SIMILAR PATTERNS OF AMINO ACIDS FOR 4QN9_B_DXCB610

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4w TAB2

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY H  42
PRO H  41
ALA H  88
None
0.56A 4qn9B-1e4wH:
undetectable
4qn9B-1e4wH:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae)
PF00625
(Guanylate_kin)
3 GLY A   8
PRO A   9
ALA A 149
None
0.54A 4qn9B-1ex6A:
0.0
4qn9B-1ex6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE


(Vibrio harveyi)
PF00171
(Aldedh)
3 GLY A 326
PRO A 325
ALA A  14
None
0.39A 4qn9B-1eyyA:
0.2
4qn9B-1eyyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00288
(GHMP_kinases_N)
3 GLY A 378
PRO A 379
ALA A 127
None
0.43A 4qn9B-1fi4A:
undetectable
4qn9B-1fi4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
3 GLY A 147
PRO A 146
ALA A  96
None
0.52A 4qn9B-1fuuA:
0.7
4qn9B-1fuuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8s MUTANT AL2 6E7P9G

(Mus musculus)
PF07686
(V-set)
3 GLY A 173
PRO A 172
ALA A 223
None
0.50A 4qn9B-1h8sA:
undetectable
4qn9B-1h8sA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)


(Mus musculus)
PF07686
(V-set)
3 GLY H 292
PRO H 291
ALA H 342
None
0.49A 4qn9B-1mfaH:
undetectable
4qn9B-1mfaH:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus)
PF00270
(DEAD)
3 GLY A 135
PRO A 134
ALA A  79
None
0.45A 4qn9B-1q0uA:
1.0
4qn9B-1q0uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae)
PF00270
(DEAD)
3 GLY A 147
PRO A 146
ALA A  96
None
0.49A 4qn9B-1qvaA:
0.8
4qn9B-1qvaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ril RIBONUCLEASE H

(Thermus
thermophilus)
PF00075
(RNase_H)
3 GLY A  18
PRO A  19
ALA A 145
None
0.41A 4qn9B-1rilA:
undetectable
4qn9B-1rilA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Zea mays)
PF00903
(Glyoxalase)
3 GLY A 162
PRO A 163
ALA A 145
None
0.55A 4qn9B-1sp8A:
undetectable
4qn9B-1sp8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus)
PF02435
(Glyco_hydro_68)
3 GLY A 429
PRO A 430
ALA A 480
None
0.53A 4qn9B-1w18A:
undetectable
4qn9B-1w18A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE


(Burkholderia
sp. WS)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 GLY A  12
PRO A  13
ALA A 311
GLY  A  12 ( 0.0A)
PRO  A  13 ( 1.1A)
ALA  A 311 ( 0.0A)
0.53A 4qn9B-1wlyA:
undetectable
4qn9B-1wlyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica)
PF00270
(DEAD)
3 GLY A 320
PRO A 319
ALA A 268
None
0.51A 4qn9B-1wrbA:
undetectable
4qn9B-1wrbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE


(Chlorobaculum
tepidum)
PF04371
(PAD_porph)
3 GLY A  99
PRO A 100
ALA A 141
None
0.47A 4qn9B-1xknA:
undetectable
4qn9B-1xknA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE


(Thermus
thermophilus)
PF00121
(TIM)
3 GLY A 157
PRO A 158
ALA A 202
None
0.48A 4qn9B-1yyaA:
undetectable
4qn9B-1yyaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arj YTS 105.18 ANTIGEN
BINDING REGION LIGHT
CHAIN


(Rattus
norvegicus)
no annotation 3 GLY L  41
PRO L  40
ALA L  84
None
0.53A 4qn9B-2arjL:
undetectable
4qn9B-2arjL:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN


(Homo sapiens)
PF07686
(V-set)
3 GLY L  41
PRO L  40
ALA L  84
None
0.50A 4qn9B-2d7tL:
undetectable
4qn9B-2d7tL:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE


(Thermus
thermophilus)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 GLY A  19
PRO A  20
ALA A 177
None
0.44A 4qn9B-2ef0A:
undetectable
4qn9B-2ef0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I


