SIMILAR PATTERNS OF AMINO ACIDS FOR 4QW1_B_BO2B201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cem | CELLULASE CELA(1,4-BETA-D-GLUCAN-GLUCANOHYDROLASE) (Ruminiclostridiumthermocellum) |
PF01270(Glyco_hydro_8) | 5 | THR A 280THR A 306GLY A 338ALA A 342THR A 380 | None | 1.18A | 4qw1V-1cemA:undetectable4qw1b-1cemA:undetectable | 4qw1V-1cemA:18.974qw1b-1cemA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | THR A 136THR A 137GLY A 283ALA A 281THR A 287 | None | 1.16A | 4qw1V-1csjA:undetectable4qw1b-1csjA:undetectable | 4qw1V-1csjA:18.794qw1b-1csjA:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | SER B 363THR B 171THR B 170THR B 167THR B 300 | NoneKCX B 219 ( 3.0A)NoneNoneNone | 1.47A | 4qw1V-1e9yB:undetectable4qw1b-1e9yB:undetectable | 4qw1V-1e9yB:18.564qw1b-1e9yB:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efy | POLY (ADP-RIBOSE)POLYMERASE (Gallus gallus) |
PF00644(PARP)PF02877(PARP_reg) | 5 | THR A 959THR A 961GLY A 974ALA A 955THR A 954 | None | 1.22A | 4qw1V-1efyA:undetectable4qw1b-1efyA:undetectable | 4qw1V-1efyA:20.664qw1b-1efyA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kny | KANAMYCINNUCLEOTIDYLTRANSFERASE (Staphylococcusaureus) |
PF07827(KNTase_C) | 5 | SER A 49THR A 186THR A 187ARG A 9GLY A 41 | APC A 556 (-2.9A)NoneAPC A 556 (-3.4A)NoneNone | 1.36A | 4qw1V-1knyA:undetectable4qw1b-1knyA:undetectable | 4qw1V-1knyA:25.634qw1b-1knyA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nex | CDC4 PROTEIN (Saccharomycescerevisiae) |
PF00400(WD40)PF12937(F-box-like) | 5 | SER B 653THR B 592THR B 593GLY B 636ALA B 649 | None | 0.98A | 4qw1V-1nexB:undetectable4qw1b-1nexB:undetectable | 4qw1V-1nexB:20.804qw1b-1nexB:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | THR H 1THR H 21LYS H 33GLY H 47ALA H 49 | None | 0.50A | 4qw1V-1q5qH:25.74qw1b-1q5qH:27.1 | 4qw1V-1q5qH:26.484qw1b-1q5qH:30.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | SER A 390THR A 237THR A 235GLY A 218ALA A 394 | NoneNoneFAD A1656 (-3.8A)NoneNone | 1.49A | 4qw1V-1qlbA:undetectable4qw1b-1qlbA:undetectable | 4qw1V-1qlbA:18.484qw1b-1qlbA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbj | PROSTAGLANDIN FSYNTHASE (Trypanosomabrucei) |
PF00248(Aldo_ket_red) | 5 | HIS A 45THR A 48THR A 76THR A 75GLY A 59 | None | 1.24A | 4qw1V-1vbjA:undetectable4qw1b-1vbjA:undetectable | 4qw1V-1vbjA:22.804qw1b-1vbjA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | SER A 271THR A 421THR A 423GLY A 15ALA A 17 | NoneNoneNoneEDO A 501 ( 4.3A)None | 1.44A | 4qw1V-1x3lA:undetectable4qw1b-1x3lA:undetectable | 4qw1V-1x3lA:21.214qw1b-1x3lA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yco | BRANCHED-CHAINPHOSPHOTRANSACYLASE (Enterococcusfaecalis) |
PF01515(PTA_PTB) | 5 | THR A 253THR A 80THR A 82GLY A 76ALA A 7 | None | 1.46A | 4qw1V-1ycoA:undetectable4qw1b-1ycoA:undetectable | 4qw1V-1ycoA:23.554qw1b-1ycoA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3z | DIALKYLGLYCINEDECARBOXYLASE (Burkholderiacepacia) |
PF00202(Aminotran_3) | 5 | HIS A 139THR A 269GLY A 248ALA A 245THR A 273 | NoneNoneNonePLP A 434 (-3.6A)None | 1.38A | 4qw1V-1z3zA:undetectable4qw1b-1z3zA:undetectable | 4qw1V-1z3zA:21.114qw1b-1z3zA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zuw | GLUTAMATE RACEMASE 1 (Bacillussubtilis) |
