SIMILAR PATTERNS OF AMINO ACIDS FOR 4QTU_B_SAMB301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahi | 7ALPHA-HYDROXYSTEROIDDEHYDROGENASE (Escherichiacoli) |
PF13561(adh_short_C2) | 5 | GLY A 18GLY A 20ILE A 43ILE A 23ARG A 113 | NAI A 302 (-3.6A)NAI A 302 ( 4.1A)NAI A 302 (-4.0A)NAI A 302 (-4.0A)None | 1.13A | 4qtuB-1ahiA:6.3 | 4qtuB-1ahiA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b25 | PROTEIN(FORMALDEHYDEFERREDOXINOXIDOREDUCTASE) (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | GLY A 36GLY A 34ILE A 41ALA A 39ARG A 587 | None | 1.02A | 4qtuB-1b25A:undetectable | 4qtuB-1b25A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp9 | PENICILLIN G AMIDASE (Providenciarettgeri) |
PF01804(Penicil_amidase) | 5 | GLY A 97GLY A 93ILE A 5SER A 24ALA A 100 | None | 1.13A | 4qtuB-1cp9A:undetectable | 4qtuB-1cp9A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0p | ANTIGEN 85-B (Mycobacteriumtuberculosis) |
PF00756(Esterase) | 5 | GLY A 88GLY A 173SER A 76ALA A 90ARG A 20 | None | 1.07A | 4qtuB-1f0pA:undetectable | 4qtuB-1f0pA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpj | GLUTAMYL-TRNAREDUCTASE (Methanopyruskandleri) |
PF00745(GlutR_dimer)PF01488(Shikimate_DH)PF05201(GlutR_N) | 5 | GLY A 134ILE A 143SER A 144ILE A 131ALA A 89 | None | 1.14A | 4qtuB-1gpjA:5.5 | 4qtuB-1gpjA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jp4 | 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE (Rattusnorvegicus) |
PF00459(Inositol_P) | 5 | TYR A 272GLY A 148GLY A 138ILE A 146ILE A 150 | None | 0.86A | 4qtuB-1jp4A:undetectable | 4qtuB-1jp4A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 74GLY A 72LEU A 95ILE A 136SER A 135 | SAH A1900 (-3.2A)SAH A1900 (-3.1A)SAH A1900 (-4.4A)SAH A1900 (-4.2A)None | 1.10A | 4qtuB-1kphA:17.0 | 4qtuB-1kphA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 6 | TYR A 16GLY A 72GLY A 74SER A 96ILE A 136ALA A 138 | SAH A1900 ( 4.2A)SAH A1900 (-3.1A)SAH A1900 (-3.2A)NoneSAH A1900 (-4.2A)SAH A1900 (-3.2A) | 0.85A | 4qtuB-1kphA:17.0 | 4qtuB-1kphA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 6 | GLY A 72GLY A 74SER A 96ILE A 136ALA A 138ARG A 146 | SAH A 900 (-3.1A)SAH A 900 (-3.4A)NoneSAH A 900 (-3.9A)SAH A 900 (-3.4A)SAH A 900 (-4.6A) | 0.87A | 4qtuB-1l1eA:16.7 | 4qtuB-1l1eA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 74GLY A 72LEU A 95ILE A 136SER A 135 | SAH A 900 (-3.4A)SAH A 900 (-3.1A)SAH A 900 (-4.1A)SAH A 900 (-3.9A)None | 1.11A | 4qtuB-1l1eA:16.7 | 4qtuB-1l1eA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldi | GLYCEROL UPTAKEFACILITATOR PROTEIN (Escherichiacoli) |
PF00230(MIP) | 5 | GLY A 247GLY A 243ILE A 158MET A 153ALA A 250 | None | 0.97A | 4qtuB-1ldiA:undetectable | 4qtuB-1ldiA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkv | HYPOTHETICAL PROTEINYJHP (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY A 44GLY A 46SER A 68ALA A 112TRP A 114 | None | 0.79A | 4qtuB-1nkvA:13.8 | 4qtuB-1nkvA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p91 | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE A (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY A 93GLY A 95SER A 118ILE A 155ALA A 157 | NoneSAM A1401 (-3.4A)NoneSAM A1401 (-4.2A)None | 0.64A | 4qtuB-1p91A:15.7 | 4qtuB-1p91A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps9 | 2,4-DIENOYL-COAREDUCTASE (Escherichiacoli) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 6 | GLY A 385GLY A 380LEU A 461ILE A 408ILE A 460ALA A 389 | NoneFAD A 701 (-2.9A)NoneNoneNoneNone | 1.27A | 4qtuB-1ps9A:undetectable | 4qtuB-1ps9A:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfr | ANTIGEN 85-A (Mycobacteriumtuberculosis) |
PF00756(Esterase) | 5 | GLY A 88GLY A 173SER A 76ALA A 90ARG A 20 | None | 1.03A | 4qtuB-1sfrA:undetectable | 4qtuB-1sfrA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74SER A 96ILE A 136ALA A 138 | SAH A1900 (-3.2A)SAH A1900 (-3.3A)NoneSAH A1900 (-3.6A)SAH A1900 (-3.1A) | 0.48A | 4qtuB-1tpyA:17.2 | 4qtuB-1tpyA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | GLY A 268GLY A 292ILE A 242ILE A 287ALA A 237 | None | 1.05A | 4qtuB-1u7gA:undetectable | 4qtuB-1u7gA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | GLY A 48ILE A 68SER A 69MET A 72ILE A 110 | SAM A 302 (-3.6A)SAM A 302 (-3.7A)SAM A 302 (-4.7A)SAM A 302 (-3.9A)SAM A 302 (-3.8A) | 0.53A | 4qtuB-1ve3A:20.0 | 4qtuB-1ve3A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 5 | GLY A 229GLY A 171LEU A 224ILE A 38ILE A 231 | None | 1.11A | 4qtuB-1vmeA:undetectable | 4qtuB-1vmeA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xtp | LMAJ004091AAA (Leishmaniamajor) |
PF05891(Methyltransf_PK) | 5 | GLY A 101GLY A 103MET A 128MET A 149ILE A 107 | SAI A 401 (-3.4A)SAI A 401 (-3.2A)SAI A 401 ( 4.9A)SAI A 401 (-4.4A)SAI A 401 (-4.9A) | 1.09A | 4qtuB-1xtpA:15.5 | 4qtuB-1xtpA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bpq | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | GLY A 137GLY A 146LEU A 144ILE A 158ALA A 179 | None | 1.08A | 4qtuB-2bpqA:2.6 | 4qtuB-2bpqA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 5 | TYR A1018GLY A1000ILE A1023ILE A 941ALA A1041 | None | 1.14A | 4qtuB-2ec5A:undetectable | 4qtuB-2ec5A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fhp | METHYLASE, PUTATIVE (Enterococcusfaecalis) |
PF03602(Cons_hypoth95) | 5 | GLY A 51GLY A 53LEU A 13ILE A 70ALA A 76 | None | 0.92A | 4qtuB-2fhpA:12.2 | 4qtuB-2fhpA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk7 | METHOXY MYCOLIC ACIDSYNTHASE 4 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 81GLY A 83SER A 105ILE A 145ALA A 147 | None | 0.61A | 4qtuB-2fk7A:15.0 | 4qtuB-2fk7A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqf | HYPOTHETICAL PROTEINHI0933 (Haemophilusinfluenzae) |
PF03486(HI0933_like) | 5 | GLY A 16GLY A 11ILE A 39ILE A 161ALA A 20 | NoneFAD A 403 (-3.1A)NoneNoneNone | 1.10A | 4qtuB-2gqfA:undetectable | 4qtuB-2gqfA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 441ILE A 410SER A 437ILE A 446ALA A 444 | NoneTPP A 600 (-4.5A)TPP A 600 (-3.5A)NoneNone | 1.12A | 4qtuB-2ihtA:undetectable | 4qtuB-2ihtA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pby | GLUTAMINASE (Geobacilluskaustophilus) |
