SIMILAR PATTERNS OF AMINO ACIDS FOR 4QWP_A_GCSA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermotoga
maritima)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 159
GLY A 135
PRO A 136
None
0.46A 4qwpA-1b3bA:
0.0
4qwpA-1b3bA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1chk CHITOSANASE

(Streptomyces
sp. N174)
PF01374
(Glyco_hydro_46)
3 TYR A 122
GLY A 151
PRO A 152
None
0.18A 4qwpA-1chkA:
34.3
4qwpA-1chkA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 160
GLY A 136
PRO A 137
None
0.52A 4qwpA-1euzA:
0.0
4qwpA-1euzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 TYR O  18
GLY O  55
PRO O  54
None
0.69A 4qwpA-1hdgO:
0.0
4qwpA-1hdgO:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE


([Clostridium]
symbiosum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 180
GLY A 156
PRO A 157
None
0.64A 4qwpA-1hrdA:
0.8
4qwpA-1hrdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji8 DISSIMILATORY
SIROHEME-SULFITE
REDUCTASE


(Pyrobaculum
aerophilum)
PF04358
(DsrC)
3 TYR A  87
GLY A  93
PRO A  94
None
0.66A 4qwpA-1ji8A:
undetectable
4qwpA-1ji8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1


(Homo sapiens)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 187
GLY A 163
PRO A 164
None
0.52A 4qwpA-1l1fA:
0.4
4qwpA-1l1fA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE


(Lactococcus
lactis)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N)
3 TYR A 477
GLY A 615
PRO A 616
None
0.40A 4qwpA-1lnsA:
0.0
4qwpA-1lnsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE


(Homo sapiens)
PF00293
(NUDIX)
3 TYR A 140
GLY A 166
PRO A 167
None
0.40A 4qwpA-1q33A:
0.0
4qwpA-1q33A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 TYR A  74
GLY A  42
PRO A  47
None
0.00A 4qwpA-1q5aA:
undetectable
4qwpA-1q5aA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN


(Shigella
flexneri)
PF02578
(Cu-oxidase_4)
3 TYR A 195
GLY A 158
PRO A 159
None
0.73A 4qwpA-1u05A:
undetectable
4qwpA-1u05A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT


(Rhodococcus
jostii)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 TYR A 256
GLY A 417
PRO A 416
None
0.58A 4qwpA-1uliA:
undetectable
4qwpA-1uliA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF01547
(SBP_bac_1)
3 TYR A  76
GLY A  85
PRO A  86
None
0.67A 4qwpA-1urdA:
undetectable
4qwpA-1urdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6)
PF00680
(RdRP_1)
3 TYR A 199
GLY A 275
PRO A 276
None
0.66A 4qwpA-1wacA:
undetectable
4qwpA-1wacA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus)
PF00704
(Glyco_hydro_18)
3 TYR A 310
GLY A 270
PRO A 271
None
0.69A 4qwpA-1wnoA:
undetectable
4qwpA-1wnoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx3 HYPOTHETICAL PROTEIN
DSRC


(Allochromatium
vinosum)
PF04358
(DsrC)
3 TYR A  88
GLY A  94
PRO A  95
None
0.64A 4qwpA-1yx3A:
undetectable
4qwpA-1yx3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE


([Candida]
tenuis)
PF00248
(Aldo_ket_red)
3 TYR A 197
GLY A 221
PRO A 222
None
0.71A 4qwpA-1z9aA:
undetectable
4qwpA-1z9aA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)


(Plasmodium
falciparum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 180
GLY A 156
PRO A 157
None
0.66A 4qwpA-2bmaA:
0.7
4qwpA-2bmaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)


(Bluetongue
virus)
PF01700
(Orbi_VP3)
3 TYR A 410
GLY A 322
PRO A 323
None
0.51A 4qwpA-2btvA:
undetectable
4qwpA-2btvA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor)
PF00067
(p450)
3 TYR A 258
GLY A  26
PRO A  27
None
0.48A 4qwpA-2dkkA:
undetectable
4qwpA-2dkkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE


(Thermus
thermophilus)
PF00171
(Aldedh)
3 TYR A 502
GLY A 196
PRO A 197
None
0.60A 4qwpA-2ehqA:
undetectable
4qwpA-2ehqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A


