SIMILAR PATTERNS OF AMINO ACIDS FOR 4QW0_K_BO2K301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		4 ALA A   9
THR A  10
ALA A  13
THR A 256
 PO4  A 322 (-3.2A)
PO4  A 322 ( 2.8A)
None
None
 0.95A 4qw0K-1a40A:
undetectable		 4qw0K-1a40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 THR A 179
ALA A   9
THR A  10
ALA A  11
 None
 0.85A 4qw0K-1airA:
undetectable		 4qw0K-1airA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akp APOKEDARCIDIN

(actinomycete
ATCC 53650) 		PF00960
(Neocarzinostat) 		4 ALA A  34
THR A  33
ALA A  32
THR A  64
 None
 0.76A 4qw0K-1akpA:
undetectable		 4qw0K-1akpA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A 180
THR A 181
ALA A 197
MET A 139
 None
 0.99A 4qw0K-1b9hA:
undetectable		 4qw0K-1b9hA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 THR A 191
ALA A  18
ALA A  22
THR A  92
 None
 0.89A 4qw0K-1efpA:
undetectable		 4qw0K-1efpA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ALA A 420
THR A 419
ALA A 418
MET A 405
 None
 0.65A 4qw0K-1eu1A:
undetectable		 4qw0K-1eu1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 THR A 182
ALA A 186
ALA A  61
THR A 300
 None
 1.03A 4qw0K-1hm7A:
undetectable		 4qw0K-1hm7A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		4 THR H   1
ALA H  20
THR H  21
LYS H  33
 CIB  H1001 (-1.9A)
CIB  H1001 (-3.8A)
CIB  H1001 (-4.5A)
CIB  H1001 (-4.0A)
 0.31A 4qw0K-1j2qH:
29.2		 4qw0K-1j2qH:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8f ENDOGLUCANASE

(Melanocarpus
albomyces) 		PF02015
(Glyco_hydro_45) 		4 THR A 108
ALA A  73
THR A  74
ALA A  75
 None
 1.03A 4qw0K-1l8fA:
undetectable		 4qw0K-1l8fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqv TOXIN-COREGULATED
PILUS SUBUNIT

(Vibrio cholerae) 		PF05946
(TcpA) 		4 THR A  64
ALA A  61
THR A  60
ALA A  59
 None
 0.78A 4qw0K-1oqvA:
undetectable		 4qw0K-1oqvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 ALA A  16
THR A  17
ALA A  18
LYS A  38
 None
 1.03A 4qw0K-1pzsA:
undetectable		 4qw0K-1pzsA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 THR H   1
ALA H  20
THR H  21
LYS H  33
 None
 0.34A 4qw0K-1q5qH:
26.1		 4qw0K-1q5qH:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		4 ALA A  54
ALA A 270
MET A 259
THR A 239
 None
None
AHZ  A 600 (-3.3A)
None
 1.03A 4qw0K-1rp0A:
undetectable		 4qw0K-1rp0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 THR A 669
ALA A 477
THR A 478
ALA A 479
 None
 0.82A 4qw0K-1rw9A:
undetectable		 4qw0K-1rw9A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 THR A 114
ALA A 170
THR A 169
ALA A 168
 None
 1.03A 4qw0K-1ulvA:
undetectable		 4qw0K-1ulvA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 THR A  42
ALA A  64
ALA A 117
MET A  94
 None
 0.94A 4qw0K-1v4gA:
undetectable		 4qw0K-1v4gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 THR A 511
ALA A 473
MET A 529
THR A 531
 None
 0.78A 4qw0K-1xpgA:
undetectable		 4qw0K-1xpgA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7x MAJOR VAULT PROTEIN

(Homo sapiens) 		PF01505
(Vault) 		4 ALA A  57
THR A  11
ALA A  12
THR A  92
 None
 1.02A 4qw0K-1y7xA:
undetectable		 4qw0K-1y7xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z06 RAS-RELATED PROTEIN
RAB-33B

