusoryzae) |
PF07519(Tannase) | 3 | TYR A 512GLY A 463PRO A 464 | None | 0.69A | 4qwpA-3wmtA:0.3 | 4qwpA-3wmtA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ziz | GH5ENDO-BETA-1,4-MANNANASE (Podosporaanserina) |
PF00150(Cellulase) | 3 | TYR A 279GLY A 245PRO A 244 | None | 0.60A | 4qwpA-3zizA:undetectable | 4qwpA-3zizA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c60 | OCHRATOXINASE (Aspergillusniger) |
PF01979(Amidohydro_1) | 3 | TYR A 160GLY A 219PRO A 220 | None | 0.55A | 4qwpA-4c60A:undetectable | 4qwpA-4c60A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7u | ENDOGLUCANASE II (Neurosporacrassa) |
PF03443(Glyco_hydro_61) | 3 | TYR A 217GLY A 85PRO A 86 | None | 0.71A | 4qwpA-4d7uA:undetectable | 4qwpA-4d7uA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eye | PROBABLEOXIDOREDUCTASE (Mycobacteroidesabscessus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | TYR A 44GLY A 11PRO A 12 | None | 0.54A | 4qwpA-4eyeA:undetectable | 4qwpA-4eyeA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4go5 | ASPARTOKINASE (Mycobacteriumtuberculosis) |
PF01842(ACT)PF13840(ACT_7) | 3 | TYR X 91GLY X 70PRO X 71 | None | 0.66A | 4qwpA-4go5X:undetectable | 4qwpA-4go5X:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kxr | PPE41 (Mycobacteriumtuberculosis) |
PF00823(PPE) | 3 | TYR B 96GLY B 20PRO B 21 | None | 0.65A | 4qwpA-4kxrB:undetectable | 4qwpA-4kxrB:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lhb | MOLYBDOPTERINADENYLYLTRANSFERASE (Pyrococcusfuriosus) |
PF00994(MoCF_biosynth) | 3 | TYR A 51GLY A 35PRO A 36 | None | 0.48A | 4qwpA-4lhbA:undetectable | 4qwpA-4lhbA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4llf | CAPSID PROTEIN (Cucumbernecrosis virus) |
PF00729(Viral_coat) | 3 | TYR A 171GLY A 180PRO A 181 | None | 0.64A | 4qwpA-4llfA:undetectable | 4qwpA-4llfA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv2 | VKORC1/THIOREDOXINDOMAIN PROTEIN (Synechococcussp.JA-2-3B'a(2-13)) |
PF07884(VKOR) | 3 | TYR A 207GLY A 235PRO A 236 | None | 0.73A | 4qwpA-4nv2A:undetectable | 4qwpA-4nv2A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ojz | PUTATIVE ALGINATELYASE (Saccharophagusdegradans) |
PF05426(Alginate_lyase)PF07940(Hepar_II_III) | 3 | TYR A 251GLY A 255PRO A 256 | None | 0.51A | 4qwpA-4ojzA:undetectable | 4qwpA-4ojzA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opm | LIPASE (Acinetobacterbaumannii) |
PF12697(Abhydrolase_6) | 3 | TYR A 116GLY A 104PRO A 103 | None | 0.74A | 4qwpA-4opmA:undetectable | 4qwpA-4opmA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 3 | TYR A 526GLY A 800PRO A 799 | None | 0.73A | 4qwpA-4u7tA:undetectable | 4qwpA-4u7tA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w4l | PPE FAMILY PROTEINPPE41 (Mycobacteriumtuberculosis) |
PF00823(PPE) | 3 | TYR B 96GLY B 20PRO B 21 | None | 0.64A | 4qwpA-4w4lB:undetectable | 4qwpA-4w4lB:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wiw | GLYCOSIDE HYDROLASEFAMILY 18 (Desulfitobacteriumhafniense) |
PF00704(Glyco_hydro_18) | 3 | TYR A 372GLY A 367PRO A 366 | None | 0.61A | 4qwpA-4wiwA:undetectable | 4qwpA-4wiwA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbz | EVDO1 (Micromonosporacarbonacea) |