(Bacillus
subtilis)
PF13377
(Peripla_BP_3)
3 TYR A 222
GLY A 186
PRO A 187
SO4  A4397 (-4.2A)
None
None
0.69A 4qwpA-2fepA:
undetectable
4qwpA-2fepA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdr GLUTATHIONE
S-TRANSFERASE


(Paraburkholderia
xenovorans)
PF02798
(GST_N)
PF13410
(GST_C_2)
3 TYR A 157
GLY A  66
PRO A  67
None
GSH  A 224 (-3.9A)
None
0.55A 4qwpA-2gdrA:
undetectable
4qwpA-2gdrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
3 TYR A 851
GLY A 776
PRO A 777
None
0.53A 4qwpA-2inyA:
undetectable
4qwpA-2inyA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF


(Deinococcus
radiodurans)
PF02463
(SMC_N)
3 TYR A 227
GLY A 247
PRO A 248
None
0.68A 4qwpA-2o5vA:
0.6
4qwpA-2o5vA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum)
PF01979
(Amidohydro_1)
3 TYR A 140
GLY A 163
PRO A 164
None
0.67A 4qwpA-2p9bA:
undetectable
4qwpA-2p9bA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r18 CAPSID ASSEMBLY
PROTEIN VP3


(Infectious
bursal disease
virus)
PF01767
(Birna_VP3)
3 TYR A 195
GLY A 202
PRO A 203
None
0.71A 4qwpA-2r18A:
undetectable
4qwpA-2r18A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans)
PF01522
(Polysacc_deac_1)
3 TYR A 172
GLY A 214
PRO A 213
None
PO4  A1313 (-3.6A)
PO4  A1313 (-4.6A)
0.70A 4qwpA-2w3zA:
undetectable
4qwpA-2w3zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE


(Bacillus
subtilis)
PF02156
(Glyco_hydro_26)
3 TYR A 278
GLY A 268
PRO A 269
None
0.57A 4qwpA-2whkA:
undetectable
4qwpA-2whkA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE


(Escherichia
coli;
[Clostridium]
symbiosum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 181
GLY A 157
PRO A 158
None
0.65A 4qwpA-2yfhA:
undetectable
4qwpA-2yfhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE


(Thermobifida
fusca)
PF13738
(Pyr_redox_3)
3 TYR A  90
GLY A 285
PRO A 286
None
0.68A 4qwpA-2ylzA:
1.7
4qwpA-2ylzA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
3 TYR A 180
GLY A 206
PRO A 207
None
CA  A1005 ( 4.2A)
None
0.55A 4qwpA-2z2xA:
undetectable
4qwpA-2z2xA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
3 TYR A 180
GLY A 206
PRO A 207
None
CA  A1003 ( 4.3A)
None
0.47A 4qwpA-2z2zA:
undetectable
4qwpA-2z2zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7j CAPSID ASSEMBLY
PROTEIN VP3


(Infectious
bursal disease
virus)
PF01767
(Birna_VP3)
3 TYR A 195
GLY A 202
PRO A 203
None
0.74A 4qwpA-2z7jA:
undetectable
4qwpA-2z7jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 169
GLY A 145
PRO A 146
None
0.62A 4qwpA-3aoeA:
undetectable
4qwpA-3aoeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
no annotation 3 TYR E 168
GLY E 144
PRO E 145
None
0.59A 4qwpA-3aoeE:
undetectable
4qwpA-3aoeE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE


(unidentified)
PF01979
(Amidohydro_1)
3 TYR A 110
GLY A 133
PRO A 134
None
0.70A 4qwpA-3be7A:
undetectable
4qwpA-3be7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE


(Bacteroides
thetaiotaomicron)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 TYR A 346
GLY A 320
PRO A 321
None
0.60A 4qwpA-3ct9A:
undetectable
4qwpA-3ct9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas
putida)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 TYR A 254
GLY A 415
PRO A 414
None
0.70A 4qwpA-3eqqA:
undetectable
4qwpA-3eqqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzg THYMIDYLATE SYNTHASE
THYX