(Homo sapiens)
PF00270
(DEAD)
3 GLY A 160
PRO A 159
ALA A 107
None
0.55A 4qn9B-2g9nA:
undetectable
4qn9B-2g9nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0u ATP-DEPENDENT RNA
HELICASE DDX48


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 165
PRO A 164
ALA A 113
None
0.52A 4qn9B-2j0uA:
undetectable
4qn9B-2j0uA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus)
PF08913
(VBS)
3 GLY A1841
PRO A1842
ALA A1903
None
0.50A 4qn9B-2kvpA:
undetectable
4qn9B-2kvpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20


(Homo sapiens)
PF00270
(DEAD)
3 GLY A 189
PRO A 188
ALA A 137
None
0.50A 4qn9B-2oxcA:
undetectable
4qn9B-2oxcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 GLY A 174
PRO A 175
ALA A 208
None
0.55A 4qn9B-2pceA:
undetectable
4qn9B-2pceA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
3 GLY A  80
PRO A  81
ALA A 105
None
0.30A 4qn9B-2qfqA:
undetectable
4qn9B-2qfqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL


(Homo sapiens)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
3 GLY A 648
PRO A 649
ALA A 578
None
0.51A 4qn9B-2xijA:
undetectable
4qn9B-2xijA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE


(Thermus
thermophilus)
PF00106
(adh_short)
3 GLY A 177
PRO A 178
ALA A 166
None
None
NAP  A 500 (-4.3A)
0.52A 4qn9B-2yutA:
2.4
4qn9B-2yutA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE


(Thermus
thermophilus)
PF03747
(ADP_ribosyl_GH)
3 GLY A 129
PRO A 130
ALA A 154
None
0.52A 4qn9B-2yzwA:
undetectable
4qn9B-2yzwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 160
PRO A 159
ALA A 107
None
0.49A 4qn9B-2zu6A:
undetectable
4qn9B-2zu6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agf GLUTAMINASE 1

(Bacillus
subtilis)
PF04960
(Glutaminase)
3 GLY A 138
PRO A 137
ALA A  84
None
0.56A 4qn9B-3agfA:
undetectable
4qn9B-3agfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES


(Corynebacterium
glutamicum)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
3 GLY A 205
PRO A 204
ALA A 327
None
0.41A 4qn9B-3c4qA:
undetectable
4qn9B-3c4qA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5


(Homo sapiens)
PF00270
(DEAD)
3 GLY A 226
PRO A 225
ALA A 174
SO4  A   3 (-3.5A)
SO4  A   3 ( 4.3A)
None
0.47A 4qn9B-3fe2A:
undetectable
4qn9B-3fe2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5


(Schizosaccharomyces
pombe)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 239
PRO A 238
ALA A 191
None
0.51A 4qn9B-3fhoA:
undetectable
4qn9B-3fhoA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
3 GLY A 376
PRO A 377
ALA A 315
None
0.51A 4qn9B-3h5lA:
undetectable
4qn9B-3h5lA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN


(Oleispira
antarctica)
PF13419
(HAD_2)
3 GLY A 137
PRO A 136
ALA A 159
None
0.40A 4qn9B-3iruA:
undetectable
4qn9B-3iruA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410


(Mycobacterium
tuberculosis)
PF07228
(SpoIIE)
PF13581
(HATPase_c_2)
3 GLY A 302
PRO A 303
ALA A 260
None
0.48A 4qn9B-3ke6A:
undetectable
4qn9B-3ke6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
3 GLY A  41
PRO A  40
ALA A  32
None
0.52A 4qn9B-3khzA:
undetectable
4qn9B-3khzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
3 GLY A 125
PRO A 124
ALA A  84
None
0.46A 4qn9B-3sh5A:
undetectable
4qn9B-3sh5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 244
PRO A 243
ALA A 187
U  B   7 ( 3.1A)
U  B   6 ( 3.9A)
None
0.52A 4qn9B-3sqwA:
undetectable
4qn9B-3sqwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)