PF04960(Glutaminase) | 5 | GLY A 292GLY A 280ILE A 42SER A 41ALA A 16 | None | 1.12A | 4qtuB-2pbyA:undetectable | 4qtuB-2pbyA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0f | RNA URIDYLYLTRANSFERASE (Trypanosomabrucei) |
PF03828(PAP_assoc) | 5 | GLY A 184GLY A 176ILE A 182ILE A 186ALA A 179 | None | 1.15A | 4qtuB-2q0fA:undetectable | 4qtuB-2q0fA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF01336(tRNA_anti-codon)PF08489(DUF1743) | 5 | GLY A 141GLY A 144LEU A 117ILE A 7ILE A 119 | None | 1.02A | 4qtuB-3au7A:undetectable | 4qtuB-3au7A:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4w | ALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 5 | GLY A 417GLY A 440ILE A 434SER A 431ALA A 416 | None | 1.05A | 4qtuB-3b4wA:4.0 | 4qtuB-3b4wA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkw | S-ADENOSYLMETHIONINEDEPENDENTMETHYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF08241(Methyltransf_11) | 5 | GLY A 50GLY A 52SER A 74MET A 77ALA A 115 | None | 0.80A | 4qtuB-3bkwA:17.3 | 4qtuB-3bkwA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2l | SAM-DEPENDENTMETHYLTRANSFERASE (Exiguobacteriumsibiricum) |
PF13649(Methyltransf_25) | 5 | GLY A 40GLY A 42SER A 62MET A 65MET A 87 | None | 0.69A | 4qtuB-3d2lA:18.0 | 4qtuB-3d2lA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dli | METHYLTRANSFERASE (Archaeoglobusfulgidus) |
PF13489(Methyltransf_23) | 5 | GLY A 290GLY A 292ILE A 312MET A 316ARG A 359 | None | 0.91A | 4qtuB-3dliA:18.2 | 4qtuB-3dliA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ege | PUTATIVEMETHYLTRANSFERASEFROM ANTIBIOTICBIOSYNTHESIS PATHWAY (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 6 | GLY A 41GLY A 43SER A 64MET A 67ILE A 100ALA A 102 | EDO A 261 (-3.2A)EDO A 261 ( 3.9A)NoneEDO A 261 ( 4.1A)NoneEDO A 261 ( 3.8A) | 0.83A | 4qtuB-3egeA:15.8 | 4qtuB-3egeA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9t | L-TYROSINEDECARBOXYLASE MFNA (Methanocaldococcusjannaschii) |
PF00282(Pyridoxal_deC) | 5 | GLY A 94GLY A 255LEU A 257SER A 253ALA A 208 | PLP A 500 (-3.5A)NoneNoneNonePLP A 500 (-3.4A) | 1.15A | 4qtuB-3f9tA:2.4 | 4qtuB-3f9tA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5l | PUTATIVES-ADENOSYLMETHIONINEDEPENDENTMETHYLTRANSFERASE (Listeriamonocytogenes) |
PF13649(Methyltransf_25) | 5 | GLY A 50GLY A 52SER A 74MET A 77ALA A 115 | None | 0.70A | 4qtuB-3g5lA:16.7 | 4qtuB-3g5lA:25.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnr | PROBABLEMETHYLTRANSFERASEBT9727_4108 (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 5 | GLY A 53GLY A 55SER A 76MET A 79ALA A 115 | None | 0.49A | 4qtuB-3hnrA:16.3 | 4qtuB-3hnrA:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il4 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Enterococcusfaecalis) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | GLY A 143GLY A 168LEU A 140ILE A 286ALA A 84 | None | 1.09A | 4qtuB-3il4A:3.0 | 4qtuB-3il4A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ils | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF00975(Thioesterase) | 5 | GLY A1940GLY A1934MET A1870ILE A2035TRP A1936 | None | 1.06A | 4qtuB-3ilsA:undetectable | 4qtuB-3ilsA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4h | PUTATIVETRANSCRIPTIONALREGULATOR (Bacilluscytotoxicus) |