(Mycobacterium
tuberculosis)
PF02511
(Thy1)
3 TYR A 189
GLY A  32
PRO A  33
None
0.62A 4qwpA-3hzgA:
undetectable
4qwpA-3hzgA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 170
GLY A 146
PRO A 147
None
0.68A 4qwpA-3k8zA:
undetectable
4qwpA-3k8zA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 171
GLY A 147
PRO A 148
None
0.66A 4qwpA-3k92A:
undetectable
4qwpA-3k92A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6


(Homo sapiens)
PF02373
(JmjC)
3 TYR A 117
GLY A 178
PRO A 179
None
0.66A 4qwpA-3ld8A:
undetectable
4qwpA-3ld8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN


(Parabacteroides
distasonis)
PF06321
(P_gingi_FimA)
3 TYR A 212
GLY A 387
PRO A 388
None
0.62A 4qwpA-3liuA:
undetectable
4qwpA-3liuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN


(Thermoplasma
volcanium)
PF12916
(DUF3834)
3 TYR A 181
GLY A   9
PRO A  10
None
ACT  A 232 ( 4.8A)
ACT  A 232 (-4.6A)
0.66A 4qwpA-3mstA:
undetectable
4qwpA-3mstA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2)
3 TYR A 406
GLY A  51
PRO A  52
None
0.57A 4qwpA-3nvqA:
undetectable
4qwpA-3nvqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 244
GLY A 220
PRO A 221
None
0.67A 4qwpA-3r3jA:
undetectable
4qwpA-3r3jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2


(Mus musculus)
PF13176
(TPR_7)
PF13424
(TPR_12)
3 TYR A 206
GLY A 156
PRO A 157
None
0.66A 4qwpA-3ro2A:
0.9
4qwpA-3ro2A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1t ASPARTOKINASE

(Mycobacterium
tuberculosis)
PF01842
(ACT)
PF13840
(ACT_7)
3 TYR A  91
GLY A  70
PRO A  71
None
0.73A 4qwpA-3s1tA:
undetectable
4qwpA-3s1tA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN


(Bacteroides
fragilis)
PF11738
(DUF3298)
PF13739
(DUF4163)
3 TYR A 169
GLY A 257
PRO A 258
None
0.69A 4qwpA-3s5tA:
undetectable
4qwpA-3s5tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I


(Solanum
habrochaites)
PF12697
(Abhydrolase_6)
3 TYR A 202
GLY A 116
PRO A 117
None
0.71A 4qwpA-3sttA:
undetectable
4qwpA-3sttA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
3 TYR A 429
GLY A 402
PRO A 403
None
0.73A 4qwpA-3vtaA:
undetectable
4qwpA-3vtaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus)
PF02516
(STT3)
3 TYR A 276
GLY A  83
PRO A  84
None
0.65A 4qwpA-3wajA:
undetectable
4qwpA-3wajA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1


(Aspergillus
oryzae)
PF07519
(Tannase)
3 TYR A 512
GLY A 463
PRO A 464
None
0.69A 4qwpA-3wmtA:
0.3
4qwpA-3wmtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF00150
(Cellulase)
3 TYR A 279
GLY A 245
PRO A 244
None
0.60A 4qwpA-3zizA:
undetectable
4qwpA-3zizA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger)
PF01979
(Amidohydro_1)
3 TYR A 160
GLY A 219
PRO A 220
None
0.55A 4qwpA-4c60A:
undetectable
4qwpA-4c60A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa)
PF03443
(Glyco_hydro_61)
3 TYR A 217
GLY A  85
PRO A  86
None
0.71A 4qwpA-4d7uA:
undetectable
4qwpA-4d7uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE


(Mycobacteroides
abscessus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 TYR A  44
GLY A  11
PRO A  12
None
0.54A 4qwpA-4eyeA:
undetectable
4qwpA-4eyeA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go5 ASPARTOKINASE

(Mycobacterium
tuberculosis)
PF01842
(ACT)
PF13840
(ACT_7)
3 TYR X  91
GLY X  70
PRO X  71
None
0.66A 4qwpA-4go5X:
undetectable
4qwpA-4go5X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr PPE41

(Mycobacterium
tuberculosis)
PF00823
(PPE)
3 TYR B  96
GLY B  20
PRO B  21
None
0.65A 4qwpA-4kxrB:
undetectable
4qwpA-4kxrB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE


