SIMILAR PATTERNS OF AMINO ACIDS FOR 4QN9_B_DXCB610
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e4w | TAB2 (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY H 42PRO H 41ALA H 88 | None | 0.56A | 4qn9B-1e4wH:undetectable | 4qn9B-1e4wH:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ex6 | GUANYLATE KINASE (Saccharomycescerevisiae) |
PF00625(Guanylate_kin) | 3 | GLY A 8PRO A 9ALA A 149 | None | 0.54A | 4qn9B-1ex6A:0.0 | 4qn9B-1ex6A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyy | ALDEHYDEDEHYDROGENASE (Vibrio harveyi) |
PF00171(Aldedh) | 3 | GLY A 326PRO A 325ALA A 14 | None | 0.39A | 4qn9B-1eyyA:0.2 | 4qn9B-1eyyA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fi4 | MEVALONATE5-DIPHOSPHATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00288(GHMP_kinases_N) | 3 | GLY A 378PRO A 379ALA A 127 | None | 0.43A | 4qn9B-1fi4A:undetectable | 4qn9B-1fi4A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fuu | YEAST INITIATIONFACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 3 | GLY A 147PRO A 146ALA A 96 | None | 0.52A | 4qn9B-1fuuA:0.7 | 4qn9B-1fuuA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h8s | MUTANT AL2 6E7P9G (Mus musculus) |
PF07686(V-set) | 3 | GLY A 173PRO A 172ALA A 223 | None | 0.50A | 4qn9B-1h8sA:undetectable | 4qn9B-1h8sA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mfa | IGG1-LAMBDA SE155-4FAB (HEAVY CHAIN) (Mus musculus) |
PF07686(V-set) | 3 | GLY H 292PRO H 291ALA H 342 | None | 0.49A | 4qn9B-1mfaH:undetectable | 4qn9B-1mfaH:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q0u | BSTDEAD (Geobacillusstearothermophilus) |
PF00270(DEAD) | 3 | GLY A 135PRO A 134ALA A 79 | None | 0.45A | 4qn9B-1q0uA:1.0 | 4qn9B-1q0uA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qva | INITIATION FACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 3 | GLY A 147PRO A 146ALA A 96 | None | 0.49A | 4qn9B-1qvaA:0.8 | 4qn9B-1qvaA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ril | RIBONUCLEASE H (Thermusthermophilus) |
PF00075(RNase_H) | 3 | GLY A 18PRO A 19ALA A 145 | None | 0.41A | 4qn9B-1rilA:undetectable | 4qn9B-1rilA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sp8 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Zea mays) |
PF00903(Glyoxalase) | 3 | GLY A 162PRO A 163ALA A 145 | None | 0.55A | 4qn9B-1sp8A:undetectable | 4qn9B-1sp8A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w18 | LEVANSUCRASE (Gluconacetobacterdiazotrophicus) |
PF02435(Glyco_hydro_68) | 3 | GLY A 429PRO A 430ALA A 480 | None | 0.53A | 4qn9B-1w18A:undetectable | 4qn9B-1w18A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wly | 2-HALOACRYLATEREDUCTASE (Burkholderiasp. WS) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | GLY A 12PRO A 13ALA A 311 | GLY A 12 ( 0.0A)PRO A 13 ( 1.1A)ALA A 311 ( 0.0A) | 0.53A | 4qn9B-1wlyA:undetectable | 4qn9B-1wlyA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wrb | DJVLGB (Dugesiajaponica) |
PF00270(DEAD) | 3 | GLY A 320PRO A 319ALA A 268 | None | 0.51A | 4qn9B-1wrbA:undetectable | 4qn9B-1wrbA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkn | PUTATIVEPEPTIDYL-ARGININEDEIMINASE (Chlorobaculumtepidum) |
PF04371(PAD_porph) | 3 | GLY A 99PRO A 100ALA A 141 | None | 0.47A | 4qn9B-1xknA:undetectable | 4qn9B-1xknA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yya | TRIOSEPHOSPHATEISOMERASE (Thermusthermophilus) |
PF00121(TIM) | 3 | GLY A 157PRO A 158ALA A 202 | None | 0.48A | 4qn9B-1yyaA:undetectable | 4qn9B-1yyaA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2arj | YTS 105.18 ANTIGENBINDING REGION LIGHTCHAIN (Rattusnorvegicus) |