(Bacillus
halodurans)
PF00496
(SBP_bac_5)
3 GLY A 160
PRO A 161
ALA A 185
None
0.52A 4qn9B-3t66A:
undetectable
4qn9B-3t66A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum)
PF13378
(MR_MLE_C)
3 GLY A 376
PRO A 377
ALA A 127
None
0.54A 4qn9B-3va8A:
1.5
4qn9B-3va8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta)
PF04261
(Dyp_perox)
3 GLY A 320
PRO A 321
ALA A 190
ASC  A 502 (-4.6A)
ASC  A 502 (-3.6A)
ASC  A 502 (-3.4A)
0.33A 4qn9B-3vxiA:
undetectable
4qn9B-3vxiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE


(Pyrococcus
abyssi)
no annotation 3 GLY A 757
PRO A 756
ALA A 970
None
0.56A 4qn9B-3wovA:
undetectable
4qn9B-3wovA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00004
(AAA)
PF00004
(AAA)
3 GLY K 213
PRO K 214
ALA L 336
None
0.40A 4qn9B-4cr4K:
undetectable
4qn9B-4cr4K:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 GLY A 372
PRO A 373
ALA A 124
None
0.56A 4qn9B-4dhgA:
undetectable
4qn9B-4dhgA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN


(Sinorhizobium
meliloti)
PF06187
(DUF993)
3 GLY A 168
PRO A 169
ALA A 212
None
0.47A 4qn9B-4dnhA:
1.7
4qn9B-4dnhA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
3 GLY A 832
PRO A 833
ALA A1210
None
0.36A 4qn9B-4f1nA:
undetectable
4qn9B-4f1nA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae)
PF00275
(EPSP_synthase)
3 GLY A 249
PRO A 250
ALA A  47
None
0.53A 4qn9B-4fqdA:
undetectable
4qn9B-4fqdA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY L  41
PRO L  40
ALA L  84
None
None
EDO  L 303 ( 4.5A)
0.51A 4qn9B-4j6rL:
undetectable
4qn9B-4j6rL:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm4 PGT 135 LIGHT CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY L  41
PRO L  40
ALA L  84
None
0.51A 4qn9B-4jm4L:
undetectable
4qn9B-4jm4L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw LIGHT CHAIN OF
ANTIBODY 12A21


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY L  41
PRO L  40
ALA L  84
None
0.52A 4qn9B-4jpwL:
undetectable
4qn9B-4jpwL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksd R2 PROTEIN

(Lama glama)
PF07686
(V-set)
3 GLY B  42
PRO B  41
ALA B  92
None
0.51A 4qn9B-4ksdB:
undetectable
4qn9B-4ksdB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]


(Brucella
abortus)
PF00080
(Sod_Cu)
3 GLY A  84
PRO A  85
ALA A 111
None
0.56A 4qn9B-4l05A:
undetectable
4qn9B-4l05A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 390
PRO A 389
ALA A 337
None
0.52A 4qn9B-4lk2A:
1.5
4qn9B-4lk2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 527
PRO A 526
ALA A 475
SO4  A 902 (-3.3A)
SO4  A 902 ( 4.8A)
None
0.49A 4qn9B-4nhoA:
undetectable
4qn9B-4nhoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
3 GLY A 316
PRO A 317
ALA A 344
None
0.39A 4qn9B-4oqjA:
undetectable
4qn9B-4oqjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
3 GLY A 305
PRO A 306
ALA A 105
None
0.35A 4qn9B-4p52A:
undetectable
4qn9B-4p52A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqh GLUTATHIONE
TRANSFERASE LAMBDA1


(Populus
trichocarpa)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 GLY A 161
PRO A 162
ALA A 203
None
0.42A 4qn9B-4pqhA:
undetectable
4qn9B-4pqhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3


(Populus
trichocarpa)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
3 GLY A 167
PRO A 168
ALA A 210
CA  A 302 (-4.6A)
None
None
0.56A 4qn9B-4pqiA:
undetectable
4qn9B-4pqiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00270
(DEAD)
3 GLY A 325
PRO A 324
ALA A 273
None
0.48A 4qn9B-4px9A:
undetectable
4qn9B-4px9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis)
PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C)
3 GLY A 519
PRO A 520
ALA A 462
None
0.55A 4qn9B-4qawA:
undetectable
4qn9B-4qawA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D