PF05721(PhyH) | 3 | TYR A 145GLY A 250PRO A 251 | None | 0.63A | 4qwpA-4xbzA:undetectable | 4qwpA-4xbzA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgi | GLUTAMATEDEHYDROGENASE (Burkholderiathailandensis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TYR A 179GLY A 155PRO A 156 | None | 0.56A | 4qwpA-4xgiA:undetectable | 4qwpA-4xgiA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuo | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF02018(CBM_4_9) | 3 | TYR A 146GLY A 57PRO A 58 | None | 0.70A | 4qwpA-4xuoA:undetectable | 4qwpA-4xuoA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xup | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF02018(CBM_4_9) | 3 | TYR A 146GLY A 57PRO A 58 | None | 0.73A | 4qwpA-4xupA:undetectable | 4qwpA-4xupA:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a30 | MITOCHONDRIALPROTEIN (Gallus gallus) |
PF03828(PAP_assoc) | 3 | TYR A 135GLY A 290PRO A 291 | None | 0.60A | 4qwpA-5a30A:undetectable | 4qwpA-5a30A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5u | PROLYL 4-HYDROXYLASE (ParameciumbursariaChlorella virus1) |
PF13640(2OG-FeII_Oxy_3) | 3 | TYR A 216GLY A 45PRO A 44 | None | 0.72A | 4qwpA-5c5uA:undetectable | 4qwpA-5c5uA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewy | PUTATIVEADP-RIBOSYLTRANSFERASE SCABIN (Streptomycesscabiei) |
no annotation | 3 | TYR A 133GLY A 82PRO A 83 | None | 0.59A | 4qwpA-5ewyA:undetectable | 4qwpA-5ewyA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5foh | POLYSACCHARIDEMONOOXYGENASE (Neurosporacrassa) |
PF03443(Glyco_hydro_61) | 3 | TYR A 212GLY A 83PRO A 84 | None | 0.72A | 4qwpA-5fohA:undetectable | 4qwpA-5fohA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 3 | TYR A 415GLY A 97PRO A 98 | None | 0.53A | 4qwpA-5fsaA:undetectable | 4qwpA-5fsaA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsm | EXO-BETA-D-GLUCOSAMINIDASE (Thermococcuskodakarensis) |
PF02449(Glyco_hydro_42) | 3 | TYR A 153GLY A 97PRO A 98 | None | 0.69A | 4qwpA-5gsmA:undetectable | 4qwpA-5gsmA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h4e | BETA 1-3 GLUCANASE (Clostridiumbeijerinckii) |
no annotation | 3 | TYR A 316GLY A 339PRO A 340 | None | 0.73A | 4qwpA-5h4eA:undetectable | 4qwpA-5h4eA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htf | FOLDASE PROTEIN PRSA1 (Listeriamonocytogenes) |
PF13616(Rotamase_3) | 3 | TYR A 201GLY A 188PRO A 189 | None | 0.70A | 4qwpA-5htfA:undetectable | 4qwpA-5htfA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ibz | UNCHARACTERIZEDPROTEIN (unculturedorganism) |
PF04199(Cyclase) | 3 | TYR A 229GLY A 81PRO A 82 | None | 0.41A | 4qwpA-5ibzA:undetectable | 4qwpA-5ibzA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iwd | DNA POLYMERASEPROCESSIVITY FACTOR (Humanbetaherpesvirus5) |
PF03325(Herpes_PAP) | 3 | TYR A 227GLY A 161PRO A 162 | None | 0.68A | 4qwpA-5iwdA:undetectable | 4qwpA-5iwdA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kd0 | AROMATICPRENYLTRANSFERASE (Aspergillusterreus) |
PF11991(Trp_DMAT) | 3 | TYR A 402GLY A 407PRO A 408 | None | 0.68A | 4qwpA-5kd0A:undetectable | 4qwpA-5kd0A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmp | TRANSLATIONINITIATION FACTORIF-3 (Thermusthermophilus) |
