SIMILAR PATTERNS OF AMINO ACIDS FOR 4QVL_H_BO2H301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 6 THR H 301
SER H 320
GLN H 322
LYS H 333
ALA H 346
ALA H 349
 None
 0.87A 4qvlH-2fhgH:
23.3
4qvlI-2fhgH:
24.0		 4qvlH-2fhgH:
26.85
4qvlI-2fhgH:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3unf PROTEASOME SUBUNIT
BETA TYPE-10

(Mus musculus) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 THR H   1
LYS H  33
ALA H  46
ALA H  49
THR H  52
 04C  H 301 (-2.5A)
04C  H 301 (-3.5A)
04C  H 301 ( 4.3A)
04C  H 301 (-3.6A)
04C  H 301 (-3.8A)
 0.47A 4qvlH-3unfH:
33.9
4qvlI-3unfH:
28.7		 4qvlH-3unfH:
46.78
4qvlI-3unfH:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 THR A 557
GLN A 505
ALA A 334
ALA A 336
ASP A 499
 None
None
None
FDA  A 801 (-3.4A)
None
 1.18A 4qvlH-4mifA:
0.0
4qvlI-4mifA:
0.0		 4qvlH-4mifA:
16.99
4qvlI-4mifA:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
SER H  20
GLN H  22
ALA H  46
ALA H  49
THR H  52
 None
 0.97A 4qvlH-5fg9H:
36.8
4qvlI-5fg9H:
22.1		 4qvlH-5fg9H:
98.31
4qvlI-5fg9H:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
SER H  20
LYS H  33
ALA H  46
ALA H  49
THR H  52
 None
 0.64A 4qvlH-5fg9H:
36.8
4qvlI-5fg9H:
22.1		 4qvlH-5fg9H:
98.31
4qvlI-5fg9H:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0h PROTEASOME SUBUNIT
BETA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 THR O   1
LYS O  33
ALA O  46
ALA O  49
THR O  52
 None
 1.03A 4qvlH-5t0hO:
28.7
4qvlI-5t0hO:
26.2		 4qvlH-5t0hO:
56.17
4qvlI-5t0hO:
20.94