SIMILAR PATTERNS OF AMINO ACIDS FOR 4QTU_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 GLY A  18
GLY A  20
ILE A  43
ILE A  23
ARG A 113
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-4.0A)
None
 1.13A 4qtuB-1ahiA:
6.3		 4qtuB-1ahiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A  36
GLY A  34
ILE A  41
ALA A  39
ARG A 587
 None
 1.02A 4qtuB-1b25A:
undetectable		 4qtuB-1b25A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 GLY A  97
GLY A  93
ILE A   5
SER A  24
ALA A 100
 None
 1.13A 4qtuB-1cp9A:
undetectable		 4qtuB-1cp9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 GLY A  88
GLY A 173
SER A  76
ALA A  90
ARG A  20
 None
 1.07A 4qtuB-1f0pA:
undetectable		 4qtuB-1f0pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 GLY A 134
ILE A 143
SER A 144
ILE A 131
ALA A  89
 None
 1.14A 4qtuB-1gpjA:
5.5		 4qtuB-1gpjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE

(Rattus
norvegicus) 		PF00459
(Inositol_P) 		5 TYR A 272
GLY A 148
GLY A 138
ILE A 146
ILE A 150
 None
 0.86A 4qtuB-1jp4A:
undetectable		 4qtuB-1jp4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  74
GLY A  72
LEU A  95
ILE A 136
SER A 135
 SAH  A1900 (-3.2A)
SAH  A1900 (-3.1A)
SAH  A1900 (-4.4A)
SAH  A1900 (-4.2A)
None
 1.10A 4qtuB-1kphA:
17.0		 4qtuB-1kphA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		6 TYR A  16
GLY A  72
GLY A  74
SER A  96
ILE A 136
ALA A 138
 SAH  A1900 ( 4.2A)
SAH  A1900 (-3.1A)
SAH  A1900 (-3.2A)
None
SAH  A1900 (-4.2A)
SAH  A1900 (-3.2A)
 0.85A 4qtuB-1kphA:
17.0		 4qtuB-1kphA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		6 GLY A  72
GLY A  74
SER A  96
ILE A 136
ALA A 138
ARG A 146
 SAH  A 900 (-3.1A)
SAH  A 900 (-3.4A)
None
SAH  A 900 (-3.9A)
SAH  A 900 (-3.4A)
SAH  A 900 (-4.6A)
 0.87A 4qtuB-1l1eA:
16.7		 4qtuB-1l1eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  74
GLY A  72
LEU A  95
ILE A 136
SER A 135
 SAH  A 900 (-3.4A)
SAH  A 900 (-3.1A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.9A)
None
 1.11A 4qtuB-1l1eA:
16.7		 4qtuB-1l1eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldi GLYCEROL UPTAKE
FACILITATOR PROTEIN