no annotation | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.53A | 4qn9B-2arjL:undetectable | 4qn9B-2arjL:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7t | ANTIPOLYHYDROXYBUTYRATEANTIBODY FV, LIGHTCHAIN (Homo sapiens) |
PF07686(V-set) | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.50A | 4qn9B-2d7tL:undetectable | 4qn9B-2d7tL:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef0 | ORNITHINECARBAMOYLTRANSFERASE (Thermusthermophilus) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | GLY A 19PRO A 20ALA A 177 | None | 0.44A | 4qn9B-2ef0A:undetectable | 4qn9B-2ef0A:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g9n | EUKARYOTICINITIATION FACTOR4A-I (Homo sapiens) |
PF00270(DEAD) | 3 | GLY A 160PRO A 159ALA A 107 | None | 0.55A | 4qn9B-2g9nA:undetectable | 4qn9B-2g9nA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0u | ATP-DEPENDENT RNAHELICASE DDX48 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 165PRO A 164ALA A 113 | None | 0.52A | 4qn9B-2j0uA:undetectable | 4qn9B-2j0uA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kvp | TALIN-1 (Mus musculus) |
PF08913(VBS) | 3 | GLY A1841PRO A1842ALA A1903 | None | 0.50A | 4qn9B-2kvpA:undetectable | 4qn9B-2kvpA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxc | PROBABLEATP-DEPENDENT RNAHELICASE DDX20 (Homo sapiens) |
PF00270(DEAD) | 3 | GLY A 189PRO A 188ALA A 137 | None | 0.50A | 4qn9B-2oxcA:undetectable | 4qn9B-2oxcA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pce | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | GLY A 174PRO A 175ALA A 208 | None | 0.55A | 4qn9B-2pceA:undetectable | 4qn9B-2pceA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfq | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 3 | GLY A 80PRO A 81ALA A 105 | None | 0.30A | 4qn9B-2qfqA:undetectable | 4qn9B-2qfqA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xij | METHYLMALONYL-COAMUTASE,MITOCHONDRIAL (Homo sapiens) |
PF01642(MM_CoA_mutase)PF02310(B12-binding) | 3 | GLY A 648PRO A 649ALA A 578 | None | 0.51A | 4qn9B-2xijA:undetectable | 4qn9B-2xijA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yut | PUTATIVE SHORT-CHAINOXIDOREDUCTASE (Thermusthermophilus) |
PF00106(adh_short) | 3 | GLY A 177PRO A 178ALA A 166 | NoneNoneNAP A 500 (-4.3A) | 0.52A | 4qn9B-2yutA:2.4 | 4qn9B-2yutA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzw | ADP-RIBOSYLGLYCOHYDROLASE (Thermusthermophilus) |
PF03747(ADP_ribosyl_GH) | 3 | GLY A 129PRO A 130ALA A 154 | None | 0.52A | 4qn9B-2yzwA:undetectable | 4qn9B-2yzwA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zu6 | EUKARYOTICINITIATION FACTOR4A-I (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 160PRO A 159ALA A 107 | None | 0.49A | 4qn9B-2zu6A:undetectable | 4qn9B-2zu6A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agf | GLUTAMINASE 1 (Bacillussubtilis) |
PF04960(Glutaminase) | 3 | GLY A 138PRO A 137ALA A 84 | None | 0.56A | 4qn9B-3agfA:undetectable | 4qn9B-3agfA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4q | PREDICTEDGLYCOSYLTRANSFERASES (Corynebacteriumglutamicum) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 3 | GLY A 205PRO A 204ALA A 327 | None | 0.41A | 4qn9B-3c4qA:undetectable | 4qn9B-3c4qA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe2 | PROBABLEATP-DEPENDENT RNAHELICASE DDX5 (Homo sapiens) |