PF01177(Asp_Glu_race) | 5 | SER A 208THR A 76THR A 78GLY A 14THR A 17 | NoneDGL A1301 (-3.7A)NoneNoneNone | 1.47A | 4qw1V-1zuwA:undetectable4qw1b-1zuwA:undetectable | 4qw1V-1zuwA:21.834qw1b-1zuwA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zx5 | MANNOSEPHOSPHATEISOMERASE, PUTATIVE (Archaeoglobusfulgidus) |
PF01238(PMI_typeI) | 5 | HIS A 175THR A 95GLY A 126ALA A 128THR A 161 | GOL A 700 (-4.1A)ACY A 506 ( 3.0A)NoneNoneNone | 1.41A | 4qw1V-1zx5A:undetectable4qw1b-1zx5A:undetectable | 4qw1V-1zx5A:23.084qw1b-1zx5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anp | LEUCYLAMINOPEPTIDASE (Vibrioproteolyticus) |
PF04389(Peptidase_M28) | 5 | SER A 100THR A 106THR A 39ALA A 112THR A 258 | None | 1.37A | 4qw1V-2anpA:undetectable4qw1b-2anpA:undetectable | 4qw1V-2anpA:21.694qw1b-2anpA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cgj | L-RHAMNULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | SER A 235THR A 282THR A 180ARG A 292THR A 238 | NoneNoneNoneNoneLFR A1481 (-3.4A) | 1.45A | 4qw1V-2cgjA:undetectable4qw1b-2cgjA:undetectable | 4qw1V-2cgjA:17.684qw1b-2cgjA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fhg | PROTEASOME, BETASUBUNIT (Mycobacteriumtuberculosis) |
no annotation | 5 | THR H 301THR H 321LYS H 333GLY H 347ALA H 349 | None | 0.58A | 4qw1V-2fhgH:25.14qw1b-2fhgH:26.0 | 4qw1V-2fhgH:26.854qw1b-2fhgH:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmt | METHIONYL-TRNA FMETFORMYLTRANSFERASE (Escherichiacoli) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 5 | HIS A 27THR A 182ARG A 103GLY A 189ALA A 187 | None | 1.45A | 4qw1V-2fmtA:undetectable4qw1b-2fmtA:undetectable | 4qw1V-2fmtA:21.454qw1b-2fmtA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fon | PEROXISOMAL ACYL-COAOXIDASE 1A (Solanumlycopersicum) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 5 | HIS A 30SER A 28THR A 35ARG A 345ALA A 26 | None | 1.46A | 4qw1V-2fonA:undetectable4qw1b-2fonA:undetectable | 4qw1V-2fonA:16.424qw1b-2fonA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g28 | PYRUVATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00456(Transketolase_N) | 5 | THR A 494THR A 495ARG A 838GLY A 629THR A 631 | None | 1.36A | 4qw1V-2g28A:undetectable4qw1b-2g28A:undetectable | 4qw1V-2g28A:13.964qw1b-2g28A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxg | L-ARABINOSEISOMERASE (Escherichiacoli) |
PF02610(Arabinose_Isome)PF11762(Arabinose_Iso_C) | 5 | HIS A 450THR A 276THR A 277GLY A 302ALA A 312 | MN A 501 (-3.6A)NoneNoneNoneNone | 1.35A | 4qw1V-2hxgA:undetectable4qw1b-2hxgA:undetectable | 4qw1V-2hxgA:19.594qw1b-2hxgA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iph | THIOL PROTEASE P3C (Norwalk virus) |
PF05416(Peptidase_C37) | 5 | THR A1028THR A1027THR A1056GLY A1155ALA A1170 | None | 1.20A | 4qw1V-2iphA:undetectable4qw1b-2iphA:undetectable | 4qw1V-2iphA:22.764qw1b-2iphA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfq | GLUTAMATE RACEMASE (Staphylococcusaureus) |
PF01177(Asp_Glu_race) | 5 | SER A 207THR A 74THR A 76GLY A 13THR A 16 | NoneDGL A1267 (-3.7A)NoneNoneNone | 1.49A | 4qw1V-2jfqA:undetectable4qw1b-2jfqA:undetectable | 4qw1V-2jfqA:19.424qw1b-2jfqA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfq | GLUTAMATE RACEMASE (Staphylococcusaureus) |
PF01177(Asp_Glu_race) | 5 | SER A 207THR A 74THR A 76GLY A 14THR A 16 | NoneDGL A1267 (-3.7A)NoneNoneNone | 1.39A | 4qw1V-2jfqA:undetectable4qw1b-2jfqA:undetectable | 4qw1V-2jfqA:19.424qw1b-2jfqA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lhs | CBP21 (Serratiamarcescens) |