(Escherichia
coli) 		PF00230
(MIP) 		5 GLY A 247
GLY A 243
ILE A 158
MET A 153
ALA A 250
 None
 0.97A 4qtuB-1ldiA:
undetectable		 4qtuB-1ldiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY A  44
GLY A  46
SER A  68
ALA A 112
TRP A 114
 None
 0.79A 4qtuB-1nkvA:
13.8		 4qtuB-1nkvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY A  93
GLY A  95
SER A 118
ILE A 155
ALA A 157
 None
SAM  A1401 (-3.4A)
None
SAM  A1401 (-4.2A)
None
 0.64A 4qtuB-1p91A:
15.7		 4qtuB-1p91A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		6 GLY A 385
GLY A 380
LEU A 461
ILE A 408
ILE A 460
ALA A 389
 None
FAD  A 701 (-2.9A)
None
None
None
None
 1.27A 4qtuB-1ps9A:
undetectable		 4qtuB-1ps9A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 GLY A  88
GLY A 173
SER A  76
ALA A  90
ARG A  20
 None
 1.03A 4qtuB-1sfrA:
undetectable		 4qtuB-1sfrA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  72
GLY A  74
SER A  96
ILE A 136
ALA A 138
 SAH  A1900 (-3.2A)
SAH  A1900 (-3.3A)
None
SAH  A1900 (-3.6A)
SAH  A1900 (-3.1A)
 0.48A 4qtuB-1tpyA:
17.2		 4qtuB-1tpyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 GLY A 268
GLY A 292
ILE A 242
ILE A 287
ALA A 237
 None
 1.05A 4qtuB-1u7gA:
undetectable		 4qtuB-1u7gA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 GLY A  48
ILE A  68
SER A  69
MET A  72
ILE A 110
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.8A)
 0.53A 4qtuB-1ve3A:
20.0		 4qtuB-1ve3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		5 GLY A 229
GLY A 171
LEU A 224
ILE A  38
ILE A 231
 None
 1.11A 4qtuB-1vmeA:
undetectable		 4qtuB-1vmeA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 GLY A 101
GLY A 103
MET A 128
MET A 149
ILE A 107
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.4A)
SAI  A 401 (-4.9A)
 1.09A 4qtuB-1xtpA:
15.5		 4qtuB-1xtpA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A 137
GLY A 146
LEU A 144
ILE A 158
ALA A 179
 None
 1.08A 4qtuB-2bpqA:
2.6		 4qtuB-2bpqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 TYR A1018
GLY A1000
ILE A1023
ILE A 941
ALA A1041
 None
 1.14A 4qtuB-2ec5A:
undetectable		 4qtuB-2ec5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		5 GLY A  51
GLY A  53
LEU A  13
ILE A  70
ALA A  76
 None
 0.92A 4qtuB-2fhpA:
12.2		 4qtuB-2fhpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  81
GLY A  83
SER A 105
ILE A 145
ALA A 147
 None
 0.61A 4qtuB-2fk7A:
15.0		 4qtuB-2fk7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		5 GLY A  16
GLY A  11
ILE A  39
ILE A 161
ALA A  20
 None
FAD  A 403 (-3.1A)
None
None
None
 1.10A 4qtuB-2gqfA:
undetectable		 4qtuB-2gqfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 441
ILE A 410
SER A 437
ILE A 446
ALA A 444
 None
TPP  A 600 (-4.5A)
TPP  A 600 (-3.5A)
None
None
 1.12A 4qtuB-2ihtA:
undetectable		 4qtuB-2ihtA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 GLY A 292
GLY A 280
ILE A  42
SER A  41
ALA A  16
 None
 1.12A 4qtuB-2pbyA:
undetectable		 4qtuB-2pbyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 GLY A 184
GLY A 176
ILE A 182
ILE A 186
ALA A 179
 None
 1.15A 4qtuB-2q0fA:
undetectable		 4qtuB-2q0fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		5 GLY A 141
GLY A 144
LEU A 117
ILE A   7
ILE A 119
 None
 1.02A 4qtuB-3au7A:
undetectable		 4qtuB-3au7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 GLY A 417
GLY A 440
ILE A 434
SER A 431
ALA A 416
 None
 1.05A 4qtuB-3b4wA:
4.0		 4qtuB-3b4wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
SER A  74
MET A  77
ALA A 115
 None
 0.80A 4qtuB-3bkwA:
17.3		 4qtuB-3bkwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 GLY A  40
GLY A  42
SER A  62
MET A  65
MET A  87
 None
 0.69A 4qtuB-3d2lA:
18.0		 4qtuB-3d2lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		5 GLY A 290
GLY A 292
ILE A 312
MET A 316
ARG A 359
 None
 0.91A 4qtuB-3dliA:
18.2		 4qtuB-3dliA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 GLY A  41
GLY A  43
SER A  64
MET A  67
ILE A 100
ALA A 102
 EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
None
EDO  A 261 ( 4.1A)
None
EDO  A 261 ( 3.8A)
 0.83A 4qtuB-3egeA:
15.8		 4qtuB-3egeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 GLY A  94
GLY A 255
LEU A 257
SER A 253
ALA A 208
 PLP  A 500 (-3.5A)
None
None
None
PLP  A 500 (-3.4A)
 1.15A 4qtuB-3f9tA:
2.4		 4qtuB-3f9tA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		5 GLY A  50
GLY A  52
SER A  74
MET A  77
ALA A 115
 None
 0.70A 4qtuB-3g5lA:
16.7		 4qtuB-3g5lA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		5 GLY A  53
GLY A  55
SER A  76
MET A  79
ALA A 115
 None
 0.49A 4qtuB-3hnrA:
16.3		 4qtuB-3hnrA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 143
GLY A 168
LEU A 140
ILE A 286
ALA A  84
 None
 1.09A 4qtuB-3il4A:
3.0		 4qtuB-3il4A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		5 GLY A1940
GLY A1934
MET A1870
ILE A2035
TRP A1936
 None
 1.06A 4qtuB-3ilsA:
undetectable		 4qtuB-3ilsA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		5 GLY A 204
GLY A 179
SER A 175
ILE A 196
ALA A 198
 None
 0.94A 4qtuB-3k4hA:
2.5		 4qtuB-3k4hA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 GLY A 248
SER A 252
ILE A 221
ALA A 223
TRP A 225
 None
None
None
None
UNL  A   1 ( 4.7A)
 1.14A 4qtuB-3l49A:
3.6		 4qtuB-3l49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		6 GLY A  61
GLY A  63
ILE A  83
SER A  84
MET A  87
ILE A 123
 None
 0.61A 4qtuB-3l8dA:
15.3		 4qtuB-3l8dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 179
LEU A 264
ILE A 207
ILE A 175
ALA A 178
 None
 1.04A 4qtuB-3l8kA:
2.5		 4qtuB-3l8kA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 310
LEU A 308
ILE A 194
SER A 169
ILE A 148
 None
 1.09A 4qtuB-3la4A:
undetectable		 4qtuB-3la4A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  25
GLY A  21
SER A 211
MET A  93
ALA A  29
 None
FDA  A 547 ( 4.7A)
None
None
None
 1.03A 4qtuB-3ljpA:
undetectable		 4qtuB-3ljpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A 102
GLY A 104
SER A   7
ILE A  37
ALA A  89
 None
 1.09A 4qtuB-3lrhA:
undetectable		 4qtuB-3lrhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		5 GLY A  87
LEU A 166
ILE A   9
MET A  55
ILE A 171
 None
 1.12A 4qtuB-3m3pA:
undetectable		 4qtuB-3m3pA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 GLY A 463
GLY A 448
LEU A 446
ILE A  12
ALA A  17
 None
FAD  A 479 (-3.4A)
None
None
None
 1.08A 4qtuB-3nksA:
2.4		 4qtuB-3nksA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS

(Yersinia pestis) 		PF00532
(Peripla_BP_1) 		5 GLY A  95
ILE A 138
SER A 139
ILE A  70
ALA A  72
 None
 0.98A 4qtuB-3qk7A:
2.1		 4qtuB-3qk7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  12
GLY A  17
LEU A 238
ILE A  81
ALA A  83
 EDO  A 315 ( 4.1A)
None
None
None
EDO  A 315 ( 3.7A)
 1.12A 4qtuB-3tl2A:
5.0		 4qtuB-3tl2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu6 PSEUDOAZURIN (BLUE
COPPER PROTEIN)

(Sinorhizobium
meliloti) 		PF00127
(Copper-bind) 		5 TYR A 108
GLY A  90
LEU A  46
SER A 112
ILE A  92
 None
 1.13A 4qtuB-3tu6A:
undetectable		 4qtuB-3tu6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 TYR A 161
GLY A 121
GLY A 125
ILE A 425
ALA A 142
 None
 1.08A 4qtuB-3upyA:
3.9		 4qtuB-3upyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A  20
GLY A  38
LEU A  36
ILE A 434
ALA A 443
 None
 1.08A 4qtuB-3vi3A:
undetectable		 4qtuB-3vi3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		5 GLY A  45
GLY A  40
LEU A  16
ALA A 160
ARG A 256
 None
 1.06A 4qtuB-3vqrA:
3.0		 4qtuB-3vqrA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 TYR A 148
GLY A  59
LEU A  61
ILE A 127
SER A 126
 None
 1.02A 4qtuB-3wwhA:
undetectable		 4qtuB-3wwhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 TYR A 159
GLY A 319
GLY A 317
LEU A 335
ILE A  25
 None
 1.12A 4qtuB-4atyA:
2.6		 4qtuB-4atyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 230
GLY A 210
LEU A 214
ILE A 242
ALA A 229
 None
NAP  A1001 ( 3.9A)
NAP  A1001 (-4.6A)
None
None
 1.10A 4qtuB-4b4uA:
2.6		 4qtuB-4b4uA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 GLY A  12
GLY A  34
LEU A  59
ILE A  21
ALA A  90
 None
 1.14A 4qtuB-4bo6A:
6.3		 4qtuB-4bo6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A  35
GLY A  37
SER A  61
ILE A  40
ARG A  88
 NAP  A 401 (-3.5A)
NAP  A 401 ( 4.9A)
NAP  A 401 (-4.4A)
NAP  A 401 (-4.0A)
COA  A 402 ( 2.8A)
 1.13A 4qtuB-4fc7A:
6.4		 4qtuB-4fc7A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		5 GLY C  15
GLY C  12
LEU C 278
ILE C   9
ALA C 267
 None
FAD  C 500 (-3.2A)
FAD  C 500 (-3.7A)
None
None
 0.99A 4qtuB-4fk1C:
3.1		 4qtuB-4fk1C:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		5 GLY B 502
LEU B 247
ILE B 190
ILE B 120
ALA B 205
 None
 1.03A 4qtuB-4i0wB:
undetectable		 4qtuB-4i0wB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 TYR A 187
GLY A 232
GLY A 234
SER A 256
MET A 259
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
 0.62A 4qtuB-4ineA:
18.8		 4qtuB-4ineA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		5 GLY A  61
GLY A  63
ILE A  84
MET A  88
ALA A 127
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
 0.73A 4qtuB-4iv8A:
18.4		 4qtuB-4iv8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TYR A 183
GLY A 228
GLY A 230
SER A 252
MET A 255
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
 0.68A 4qtuB-4kriA:
19.2		 4qtuB-4kriA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 GLY A  58
GLY A 106
ILE A  56
MET A  51
ILE A  78
 None
 1.13A 4qtuB-4ldsA:
undetectable		 4qtuB-4ldsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msx PRE-MRNA-SPLICING
FACTOR SAD1