PF13377(Peripla_BP_3) | 5 | GLY A 204GLY A 179SER A 175ILE A 196ALA A 198 | None | 0.94A | 4qtuB-3k4hA:2.5 | 4qtuB-3k4hA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l49 | ABC SUGAR (RIBOSE)TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGSUBUNIT (Rhodobactersphaeroides) |
PF13407(Peripla_BP_4) | 5 | GLY A 248SER A 252ILE A 221ALA A 223TRP A 225 | NoneNoneNoneNoneUNL A 1 ( 4.7A) | 1.14A | 4qtuB-3l49A:3.6 | 4qtuB-3l49A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8d | METHYLTRANSFERASE (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 6 | GLY A 61GLY A 63ILE A 83SER A 84MET A 87ILE A 123 | None | 0.61A | 4qtuB-3l8dA:15.3 | 4qtuB-3l8dA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 179LEU A 264ILE A 207ILE A 175ALA A 178 | None | 1.04A | 4qtuB-3l8kA:2.5 | 4qtuB-3l8kA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la4 | UREASE (Canavaliaensiformis) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | GLY A 310LEU A 308ILE A 194SER A 169ILE A 148 | None | 1.09A | 4qtuB-3la4A:undetectable | 4qtuB-3la4A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 25GLY A 21SER A 211MET A 93ALA A 29 | NoneFDA A 547 ( 4.7A)NoneNoneNone | 1.03A | 4qtuB-3ljpA:undetectable | 4qtuB-3ljpA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrh | ANTI-HUNTINGTIN VLDOMAIN (Homo sapiens) |
PF07686(V-set) | 5 | GLY A 102GLY A 104SER A 7ILE A 37ALA A 89 | None | 1.09A | 4qtuB-3lrhA:undetectable | 4qtuB-3lrhA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m3p | GLUTAMINE AMIDOTRANSFERASE (Methylobacillusflagellatus) |
PF00117(GATase) | 5 | GLY A 87LEU A 166ILE A 9MET A 55ILE A 171 | None | 1.12A | 4qtuB-3m3pA:undetectable | 4qtuB-3m3pA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nks | PROTOPORPHYRINOGENOXIDASE (Homo sapiens) |
PF01593(Amino_oxidase) | 5 | GLY A 463GLY A 448LEU A 446ILE A 12ALA A 17 | NoneFAD A 479 (-3.4A)NoneNoneNone | 1.08A | 4qtuB-3nksA:2.4 | 4qtuB-3nksA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 5 | GLY A 95ILE A 138SER A 139ILE A 70ALA A 72 | None | 0.98A | 4qtuB-3qk7A:2.1 | 4qtuB-3qk7A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl2 | MALATE DEHYDROGENASE (Bacillusanthracis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 12GLY A 17LEU A 238ILE A 81ALA A 83 | EDO A 315 ( 4.1A)NoneNoneNoneEDO A 315 ( 3.7A) | 1.12A | 4qtuB-3tl2A:5.0 | 4qtuB-3tl2A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tu6 | PSEUDOAZURIN (BLUECOPPER PROTEIN) (Sinorhizobiummeliloti) |
PF00127(Copper-bind) | 5 | TYR A 108GLY A 90LEU A 46SER A 112ILE A 92 | None | 1.13A | 4qtuB-3tu6A:undetectable | 4qtuB-3tu6A:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 5 | TYR A 161GLY A 121GLY A 125ILE A 425ALA A 142 | None | 1.08A | 4qtuB-3upyA:3.9 | 4qtuB-3upyA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi3 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | GLY A 20GLY A 38LEU A 36ILE A 434ALA A 443 | None | 1.08A | 4qtuB-3vi3A:undetectable | 4qtuB-3vi3A:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vqr | PUTATIVEOXIDOREDUCTASE (Aeropyrumpernix) |