PF03067(LPMO_10) | 6 | HIS A 47SER A 50THR A 97THR A 108ARG A 10ALA A 49 | None | 1.42A | 4qw1V-2lhsA:undetectable4qw1b-2lhsA:undetectable | 4qw1V-2lhsA:19.414qw1b-2lhsA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzh | 2C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Mycolicibacteriumsmegmatis) |
PF02542(YgbB) | 5 | THR A 134THR A 133THR A 132ARG A 142GLY A 143 | NoneCDP A1158 (-2.7A)CDP A1158 (-3.3A)NoneNone | 1.42A | 4qw1V-2uzhA:undetectable4qw1b-2uzhA:undetectable | 4qw1V-2uzhA:22.224qw1b-2uzhA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xym | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | THR A 136THR A 137GLY A 283ALA A 281THR A 287 | None | 1.28A | 4qw1V-2xymA:undetectable4qw1b-2xymA:undetectable | 4qw1V-2xymA:17.744qw1b-2xymA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfq | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Peptoniphilusasaccharolyticus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | THR A 225THR A 227THR A 191GLY A 221ALA A 299 | None | 1.42A | 4qw1V-2yfqA:undetectable4qw1b-2yfqA:undetectable | 4qw1V-2yfqA:19.424qw1b-2yfqA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4u | DIHYDRODIPICOLINATESYNTHASE (Agrobacteriumfabrum) |
PF00701(DHDPS) | 5 | SER A 211THR A 247GLY A 45ALA A 10THR A 42 | None | 1.32A | 4qw1V-3b4uA:undetectable4qw1b-3b4uA:undetectable | 4qw1V-3b4uA:24.354qw1b-3b4uA:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5i | S-ADENOSYL-L-METHIONINE:SALICYLIC ACIDCARBOXYLMETHYLTRANSFERASE-LIKE PROTEIN (Arabidopsisthaliana) |
PF03492(Methyltransf_7) | 5 | SER A 175THR A 192THR A 193THR A 194ARG A 180 | None | 1.49A | 4qw1V-3b5iA:undetectable4qw1b-3b5iA:undetectable | 4qw1V-3b5iA:20.744qw1b-3b5iA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eyt | UNCHARACTERIZEDPROTEIN SPOA0173 (Ruegeriapomeroyi) |
PF00578(AhpC-TSA) | 5 | HIS A 130SER A 117THR A 106GLY A 64ALA A 32 | None | 1.35A | 4qw1V-3eytA:undetectable4qw1b-3eytA:undetectable | 4qw1V-3eytA:22.174qw1b-3eytA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3k | UNCHARACTERIZEDPROTEIN YKR043C (Saccharomycescerevisiae) |
PF00300(His_Phos_1) | 5 | SER A 19THR A 43THR A 73GLY A 236ALA A 234 | None | 1.28A | 4qw1V-3f3kA:undetectable4qw1b-3f3kA:undetectable | 4qw1V-3f3kA:22.074qw1b-3f3kA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4m | TUMOR NECROSISFACTOR,ALPHA-INDUCEDPROTEIN 8-LIKEPROTEIN 2 (Homo sapiens) |
PF05527(DUF758) | 5 | HIS A 167THR A 50GLY A 154ALA A 158THR A 157 | None | 1.30A | 4qw1V-3f4mA:undetectable4qw1b-3f4mA:undetectable | 4qw1V-3f4mA:21.284qw1b-3f4mA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g10 | CCR4-NOT COMPLEXSUBUNIT CAF1 (Schizosaccharomycespombe) |
PF04857(CAF1) | 5 | SER A 92THR A 165GLY A 88ALA A 90THR A 104 | None | 1.23A | 4qw1V-3g10A:undetectable4qw1b-3g10A:undetectable | 4qw1V-3g10A:19.884qw1b-3g10A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmu | AMINOTRANSFERASE,CLASS III (Ruegeriapomeroyi) |
PF00202(Aminotran_3) | 5 | SER A 324THR A 287THR A 129GLY A 123ALA A 120 | NoneNoneNoneSO4 A 471 (-3.3A)None | 1.47A | 4qw1V-3hmuA:undetectable4qw1b-3hmuA:undetectable | 4qw1V-3hmuA:19.174qw1b-3hmuA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | THR A 197THR A 172THR A 174GLY A 244ALA A 355 | None | 1.45A | 4qw1V-3kzuA:undetectable4qw1b-3kzuA:undetectable | 4qw1V-3kzuA:21.264qw1b-3kzuA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l9x | GLUTATHIONE-REGULATED POTASSIUM-EFFLUXSYSTEM PROTEIN KEFC,LINKER, ANCILLARYPROTEIN KEFF (Escherichiacoli) |