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		5 GLY A 423
GLY A 151
LEU A 210
ILE A 407
ALA A 155
 None
 1.04A 4qtuB-4msxA:
undetectable		 4qtuB-4msxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 GLY A 357
GLY A 335
ILE A 300
ILE A  44
ALA A  46
 IMP  A 500 (-3.5A)
IMP  A 500 (-3.5A)
None
None
IMP  A 500 (-3.3A)
 1.11A 4qtuB-4mz1A:
undetectable		 4qtuB-4mz1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		5 GLY A  70
GLY A  72
ILE A  92
SER A  93
MET A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.2A)
 0.45A 4qtuB-4qdkA:
17.4		 4qtuB-4qdkA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis) 		PF13561
(adh_short_C2) 		5 GLY A 184
GLY A 215
ILE A 208
SER A 206
ILE A 242
 None
 1.10A 4qtuB-4qedA:
5.5		 4qtuB-4qedA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		12 TYR B  14
GLY B  55
GLY B  57
LEU B  60
ILE B  78
SER B  79
MET B  82
MET B 100
ILE B 117
ALA B 119
TRP B 122
ARG B 136
 None
SAM  B 301 (-3.7A)
SAM  B 301 (-3.3A)
SAM  B 301 (-4.0A)
SAM  B 301 (-3.7A)
EDO  B 310 ( 3.0A)
SAM  B 301 (-4.4A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.2A)
SAM  B 301 (-3.5A)
SAM  B 301 ( 4.1A)
SAM  B 301 ( 4.6A)
 0.00A 4qtuB-4qtuB:
39.9		 4qtuB-4qtuB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 TYR A  19
GLY A  63
GLY A  65
ILE A  86
ALA A 129
 SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.3A)
 0.73A 4qtuB-4r6wA:
18.9		 4qtuB-4r6wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE

(Staphylococcus
aureus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLY A  14
GLY A   9
ILE A  38
ILE A  67
ALA A  18
 None
NAP  A 500 ( 3.8A)
None
None
None
 1.13A 4qtuB-4s3mA:
4.5		 4qtuB-4s3mA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3346
GLY A3270
LEU A3296
SER A3325
ALA A3499
 None
 1.09A 4qtuB-4tktA:
undetectable		 4qtuB-4tktA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ure CYCLOHEXANOL
DEHYDROGENASE

(Aromatoleum
aromaticum) 		PF13561
(adh_short_C2) 		6 GLY A  12
GLY A  14
ILE A  37
SER A  38
ILE A  17
ARG A 109
 None
 1.44A 4qtuB-4ureA:
6.8		 4qtuB-4ureA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 TYR A 137
GLY A 131
LEU A 156
SER A 133
ALA A 110
 None
 1.13A 4qtuB-4x0eA:
undetectable		 4qtuB-4x0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 TYR A 137
GLY A 131
SER A 133
ILE A 114
ALA A 110
 None
 0.99A 4qtuB-4x0eA:
undetectable		 4qtuB-4x0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 TYR A 137
GLY A 131
LEU A 156
SER A 133
ALA A 110
 None
None
None
None
NAP  A 301 (-3.6A)
 0.96A 4qtuB-4ybrA:
undetectable		 4qtuB-4ybrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 TYR A 137
GLY A 131
SER A 133
ILE A 114
ALA A 110
 None
None
None
NAP  A 301 (-3.9A)
NAP  A 301 (-3.6A)
 0.92A 4qtuB-4ybrA:
undetectable		 4qtuB-4ybrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		5 GLY A 109
GLY A  71
LEU A  69
SER A 106
ALA A  98
 None
None
None
A  D  14 ( 2.7A)
U  D  16 ( 3.3A)
 0.94A 4qtuB-4ycoA:
undetectable		 4qtuB-4ycoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 GLY A 422
GLY A 425
LEU A  16
ILE A 315
ALA A 310
 None
 1.11A 4qtuB-4zg8A:
undetectable		 4qtuB-4zg8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		6 GLY A 568
LEU A 488
ILE A 566
SER A 563
ILE A 522
ALA A 570
 None
 1.38A 4qtuB-4zlgA:
undetectable		 4qtuB-4zlgA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 GLY A 142
GLY A 140
LEU A 183
SER A 135
ALA A  88
 None
None
None
CNC  A 501 ( 4.0A)
None
 1.09A 4qtuB-4zrqA:
undetectable		 4qtuB-4zrqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 GLY A 299
GLY A 323
ILE A 296
ILE A 318
ALA A 267
 None
 1.01A 4qtuB-5aexA:
undetectable		 4qtuB-5aexA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE

(Yarrowia
lipolytica) 		PF08241
(Methyltransf_11) 		5 GLY Z  64
GLY Z  66
SER Z  85
ILE Z 122
ARG Z 133
 None
 0.90A 4qtuB-5cm2Z:
15.1		 4qtuB-5cm2Z:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY X 223
LEU X 219
SER X 243
ALA X 240
ARG X 260
 None
 1.02A 4qtuB-5evyX:
undetectable		 4qtuB-5evyX:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 TYR A  73
GLY A 208
ILE A 206
ILE A   6
ALA A   8
 None
 1.09A 4qtuB-5jnqA:
undetectable		 4qtuB-5jnqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 107
GLY A 105
LEU A 101
ILE A 111
SER A 112
 None
 1.06A 4qtuB-5jscA:
undetectable		 4qtuB-5jscA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 TYR A 252
GLY A  82
GLY A  80
ILE A  87
ALA A  85
 None
None
NAD  A 901 (-3.0A)
None
None
 1.11A 4qtuB-5jydA:
6.7		 4qtuB-5jydA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 GLY A 655
GLY A 686
LEU A 631
ILE B1790
ALA B1800
 None
 0.98A 4qtuB-5k8dA:
undetectable		 4qtuB-5k8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 GLY A 686
LEU A 631
ILE B1790
SER B1791
ALA B1800
 None
 1.11A 4qtuB-5k8dA:
undetectable		 4qtuB-5k8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 GLY A 680
GLY A 664
LEU A 666
SER A 683
ALA A 714
 None
 1.14A 4qtuB-5m11A:
undetectable		 4qtuB-5m11A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 GLY A 945
ILE A 810
SER A 809
MET A 806
ILE A 947
 None
 1.10A 4qtuB-5mqsA:
undetectable		 4qtuB-5mqsA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		5 GLY A 119
ILE A 132
ILE A 122
ALA A  86
ARG A  95
 None
 1.14A 4qtuB-5nyjA:
undetectable		 4qtuB-5nyjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 GLY A 365
ILE A 371
SER A 368
ILE A 344
TRP A 340
 None
None
EDO  A 902 (-3.6A)
None
None
 1.13A 4qtuB-5o0sA:
undetectable		 4qtuB-5o0sA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 GLY A  89
LEU A 168
SER A 533
ILE A  86
ALA A 520
 None
 1.03A 4qtuB-5tj3A:
undetectable		 4qtuB-5tj3A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 5 TYR A 484
GLY A 542
GLY A 544
LEU A 547
SER A 565
 SAH  A1002 ( 3.8A)
SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 (-3.7A)
SAH  A1002 ( 4.9A)
 0.83A 4qtuB-5wmmA:
14.4		 4qtuB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhu FERREDOXIN--NADP
REDUCTASE

(Bacillus
subtilis) 		no annotation 5 GLY A  14
GLY A  15
LEU A  86
ILE A  18
ILE A  36
 FAD  A1000 (-3.3A)
None
None
FAD  A1000 (-3.9A)
None
 1.10A 4qtuB-5xhuA:
3.0		 4qtuB-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 GLY A2299
ILE A2245
SER A2246
MET A2396
ALA A2224
 None
 1.11A 4qtuB-5y2aA:
undetectable		 4qtuB-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 GLY A  83
GLY A  44
LEU A  46
ILE A  56
ALA A  30
 None
 0.99A 4qtuB-6d47A:
undetectable		 4qtuB-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 5 GLY A  46
GLY A  48
SER A  71
MET A  74
ALA A 112
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
 0.70A 4qtuB-6f5zA:
20.1		 4qtuB-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap8 TRANSLATION
INITIATION FACTOR
EIF4E

