SIMILAR PATTERNS OF AMINO ACIDS FOR 4QOP_B_HQEB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 123
PRO A 124
PHE A 149
LEU A 196
PHE A 197
 None
 0.36A 4qopB-1a4eA:
53.3		 4qopB-1a4eA:
41.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		5 PHE A  62
LEU A 147
LEU A 136
PHE A 135
ASP A  81
 None
 1.21A 4qopB-1bx0A:
0.2		 4qopB-1bx0A:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
 ACT  A5000 ( 4.9A)
None
None
None
None
 0.36A 4qopB-1dgfA:
56.3		 4qopB-1dgfA:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krt LYSYL-TRNA
SYNTHETASE (PRODUCT
OF LYSS GENE)

(Escherichia
coli) 		PF01336
(tRNA_anti-codon) 		5 ILE A 138
PHE A 113
LEU A  97
LEU A 122
ASP A  90
 None
 1.49A 4qopB-1krtA:
undetectable		 4qopB-1krtA:
11.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 130
PRO A 131
PHE A 156
LEU A 201
ASP A 181
 None
 0.83A 4qopB-1m7sA:
55.9		 4qopB-1m7sA:
49.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 PRO A 121
TYR A 246
LEU A 120
PHE A 235
ASP A 243
 None
 1.41A 4qopB-1nj8A:
0.0		 4qopB-1nj8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q80 SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Hediste
diversicolor) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ILE A  15
PRO A  95
PHE A 158
LEU A  96
PHE A 150
 None
 1.32A 4qopB-1q80A:
0.0		 4qopB-1q80A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 ILE A 162
PHE A 254
LEU A 256
LEU A 184
ASP A 178
 None
 1.36A 4qopB-1ru3A:
undetectable		 4qopB-1ru3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ILE A 184
PHE A 269
LEU A 232
LEU A 270
ASP A  57
 None
 1.30A 4qopB-1tzbA:
undetectable		 4qopB-1tzbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01634
(HisG) 		5 ILE E   6
PHE E 190
LEU E   4
LEU E 194
PHE E  79
 None
 1.45A 4qopB-1usyE:
undetectable		 4qopB-1usyE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		5 ILE A   2
PHE A  31
LEU A  29
LEU A 266
PHE A 263
 None
 1.44A 4qopB-1ycoA:
undetectable		 4qopB-1ycoA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		5 ILE A 406
PHE A 278
LEU A 409
LEU A 364
PHE A 367
 None
 1.19A 4qopB-2bw3A:
undetectable		 4qopB-2bw3A:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		8 ILE A  98
ASP A 109
PRO A 110
PHE A 135
LEU A 149
TYR A 163
PHE A 181
ASP A 446
 None
 0.26A 4qopB-2j2mA:
60.1		 4qopB-2j2mA:
63.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 453
PHE A 408
LEU A 432
LEU A 439
PHE A 487
 ILE  A 453 ( 0.4A)
PHE  A 408 ( 1.3A)
LEU  A 432 ( 0.5A)
LEU  A 439 ( 0.5A)
PHE  A 487 ( 1.3A)
 1.08A 4qopB-2vbfA:
undetectable		 4qopB-2vbfA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 118
PRO A 119
PHE A 144
LEU A 189
PHE A 190
 None
 0.47A 4qopB-2xq1A:
53.1		 4qopB-2xq1A:
44.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		5 PHE A 122
LEU A 145
TYR A 384
PHE A  72
ASP A 373
 None
 1.46A 4qopB-3e79A:
undetectable		 4qopB-3e79A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BS18A

(Homo sapiens) 		PF00453
(Ribosomal_L20) 		5 PRO r  71
PHE r  92
LEU r  88
TYR r  81
LEU r 107
 None
 1.23A 4qopB-3j7yr:
undetectable		 4qopB-3j7yr:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 ILE A 182
ASP A 180
LEU A 237
LEU A 114
PHE A 171
 None
 1.45A 4qopB-3mx3A:
undetectable		 4qopB-3mx3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrh UNCHARACTERIZED
PROTEIN BF1032

(Bacteroides
fragilis) 		PF16702
(DUF5063) 		5 ILE A 112
PHE A  38
LEU A 164
LEU A  27
PHE A  23
 None
 1.19A 4qopB-3nrhA:
undetectable		 4qopB-3nrhA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 PRO A 206
PHE A 246
LEU A 331
LEU A 355
PHE A 353
 None
 1.32A 4qopB-3pf2A:
undetectable		 4qopB-3pf2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 ILE B 429
PHE B 419
LEU B 426
LEU B 455
PHE B 451
 None
 1.44A 4qopB-3s4wB:
undetectable		 4qopB-3s4wB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlx ADENYLATE KINASE 2