PF02254(TrkA_N)PF02525(Flavodoxin_2) | 5 | HIS A1008SER A1014THR A1105THR A1106ALA A1016 | FMN A2400 (-4.1A)FMN A2400 (-2.7A)FMN A2400 (-3.6A)FMN A2400 (-3.9A)FMN A2400 (-3.6A) | 1.47A | 4qw1V-3l9xA:undetectable4qw1b-3l9xA:undetectable | 4qw1V-3l9xA:19.404qw1b-3l9xA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la4 | UREASE (Canavaliaensiformis) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | SER A 634THR A 442THR A 441THR A 438THR A 571 | NoneKCX A 490 ( 3.4A)NoneNoneNone | 1.44A | 4qw1V-3la4A:undetectable4qw1b-3la4A:undetectable | 4qw1V-3la4A:15.164qw1b-3la4A:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ln7 | GLUTATHIONEBIOSYNTHESISBIFUNCTIONAL PROTEINGSHAB (Pasteurellamultocida) |
PF02655(ATP-grasp_3)PF04262(Glu_cys_ligase) | 5 | SER A 483THR A 476GLY A 585ALA A 696THR A 691 | None | 1.04A | 4qw1V-3ln7A:undetectable4qw1b-3ln7A:undetectable | 4qw1V-3ln7A:16.054qw1b-3ln7A:14.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1a | PUTATIVEDEHYDROGENASE (Streptomycesavermitilis) |
PF00106(adh_short) | 5 | SER A 149THR A 98THR A 99ALA A 150THR A 154 | None | 1.41A | 4qw1V-3m1aA:undetectable4qw1b-3m1aA:undetectable | 4qw1V-3m1aA:22.824qw1b-3m1aA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg6 | PROTEASOME COMPONENTPRE3 (Saccharomycescerevisiae) |
no annotation | 9 | THR N 1THR N 20THR N 21THR N 22LYS N 33ARG N 45GLY N 47ALA N 49THR N 52 | None | 0.49A | 4qw1V-3mg6N:29.34qw1b-3mg6N:38.6 | 4qw1V-3mg6N:29.494qw1b-3mg6N:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg6 | PROTEASOME COMPONENTPRE3 (Saccharomycescerevisiae) |
no annotation | 5 | THR N 21ARG N 45GLY N 47ALA N 49THR N 52 | None | 1.43A | 4qw1V-3mg6N:29.34qw1b-3mg6N:38.6 | 4qw1V-3mg6N:29.494qw1b-3mg6N:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muu | STRUCTURALPOLYPROTEIN (Sindbis virus) |
PF00943(Alpha_E2_glycop)PF01589(Alpha_E1_glycop) | 5 | THR A 413THR A 412GLY A 435ALA A 466THR A 437 | None | 1.41A | 4qw1V-3muuA:undetectable4qw1b-3muuA:undetectable | 4qw1V-3muuA:16.394qw1b-3muuA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgk | UREASE SUBUNIT BETA2 (Helicobactermustelae) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | SER C 362THR C 170THR C 169THR C 166THR C 299 | NoneKCX C 218 ( 3.4A)NoneNoneNone | 1.40A | 4qw1V-3qgkC:undetectable4qw1b-3qgkC:undetectable | 4qw1V-3qgkC:18.734qw1b-3qgkC:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rfw | CELL-BINDING FACTOR2 (Campylobacterjejuni) |
PF13616(Rotamase_3) | 5 | THR A 209THR A 211THR A 212THR A 213ALA A 201 | None | 1.35A | 4qw1V-3rfwA:undetectable4qw1b-3rfwA:undetectable | 4qw1V-3rfwA:23.134qw1b-3rfwA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tjr | SHORT CHAINDEHYDROGENASE (Mycobacteriumavium) |
PF00106(adh_short) | 5 | SER A 230THR A 145THR A 238ALA A 231THR A 195 | NoneUNL A 281 ( 3.8A)NoneNoneUNL A 281 ( 2.6A) | 1.28A | 4qw1V-3tjrA:undetectable4qw1b-3tjrA:undetectable | 4qw1V-3tjrA:21.594qw1b-3tjrA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uhj | PROBABLE GLYCEROLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00465(Fe-ADH) | 5 | SER A 147THR A 121GLY A 115ALA A 144THR A 142 | NoneNoneGOL A 487 ( 3.8A)NoneGOL A 487 (-3.6A) | 1.26A | 4qw1V-3uhjA:undetectable4qw1b-3uhjA:undetectable | 4qw1V-3uhjA:21.544qw1b-3uhjA:20.