PF01266(DAO) | 5 | GLY A 45GLY A 40LEU A 16ALA A 160ARG A 256 | None | 1.06A | 4qtuB-3vqrA:3.0 | 4qtuB-3vqrA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwh | (R)-AMINETRANSAMINASE (Arthrobactersp. KNK168) |
PF01063(Aminotran_4) | 5 | TYR A 148GLY A 59LEU A 61ILE A 127SER A 126 | None | 1.02A | 4qtuB-3wwhA:undetectable | 4qtuB-3wwhA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aty | TEREPHTHALATE1,2-CIS-DIHYDRODIOLDEHYDROGENASE (Paraburkholderiaxenovorans) |
PF04166(PdxA) | 5 | TYR A 159GLY A 319GLY A 317LEU A 335ILE A 25 | None | 1.12A | 4qtuB-4atyA:2.6 | 4qtuB-4atyA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4u | BIFUNCTIONAL PROTEINFOLD (Acinetobacterbaumannii) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | GLY A 230GLY A 210LEU A 214ILE A 242ALA A 229 | NoneNAP A1001 ( 3.9A)NAP A1001 (-4.6A)NoneNone | 1.10A | 4qtuB-4b4uA:2.6 | 4qtuB-4b4uA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bo6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE FABG (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | GLY A 12GLY A 34LEU A 59ILE A 21ALA A 90 | None | 1.14A | 4qtuB-4bo6A:6.3 | 4qtuB-4bo6A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc7 | PEROXISOMAL2,4-DIENOYL-COAREDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | GLY A 35GLY A 37SER A 61ILE A 40ARG A 88 | NAP A 401 (-3.5A)NAP A 401 ( 4.9A)NAP A 401 (-4.4A)NAP A 401 (-4.0A)COA A 402 ( 2.8A) | 1.13A | 4qtuB-4fc7A:6.4 | 4qtuB-4fc7A:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk1 | PUTATIVE THIOREDOXINREDUCTASE (Bacillusanthracis) |
PF07992(Pyr_redox_2) | 5 | GLY C 15GLY C 12LEU C 278ILE C 9ALA C 267 | NoneFAD C 500 (-3.2A)FAD C 500 (-3.7A)NoneNone | 0.99A | 4qtuB-4fk1C:3.1 | 4qtuB-4fk1C:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0w | PROTEASE CSPB (Clostridiumperfringens) |
PF00082(Peptidase_S8) | 5 | GLY B 502LEU B 247ILE B 190ILE B 120ALA B 205 | None | 1.03A | 4qtuB-4i0wB:undetectable | 4qtuB-4i0wB:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | TYR A 187GLY A 232GLY A 234SER A 256MET A 259 | SAH A 501 ( 4.1A)SAH A 501 (-3.6A)SAH A 501 (-3.6A)SAH A 501 (-4.5A)SAH A 501 (-3.9A) | 0.62A | 4qtuB-4ineA:18.8 | 4qtuB-4ineA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv8 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumknowlesi) |
PF08241(Methyltransf_11) | 5 | GLY A 61GLY A 63ILE A 84MET A 88ALA A 127 | SAM A 301 (-3.5A)SAM A 301 ( 3.9A)SAM A 301 (-3.8A)SAM A 301 (-3.3A)SAM A 301 (-3.4A) | 0.73A | 4qtuB-4iv8A:18.4 | 4qtuB-4iv8A:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | TYR A 183GLY A 228GLY A 230SER A 252MET A 255 | SAH A 701 ( 4.2A)SAH A 701 (-3.5A)SAH A 701 (-3.5A)SAH A 701 (-4.7A)SAH A 701 (-3.9A) | 0.68A | 4qtuB-4kriA:19.2 | 4qtuB-4kriA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lds | BICYCLOMYCINRESISTANCE PROTEINTCAB (Staphylococcusepidermidis) |
