SIMILAR PATTERNS OF AMINO ACIDS FOR 4QMZ_A_B49A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  71
VAL A  78
ALA A  91
MET A 138
LEU A 141
LEU A 193
 STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
STU  A 401 (-3.9A)
STU  A 401 (-4.7A)
 0.90A 4qmzA-1nxkA:
24.0		 4qmzA-1nxkA:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ILE A 211
GLY A 212
VAL A 219
ALA A 230
TYR A 282
LEU A 340
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
 0.68A 4qmzA-1py5A:
25.9		 4qmzA-1py5A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 345
VAL A 352
ALA A 367
MET A 414
GLY A 418
LEU A 468
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.52A 4qmzA-1u59A:
28.5		 4qmzA-1u59A:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LEU A 158
 None
 0.51A 4qmzA-1u5qA:
36.8		 4qmzA-1u5qA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
VAL A  42
ALA A  55
TYR A 107
LEU A 158
 None
 0.41A 4qmzA-1u5qA:
36.8		 4qmzA-1u5qA:
39.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  10
GLY A  11
VAL A  18
ALA A  30
LEU A  82
LEU A 132
 None
 0.45A 4qmzA-1v0bA:
23.8		 4qmzA-1v0bA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A 251
GLY A 252
VAL A 259
ALA A 272
TYR A 325
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
 0.67A 4qmzA-1zrzA:
21.5		 4qmzA-1zrzA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 455
GLY A 456
VAL A 463
ALA A 476
MET A 523
LEU A 526
 None
 0.68A 4qmzA-2f57A:
36.2		 4qmzA-2f57A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 455
VAL A 463
ALA A 476
MET A 523
LEU A 526
LEU A 575
 None
 0.73A 4qmzA-2f57A:
36.2		 4qmzA-2f57A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.61A 4qmzA-2gcdA:
36.7		 4qmzA-2gcdA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
LEU A 182
 None
 0.83A 4qmzA-2hakA:
21.6		 4qmzA-2hakA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 349
VAL A 356
ALA A 369
THR A 404
MET A 420
TYR A 422
 PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-3.2A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
 0.54A 4qmzA-2i0eA:
28.4		 4qmzA-2i0eA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
GLY A 505
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
 0.96A 4qmzA-2j0jA:
25.9		 4qmzA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.69A 4qmzA-2j0jA:
25.9		 4qmzA-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
GLY A  11
VAL A  18
ALA A  31
LEU A  83
LEU A 134
 None
 0.64A 4qmzA-2jgzA:
29.1		 4qmzA-2jgzA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
GLY A 505
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
 0.77A 4qmzA-2jkmA:
26.1		 4qmzA-2jkmA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
 0.59A 4qmzA-2jkmA:
26.1		 4qmzA-2jkmA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
GLY B  48
VAL B  55
ALA B  67
TYR B 116
LEU B 171
 None
 0.59A 4qmzA-2qkwB:
26.3		 4qmzA-2qkwB:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 681
GLY A 682
VAL A 689
ALA A 705
TYR A 755
LEU A 807
 None
 0.67A 4qmzA-2r2pA:
29.4		 4qmzA-2r2pA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 205
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.67A 4qmzA-2v55A:
26.5		 4qmzA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  77
GLY A  78
VAL A  85
ALA A  98
THR A 132
MET A 148
TYR A 150
LEU A 202
 BI8  A1417 (-4.1A)
BI8  A1417 ( 3.9A)
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-3.6A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
 0.64A 4qmzA-2vd5A:
28.1		 4qmzA-2vd5A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  56
VAL C  63
ALA C  76
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.57A 4qmzA-2wtkC:
22.8		 4qmzA-2wtkC:
26.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		10 GLY A  27
VAL A  34
ALA A  47
THR A  79
MET A  95
TYR A  97
LEU A  98
GLY A  99
LEU A 147
TYR A 287
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.7A)
J60  A1294 (-4.8A)
None
 0.55A 4qmzA-2xikA:
35.7		 4qmzA-2xikA:
84.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
GLY A 628
VAL A 635
ALA A 651
TYR A 701
LEU A 753
 None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
 0.57A 4qmzA-2xyuA:
19.4		 4qmzA-2xyuA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  23
GLY A  24
VAL A  31
ALA A  44
MET A  92
LEU A  95
LEU A 153
 ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
ANP  A   1 (-4.1A)
None
 0.76A 4qmzA-3dakA:
26.8		 4qmzA-3dakA:
44.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
GLY A 151
VAL A 158
ALA A 169
MET A 220
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.35A 4qmzA-3dtcA:
25.3		 4qmzA-3dtcA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
GLY A 151
VAL A 158
MET A 220
GLY A 225
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.7A)
None
VIN  A6331 (-4.5A)
 0.98A 4qmzA-3dtcA:
25.3		 4qmzA-3dtcA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
VAL A  42
ALA A  55
MET A 102
LEU A 155
 DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
 0.67A 4qmzA-3f3zA:
22.8		 4qmzA-3f3zA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
LEU A 185
 None
 0.76A 4qmzA-3fe3A:
23.0		 4qmzA-3fe3A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 209
GLY A 210
VAL A 217
ALA A 228
TYR A 281
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-4.6A)
 0.62A 4qmzA-3g2fA:
26.4		 4qmzA-3g2fA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
LEU A 182
 None
 0.57A 4qmzA-3iecA:
29.3		 4qmzA-3iecA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ILE A 210
GLY A 211
VAL A 218
ALA A 229
TYR A 281
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.52A 4qmzA-3mdyA:
26.5		 4qmzA-3mdyA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.61A 4qmzA-3mtlA:
23.5		 4qmzA-3mtlA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
LEU A 173
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
 0.70A 4qmzA-3mvjA:
30.0		 4qmzA-3mvjA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 GLY A 349
VAL A 356
ALA A 369
THR A 404
MET A 420
TYR A 422
 ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 ( 3.8A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
 0.66A 4qmzA-3pfqA:
21.4		 4qmzA-3pfqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLY A 558
VAL A 565
ALA A 576
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.54A 4qmzA-3ppzA:
30.6		 4qmzA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ILE A 557
GLY A 558
VAL A 565
ALA A 576
TYR A 627
LEU A 628
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
 0.63A 4qmzA-3ppzA:
30.6		 4qmzA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  82
GLY A  83
VAL A  90
ALA A 103
THR A 137
MET A 153
TYR A 155
LEU A 207
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.73A 4qmzA-3qfvA:
21.6		 4qmzA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 362
VAL A 369
ALA A 382
THR A 417
MET A 433
LEU A 486
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.2A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.50A 4qmzA-3txoA:
18.6		 4qmzA-3txoA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
GLY A  84
VAL A  91
ALA A 104
THR A 138
MET A 154
TYR A 156
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.64A 4qmzA-4aw2A:
27.5		 4qmzA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A  83
GLY A  84
VAL A  91
THR A 138
MET A 154
GLY A 160
 None
 0.69A 4qmzA-4aw2A:
27.5		 4qmzA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
GLY A  65
ALA A  85
MET A 131
GLY A 135
LEU A 199
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
None
F8E  A1340 (-3.8A)
 0.99A 4qmzA-4btmA:
25.7		 4qmzA-4btmA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
 0.79A 4qmzA-4cfhA:
19.9		 4qmzA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
GLY A 568
VAL A 575
ALA A 588
MET A 636
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 0.81A 4qmzA-4e93A:
29.6		 4qmzA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  64
GLY A  65
VAL A  72
ALA A  88
MET A 134
TYR A 136
LEU A 137
LEU A 184
 None
ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
ADP  A 601 (-4.1A)
None
ADP  A 601 ( 4.9A)
 0.80A 4qmzA-4f99A:
17.2		 4qmzA-4f99A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
LEU A 398
LEU A 447
 None
ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
ANP  A1001 (-4.6A)
ANP  A1001 (-4.7A)
 0.63A 4qmzA-4fieA:
36.7		 4qmzA-4fieA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 103
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.3A)
STU  A 401 (-4.7A)
 0.61A 4qmzA-4fr4A:
28.5		 4qmzA-4fr4A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
 GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