PF00270(DEAD) | 3 | GLY A 226PRO A 225ALA A 174 | SO4 A 3 (-3.5A)SO4 A 3 ( 4.3A)None | 0.47A | 4qn9B-3fe2A:undetectable | 4qn9B-3fe2A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fho | ATP-DEPENDENT RNAHELICASE DBP5 (Schizosaccharomycespombe) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 239PRO A 238ALA A 191 | None | 0.51A | 4qn9B-3fhoA:undetectable | 4qn9B-3fhoA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 3 | GLY A 376PRO A 377ALA A 315 | None | 0.51A | 4qn9B-3h5lA:undetectable | 4qn9B-3h5lA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iru | PHOSHONOACETALDEHYDEHYDROLASE LIKEPROTEIN (Oleispiraantarctica) |
PF13419(HAD_2) | 3 | GLY A 137PRO A 136ALA A 159 | None | 0.40A | 4qn9B-3iruA:undetectable | 4qn9B-3iruA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ke6 | PROTEINRV1364C/MT1410 (Mycobacteriumtuberculosis) |
PF07228(SpoIIE)PF13581(HATPase_c_2) | 3 | GLY A 302PRO A 303ALA A 260 | None | 0.48A | 4qn9B-3ke6A:undetectable | 4qn9B-3ke6A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khz | PUTATIVE DIPEPTIDASESACOL1801 (Staphylococcusaureus) |
PF01546(Peptidase_M20) | 3 | GLY A 41PRO A 40ALA A 32 | None | 0.52A | 4qn9B-3khzA:undetectable | 4qn9B-3khzA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sh5 | LG3 PEPTIDE (Homo sapiens) |
PF00054(Laminin_G_1) | 3 | GLY A 125PRO A 124ALA A 84 | None | 0.46A | 4qn9B-3sh5A:undetectable | 4qn9B-3sh5A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqw | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 244PRO A 243ALA A 187 | U B 7 ( 3.1A) U B 6 ( 3.9A)None | 0.52A | 4qn9B-3sqwA:undetectable | 4qn9B-3sqwA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t66 | NICKEL ABCTRANSPORTER(NICKEL-BINDINGPROTEIN) (Bacillushalodurans) |
PF00496(SBP_bac_5) | 3 | GLY A 160PRO A 161ALA A 185 | None | 0.52A | 4qn9B-3t66A:undetectable | 4qn9B-3t66A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 3 | GLY A 376PRO A 377ALA A 127 | None | 0.54A | 4qn9B-3va8A:1.5 | 4qn9B-3va8A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vxi | DYP (Bjerkanderaadusta) |
PF04261(Dyp_perox) | 3 | GLY A 320PRO A 321ALA A 190 | ASC A 502 (-4.6A)ASC A 502 (-3.6A)ASC A 502 (-3.4A) | 0.33A | 4qn9B-3vxiA:undetectable | 4qn9B-3vxiA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wov | OLIGOSACCHARYLTRANSFERASE (Pyrococcusabyssi) |
no annotation | 3 | GLY A 757PRO A 756ALA A 970 | None | 0.56A | 4qn9B-3wovA:undetectable | 4qn9B-3wovA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr4 | 26S PROTEASEREGULATORY SUBUNIT6B HOMOLOG26S PROTEASE SUBUNITRPT4 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00004(AAA)PF00004(AAA) | 3 | GLY K 213PRO K 214ALA L 336 | None | 0.40A | 4qn9B-4cr4K:undetectable | 4qn9B-4cr4K:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | GLY A 372PRO A 373ALA A 124 | None | 0.56A | 4qn9B-4dhgA:undetectable | 4qn9B-4dhgA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnh | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF06187(DUF993) | 3 | GLY A 168PRO A 169ALA A 212 | None | 0.47A | 4qn9B-4dnhA:1.7 | 4qn9B-4dnhA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1n | KPAGO (Vanderwaltozymapolyspora) |
PF02171(Piwi) | 3 | GLY A 832PRO A 833ALA A1210 | None | 0.36A | 4qn9B-4f1nA:undetectable | 4qn9B-4f1nA:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqd | NIKO PROTEIN (Streptomycestendae) |
PF00275(EPSP_synthase) | 3 | GLY A 249PRO A 250ALA A 47 | None | 0.53A | 4qn9B-4fqdA:undetectable | 4qn9B-4fqdA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6r | LIGHT CHAIN OFANTIBODY VRC23 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY L 41PRO L 40ALA L 84 | NoneNoneEDO L 303 ( 4.5A) | 0.51A | 4qn9B-4j6rL:undetectable | 4qn9B-4j6rL:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jm4 | PGT 135 LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.51A | 4qn9B-4jm4L:undetectable | 4qn9B-4jm4L:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jpw | LIGHT CHAIN OFANTIBODY 12A21 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.52A | 4qn9B-4jpwL:undetectable | 4qn9B-4jpwL:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ksd | R2 PROTEIN (Lama glama) |