(Mus musculus) 		PF00071
(Ras) 		4 THR A  62
ALA A  64
THR A  65
ALA A  90
 GNP  A 204 (-3.6A)
GNP  A 204 (-3.6A)
MG  A 203 ( 3.1A)
None
 0.97A 4qw0K-1z06A:
undetectable		 4qw0K-1z06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2beo LISTERIOLYSIN
REGULATORY PROTEIN

(Listeria
monocytogenes) 		PF13545
(HTH_Crp_2) 		4 ALA A  92
THR A  93
ALA A  94
THR A  46
 None
 1.02A 4qw0K-2beoA:
undetectable		 4qw0K-2beoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 4 THR A 380
ALA A 377
THR A 360
ALA A 359
 None
 0.97A 4qw0K-2d4yA:
undetectable		 4qw0K-2d4yA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 455
ALA A 350
THR A 351
ALA A 491
 None
 0.96A 4qw0K-2e6kA:
undetectable		 4qw0K-2e6kA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		4 ALA A   9
THR A  36
ALA A  35
MET A  45
 None
 0.85A 4qw0K-2fexA:
undetectable		 4qw0K-2fexA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 THR A  94
THR A 377
ALA A 376
THR A  65
 None
 1.03A 4qw0K-2ftwA:
undetectable		 4qw0K-2ftwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hup RAS-RELATED PROTEIN
RAB-43

(Homo sapiens) 		PF00071
(Ras) 		4 THR A  56
THR A  74
ALA A  75
THR A  32
 None
None
None
MG  A 202 ( 3.0A)
 1.02A 4qw0K-2hupA:
undetectable		 4qw0K-2hupA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9w HYPOTHETICAL PROTEIN

(Psychrobacter
arcticus) 		PF02810
(SEC-C) 		4 ALA A  49
THR A  51
ALA A  52
THR A  58
 None
 0.99A 4qw0K-2i9wA:
undetectable		 4qw0K-2i9wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 ALA A 140
THR A 141
ALA A 142
THR A 104
 None
 1.02A 4qw0K-2j5tA:
undetectable		 4qw0K-2j5tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  41
ALA A  38
LYS A 344
THR A 319
 None
 1.01A 4qw0K-2ox4A:
undetectable		 4qw0K-2ox4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 THR A 135
ALA A  95
ALA A  97
THR A 337
 None
 1.02A 4qw0K-2r26A:
undetectable		 4qw0K-2r26A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhm PUTATIVE KINASE

(Chloroflexus
aurantiacus) 		PF13671
(AAA_33) 		4 THR A  18
ALA A  14
THR A  15
ALA A 112
 CL  A 193 (-4.2A)
None
None
None
 1.04A 4qw0K-2rhmA:
undetectable		 4qw0K-2rhmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 THR A 104
ALA A   6
THR A   5
ALA A   4
 None
 1.01A 4qw0K-2rttA:
undetectable		 4qw0K-2rttA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ALA G 905
THR G 906
ALA G 911
THR G 916
 None
 0.94A 4qw0K-2uv8G:
undetectable		 4qw0K-2uv8G:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 THR A  27
THR A 484
ALA A 483
THR A  80
 None
 1.01A 4qw0K-2v7gA:
undetectable		 4qw0K-2v7gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 THR A 773
ALA A 764
THR A 765
ALA A 766
 None
 0.56A 4qw0K-2y8nA:
undetectable		 4qw0K-2y8nA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 4 ALA X   9
THR X  10
ALA X  13
THR X 256
 PO4  X2322 (-3.2A)
PO4  X2322 (-2.9A)
None
None
 0.91A 4qw0K-2z22X:
undetectable		 4qw0K-2z22X:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 THR B 526
THR B 550
ALA B 551
THR B 338
 CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.6A)
CDS  B 901 ( 3.7A)
None
 0.99A 4qw0K-2z2mB:
undetectable		 4qw0K-2z2mB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		4 ALA A  32
THR A  31
ALA A  30
THR A  37
 None
 0.99A 4qw0K-3c02A:
undetectable		 4qw0K-3c02A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp7 ALKALINE SERINE
PROTEASE AL20