GOL  B1000 ( 4.4A)
 0.75A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  31
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 151
 None
GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 ( 4.4A)
 0.87A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE B  30
ALA B  51
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
 GOL  B1000 (-4.1A)
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
GOL  B1000 ( 4.4A)
 1.03A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE B  30
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
LEU B 151
 GOL  B1000 (-4.1A)
None
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
GOL  B1000 ( 4.4A)
 1.07A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
LEU B 151
 None
GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
GOL  B1000 ( 4.4A)
 0.80A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 856
VAL A 863
ALA A 880
MET A 929
TYR A 931
LEU A 932
LEU A 983
 IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
 0.45A 4qmzA-4gl9A:
27.1		 4qmzA-4gl9A:
29.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 157
VAL A 164
ALA A 177
THR A 211
MET A 227
TYR A 229
 GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 4.0A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
 0.43A 4qmzA-4gv1A:
30.1		 4qmzA-4gv1A:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 829
VAL A 836
ALA A 853
MET A 902
TYR A 904
LEU A 905
LEU A 956
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
19S  A1201 (-4.5A)
 0.52A 4qmzA-4hviA:
21.1		 4qmzA-4hviA:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
GLY A 414
VAL A 421
ALA A 434
MET A 481
LEU A 484
LEU A 533
 B49  A 701 (-4.2A)
B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.5A)
 0.38A 4qmzA-4ks8A:
38.1		 4qmzA-4ks8A:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 413
GLY A 414
VAL A 421
LEU A 484
GLY A 486
LEU A 533
 B49  A 701 (-4.2A)
B49  A 701 ( 4.3A)
None
B49  A 701 (-4.4A)
None
B49  A 701 (-4.5A)
 0.97A 4qmzA-4ks8A:
38.1		 4qmzA-4ks8A:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
GLY A 103
LEU A 153
 None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
None
GOL  A 403 ( 4.4A)
 0.55A 4qmzA-4lg4A:
33.3		 4qmzA-4lg4A:
50.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		11 GLY B  31
VAL B  38
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
TYR B 291
LYS B 295
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.9A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
None
ADP  B 500 (-4.7A)
None
None
 0.64A 4qmzA-4o27B:
33.5		 4qmzA-4o27B:
94.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 628
VAL A 635
ALA A 648
MET A 701
TYR A 703
LEU A 753
 None
 0.69A 4qmzA-4otdA:
29.1		 4qmzA-4otdA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 619
GLY A 620
VAL A 627
ALA A 644
TYR A 694
LEU A 746
 None
 0.43A 4qmzA-4p2kA:
29.0		 4qmzA-4p2kA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A 387
VAL A 394
ALA A 407
THR A 442
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.64A 4qmzA-4q9zA:
29.5		 4qmzA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
GLY A  28
VAL A  35
ALA A  49
MET A 104
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.4A)
ANP  A 402 (-4.6A)
 0.68A 4qmzA-4qnyA:
26.1		 4qmzA-4qnyA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 346
VAL A 353
ALA A 366
THR A 401
MET A 417
TYR A 419
 3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
 0.54A 4qmzA-4ra4A:
29.3		 4qmzA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.62A 4qmzA-4rewA:
29.3		 4qmzA-4rewA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 150
GLY A 151
VAL A 158
ALA A 169
MET A 220
GLY A 226
 None
 0.80A 4qmzA-4uy9A:
23.9		 4qmzA-4uy9A:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 150
GLY A 151
VAL A 158
ALA A 169
MET A 220
LEU A 275
 None
 0.64A 4qmzA-4uy9A:
23.9		 4qmzA-4uy9A:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.73A 4qmzA-4wb7A:
30.1		 4qmzA-4wb7A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
LEU A 398
LEU A 447
 None
ATP  A 601 ( 4.1A)
ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-4.3A)
ATP  A 601 (-4.3A)
None
 0.54A 4qmzA-4xbrA:
28.2		 4qmzA-4xbrA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
GLY A  11
VAL A  18
ALA A  31
LEU A  83
LEU A 135
 None