(Homo sapiens)
PF12706
(Lactamase_B_2)
3 GLY A 161
PRO A 162
ALA A 348
3PE  A 503 ( 4.5A)
3PE  A 503 ( 4.7A)
None
0.07A 4qn9B-4qn9A:
60.5
4qn9B-4qn9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn3 HAD SUPERFAMILY
HYDROLASE


(Geobacter
sulfurreducens)
PF13419
(HAD_2)
3 GLY A 164
PRO A 165
ALA A 184
None
0.50A 4qn9B-4rn3A:
undetectable
4qn9B-4rn3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 244
PRO A 243
ALA A 187
A  B   6 ( 3.4A)
A  B   5 ( 4.1A)
None
0.49A 4qn9B-4tz0A:
undetectable
4qn9B-4tz0A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 319
PRO A 318
ALA A 261
None
0.54A 4qn9B-4w7sA:
undetectable
4qn9B-4w7sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE


(Streptomyces
lividans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
3 GLY A 304
PRO A 305
ALA A 100
None
EDO  A 718 ( 4.1A)
EDO  A 718 ( 3.7A)
0.48A 4qn9B-4wd1A:
undetectable
4qn9B-4wd1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B


(Mycolicibacterium
brisbanense)
no annotation 3 GLY E 148
PRO E 149
ALA E  71
None
0.55A 4qn9B-4whbE:
1.4
4qn9B-4whbE:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR


(Homo sapiens)
PF00047
(ig)
3 GLY A 201
PRO A 202
ALA A 280
None
0.53A 4qn9B-4wrlA:
undetectable
4qn9B-4wrlA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR


(Homo sapiens)
PF00047
(ig)
PF13927
(Ig_3)
3 GLY A 201
PRO A 202
ALA A 280
None
0.53A 4qn9B-4wrmA:
undetectable
4qn9B-4wrmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE


(Sulfolobus
solfataricus)
PF00288
(GHMP_kinases_N)
3 GLY A 318
PRO A 319
ALA A 113
SO4  A 401 (-4.3A)
None
None
0.37A 4qn9B-4z7yA:
undetectable
4qn9B-4z7yA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP


(Stichodactyla
gigantea)
PF01353
(GFP)
3 GLY A 129
PRO A 130
ALA A 164
None
0.55A 4qn9B-4zb1A:
undetectable
4qn9B-4zb1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbl PHOTOSESITIZER
MKILLERORANGE


(Hydrozoa)
PF01353
(GFP)
3 GLY A 132
PRO A 133
ALA A 168
None
0.51A 4qn9B-4zblA:
undetectable
4qn9B-4zblA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
3 GLY B 371
PRO B 372
ALA B 328
None
0.48A 4qn9B-5a8rB:
undetectable
4qn9B-5a8rB:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Mus musculus)
PF12777
(MT)
3 GLY A3388
PRO A3389
ALA A3290
None
0.54A 4qn9B-5ayhA:
undetectable
4qn9B-5ayhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II)
3 GLY A 319
PRO A 318
ALA A 346
TPP  B 402 ( 4.6A)
TPP  B 402 (-4.6A)
None
0.47A 4qn9B-5b47A:
undetectable
4qn9B-5b47A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
3 GLY A 403
PRO A 404
ALA A 338
None
0.51A 4qn9B-5cerA:
undetectable
4qn9B-5cerA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmg RB86 ANTIBODY FAB
FRAGMENT LIGHT CHAIN