PF00707(IF3_C)PF05198(IF3_N) | 3 | TYR X 5GLY X 49PRO X 50 | None | 0.65A | 4qwpA-5lmpX:undetectable | 4qwpA-5lmpX:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkk | MULTIDRUG RESISTANCEABC TRANSPORTERATP-BINDING ANDPERMEASE PROTEIN (Thermusthermophilus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | TYR A 410GLY A 123PRO A 122 | None | 0.60A | 4qwpA-5mkkA:undetectable | 4qwpA-5mkkA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mza | ERYTHROCYTE MEMBRANEPROTEIN 1 (PFEMP1) (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 3 | TYR A1104GLY A1084PRO A1085 | None | 0.63A | 4qwpA-5mzaA:undetectable | 4qwpA-5mzaA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nns | GLYCOSYL HYDROLASEFAMILY 61, 2 PROTEIN (Heterobasidionirregulare) |
no annotation | 3 | TYR A 215GLY A 83PRO A 84 | NAG A 301 (-4.9A)NoneNone | 0.55A | 4qwpA-5nnsA:undetectable | 4qwpA-5nnsA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tkf | LYTIC POLYSACCHARIDEMONOOXYGENASE (Neurosporacrassa) |
PF03443(Glyco_hydro_61) | 3 | TYR A 213GLY A 86PRO A 87 | None | 0.71A | 4qwpA-5tkfA:undetectable | 4qwpA-5tkfA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tlc | DIBENZOTHIOPHENEDESULFURIZATIONENZYME A (Bacillussubtilis) |
PF00296(Bac_luciferase) | 3 | TYR A 199GLY A 211PRO A 212 | None | 0.61A | 4qwpA-5tlcA:undetectable | 4qwpA-5tlcA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ufv | GLYCOSIDE HYDROLASEFAMILY 61 PROTEIN (Thermothelomycesthermophila) |
PF03443(Glyco_hydro_61) | 3 | TYR A 217GLY A 78PRO A 79 | None | 0.72A | 4qwpA-5ufvA:undetectable | 4qwpA-5ufvA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvq | SCABIN (Streptomycesscabiei) |
no annotation | 3 | TYR A 133GLY A 82PRO A 83 | None | 0.54A | 4qwpA-5uvqA:undetectable | 4qwpA-5uvqA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1w | GLYCOSIDE HYDROLASE (Bacillushalodurans) |
PF03639(Glyco_hydro_81) | 3 | TYR A 574GLY A 353PRO A 352 | None | 0.66A | 4qwpA-5v1wA:undetectable | 4qwpA-5v1wA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 3 | TYR C 585GLY C 149PRO C 150 | None | 0.56A | 4qwpA-5x6xC:undetectable | 4qwpA-5x6xC:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | X-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 5X-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 6 (Homo sapiens) |
PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 3 | TYR B 316GLY A 112PRO A 111 | None | 0.71A | 4qwpA-5y3rB:undetectable | 4qwpA-5y3rB:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6r | GENOME POLYPROTEIN (Pestivirus C) |
no annotation | 3 | TYR A 553GLY A 516PRO A 515 | None | 0.67A | 4qwpA-5y6rA:undetectable | 4qwpA-5y6rA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 3 | TYR A 664GLY A 681PRO A 682 | None | 0.71A | 4qwpA-5zalA:undetectable | 4qwpA-5zalA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dgi | D-ALANINE--D-ALANINELIGASE (Vibrio cholerae) |
no annotation | 3 | TYR A 103GLY A 107PRO A 108 | NoneNoneGOL A 401 (-4.6A) | 0.71A | 4qwpA-6dgiA:undetectable | 4qwpA-6dgiA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
no annotation | 3 | TYR A 117GLY A 178PRO A 179 | None | 0.67A | 4qwpA-6fqcA:undetectable | 4qwpA-6fqcA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fwv | - (-) |
no annotation | 3 | TYR A 71GLY A 75PRO A 76 | None | 0.51A | 4qwpA-6fwvA:undetectable | 4qwpA-6fwvA:undetectable |