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3unf | PROTEASOME SUBUNITBETA TYPE-10 (Mus musculus) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 6 | THR H 1THR H 21LYS H 33GLY H 47ALA H 49THR H 52 | 04C H 301 (-2.5A)04C H 301 (-3.9A)04C H 301 (-3.5A)04C H 301 (-3.7A)04C H 301 (-3.6A)04C H 301 (-3.8A) | 0.65A | 4qw1V-3unfH:35.84qw1b-3unfH:31.0 | 4qw1V-3unfH:46.784qw1b-3unfH:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up8 | PUTATIVE2,5-DIKETO-D-GLUCONIC ACID REDUCTASE B (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 5 | HIS A 40THR A 43THR A 71THR A 70GLY A 54 | None | 1.28A | 4qw1V-3up8A:undetectable4qw1b-3up8A:undetectable | 4qw1V-3up8A:24.684qw1b-3up8A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqf | D-THREO-3-HYDROXYASPARTATE DEHYDRATASE (Delftia sp.HT23) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 5 | HIS A 140SER A 176THR A 44GLY A 236THR A 218 | NoneNoneNonePLP A 401 (-3.4A)PLP A 401 (-3.6A) | 1.47A | 4qw1V-3wqfA:undetectable4qw1b-3wqfA:undetectable | 4qw1V-3wqfA:21.754qw1b-3wqfA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 5 | HIS A 585THR A 535THR A 536GLY A 29ALA A 581 | MG A1005 (-3.7A)NFU A1004 (-3.7A)NoneNoneNone | 1.25A | 4qw1V-4c3oA:undetectable4qw1b-4c3oA:undetectable | 4qw1V-4c3oA:18.174qw1b-4c3oA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dez | DNA POLYMERASE IV 1 (Mycolicibacteriumsmegmatis) |
PF00817(IMS) | 5 | THR A 200THR A 191THR A 190GLY A 198ALA A 196 | None | 1.36A | 4qw1V-4dezA:undetectable4qw1b-4dezA:undetectable | 4qw1V-4dezA:20.334qw1b-4dezA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqy | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Burkholderiathailandensis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | HIS A 141THR A 51THR A 106THR A 99GLY A 67 | None | 1.46A | 4qw1V-4eqyA:undetectable4qw1b-4eqyA:undetectable | 4qw1V-4eqyA:23.754qw1b-4eqyA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc7 | PEROXISOMAL2,4-DIENOYL-COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | SER A 248THR A 166THR A 164GLY A 209ALA A 267 | None | 1.43A | 4qw1V-4fc7A:undetectable4qw1b-4fc7A:undetectable | 4qw1V-4fc7A:20.424qw1b-4fc7A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7e | UREASE (Cajanus cajan) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | SER B 634THR B 442THR B 441THR B 438THR B 571 | NoneKCX B 490 ( 3.5A)NoneNoneNone | 1.44A | 4qw1V-4g7eB:undetectable4qw1b-4g7eB:undetectable | 4qw1V-4g7eB:14.554qw1b-4g7eB:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gij | PSEUDOURIDINE-5'-PHOSPHATE GLYCOSIDASE (Escherichiacoli) |
PF04227(Indigoidine_A) | 5 | SER A 201THR A 174THR A 175GLY A 164ALA A 195 | None | 1.24A | 4qw1V-4gijA:undetectable4qw1b-4gijA:undetectable | 4qw1V-4gijA:23.374qw1b-4gijA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hbc | ANTIGEN BINDINGFRAGMENT,IMMUNOGLOBULIN IGG -HEAVY CHAIN (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | SER H 6THR H 74THR H 73ALA H 20THR H 18 | None | 1.44A | 4qw1V-4hbcH:undetectable4qw1b-4hbcH:undetectable | 4qw1V-4hbcH:21.434qw1b-4hbcH:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ibn | RIBONUCLEASE H (unculturedorganism) |