PF00083(Sugar_tr) | 5 | GLY A 58GLY A 106ILE A 56MET A 51ILE A 78 | None | 1.13A | 4qtuB-4ldsA:undetectable | 4qtuB-4ldsA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4msx | PRE-MRNA-SPLICINGFACTOR SAD1 (Saccharomycescerevisiae) |
PF00443(UCH)PF02148(zf-UBP) | 5 | GLY A 423GLY A 151LEU A 210ILE A 407ALA A 155 | None | 1.04A | 4qtuB-4msxA:undetectable | 4qtuB-4msxA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Campylobacterjejuni) |
PF00478(IMPDH) | 5 | GLY A 357GLY A 335ILE A 300ILE A 44ALA A 46 | IMP A 500 (-3.5A)IMP A 500 (-3.5A)NoneNoneIMP A 500 (-3.3A) | 1.11A | 4qtuB-4mz1A:undetectable | 4qtuB-4mz1A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdk | MAGNESIUM-PROTOPORPHYRINO-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF07109(Mg-por_mtran_C) | 5 | GLY A 70GLY A 72ILE A 92SER A 93MET A 96 | SAH A 301 (-3.4A)SAH A 301 (-3.6A)SAH A 301 (-3.6A)SAH A 301 (-4.6A)SAH A 301 (-4.2A) | 0.45A | 4qtuB-4qdkA:17.4 | 4qtuB-4qdkA:26.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qed | ELXO (Staphylococcusepidermidis) |
PF13561(adh_short_C2) | 5 | GLY A 184GLY A 215ILE A 208SER A 206ILE A 242 | None | 1.10A | 4qtuB-4qedA:5.5 | 4qtuB-4qedA:20.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qtu | PUTATIVEMETHYLTRANSFERASEBUD23 (Saccharomycescerevisiae) |
PF08241(Methyltransf_11) | 12 | TYR B 14GLY B 55GLY B 57LEU B 60ILE B 78SER B 79MET B 82MET B 100ILE B 117ALA B 119TRP B 122ARG B 136 | NoneSAM B 301 (-3.7A)SAM B 301 (-3.3A)SAM B 301 (-4.0A)SAM B 301 (-3.7A)EDO B 310 ( 3.0A)SAM B 301 (-4.4A)SAM B 301 (-4.2A)SAM B 301 (-4.2A)SAM B 301 (-3.5A)SAM B 301 ( 4.1A)SAM B 301 ( 4.6A) | 0.00A | 4qtuB-4qtuB:39.9 | 4qtuB-4qtuB:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 5 | TYR A 19GLY A 63GLY A 65ILE A 86ALA A 129 | SAH A 302 ( 4.1A)SAH A 302 (-3.7A)SAH A 302 (-3.6A)SAH A 302 (-3.7A)SAH A 302 (-3.3A) | 0.73A | 4qtuB-4r6wA:18.9 | 4qtuB-4r6wA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3m | 2-DEHYDROPANTOATE2-REDUCTASE (Staphylococcusaureus) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | GLY A 14GLY A 9ILE A 38ILE A 67ALA A 18 | NoneNAP A 500 ( 3.8A)NoneNoneNone | 1.13A | 4qtuB-4s3mA:4.5 | 4qtuB-4s3mA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkt | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A3346GLY A3270LEU A3296SER A3325ALA A3499 | None | 1.09A | 4qtuB-4tktA:undetectable | 4qtuB-4tktA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ure | CYCLOHEXANOLDEHYDROGENASE (Aromatoleumaromaticum) |
PF13561(adh_short_C2) | 6 | GLY A 12GLY A 14ILE A 37SER A 38ILE A 17ARG A 109 | None | 1.44A | 4qtuB-4ureA:6.8 | 4qtuB-4ureA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0e | PROBABLENICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 5 | TYR A 137GLY A 131LEU A 156SER A 133ALA A 110 | None | 1.13A | 4qtuB-4x0eA:undetectable | 4qtuB-4x0eA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0e | PROBABLENICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 5 | TYR A 137GLY A 131SER A 133ILE A 114ALA A 110 | None | 0.99A | 4qtuB-4x0eA:undetectable | 