(Nesterenkonia
aethiopica) 		PF13365
(Trypsin_2) 		4 THR A  35
ALA A  37
THR A  38
ALA A  39
 None
 1.01A 4qw0K-3cp7A:
undetectable		 4qw0K-3cp7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		4 ALA A   7
THR A   6
MET A 103
THR A 105
 None
 0.89A 4qw0K-3ezjA:
undetectable		 4qw0K-3ezjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdf PROBABLE
NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Cladosporium
herbarum) 		PF13561
(adh_short_C2) 		4 THR A  26
THR A 158
ALA A 159
THR A 136
 None
 0.90A 4qw0K-3gdfA:
undetectable		 4qw0K-3gdfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA B  43
THR B  84
ALA B  83
THR A 207
 None
MCN  B 921 ( 4.5A)
None
MG  A 426 (-3.8A)
 1.03A 4qw0K-3hrdB:
undetectable		 4qw0K-3hrdB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j83 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 THR A  40
ALA A 125
THR A 124
ALA A 123
 None
 0.94A 4qw0K-3j83A:
undetectable		 4qw0K-3j83A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 ALA A  56
THR A  83
ALA A  82
THR A  22
 None
 0.94A 4qw0K-3n2tA:
undetectable		 4qw0K-3n2tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		4 THR A 103
ALA A  53
THR A  92
ALA A  91
 None
 1.01A 4qw0K-3r5bA:
undetectable		 4qw0K-3r5bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 ALA A 250
THR A 249
ALA A 248
THR A 345
 None
 0.96A 4qw0K-3t1pA:
undetectable		 4qw0K-3t1pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unf PROTEASOME SUBUNIT
BETA TYPE-10