PF00075(RNase_H) | 5 | HIS A 152THR A 95THR A 94GLY A 39ALA A 158 | None | 1.21A | 4qw1V-4ibnA:undetectable4qw1b-4ibnA:undetectable | 4qw1V-4ibnA:21.184qw1b-4ibnA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itx | CYSTATHIONINEBETA-LYASE METC (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 5 | SER A 114THR A 160GLY A 157ALA A 110THR A 107 | None | 1.27A | 4qw1V-4itxA:undetectable4qw1b-4itxA:undetectable | 4qw1V-4itxA:20.424qw1b-4itxA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ius | GCN5-RELATEDN-ACETYLTRANSFERASE (Kribbellaflavida) |
PF00583(Acetyltransf_1) | 5 | THR A 176THR A 183GLY A 187ALA A 173THR A 172 | EDO A 504 (-3.4A)NoneNoneNoneNone | 1.46A | 4qw1V-4iusA:undetectable4qw1b-4iusA:undetectable | 4qw1V-4iusA:20.204qw1b-4iusA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oie | NON-STRUCTURALPROTEIN NS1 (West Nile virus) |
PF00948(Flavi_NS1) | 5 | SER A 348THR A 325ARG A 336GLY A 332ALA A 297 | None | 1.33A | 4qw1V-4oieA:undetectable4qw1b-4oieA:undetectable | 4qw1V-4oieA:22.454qw1b-4oieA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppy | PUTATIVEACYLHYDROLASE (Bacteroidesfragilis) |
PF13472(Lipase_GDSL_2) | 5 | THR A 151THR A 150THR A 149ALA A 112THR A 128 | None | 1.42A | 4qw1V-4ppyA:undetectable4qw1b-4ppyA:undetectable | 4qw1V-4ppyA:21.054qw1b-4ppyA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi7 | CELLOBIOSEDEHYDROGENASE (Neurosporacrassa) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 5 | HIS A 268SER A 264THR A 749GLY A 317ALA A 319 | NoneNoneFAD A 902 (-3.8A)FAD A 902 (-3.3A)None | 1.24A | 4qw1V-4qi7A:undetectable4qw1b-4qi7A:undetectable | 4qw1V-4qi7A:13.684qw1b-4qi7A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qv9 | PROTEASOME SUBUNITBETA TYPE-5 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | THR K 1THR K 21LYS K 33GLY K 47ALA K 49 | None | 0.54A | 4qw1V-4qv9K:29.24qw1b-4qv9K:28.9 | 4qw1V-4qv9K:29.294qw1b-4qv9K:27.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqo | METHANOLDEHYDROGENASEPROTEIN, LARGESUBUNIT (Methylococcuscapsulatus) |
no annotation | 5 | HIS B 160THR B 185ARG B 225GLY B 200THR B 213 | None | 1.11A | 4qw1V-4tqoB:undetectable4qw1b-4tqoB:undetectable | 4qw1V-4tqoB:19.584qw1b-4tqoB:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx1 | ESTERASE (Sinorhizobiummeliloti) |
PF13472(Lipase_GDSL_2) | 5 | HIS A 23THR A 140THR A 184THR A 183ALA A 17 | None | 1.17A | 4qw1V-4tx1A:undetectable4qw1b-4tx1A:undetectable | 4qw1V-4tx1A:20.334qw1b-4tx1A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1r | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE, PLATELET TYPE (Homo sapiens) |
PF00365(PFK) | 5 | THR A 698THR A 409ARG A 396GLY A 436ALA A 438 | None | 1.37A | 4qw1V-4u1rA:undetectable4qw1b-4u1rA:undetectable | 4qw1V-4u1rA:16.354qw1b-4u1rA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 5 | HIS A 186SER A 185THR A 103THR A 379GLY A 105 | NoneNoneNoneNoneATP A 501 (-3.5A) | 1.49A | 4qw1V-4wb7A:undetectable4qw1b-4wb7A:undetectable | 4qw1V-4wb7A:18.944qw1b-4wb7A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4whb | PHENYLUREA HYDROLASEB (Mycolicibacteriumbrisbanense) |
no annotation | 5 | HIS E 273THR E 113GLY E 145ALA E 208THR E 230 | None | 1.42A | 4qw1V-4whbE:undetectable4qw1b-4whbE:undetectable | 4qw1V-4whbE:21.854qw1b-4whbE:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 5 | THR A 324THR A 285GLY A 312ALA A 270THR A 269 | NoneNoneFMN A 602 ( 4.8A)NoneNone | 1.29A | 4qw1V-4z9rA:undetectable4qw1b-4z9rA:undetectable | 4qw1V-4z9rA:18.134qw1b-4z9rA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | SER A 647THR A 214ARG A 501GLY A 233THR A 502 | None | 1.42A | 4qw1V-5az4A:undetectable4qw1b-5az4A:undetectable | 4qw1V-5az4A:16.174qw1b-5az4A:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | THR A 214THR A 216THR A 217ARG A 501THR A 502 | None | 1.11A | 4qw1V-5az4A:undetectable4qw1b-5az4A:undetectable | 4qw1V-5az4A:16.174qw1b-5az4A:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chl | HISTONE H2A.Z (Homo sapiens) |