(Saccharomyces
cerevisiae) 		PF01652
(IF4E) 		4 GLN A 118
SER A 116
ASP A  92
ASP A  53
 None
None
M7G  A 214 (-3.6A)
M7G  A 214 ( 4.9A)
 1.33A 4qtuB-1ap8A:
undetectable		 4qtuB-1ap8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TYR A  26
SER A  20
ASP A  83
ASP A  49
 None
None
FEO  A 404 (-2.2A)
None
 1.24A 4qtuB-1e5dA:
2.2		 4qtuB-1e5dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 TYR A  52
GLN A 370
SER A 185
ASP A 113
 None
None
AKB  A1200 ( 2.9A)
None
 1.17A 4qtuB-1fc4A:
2.6		 4qtuB-1fc4A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		4 TYR A 294
GLN A 334
SER A 363
ASP A 301
 None
 1.19A 4qtuB-1hg8A:
undetectable		 4qtuB-1hg8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 TYR A 237
SER A 288
ASP A 292
ASP A  16
 None
None
PRH  A 401 ( 2.5A)
PRH  A 401 (-3.4A)
 1.16A 4qtuB-1krmA:
undetectable		 4qtuB-1krmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 TYR A  28
GLN A 254
SER A 252
ASP A 878
 UPL  A2014 (-4.6A)
None
None
UPL  A2014 (-4.2A)
 1.00A 4qtuB-1lshA:
undetectable		 4qtuB-1lshA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 GLN A 235
SER A 219
ASP A 252
ASP A 258
 None
 1.48A 4qtuB-1m1cA:
undetectable		 4qtuB-1m1cA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A 171
SER A 365
ASP A 214
ASP A 262
 None
None
GLC  A 904 (-3.9A)
GLC  A 903 ( 4.0A)
 1.02A 4qtuB-1q2eA:
undetectable		 4qtuB-1q2eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		4 TYR A 168
SER A 369
ASP A 211
ASP A 259
 None
 1.25A 4qtuB-1q9hA:
undetectable		 4qtuB-1q9hA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 GLN A  71
SER A 203
ASP A 257
ASP A 278
 None
 1.15A 4qtuB-1qcxA:
undetectable		 4qtuB-1qcxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vel STARVATION-INDUCED
DNA PROTECTING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		4 TYR A 113
GLN A  57
ASP A  30
ASP A  89
 None
 1.28A 4qtuB-1velA:
undetectable		 4qtuB-1velA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 GLN A 135
SER A 133
ASP A 200
ASP A 218
 None
None
None
MLY  A 221 ( 4.6A)
 1.35A 4qtuB-1xkpA:
undetectable		 4qtuB-1xkpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 GLN A 135
SER A 133
ASP A 200
ASP A 218
 None
None
None
MLY  A 221 ( 3.6A)
 1.27A 4qtuB-1xl3A:
undetectable		 4qtuB-1xl3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 TYR A 168
SER A 362
ASP A 209
ASP A 251
 None
None
None
LAT  A 500 ( 3.8A)
 1.23A 4qtuB-1z3vA:
undetectable		 4qtuB-1z3vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A  11
GLN A 364
SER A 363
ASP A 297
 None
 1.49A 4qtuB-2aeyA:
undetectable		 4qtuB-2aeyA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 TYR A 178
GLN A 175
SER A 145
ASP A 220
 None
None
None
COA  A 500 (-4.9A)
 1.10A 4qtuB-2d52A:
undetectable		 4qtuB-2d52A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		4 TYR A 171
SER A 364
ASP A 214
ASP A 262
 None
None
CTR  A 431 (-4.2A)
CTR  A 431 ( 4.5A)
 1.18A 4qtuB-2rfzA:
undetectable		 4qtuB-2rfzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj6 ASCORBATE PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 TYR A   5
GLN A 240
SER A 243
ASP A  95
 None
 1.35A 4qtuB-2xj6A:
undetectable		 4qtuB-2xj6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 173
SER A 373
ASP A 216
ASP A 262
 None
 1.03A 4qtuB-2yg1A:
undetectable		 4qtuB-2yg1A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 184
SER A 378
ASP A 227
ASP A 275
 None
 1.05A 4qtuB-2yokA:
undetectable		 4qtuB-2yokA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 GLN A 340
SER A 339
ASP A  21
ASP A  19
 None
 1.45A 4qtuB-3aquA:
undetectable		 4qtuB-3aquA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 138
GLN A 136
ASP A  82
ASP A  74
 None
 1.40A 4qtuB-3b6uA:
undetectable		 4qtuB-3b6uA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 TYR B 338
GLN B 449
ASP B 334
ASP B 175
 None
 1.43A 4qtuB-3hkzB:
undetectable		 4qtuB-3hkzB:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLN A 351
SER A 358
ASP A 375
ASP A 377
 None
None
EDO  A   9 ( 4.8A)
None
 1.25A 4qtuB-3ihvA:
undetectable		 4qtuB-3ihvA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 TYR W 177
GLN W  60
ASP W 268
ASP W 286
 None
 1.35A 4qtuB-3iylW:
11.9		 4qtuB-3iylW:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcp MULTIPLE COAGULATION
FACTOR DEFICIENCY
PROTEIN 2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 TYR C  82
SER C  94
ASP C  89
ASP C 133
 None
None
None
CA  C 159 (-2.9A)
 1.44A 4qtuB-3lcpC:
undetectable		 4qtuB-3lcpC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		4 TYR A  66
GLN A  34
ASP A  39
ASP A 445
 GOL  A 636 (-4.2A)
None
None
None
 1.50A 4qtuB-3loyA:
undetectable		 4qtuB-3loyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 GLN A 416
SER A  53
ASP A 100
ASP A 290
 None
 1.38A 4qtuB-3mznA:
undetectable		 4qtuB-3mznA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN

(Lama glama;
Trypanosoma
brucei;
Trypanosoma
brucei) 		PF07686
(V-set)
no annotation
PF00436
(SSB) 		4 TYR D 117
GLN D 119
SER C 324
ASP A 116
 None
 1.47A 4qtuB-3stbD:
undetectable		 4qtuB-3stbD:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 TYR A 217
GLN A 164
ASP A 136
ASP A 343
 PHE  A 400 (-4.8A)
None
None
None
 1.08A 4qtuB-3td9A:
3.1		 4qtuB-3td9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A 328
GLN A 563
ASP A 513
ASP A 344
 None
None
UMP  A 611 (-4.9A)
None
 1.45A 4qtuB-3um6A:
undetectable		 4qtuB-3um6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 TYR A  89
GLN A  72
SER A  38
ASP A 183
 None
None
None
MN  A 302 ( 3.2A)
 1.42A 4qtuB-3vnkA:
undetectable		 4qtuB-3vnkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 TYR A 165
GLN A 162
SER A 132
ASP A 207
 TYR  A 165 ( 1.3A)
GLN  A 162 ( 0.6A)
SER  A 132 ( 0.0A)
ASP  A 207 ( 0.6A)
 1.06A 4qtuB-3wd7A:
undetectable		 4qtuB-3wd7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		4 TYR A 115
SER A 112
ASP A 155
ASP A 286
 None
 1.47A 4qtuB-3wj2A:
3.0		 4qtuB-3wj2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		4 TYR A 220
SER A 212
ASP A 117
ASP A 119
 None
 1.32A 4qtuB-3wxwA:
undetectable		 4qtuB-3wxwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 TYR A  96
SER A 132
ASP A 392
ASP A 400
 FMN  A 500 (-3.4A)
FMN  A 500 (-2.6A)
None
None
 1.20A 4qtuB-3x0yA:
undetectable		 4qtuB-3x0yA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 636
GLN A 634
ASP A 558
ASP A 538
 None
 1.34A 4qtuB-3zz1A:
undetectable		 4qtuB-3zz1A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLN A 236
SER A 153
ASP A 195
ASP A 120
 None
 1.24A 4qtuB-4c30A:
4.1		 4qtuB-4c30A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		4 TYR A 172
SER A 370
ASP A 215
ASP A 263
 None
PEG  A1439 ( 4.8A)
PEG  A1439 ( 3.9A)
None
 1.03A 4qtuB-4csiA:
undetectable		 4qtuB-4csiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6z APICOPLAST TIC22,
PUTATIVE