PF07686(V-set) | 3 | GLY B 42PRO B 41ALA B 92 | None | 0.51A | 4qn9B-4ksdB:undetectable | 4qn9B-4ksdB:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l05 | SUPEROXIDE DISMUTASE[CU-ZN] (Brucellaabortus) |
PF00080(Sod_Cu) | 3 | GLY A 84PRO A 85ALA A 111 | None | 0.56A | 4qn9B-4l05A:undetectable | 4qn9B-4l05A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk2 | PRE-MRNA-PROCESSINGATP-DEPENDENT RNAHELICASE PRP5 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 390PRO A 389ALA A 337 | None | 0.52A | 4qn9B-4lk2A:1.5 | 4qn9B-4lk2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nho | PROBABLEATP-DEPENDENT RNAHELICASE DDX23 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 527PRO A 526ALA A 475 | SO4 A 902 (-3.3A)SO4 A 902 ( 4.8A)None | 0.49A | 4qn9B-4nhoA:undetectable | 4qn9B-4nhoA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqj | PKS (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 3 | GLY A 316PRO A 317ALA A 344 | None | 0.39A | 4qn9B-4oqjA:undetectable | 4qn9B-4oqjA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p52 | HOMOSERINE KINASE (Cytophagahutchinsonii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | GLY A 305PRO A 306ALA A 105 | None | 0.35A | 4qn9B-4p52A:undetectable | 4qn9B-4p52A:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pqh | GLUTATHIONETRANSFERASE LAMBDA1 (Populustrichocarpa) |
PF13410(GST_C_2)PF13417(GST_N_3) | 3 | GLY A 161PRO A 162ALA A 203 | None | 0.42A | 4qn9B-4pqhA:undetectable | 4qn9B-4pqhA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pqi | IN2-1 FAMILYPROTEIN, GLUTATHIONETRANSFERASE LAMBDA3 (Populustrichocarpa) |
PF13410(GST_C_2)PF13417(GST_N_3) | 3 | GLY A 167PRO A 168ALA A 210 | CA A 302 (-4.6A)NoneNone | 0.56A | 4qn9B-4pqiA:undetectable | 4qn9B-4pqiA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4px9 | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00270(DEAD) | 3 | GLY A 325PRO A 324ALA A 273 | None | 0.48A | 4qn9B-4px9A:undetectable | 4qn9B-4px9A:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qaw | XYN30D (Paenibacillusbarcinonensis) |
PF03422(CBM_6)PF17189(Glyco_hydro_30C) | 3 | GLY A 519PRO A 520ALA A 462 | None | 0.55A | 4qn9B-4qawA:undetectable | 4qn9B-4qawA:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qn9 | N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D (Homo sapiens) |
PF12706(Lactamase_B_2) | 3 | GLY A 161PRO A 162ALA A 348 | 3PE A 503 ( 4.5A)3PE A 503 ( 4.7A)None | 0.07A | 4qn9B-4qn9A:60.5 | 4qn9B-4qn9A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rn3 | HAD SUPERFAMILYHYDROLASE (Geobactersulfurreducens) |
PF13419(HAD_2) | 3 | GLY A 164PRO A 165ALA A 184 | None | 0.50A | 4qn9B-4rn3A:undetectable | 4qn9B-4rn3A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tz0 | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 244PRO A 243ALA A 187 | A B 6 ( 3.4A) A B 5 ( 4.1A)None | 0.49A | 4qn9B-4tz0A:undetectable | 4qn9B-4tz0A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7s | PRE-MRNA-SPLICINGATP-DEPENDENT RNAHELICASE PRP28 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 319PRO A 318ALA A 261 | None | 0.54A | 4qn9B-4w7sA:undetectable | 4qn9B-4w7sA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd1 | ACETOACETATE-COALIGASE (Streptomyceslividans) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 3 | GLY A 304PRO A 305ALA A 100 | NoneEDO A 718 ( 4.1A)EDO A 718 ( 3.7A) | 0.48A | 4qn9B-4wd1A:undetectable | 4qn9B-4wd1A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4whb | PHENYLUREA HYDROLASEB (Mycolicibacteriumbrisbanense) |