(Mus musculus) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		4 THR H   1
ALA H  20
THR H  21
LYS H  33
 04C  H 301 (-2.5A)
04C  H 301 (-3.9A)
04C  H 301 (-3.9A)
04C  H 301 (-3.5A)
 0.39A 4qw0K-3unfH:
30.2		 4qw0K-3unfH:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ALA A 156
THR A 155
ALA A 154
THR A 160
 None
 1.01A 4qw0K-3v8bA:
undetectable		 4qw0K-3v8bA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 THR A 206
ALA A 154
THR A 155
ALA A 156
 None
 1.03A 4qw0K-3v8bA:
undetectable		 4qw0K-3v8bA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR L   1
ALA L  20
THR L  21
ALA L  22
LYS L  33
 None
 0.26A 4qw0K-3wxrL:
38.6		 4qw0K-3wxrL:
99.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		4 THR A 140
ALA A 132
ALA A 115
THR A 122
 None
 0.98A 4qw0K-3ztyA:
undetectable		 4qw0K-3ztyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 ALA A 356
THR A 355
ALA A 354
THR A 181
 None
 0.52A 4qw0K-4au2A:
undetectable		 4qw0K-4au2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		5 THR A 283
ALA A 223
THR A 224
ALA A 225
MET A 279
 None
 1.48A 4qw0K-4csiA:
undetectable		 4qw0K-4csiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		4 ALA A 107
THR A 168
ALA A 167
THR A  88
 None
 0.63A 4qw0K-4e2sA:
undetectable		 4qw0K-4e2sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ALA A 325
THR A 326
ALA A 327
THR A 358
 JHZ  A 504 ( 4.9A)
JHZ  A 504 (-4.0A)
JHZ  A 504 (-3.6A)
None
 1.04A 4qw0K-4e2zA:
undetectable		 4qw0K-4e2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		5 THR B 140
ALA B  40
THR B  43
ALA B  42
THR B  96
 None
 1.26A 4qw0K-4f0uB:
undetectable		 4qw0K-4f0uB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 ALA A  31
THR A  32
ALA A  33
LYS A  45
 None
 0.95A 4qw0K-4fe2A:
undetectable		 4qw0K-4fe2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 THR A   1
ALA A  20
LYS A  33
THR A  50
 None
 0.98A 4qw0K-4g4eA:
20.9		 4qw0K-4g4eA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 THR A   1
ALA A  20
THR A  21
LYS A  33
 None
 0.57A 4qw0K-4g4eA:
20.9		 4qw0K-4g4eA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 THR A 390
THR A 410
ALA A 411
THR A 422
 None
 0.88A 4qw0K-4grhA:
undetectable		 4qw0K-4grhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		4 THR A 390
ALA A 388
THR A 366
ALA A 367
 None
 1.03A 4qw0K-4hvlA:
undetectable		 4qw0K-4hvlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 THR A 216
ALA A 196
THR A 195
ALA A 194
 None
SO4  A 402 (-3.3A)
None
None
 0.82A 4qw0K-4idaA:
undetectable		 4qw0K-4idaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		4 ALA A 244
THR A 243
ALA A 242
THR A 223
 None
 0.76A 4qw0K-4iusA:
undetectable		 4qw0K-4iusA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 THR A 390
ALA A 388
THR A 366
ALA A 367
 None
 0.98A 4qw0K-4m1zA:
undetectable		 4qw0K-4m1zA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A 235
THR A 236
ALA A 237
MET A 208
 None
 1.03A 4qw0K-4o4xA:
undetectable		 4qw0K-4o4xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		4 THR A  37
ALA A  33
THR A  32
ALA A  31
 None
PO4  A 302 (-3.7A)
None
None
 0.91A 4qw0K-4o7zA:
undetectable		 4qw0K-4o7zA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 132
ALA A 122
THR A 121
ALA A 120
 None
 1.00A 4qw0K-4qn3A:
undetectable		 4qw0K-4qn3A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
ALA K  20
THR K  21
ALA K  22
LYS K  33
 None
 0.22A 4qw0K-4qv9K:
39.4		 4qw0K-4qv9K:
98.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ALA A 209
THR A 212
ALA A 214
THR A 224
 None
 1.02A 4qw0K-4qvgA:
undetectable		 4qw0K-4qvgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A2659
ALA A2626
THR A2625
ALA A2624
 None
 0.90A 4qw0K-4rlvA:
undetectable		 4qw0K-4rlvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		4 THR A 372
THR A 351
ALA A 352
THR A 378
 None
 0.89A 4qw0K-4s1wA:
undetectable		 4qw0K-4s1wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 THR A 159
ALA A 201
THR A 200
ALA A 199
 None
 1.01A 4qw0K-4umvA:
undetectable		 4qw0K-4umvA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		4 ALA A  36
THR A  35
ALA A 253
THR A  46
 None
 1.03A 4qw0K-4wjmA:
undetectable		 4qw0K-4wjmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 125
THR A 124
ALA A 123
THR A  40
 None
None
None
CL  A 501 (-4.1A)
 0.97A 4qw0K-4xxnA:
undetectable		 4qw0K-4xxnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 THR A  11
THR A  21
ALA A  20
THR A 583
 None
 0.98A 4qw0K-4zdaA:
undetectable		 4qw0K-4zdaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		4 ALA A 172
THR A 171
ALA A 170
THR A 144
 None
 0.90A 4qw0K-5aweA:
undetectable		 4qw0K-5aweA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxf ENVELOPE
GLYCOPROTEIN B

(Human
betaherpesvirus
5) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 THR A 221
THR A 256
ALA A 257
THR A 270
 None
 0.87A 4qw0K-5cxfA:
undetectable		 4qw0K-5cxfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		4 THR A 214
THR A 218
ALA A 221
THR A 308
 ANP  A 701 (-4.5A)
ANP  A 701 (-3.5A)
None
None
 0.99A 4qw0K-5dgkA:
undetectable		 4qw0K-5dgkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 THR I   1
ALA I  20
THR I  21
LYS I  33
 7F1  I 300 (-2.7A)
7F1  I 300 (-3.6A)
None
7F1  I 300 (-4.7A)
 0.90A 4qw0K-5fmgI:
27.7		 4qw0K-5fmgI:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 THR A 366
ALA A 521
THR A 522
THR A 357
 None
 1.01A 4qw0K-5gl7A:
undetectable		 4qw0K-5gl7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		4 THR A  35
THR A 210
ALA A 209
THR A 201
 None
 0.94A 4qw0K-5gm3A:
undetectable		 4qw0K-5gm3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 THR A 266
ALA A 224
THR A 225
THR A 162
 None
 0.92A 4qw0K-5h1cA:
undetectable		 4qw0K-5h1cA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN

(Puumala
orthohantavirus) 		PF01561
(Hanta_G2) 		4 ALA A 986
THR A 985
ALA A 984
THR A1038
 None
 1.03A 4qw0K-5j9hA:
undetectable		 4qw0K-5j9hA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
ALA K  20
THR K  21
ALA K  22
LYS K  33
 None
 0.41A 4qw0K-5l5wK:
38.0		 4qw0K-5l5wK:
81.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		4 ALA A 211
THR A 168
ALA A 167
THR A 121
 AKG  A 302 (-3.4A)
AKG  A 302 (-3.0A)
None
None
 0.77A 4qw0K-5m0tA:
undetectable		 4qw0K-5m0tA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
ALA K  20
ALA K  22
LYS K  33
MET K  45
 7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
None
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
 0.21A 4qw0K-5m2bK:
38.2		 4qw0K-5m2bK:
75.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 ALA A 398
THR A 401
ALA A 402
THR A 387
 None
 0.97A 4qw0K-5mpqA:
undetectable		 4qw0K-5mpqA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 ALA A 368
THR A 341
ALA A 340
THR A 391
 None
 0.88A 4qw0K-5nxkA:
undetectable		 4qw0K-5nxkA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0g PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		PF00227
(Proteasome) 		5 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
 None
 0.94A 4qw0K-5t0gR:
32.6		 4qw0K-5t0gR:
64.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ALA A 325
THR A 326
ALA A 327
THR A 358
 None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.5A)
None
 1.01A 4qw0K-5t67A:
undetectable		 4qw0K-5t67A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 THR B 137
ALA B  40
THR B  43
ALA B  42
THR B  93
 None
None
NA  B 209 (-3.8A)
NA  B 209 ( 3.7A)
None
 1.29A 4qw0K-5tjfB:
undetectable		 4qw0K-5tjfB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 THR A  40
ALA A  60
THR A  63
ALA A  65
 None
 1.01A 4qw0K-5tusA:
undetectable		 4qw0K-5tusA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		no annotation 5 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
 None
 0.56A 4qw0K-5vfrR:
33.3		 4qw0K-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 4 ALA F 161
THR F 160
ALA F 159
THR F 144
 None
 1.04A 4qw0K-5wb0F:
undetectable		 4qw0K-5wb0F:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D

(Escherichia
coli) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		4 ALA A 421
THR A 422
ALA A 329
THR A 466
 None
 0.90A 4qw0K-5wq7A:
undetectable		 4qw0K-5wq7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A 658
ALA A 625
THR A 624
ALA A 623
 None
 0.73A 4qw0K-5y4fA:
undetectable		 4qw0K-5y4fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 4 THR B   1
ALA B  20
THR B  21
LYS B  33
 None
 0.60A 4qw0K-6avoB:
21.3		 4qw0K-6avoB:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 5 THR C   1
ALA C  20
ALA C  22
LYS C  33
MET C  45
 BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
 0.63A 4qw0K-6avoC:
33.7		 4qw0K-6avoC:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE

(Francisella
tularensis) 		no annotation 4 THR A 247
ALA A 113
THR A 114
ALA A 115
 None
 0.68A 4qw0K-6bwtA:
undetectable		 4qw0K-6bwtA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 4 THR D 354
ALA D 368
THR D 367
ALA D 366
 None
 0.94A 4qw0K-6eojD:
undetectable		 4qw0K-6eojD:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 271
THR A 274
ALA A 275
THR A 233
 None
 1.02A 4qw0K-9rubA:
undetectable		 4qw0K-9rubA:
17.97