SIMILAR PATTERNS OF AMINO ACIDS FOR 4QN9_B_DXCB601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seb ENTEROTOXIN TYPE B

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR D 217
TYR D  28
ARG D 165
THR D 164
 None
 1.37A 4qn9A-1sebD:
0.0
4qn9B-1sebD:
0.0		 4qn9A-1sebD:
19.04
4qn9B-1sebD:
19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		4 TYR A 188
TRP A 218
ARG A 257
THR A 258
 3PE  A 503 ( 4.9A)
DXC  A 504 ( 3.9A)
None
DXC  A 507 (-3.7A)
 0.12A 4qn9A-4qn9A:
61.9
4qn9B-4qn9A:
60.5		 4qn9A-4qn9A:
100.00
4qn9B-4qn9A:
100.00