no annotation | 3 | GLY E 148PRO E 149ALA E 71 | None | 0.55A | 4qn9B-4whbE:1.4 | 4qn9B-4whbE:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrl | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR (Homo sapiens) |
PF00047(ig) | 3 | GLY A 201PRO A 202ALA A 280 | None | 0.53A | 4qn9B-4wrlA:undetectable | 4qn9B-4wrlA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrm | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR (Homo sapiens) |
PF00047(ig)PF13927(Ig_3) | 3 | GLY A 201PRO A 202ALA A 280 | None | 0.53A | 4qn9B-4wrmA:undetectable | 4qn9B-4wrmA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7y | DIPHOSPHOMEVALONATEDECARBOXYLASE (Sulfolobussolfataricus) |
PF00288(GHMP_kinases_N) | 3 | GLY A 318PRO A 319ALA A 113 | SO4 A 401 (-4.3A)NoneNone | 0.37A | 4qn9B-4z7yA:undetectable | 4qn9B-4z7yA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zb1 | BLUE CHROMOPROTEIN,SGBP (Stichodactylagigantea) |
PF01353(GFP) | 3 | GLY A 129PRO A 130ALA A 164 | None | 0.55A | 4qn9B-4zb1A:undetectable | 4qn9B-4zb1A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zbl | PHOTOSESITIZERMKILLERORANGE (Hydrozoa) |
PF01353(GFP) | 3 | GLY A 132PRO A 133ALA A 168 | None | 0.51A | 4qn9B-4zblA:undetectable | 4qn9B-4zblA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITGAMMA (Methanothermobactermarburgensis) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 3 | GLY B 371PRO B 372ALA B 328 | None | 0.48A | 4qn9B-5a8rB:undetectable | 4qn9B-5a8rB:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayh | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Mus musculus) |
PF12777(MT) | 3 | GLY A3388PRO A3389ALA A3290 | None | 0.54A | 4qn9B-5ayhA:undetectable | 4qn9B-5ayhA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b47 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N)PF17147(PFOR_II) | 3 | GLY A 319PRO A 318ALA A 346 | TPP B 402 ( 4.6A)TPP B 402 (-4.6A)None | 0.47A | 4qn9B-5b47A:undetectable | 4qn9B-5b47A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cer | BD0816 (Bdellovibriobacteriovorus) |
PF02113(Peptidase_S13) | 3 | GLY A 403PRO A 404ALA A 338 | None | 0.51A | 4qn9B-5cerA:undetectable | 4qn9B-5cerA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmg | RB86 ANTIBODY FABFRAGMENT LIGHT CHAIN (Oryctolaguscuniculus) |
no annotation | 3 | GLY L 607PRO L 606ALA L 730 | None | 0.56A | 4qn9B-5dmgL:undetectable | 4qn9B-5dmgL:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7j | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 325PRO A 324ALA A 273 | None | 0.48A | 4qn9B-5e7jA:undetectable | 4qn9B-5e7jA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5elx | ATP-DEPENDENT RNAHELICASE DBP5 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLY A 217PRO A 216ALA A 169 | U B 5 ( 3.3A) U B 4 ( 3.8A)None | 0.53A | 4qn9B-5elxA:undetectable | 4qn9B-5elxA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | GLY A1232PRO A1233ALA A 431 | None | 0.32A | 4qn9B-5epgA:undetectable | 4qn9B-5epgA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 3 | GLY A1141PRO A1142ALA A1150 | None | 0.51A | 4qn9B-5eqqA:undetectable | 4qn9B-5eqqA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gju | ATP-DEPENDENT RNAHELICASE DEAD (Escherichiacoli) |
PF00270(DEAD) | 3 | GLY A 134PRO A 133ALA A 81 | None | 0.51A | 4qn9B-5gjuA:undetectable | 4qn9B-5gjuA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxb | NANOBODY (Vicugna pacos) |