4qtuB-4x0eA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ybr | NICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 5 | TYR A 137GLY A 131LEU A 156SER A 133ALA A 110 | NoneNoneNoneNoneNAP A 301 (-3.6A) | 0.96A | 4qtuB-4ybrA:undetectable | 4qtuB-4ybrA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ybr | NICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 5 | TYR A 137GLY A 131SER A 133ILE A 114ALA A 110 | NoneNoneNoneNAP A 301 (-3.9A)NAP A 301 (-3.6A) | 0.92A | 4qtuB-4ybrA:undetectable | 4qtuB-4ybrA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yco | TRNA-DIHYDROURIDINESYNTHASE C (Escherichiacoli) |
PF01207(Dus) | 5 | GLY A 109GLY A 71LEU A 69SER A 106ALA A 98 | NoneNoneNone A D 14 ( 2.7A) U D 16 ( 3.3A) | 0.94A | 4qtuB-4ycoA:undetectable | 4qtuB-4ycoA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg8 | ENDOGLUCANASE (Perinereisbrevicirris) |
PF00759(Glyco_hydro_9) | 5 | GLY A 422GLY A 425LEU A 16ILE A 315ALA A 310 | None | 1.11A | 4qtuB-4zg8A:undetectable | 4qtuB-4zg8A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlg | PUTATIVE B-GLYCANPHOSPHORYLASE (Saccharophagusdegradans) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 6 | GLY A 568LEU A 488ILE A 566SER A 563ILE A 522ALA A 570 | None | 1.38A | 4qtuB-4zlgA:undetectable | 4qtuB-4zlgA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrq | TRANSCOBALAMIN-2 (Homo sapiens) |
PF01122(Cobalamin_bind)PF14478(DUF4430) | 5 | GLY A 142GLY A 140LEU A 183SER A 135ALA A 88 | NoneNoneNoneCNC A 501 ( 4.0A)None | 1.09A | 4qtuB-4zrqA:undetectable | 4qtuB-4zrqA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aex | AMMONIUM TRANSPORTERMEP2 (Saccharomycescerevisiae) |
PF00909(Ammonium_transp) | 5 | GLY A 299GLY A 323ILE A 296ILE A 318ALA A 267 | None | 1.01A | 4qtuB-5aexA:undetectable | 4qtuB-5aexA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cm2 | TRNAMETHYLTRANSFERASE (Yarrowialipolytica) |
PF08241(Methyltransf_11) | 5 | GLY Z 64GLY Z 66SER Z 85ILE Z 122ARG Z 133 | None | 0.90A | 4qtuB-5cm2Z:15.1 | 4qtuB-5cm2Z:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evy | SALICYLATEHYDROXYLASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 5 | GLY X 223LEU X 219SER X 243ALA X 240ARG X 260 | None | 1.02A | 4qtuB-5evyX:undetectable | 4qtuB-5evyX:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnq | PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE ([Clostridium]bolteae) |
PF00953(Glycos_transf_4)PF10555(MraY_sig1) | 5 | TYR A 73GLY A 208ILE A 206ILE A 6ALA A 8 | None | 1.09A | 4qtuB-5jnqA:undetectable | 4qtuB-5jnqA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jsc | PUTATIVE ACYL-COADEHYDROGENASE (Paraburkholderiaxenovorans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | GLY A 107GLY A 105LEU A 101ILE A 111SER A 112 | None | 1.06A | 4qtuB-5jscA:undetectable | 4qtuB-5jscA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jyd | SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | TYR A 252GLY A 82GLY A 80ILE A 87ALA A 85 | NoneNoneNAD A 901 (-3.0A)NoneNone | 1.11A | 4qtuB-5jydA:6.7 | 