(Oryctolagus
cuniculus)
no annotation 3 GLY L 607
PRO L 606
ALA L 730
None
0.56A 4qn9B-5dmgL:
undetectable
4qn9B-5dmgL:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 325
PRO A 324
ALA A 273
None
0.48A 4qn9B-5e7jA:
undetectable
4qn9B-5e7jA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLY A 217
PRO A 216
ALA A 169
U  B   5 ( 3.3A)
U  B   4 ( 3.8A)
None
0.53A 4qn9B-5elxA:
undetectable
4qn9B-5elxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 GLY A1232
PRO A1233
ALA A 431
None
0.32A 4qn9B-5epgA:
undetectable
4qn9B-5epgA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqq NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
3 GLY A1141
PRO A1142
ALA A1150
None
0.51A 4qn9B-5eqqA:
undetectable
4qn9B-5eqqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD


(Escherichia
coli)
PF00270
(DEAD)
3 GLY A 134
PRO A 133
ALA A  81
None
0.51A 4qn9B-5gjuA:
undetectable
4qn9B-5gjuA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
3 GLY B  42
PRO B  41
ALA B  92
None
0.49A 4qn9B-5gxbB:
undetectable
4qn9B-5gxbB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
3 GLY A  24
PRO A  23
ALA A   8
None
0.48A 4qn9B-5h42A:
undetectable
4qn9B-5h42A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN


(uncultured
marine
bacterium)
PF03480
(DctP)
3 GLY A 299
PRO A 300
ALA A 160
None
0.51A 4qn9B-5i5pA:
undetectable
4qn9B-5i5pA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 LIGHT
CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY L  41
PRO L  40
ALA L  84
None
0.51A 4qn9B-5iltL:
undetectable
4qn9B-5iltL:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA


(Geobacillus
stearothermophilus)
no annotation 3 GLY B 129
PRO B 128
ALA B  77
None
0.49A 4qn9B-5ivlB:
undetectable
4qn9B-5ivlB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 GLY A 373
PRO A 374
ALA A 220
None
0.55A 4qn9B-5ja1A:
undetectable
4qn9B-5ja1A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU


(Thermotoga
maritima)
PF12822
(ECF_trnsprt)
3 GLY A  51
PRO A  52
ALA A  91
None
0.41A 4qn9B-5kbwA:
undetectable
4qn9B-5kbwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE


(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 GLY A 128
PRO A 127
ALA A 256
None
0.56A 4qn9B-5keiA:
1.4
4qn9B-5keiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA


(Methanothermococcus
thermolithotrophicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
3 GLY B 371
PRO B 372
ALA B 328
None
0.56A 4qn9B-5n1qB:
undetectable
4qn9B-5n1qB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE


(Brucella suis)
PF00106
(adh_short)
3 GLY A  95
PRO A  96
ALA A 141
None
0.44A 4qn9B-5tgdA:
2.4
4qn9B-5tgdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN


(Vanderwaltozyma
polyspora)
no annotation 3 GLY A 832
PRO A 833
ALA A1210
None
0.54A 4qn9B-5theA:
undetectable
4qn9B-5theA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN


(Homo sapiens)
no annotation 3 GLY L  41
PRO L  40
ALA L  84
None
0.56A 4qn9B-5uy3L:
undetectable
4qn9B-5uy3L:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlp FAB7G7 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY H  42
PRO H  41
ALA H  92
None
0.48A 4qn9B-5vlpH:
undetectable
4qn9B-5vlpH:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN


(Homo sapiens)
no annotation 3 GLY D  42
PRO D  41
ALA D  88
None
0.54A 4qn9B-5wduD:
undetectable
4qn9B-5wduD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM


(Rhodobacter
capsulatus)
no annotation 3 GLY M  81
PRO M  82
ALA M 123
None
0.52A 4qn9B-5x41M:
undetectable
4qn9B-5x41M:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1


(Saccharomyces
cerevisiae)
no annotation 3 GLY A 242
PRO A 243
ALA A 204
None
0.55A 4qn9B-5y58A:
undetectable
4qn9B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY


(Mus musculus)
no annotation 3 GLY D  48
PRO D  47
ALA D  91
None
0.28A 4qn9B-6eqcD:
undetectable
4qn9B-6eqcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE


(Pseudomonas
aeruginosa)
no annotation 3 GLY A 525
PRO A 524
ALA A 516
None
0.52A 4qn9B-6fbtA:
undetectable
4qn9B-6fbtA:
undetectable