(Pyrococcus
furiosus)
PF00994
(MoCF_biosynth)
3 TYR A  51
GLY A  35
PRO A  36
None
0.48A 4qwpA-4lhbA:
undetectable
4qwpA-4lhbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus)
PF00729
(Viral_coat)
3 TYR A 171
GLY A 180
PRO A 181
None
0.64A 4qwpA-4llfA:
undetectable
4qwpA-4llfA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN


(Synechococcus
sp.
JA-2-3B'a(2-13))
PF07884
(VKOR)
3 TYR A 207
GLY A 235
PRO A 236
None
0.73A 4qwpA-4nv2A:
undetectable
4qwpA-4nv2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE


(Saccharophagus
degradans)
PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III)
3 TYR A 251
GLY A 255
PRO A 256
None
0.51A 4qwpA-4ojzA:
undetectable
4qwpA-4ojzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii)
PF12697
(Abhydrolase_6)
3 TYR A 116
GLY A 104
PRO A 103
None
0.74A 4qwpA-4opmA:
undetectable
4qwpA-4opmA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00145
(DNA_methylase)
3 TYR A 526
GLY A 800
PRO A 799
None
0.73A 4qwpA-4u7tA:
undetectable
4qwpA-4u7tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4l PPE FAMILY PROTEIN
PPE41


(Mycobacterium
tuberculosis)
PF00823
(PPE)
3 TYR B  96
GLY B  20
PRO B  21
None
0.64A 4qwpA-4w4lB:
undetectable
4qwpA-4w4lB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18


(Desulfitobacterium
hafniense)
PF00704
(Glyco_hydro_18)
3 TYR A 372
GLY A 367
PRO A 366
None
0.61A 4qwpA-4wiwA:
undetectable
4qwpA-4wiwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea)
PF05721
(PhyH)
3 TYR A 145
GLY A 250
PRO A 251
None
0.63A 4qwpA-4xbzA:
undetectable
4qwpA-4xbzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 TYR A 179
GLY A 155
PRO A 156
None
0.56A 4qwpA-4xgiA:
undetectable
4qwpA-4xgiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuo ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF02018
(CBM_4_9)
3 TYR A 146
GLY A  57
PRO A  58
None
0.70A 4qwpA-4xuoA:
undetectable
4qwpA-4xuoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF02018
(CBM_4_9)
3 TYR A 146
GLY A  57
PRO A  58
None
0.73A 4qwpA-4xupA:
undetectable
4qwpA-4xupA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN


(Gallus gallus)
PF03828
(PAP_assoc)
3 TYR A 135
GLY A 290
PRO A 291
None
0.60A 4qwpA-5a30A:
undetectable
4qwpA-5a30A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5u PROLYL 4-HYDROXYLASE

(Paramecium
bursaria
Chlorella virus
1)
PF13640
(2OG-FeII_Oxy_3)
3 TYR A 216
GLY A  45
PRO A  44
None
0.72A 4qwpA-5c5uA:
undetectable
4qwpA-5c5uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewy PUTATIVE
ADP-RIBOSYLTRANSFERA
SE SCABIN


(Streptomyces
scabiei)
no annotation 3 TYR A 133
GLY A  82
PRO A  83
None
0.59A 4qwpA-5ewyA:
undetectable
4qwpA-5ewyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE


(Neurospora
crassa)
PF03443
(Glyco_hydro_61)
3 TYR A 212
GLY A  83
PRO A  84
None
0.72A 4qwpA-5fohA:
undetectable
4qwpA-5fohA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans)
PF00067
(p450)
3 TYR A 415
GLY A  97
PRO A  98
None
0.53A 4qwpA-5fsaA:
undetectable
4qwpA-5fsaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
3 TYR A 153
GLY A  97
PRO A  98
None
0.69A 4qwpA-5gsmA:
undetectable
4qwpA-5gsmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii)
no annotation 3 TYR A 316
GLY A 339
PRO A 340
None
0.73A 4qwpA-5h4eA:
undetectable
4qwpA-5h4eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htf FOLDASE PROTEIN PRSA
1