(Plasmodium
falciparum) 		PF04278
(Tic22) 		4 GLN A 262
SER A 263
ASP A 108
ASP A 115
 None
 1.41A 4qtuB-4e6zA:
undetectable		 4qtuB-4e6zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 TYR A 407
GLN A 106
SER A 371
ASP A 350
 None
 1.37A 4qtuB-4egvA:
undetectable		 4qtuB-4egvA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		4 GLN A 417
SER A 360
ASP A 237
ASP A 253
 None
 1.21A 4qtuB-4f6oA:
2.6		 4qtuB-4f6oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 TYR A 229
SER A 203
ASP A 195
ASP A  33
 None
 1.46A 4qtuB-4gniA:
undetectable		 4qtuB-4gniA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 TYR A 192
SER A 390
ASP A 235
ASP A 282
 None
None
None
CBI  A 501 ( 3.8A)
 1.27A 4qtuB-4haqA:
undetectable		 4qtuB-4haqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkw BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF07686
(V-set) 		4 GLN A  47
SER A  42
ASP A  93
ASP A  20
 None
 1.36A 4qtuB-4jkwA:
undetectable		 4qtuB-4jkwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kn5 METHYLTHIOADENOSINE
NUCLEOSIDASE

(Weissella
paramesenteroides) 		PF01048
(PNP_UDP_1) 		4 TYR A   3
GLN A 230
ASP A 122
ASP A  93
 None
 1.44A 4qtuB-4kn5A:
undetectable		 4qtuB-4kn5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD

(Salmonella
enterica) 		PF04453
(OstA_C) 		4 TYR A 665
GLN A 536
SER A 537
ASP A 594
 None
 1.28A 4qtuB-4n4rA:
undetectable		 4qtuB-4n4rA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 GLN A 256
SER A 254
ASP A 247
ASP A 243
 None
 1.31A 4qtuB-4nuzA:
undetectable		 4qtuB-4nuzA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pws PROLINE-RICH 28 KDA
ANTIGEN

(Mycobacterium
tuberculosis) 		PF10738
(Lpp-LpqN) 		4 TYR A 218
SER A 246
ASP A 189
ASP A 108
 None
 1.22A 4qtuB-4pwsA:
undetectable		 4qtuB-4pwsA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 TYR B  22
GLN B  32
SER B  61
ASP B  77
ASP B  99
 SAM  B 301 (-4.6A)
SAM  B 301 (-3.7A)
SAM  B 301 (-3.0A)
SAM  B 301 (-2.6A)
SAM  B 301 (-3.7A)
 0.02A 4qtuB-4qtuB:
39.9		 4qtuB-4qtuB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 171
SER A 372
ASP A 214
ASP A 262
 None
None
None
U63  A1443 ( 3.9A)
 1.06A 4qtuB-4v20A:
undetectable		 4qtuB-4v20A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 TYR A  17
GLN A  97
SER A  29
ASP A  22
 None
 0.96A 4qtuB-4wpxA:
undetectable		 4qtuB-4wpxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz0 E3 UBIQUITIN-PROTEIN
LIGASE LUBX