PF07686(V-set) | 3 | GLY B 42PRO B 41ALA B 92 | None | 0.49A | 4qn9B-5gxbB:undetectable | 4qn9B-5gxbB:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 3 | GLY A 24PRO A 23ALA A 8 | None | 0.48A | 4qn9B-5h42A:undetectable | 4qn9B-5h42A:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5p | TRAP TRANSPORTERSOLUTE BINDINGPROTEIN (unculturedmarinebacterium) |
PF03480(DctP) | 3 | GLY A 299PRO A 300ALA A 160 | None | 0.51A | 4qn9B-5i5pA:undetectable | 4qn9B-5i5pA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilt | BOVINE FAB A01 LIGHTCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.51A | 4qn9B-5iltL:undetectable | 4qn9B-5iltL:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ivl | DEAD-BOXATP-DEPENDENT RNAHELICASE CSHA (Geobacillusstearothermophilus) |
no annotation | 3 | GLY B 129PRO B 128ALA B 77 | None | 0.49A | 4qn9B-5ivlB:undetectable | 4qn9B-5ivlB:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 3 | GLY A 373PRO A 374ALA A 220 | None | 0.55A | 4qn9B-5ja1A:undetectable | 4qn9B-5ja1A:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbw | RIBOFLAVINTRANSPORTER RIBU (Thermotogamaritima) |
PF12822(ECF_trnsprt) | 3 | GLY A 51PRO A 52ALA A 91 | None | 0.41A | 4qn9B-5kbwA:undetectable | 4qn9B-5kbwA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kei | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | GLY A 128PRO A 127ALA A 256 | None | 0.56A | 4qn9B-5keiA:1.4 | 4qn9B-5keiA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1q | METHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT BETA (Methanothermococcusthermolithotrophicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 3 | GLY B 371PRO B 372ALA B 328 | None | 0.56A | 4qn9B-5n1qB:undetectable | 4qn9B-5n1qB:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tgd | FOLM ALTERNATIVEDIHYDROFOLATEREDUCTASE (Brucella suis) |
PF00106(adh_short) | 3 | GLY A 95PRO A 96ALA A 141 | None | 0.44A | 4qn9B-5tgdA:2.4 | 4qn9B-5tgdA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5the | UNCHARACTERIZEDPROTEIN (Vanderwaltozymapolyspora) |
no annotation | 3 | GLY A 832PRO A 833ALA A1210 | None | 0.54A | 4qn9B-5theA:undetectable | 4qn9B-5theA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uy3 | ANTIBODY PGT144 FABLIGHT CHAIN (Homo sapiens) |
no annotation | 3 | GLY L 41PRO L 40ALA L 84 | None | 0.56A | 4qn9B-5uy3L:undetectable | 4qn9B-5uy3L:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlp | FAB7G7 HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | GLY H 42PRO H 41ALA H 92 | None | 0.48A | 4qn9B-5vlpH:undetectable | 4qn9B-5vlpH:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdu | BNAB NIH45-46 SCFVHEAVY CHAIN (Homo sapiens) |
no annotation | 3 | GLY D 42PRO D 41ALA D 88 | None | 0.54A | 4qn9B-5wduD:undetectable | 4qn9B-5wduD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x41 | COBALT TRANSPORTPROTEIN CBIM (Rhodobactercapsulatus) |
no annotation | 3 | GLY M 81PRO M 82ALA M 123 | None | 0.52A | 4qn9B-5x41M:undetectable | 4qn9B-5x41M:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y58 | ATP-DEPENDENT DNAHELICASE II SUBUNIT1 (Saccharomycescerevisiae) |
no annotation | 3 | GLY A 242PRO A 243ALA A 204 | None | 0.55A | 4qn9B-5y58A:undetectable | 4qn9B-5y58A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqc | SCFV OF 9C12ANTIBODY (Mus musculus) |
no annotation | 3 | GLY D 48PRO D 47ALA D 91 | None | 0.28A | 4qn9B-6eqcD:undetectable | 4qn9B-6eqcD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fbt | LYTIC MUREINTRANSGLYCOSYLASE (Pseudomonasaeruginosa) |
no annotation | 3 | GLY A 525PRO A 524ALA A 516 | None | 0.52A | 4qn9B-6fbtA:undetectable | 4qn9B-6fbtA:undetectable |