4qtuB-5jydA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIIICOAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens;Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3)PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 5 | GLY A 655GLY A 686LEU A 631ILE B1790ALA B1800 | None | 0.98A | 4qtuB-5k8dA:undetectable | 4qtuB-5k8dA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIIICOAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens;Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3)PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 5 | GLY A 686LEU A 631ILE B1790SER B1791ALA B1800 | None | 1.11A | 4qtuB-5k8dA:undetectable | 4qtuB-5k8dA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m11 | IMMUNOREACTIVE 84KDANTIGEN PG93 (Porphyromonasgingivalis) |
no annotation | 5 | GLY A 680GLY A 664LEU A 666SER A 683ALA A 714 | None | 1.14A | 4qtuB-5m11A:undetectable | 4qtuB-5m11A:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 5 | GLY A 945ILE A 810SER A 809MET A 806ILE A 947 | None | 1.10A | 4qtuB-5mqsA:undetectable | 4qtuB-5mqsA:11.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyj | ANBU (Hyphomicrobiumsp. MC1) |
PF00227(Proteasome) | 5 | GLY A 119ILE A 132ILE A 122ALA A 86ARG A 95 | None | 1.14A | 4qtuB-5nyjA:undetectable | 4qtuB-5nyjA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0s | GLUCOSYLCERAMIDASE (Thermoanaerobacteriumxylanolyticum) |
PF04685(DUF608)PF12215(Glyco_hydr_116N)PF17168(DUF5127) | 5 | GLY A 365ILE A 371SER A 368ILE A 344TRP A 340 | NoneNoneEDO A 902 (-3.6A)NoneNone | 1.13A | 4qtuB-5o0sA:undetectable | 4qtuB-5o0sA:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj3 | ALKALINE PHOSPHATASEPAFA (Elizabethkingiameningoseptica) |
PF01663(Phosphodiest) | 5 | GLY A 89LEU A 168SER A 533ILE A 86ALA A 520 | None | 1.03A | 4qtuB-5tj3A:undetectable | 4qtuB-5tj3A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wmm | NRPS (Micromonosporasp. ML1) |
no annotation | 5 | TYR A 484GLY A 542GLY A 544LEU A 547SER A 565 | SAH A1002 ( 3.8A)SAH A1002 (-3.7A)SAH A1002 (-3.4A)SAH A1002 (-3.7A)SAH A1002 ( 4.9A) | 0.83A | 4qtuB-5wmmA:14.4 | 4qtuB-5wmmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhu | FERREDOXIN--NADPREDUCTASE (Bacillussubtilis) |
no annotation | 5 | GLY A 14GLY A 15LEU A 86ILE A 18ILE A 36 | FAD A1000 (-3.3A)NoneNoneFAD A1000 (-3.9A)None | 1.10A | 4qtuB-5xhuA:3.0 | 4qtuB-5xhuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2a | INSECT GROUP IICHITINASE (Ostriniafurnacalis) |
no annotation | 5 | GLY A2299ILE A2245SER A2246MET A2396ALA A2224 | None | 1.11A | 4qtuB-5y2aA:undetectable | 4qtuB-5y2aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d47 | BETA SLIDING CLAMP (Mycobacteriummarinum) |
no annotation | 5 | GLY A 83GLY A 44LEU A 46ILE A 56ALA A 30 | None | 0.99A | 4qtuB-6d47A:undetectable | 4qtuB-6d47A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5z | 24-STEROLC-METHYLTRANSFERASE (Haloferaxvolcanii) |
no annotation | 5 | GLY A 46GLY A 48SER A 71MET A 74ALA A 112 | SAH A 301 (-3.5A)SAH A 301 ( 3.7A)NoneSAH A 301 (-4.0A)SAH A 301 (-3.5A) | 0.70A | 4qtuB-6f5zA:20.1 | 4qtuB-6f5zA:undetectable |