(Legionella
pneumophila) 		PF04564
(U-box) 		4 TYR A  56
GLN A  73
SER A  74
ASP A  10
 None
 1.35A 4qtuB-4wz0A:
undetectable		 4qtuB-4wz0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 168
SER A 369
ASP A 211
ASP A 259
 None
CE6  A 505 (-2.7A)
K  A 506 ( 4.7A)
CL  A 510 (-3.4A)
 1.10A 4qtuB-4xebA:
undetectable		 4qtuB-4xebA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yge MULTIPLE COAGULATION
FACTOR DEFICIENCY
PROTEIN 2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 TYR B  82
SER B  94
ASP B  89
ASP B 133
 None
None
CA  B 502 ( 4.7A)
CA  B 501 (-2.7A)
 1.48A 4qtuB-4ygeB:
undetectable		 4qtuB-4ygeB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 GLN A 468
SER A 444
ASP A 123
ASP A 200
 None
 1.31A 4qtuB-4zcfA:
2.4		 4qtuB-4zcfA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 170
SER A 371
ASP A 213
ASP A 261
 None
 1.13A 4qtuB-4zzpA:
undetectable		 4qtuB-4zzpA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 170
SER A 371
ASP A 213
ASP A 261
 None
 1.14A 4qtuB-4zzqA:
undetectable		 4qtuB-4zzqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 171
SER A 369
ASP A 214
ASP A 262
 None
 1.07A 4qtuB-5ampA:
undetectable		 4qtuB-5ampA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 4 TYR A  36
SER A 337
ASP A 312
ASP A 267
 None
None
BGC  A 701 ( 4.0A)
None
 1.49A 4qtuB-5awpA:
undetectable		 4qtuB-5awpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 GLN A 791
SER A 766
ASP A 763
ASP A 684
 None
 1.48A 4qtuB-5eawA:
3.2		 4qtuB-5eawA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 GLN A 130
SER A 131
ASP A 221
ASP A 216
 None
 1.35A 4qtuB-5ficA:
undetectable		 4qtuB-5ficA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 TYR A 453
GLN A 367
SER A 301
ASP A 283
 None
 1.44A 4qtuB-5fn4A:
undetectable		 4qtuB-5fn4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 TYR G 352
GLN G 494
SER G 383
ASP G 512
 None
 1.40A 4qtuB-5h0rG:
undetectable		 4qtuB-5h0rG:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 GLN A 143
SER A 142
ASP A  42
ASP A  63
 None
 1.14A 4qtuB-5h67A:
undetectable		 4qtuB-5h67A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 TYR A 129
GLN A 391
ASP A 206
ASP A 189
 BEM  A 502 ( 4.4A)
MAW  A 501 ( 3.7A)
None
None
 1.47A 4qtuB-5h71A:
undetectable		 4qtuB-5h71A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 779
GLN A 777
ASP A 628
ASP A 601
 None
 1.26A 4qtuB-5ju6A:
undetectable		 4qtuB-5ju6A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 TYR A 674
GLN A 540
ASP A 703
ASP A 797
 None
 1.26A 4qtuB-5ljoA:
undetectable		 4qtuB-5ljoA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		4 TYR A 195
SER A 399
ASP A 238
ASP A 286
 None
None
GOL  A 501 (-2.9A)
None
 1.06A 4qtuB-5mchA:
undetectable		 4qtuB-5mchA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4C

(Nora virus) 		no annotation 4 GLN A  86
SER A  82
ASP A  65
ASP A 292
 None
 1.34A 4qtuB-5mm2A:
undetectable		 4qtuB-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 4 GLN A 261
SER A 262
ASP A 118
ASP A 141
 None
 1.26A 4qtuB-5ndlA:
undetectable		 4qtuB-5ndlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 4 TYR A 403
GLN A 374
SER A 358
ASP A 210
 None
 1.23A 4qtuB-5npyA:
undetectable		 4qtuB-5npyA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 TYR A 171
SER A 365
ASP A 214
ASP A 262
 None
BTB  A 604 ( 4.9A)
BTB  A 604 ( 3.4A)
GOL  A 608 (-4.6A)
 1.05A 4qtuB-5o5dA:
undetectable		 4qtuB-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 GLN A  54
SER A   9
ASP A  33
ASP A 283
 None
 1.45A 4qtuB-5vaeA:
undetectable		 4qtuB-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 TYR A 172
SER A 370
ASP A 215
ASP A 263
 None
None
None
CTR  A 506 ( 3.8A)
 1.11A 4qtuB-5w11A:
undetectable		 4qtuB-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 TYR A 415
GLN A 538
SER A 535
ASP A 332
 None
 1.47A 4qtuB-5w7dA:
2.1		 4qtuB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 TYR A 371
GLN A 108
SER A 104
ASP A 313
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
None
None
 1.38A 4qtuB-5x62A:
13.8		 4qtuB-5x62A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc3 -

(-) 		no annotation 4 TYR B 347
GLN B 351
SER B 317
ASP B 308
 None
 1.37A 4qtuB-5zc3B:
undetectable		 4qtuB-5zc3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 4 TYR A 296
SER A 221
ASP A 125
ASP A   5
 None
 1.45A 4qtuB-6b2yA:
undetectable		 4qtuB-6b2yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 GLN A 713
SER A1430
ASP A1460
ASP A1465
 MG  A1603 ( 2.3A)
ATP  A1601 (-2.9A)
None
None
 1.46A 4qtuB-6bhuA:
undetectable		 4qtuB-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 TYR A 373
GLN A 487
SER A 486
ASP A 421
 None
 1.26A 4qtuB-6d6vA:
undetectable		 4qtuB-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 4 TYR A 391
GLN A  68
SER A  69
ASP A 422
 None
 1.47A 4qtuB-6dftA:
undetectable		 4qtuB-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 TYR A 275
GLN A 279
ASP A 313
ASP A 347
 None
 1.26A 4qtuB-6ei1A:
undetectable		 4qtuB-6ei1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 GLN D 132
SER D 303
ASP D 136
ASP D 364
 None
 1.41A 4qtuB-6f5dD:
undetectable		 4qtuB-6f5dD:
undetectable