SIMILAR PATTERNS OF AMINO ACIDS FOR 4QN9_A_DXCA505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		4 TYR A 193
TRP A 218
LYS A 221
CYH A 222
 DXC  A 504 (-4.8A)
DXC  A 504 ( 3.9A)
DXC  A 504 (-4.8A)
DXC  A 504 (-3.6A)
 0.11A 4qn9A-4qn9A:
61.9
4qn9B-4qn9A:
60.5		 4qn9A-4qn9A:
100.00
4qn9B-4qn9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 TYR A 265
TRP A 149
LYS A 150
CYH A  97
 None
 1.42A 4qn9A-4rslA:
0.0
4qn9B-4rslA:
0.0		 4qn9A-4rslA:
22.22
4qn9B-4rslA:
22.22