(Plasmodium
falciparum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 ILE A  32
PHE A 109
LEU A 111
TYR A 114
LEU A 128
 None
None
None
AMP  A 245 (-4.9A)
None
 1.20A 4qopB-3tlxA:
undetectable		 4qopB-3tlxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 475
PHE A 503
LEU A 430
LEU A 402
ASP A 480
 None
 1.29A 4qopB-3v9eA:
undetectable		 4qopB-3v9eA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A 176
PHE A 134
LEU A 179
LEU A 200
PHE A 190
 None
 1.43A 4qopB-3wfoA:
undetectable		 4qopB-3wfoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		5 PRO A 385
LEU A 285
TYR A 288
LEU A  76
PHE A  67
 None
 1.46A 4qopB-4aplA:
undetectable		 4qopB-4aplA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 ASP A 243
PHE A 534
LEU A 156
LEU A 216
ASP A 517
 None
 1.32A 4qopB-4bbwA:
undetectable		 4qopB-4bbwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ILE A 817
PHE A 754
LEU A 661
LEU A 750
PHE A 746
 None
 1.41A 4qopB-4e93A:
undetectable		 4qopB-4e93A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 ILE A 511
PRO A 503
PHE A 401
LEU A 346
LEU A 405
 None
 1.40A 4qopB-4ft2A:
undetectable		 4qopB-4ft2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A1126
PHE A1048
LEU A 954
LEU A1044
PHE A1040
 None
 1.33A 4qopB-4gl9A:
undetectable		 4qopB-4gl9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 ASP A 259
PHE A 550
LEU A 172
LEU A 232
ASP A 533
 None
 1.40A 4qopB-4q6kA:
undetectable		 4qopB-4q6kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn8 VIPE

(Legionella
pneumophila) 		no annotation 5 ILE A  22
PHE A 105
LEU A  17
LEU A 101
PHE A  36
 None
 1.30A 4qopB-4qn8A:
undetectable		 4qopB-4qn8A:
16.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		9 ILE A  99
ASP A 110
PRO A 111
PHE A 136
LEU A 150
TYR A 164
LEU A 181
PHE A 182
ASP A 447
 None
2CH  A 503 (-4.1A)
None
2CH  A 503 (-4.1A)
2CH  A 503 (-4.2A)
2CH  A 503 (-4.1A)
2CH  A 503 (-4.8A)
2CH  A 503 ( 4.8A)
2CH  A 503 ( 4.6A)
 0.12A 4qopB-4qorA:
64.3		 4qopB-4qorA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens) 		PF02191
(OLF) 		5 ILE A 465
PHE A 430
LEU A 248
LEU A 486
ASP A 498
 None
 1.45A 4qopB-4wxuA:
undetectable		 4qopB-4wxuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 ILE A 357
PHE A 336
LEU A  98
LEU A 340
ASP A 324
 None
 0.93A 4qopB-5b2oA:
undetectable		 4qopB-5b2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 ILE A 319
PRO A 411
PHE A 402
LEU A 378
TYR A 315
 None
 1.40A 4qopB-5fdnA:
undetectable		 4qopB-5fdnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE B 254
LEU B 269
TYR B 293
LEU B 280
PHE B 304
 None
 1.40A 4qopB-5gqrB:
undetectable		 4qopB-5gqrB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 535
PHE A 502
LEU A 511
LEU A 499
PHE A 518
 None
 1.41A 4qopB-5gr8A:
undetectable		 4qopB-5gr8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 ILE A 668
PHE A 697
LEU A 745
LEU A 644
PHE A 604
 None
 1.46A 4qopB-5k04A:
undetectable		 4qopB-5k04A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzy SMOOTHENED

(Xenopus laevis) 		PF01392
(Fz) 		5 ILE A  95
LEU A  99
TYR A 103
PHE A 139
ASP A  68
 None
None
None
None
CY8  A1201 (-4.2A)
 1.43A 4qopB-5kzyA:
undetectable		 4qopB-5kzyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln4 PH 6 ANTIGEN,PH 6
ANTIGEN

(Yersinia pestis) 		no annotation 5 PRO A  48
PHE A 110
LEU A  67
LEU A  46
ASP A  93
 None
 1.41A 4qopB-5ln4A:
undetectable		 4qopB-5ln4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 ILE A 507
PHE A  89
LEU A 521
LEU A  93
ASP A 112
 None
 1.27A 4qopB-5oexA:
undetectable		 4qopB-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 209
PHE A 275
LEU A 221
LEU A 256
PHE A 194
 None
 1.47A 4qopB-5suiA:
undetectable		 4qopB-5suiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 5 ILE A 189
LEU A 375
TYR A  98
LEU A 297
ASP A 290
 None
 1.34A 4qopB-6eslA:
undetectable		 4qopB-6eslA:
10.70