PF00125(Histone)PF16211(Histone_H2A_C) | 5 | SER B 128THR B 57GLY B 121ALA B 124THR B 123 | None | 1.09A | 4qw1V-5chlB:undetectable4qw1b-5chlB:undetectable | 4qw1V-5chlB:20.914qw1b-5chlB:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fg9 | PROTEASOME SUBUNITBETA TYPE-2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 6 | THR H 1THR H 21LYS H 33GLY H 47ALA H 49THR H 52 | None | 0.43A | 4qw1V-5fg9H:37.24qw1b-5fg9H:28.1 | 4qw1V-5fg9H:98.314qw1b-5fg9H:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l5w | PROTEASOME SUBUNITBETATYPE-5,PROTEASOMESUBUNIT BETA TYPE-5 (Homo sapiens;Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | THR K 1THR K 21LYS K 33GLY K 47ALA K 49 | None | 0.76A | 4qw1V-5l5wK:29.14qw1b-5l5wK:28.8 | 4qw1V-5l5wK:29.614qw1b-5l5wK:28.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | HIS A 468SER A 481THR A 222THR A 474GLY A 14 | NoneNoneNoneFAD A1801 (-4.3A)FAD A1801 (-3.3A) | 1.28A | 4qw1V-5laeA:undetectable4qw1b-5laeA:undetectable | 4qw1V-5laeA:18.154qw1b-5laeA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | HIS A 468THR A 222THR A 475THR A 474GLY A 14 | NoneNoneFAD A1801 (-3.2A)FAD A1801 (-4.3A)FAD A1801 (-3.3A) | 1.21A | 4qw1V-5laeA:undetectable4qw1b-5laeA:undetectable | 4qw1V-5laeA:18.154qw1b-5laeA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | SER A 481THR A 222THR A 474GLY A 14ALA A 16 | NoneNoneFAD A1801 (-4.3A)FAD A1801 (-3.3A)FAD A1801 (-3.2A) | 1.34A | 4qw1V-5laeA:undetectable4qw1b-5laeA:undetectable | 4qw1V-5laeA:18.154qw1b-5laeA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | THR A 222THR A 475THR A 474GLY A 14ALA A 16 | NoneFAD A1801 (-3.2A)FAD A1801 (-4.3A)FAD A1801 (-3.3A)FAD A1801 (-3.2A) | 1.27A | 4qw1V-5laeA:undetectable4qw1b-5laeA:undetectable | 4qw1V-5laeA:18.154qw1b-5laeA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0t | ALPHA-KETOGLUTARATE-DEPENDENT NON-HEMEIRON OXYGENASE EASH (Aspergillusjaponicus) |
PF05721(PhyH) | 5 | THR A 121THR A 216GLY A 212ALA A 167THR A 168 | NoneNoneNoneNoneAKG A 302 (-3.0A) | 1.45A | 4qw1V-5m0tA:undetectable4qw1b-5m0tA:undetectable | 4qw1V-5m0tA:23.234qw1b-5m0tA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhf | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Mus musculus) |
no annotation | 5 | HIS A 159THR A 247THR A 188GLY A 250THR A 355 | None | 1.44A | 4qw1V-5mhfA:undetectable4qw1b-5mhfA:undetectable | 4qw1V-5mhfA:14.724qw1b-5mhfA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 5 | SER A 713THR A 345THR A 341ALA A 698THR A 700 | None | 1.46A | 4qw1V-5mpmA:undetectable4qw1b-5mpmA:undetectable | 4qw1V-5mpmA:17.264qw1b-5mpmA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5njf | METALLOPROTEASE PMBAMETALLOPROTEASE TLDD (Escherichiacoli) |
PF01523(PmbA_TldD) | 5 | THR A 426LYS B 238GLY A 246ALA B 448THR B 241 | None | 1.34A | 4qw1V-5njfA:undetectable4qw1b-5njfA:undetectable | 4qw1V-5njfA:19.244qw1b-5njfA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyj | ANBU (Hyphomicrobiumsp. MC1) |