(Listeria
monocytogenes)
PF13616
(Rotamase_3)
3 TYR A 201
GLY A 188
PRO A 189
None
0.70A 4qwpA-5htfA:
undetectable
4qwpA-5htfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibz UNCHARACTERIZED
PROTEIN


(uncultured
organism)
PF04199
(Cyclase)
3 TYR A 229
GLY A  81
PRO A  82
None
0.41A 4qwpA-5ibzA:
undetectable
4qwpA-5ibzA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwd DNA POLYMERASE
PROCESSIVITY FACTOR


(Human
betaherpesvirus
5)
PF03325
(Herpes_PAP)
3 TYR A 227
GLY A 161
PRO A 162
None
0.68A 4qwpA-5iwdA:
undetectable
4qwpA-5iwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE


(Aspergillus
terreus)
PF11991
(Trp_DMAT)
3 TYR A 402
GLY A 407
PRO A 408
None
0.68A 4qwpA-5kd0A:
undetectable
4qwpA-5kd0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmp TRANSLATION
INITIATION FACTOR
IF-3


(Thermus
thermophilus)
PF00707
(IF3_C)
PF05198
(IF3_N)
3 TYR X   5
GLY X  49
PRO X  50
None
0.65A 4qwpA-5lmpX:
undetectable
4qwpA-5lmpX:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 TYR A 410
GLY A 123
PRO A 122
None
0.60A 4qwpA-5mkkA:
undetectable
4qwpA-5mkkA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
3 TYR A1104
GLY A1084
PRO A1085
None
0.63A 4qwpA-5mzaA:
undetectable
4qwpA-5mzaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN


(Heterobasidion
irregulare)
no annotation 3 TYR A 215
GLY A  83
PRO A  84
NAG  A 301 (-4.9A)
None
None
0.55A 4qwpA-5nnsA:
undetectable
4qwpA-5nnsA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE


(Neurospora
crassa)
PF03443
(Glyco_hydro_61)
3 TYR A 213
GLY A  86
PRO A  87
None
0.71A 4qwpA-5tkfA:
undetectable
4qwpA-5tkfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A


(Bacillus
subtilis)
PF00296
(Bac_luciferase)
3 TYR A 199
GLY A 211
PRO A 212
None
0.61A 4qwpA-5tlcA:
undetectable
4qwpA-5tlcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN


(Thermothelomyces
thermophila)
PF03443
(Glyco_hydro_61)
3 TYR A 217
GLY A  78
PRO A  79
None
0.72A 4qwpA-5ufvA:
undetectable
4qwpA-5ufvA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvq SCABIN

(Streptomyces
scabiei)
no annotation 3 TYR A 133
GLY A  82
PRO A  83
None
0.54A 4qwpA-5uvqA:
undetectable
4qwpA-5uvqA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
3 TYR A 574
GLY A 353
PRO A 352
None
0.66A 4qwpA-5v1wA:
undetectable
4qwpA-5v1wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 3 TYR C 585
GLY C 149
PRO C 150
None
0.56A 4qwpA-5x6xC:
undetectable
4qwpA-5x6xC:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6


(Homo sapiens)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
3 TYR B 316
GLY A 112
PRO A 111
None
0.71A 4qwpA-5y3rB:
undetectable
4qwpA-5y3rB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C)
no annotation 3 TYR A 553
GLY A 516
PRO A 515
None
0.67A 4qwpA-5y6rA:
undetectable
4qwpA-5y6rA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER


(Homo sapiens)
no annotation 3 TYR A 664
GLY A 681
PRO A 682
None
0.71A 4qwpA-5zalA:
undetectable
4qwpA-5zalA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE


(Vibrio cholerae)
no annotation 3 TYR A 103
GLY A 107
PRO A 108
None
None
GOL  A 401 (-4.6A)
0.71A 4qwpA-6dgiA:
undetectable
4qwpA-6dgiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6


(Homo sapiens)
no annotation 3 TYR A 117
GLY A 178
PRO A 179
None
0.67A 4qwpA-6fqcA:
undetectable
4qwpA-6fqcA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwv -

(-)
no annotation 3 TYR A  71
GLY A  75
PRO A  76
None
0.51A 4qwpA-6fwvA:
undetectable
4qwpA-6fwvA:
undetectable