PF00227(Proteasome) | 5 | THR A 1THR A 20LYS A 32GLY A 50THR A 55 | None | 0.86A | 4qw1V-5nyjA:5.74qw1b-5nyjA:21.6 | 4qw1V-5nyjA:26.894qw1b-5nyjA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0w | NB474 (Vicugna pacos) |
PF07686(V-set) | 5 | THR E 104THR E 123ARG E 76GLY E 35ALA E 33 | None | 1.46A | 4qw1V-5o0wE:undetectable4qw1b-5o0wE:undetectable | 4qw1V-5o0wE:18.974qw1b-5o0wE:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osn | CAPSID PROTEIN (Enterovirus E) |
PF00073(Rhv) | 5 | SER B 57THR B 233THR B 52GLY B 91ALA B 58 | None | 1.41A | 4qw1V-5osnB:undetectable4qw1b-5osnB:undetectable | 4qw1V-5osnB:22.224qw1b-5osnB:24.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovt | BPH (Thiobacillusdenitrificans) |
no annotation | 5 | THR A 1THR A 20LYS A 37GLY A 50ALA A 52 | PO4 A 301 ( 4.5A)NoneNonePO4 A 301 (-4.1A)None | 0.46A | 4qw1V-5ovtA:19.64qw1b-5ovtA:3.6 | 4qw1V-5ovtA:20.344qw1b-5ovtA:22.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0h | PROTEASOME SUBUNITBETA TYPE-7 (Homo sapiens) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 5 | THR O 1LYS O 33GLY O 47ALA O 49THR O 52 | None | 0.96A | 4qw1V-5t0hO:29.84qw1b-5t0hO:27.7 | 4qw1V-5t0hO:56.174qw1b-5t0hO:30.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1w | GLYCOSIDE HYDROLASE (Bacillushalodurans) |
PF03639(Glyco_hydro_81) | 5 | SER A 319THR A 286THR A 287THR A 288ALA A 317 | NoneEDO A 818 (-4.2A)NoneEDO A 818 (-4.1A)None | 0.97A | 4qw1V-5v1wA:undetectable4qw1b-5v1wA:undetectable | 4qw1V-5v1wA:15.014qw1b-5v1wA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfr | PROTEASOME SUBUNITBETA TYPE-5 (Homo sapiens) |
no annotation | 5 | THR R 1THR R 21LYS R 33GLY R 47ALA R 49 | None | 0.63A | 4qw1V-5vfrR:27.64qw1b-5vfrR:28.0 | 4qw1V-5vfrR:undetectable4qw1b-5vfrR:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlp | FAB7G7 HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | HIS H 210SER H 160THR H 127ALA H 9THR H 118 | None | 1.45A | 4qw1V-5vlpH:undetectable4qw1b-5vlpH:undetectable | 4qw1V-5vlpH:22.274qw1b-5vlpH:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x62 | CARNOSINEN-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF07942(N2227) | 5 | HIS A 250SER A 281THR A 336THR A 318GLY A 315 | None | 1.16A | 4qw1V-5x62A:undetectable4qw1b-5x62A:undetectable | 4qw1V-5x62A:18.344qw1b-5x62A:20.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6avo | PROTEASOME SUBUNITBETA TYPE-10PROTEASOME SUBUNITBETA TYPE-9 (Homo sapiens) |
no annotation | 6 | HIS B 114SER B 118THR A 1LYS A 33GLY A 47ALA A 49 | None | 0.59A | 4qw1V-6avoB:21.74qw1b-6avoB:21.4 | 4qw1V-6avoB:43.404qw1b-6avoB:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cbo | C-6'AMINOTRANSFERASE (Micromonosporaechinospora) |
no annotation | 5 | SER A 238THR A 271THR A 272ARG A 105ALA A 266 | None | 1.44A | 4qw1V-6cboA:undetectable4qw1b-6cboA:undetectable | 4qw1V-6cboA:13.144qw1b-6cboA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccz | SERINEHYDROXYMETHYLTRANSFERASE (Medicagotruncatula) |
no annotation | 5 | HIS A 209SER A 211THR A 313THR A 314THR A 315 | LLP A 318 (-3.5A)LLP A 318 ( 3.8A)NoneFMT A 613 ( 4.6A)FMT A 613 (-3.6A) | 1.40A | 4qw1V-6cczA:undetectable4qw1b-6cczA:undetectable | 4qw1V-6cczA:16.594qw1b-6cczA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN5 (Mus musculus) |
no annotation | 5 | THR L 404THR L 275THR L 276ALA L 282THR L 412 | None | 1.19A | 4qw1V-6g2jL:undetectable4qw1b-6g2jL:undetectable | 4qw1V-6g2jL:17.054qw1b-6g2jL:17.02 |