 0.68A 4qmzA-4yc6A:
24.5		 4qmzA-4yc6A:
29.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
GLY A 470
VAL A 477
ALA A 488
TYR A 541
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.66A 4qmzA-4yffA:
19.0		 4qmzA-4yffA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.60A 4qmzA-5ci7A:
29.7		 4qmzA-5ci7A:
29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
MET A 105
GLY A 109
LEU A 160
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
MET  A 105 (-0.0A)
GLY  A 109 ( 0.0A)
LEU  A 160 (-0.6A)
 0.51A 4qmzA-5d7aA:
24.6		 4qmzA-5d7aA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 153
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
ANP  A 401 (-4.1A)
None
 0.58A 4qmzA-5dbxA:
27.8		 4qmzA-5dbxA:
43.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A  81
GLY A  82
VAL A  89
ALA A 102
LEU A 153
LEU A 211
 ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.1A)
None
 0.76A 4qmzA-5dbxA:
27.8		 4qmzA-5dbxA:
43.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
 0.65A 4qmzA-5es1A:
27.2		 4qmzA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 ILE A  85
GLY A  86
VAL A  93
ALA A 104
TYR A 149
LEU A 214
 ADP  A 401 ( 4.9A)
ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 (-4.4A)
 0.54A 4qmzA-5gzaA:
12.6		 4qmzA-5gzaA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 ILE A  24
GLY A  25
VAL A  32
ALA A  45
TYR A  96
LEU A 147
 None
None
None
None
PO4  A 401 (-4.8A)
None
 0.86A 4qmzA-5ig1A:
31.2		 4qmzA-5ig1A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.74A 4qmzA-5isoA:
29.2		 4qmzA-5isoA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  23
VAL A  30
ALA A  43
MET A  90
GLY A  94
LEU A 143
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.67A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
GLY A  23
VAL A  30
ALA A  43
GLY A  94
LEU A 143
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.49A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.44A 4qmzA-5jznA:
29.0		 4qmzA-5jznA:
29.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A 276
GLY A 277
VAL A 284
ALA A 297
MET A 344
TYR A 346
LEU A 347
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
 0.52A 4qmzA-5kbrA:
18.4		 4qmzA-5kbrA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  49
ALA A  60
MET A 110
TYR A 112
LEU A 113
LEU A 163
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.1A)
STU  A 901 (-4.5A)
 0.42A 4qmzA-5lohA:
24.8		 4qmzA-5lohA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 GLY A 359
VAL A 366
ALA A 379
MET A 429
LEU A 432
LEU A 482
 ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 (-4.7A)
ANP  A 801 (-4.8A)
 0.61A 4qmzA-5nclA:
22.7		 4qmzA-5nclA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 6 ILE C  15
GLY C  16
ALA C  36
MET C  82
LEU C  85
GLY C  86
 9XK  C 301 (-4.2A)
None
9XK  C 301 ( 3.7A)
9XK  C 301 (-4.2A)
9XK  C 301 (-3.8A)
9XK  C 301 (-3.7A)
 0.68A 4qmzA-5oktC:
25.1		 4qmzA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 ILE A  17
GLY A  18
VAL A  25
ALA A  38
TYR A  88
LEU A 139
 7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
 0.39A 4qmzA-5tvtA:
28.4		 4qmzA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
GLY A  99
VAL A 106
ALA A 119
MET A 169
TYR A 171
LEU A 221
 None
 0.56A 4qmzA-5u7qA:
27.7		 4qmzA-5u7qA:
28.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
LEU A 398
LEU A 447
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.4A)
M77  A 601 (-4.6A)
 0.62A 4qmzA-5vefA:
37.4		 4qmzA-5vefA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 ILE A 327
GLY A 328
VAL A 335
LEU A 398
GLY A 400
LEU A 447
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 (-4.4A)
None
M77  A 601 (-4.6A)
 0.85A 4qmzA-5vefA:
37.4		 4qmzA-5vefA:
35.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 GLY A  29
VAL A  36
ALA A  49
MET A  96
TYR A  98
LEU A 150
 VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
VX6  A 402 (-4.3A)
VX6  A 402 (-4.4A)
 0.60A 4qmzA-5wnmA:
26.7		 4qmzA-5wnmA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 ILE A  75
GLY A  76
VAL A  83
ALA A  95
TYR A 143
LEU A 206
 ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-4.5A)
 0.72A 4qmzA-5xd6A:
12.4		 4qmzA-5xd6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ILE A 215
GLY A 216
VAL A 223
ALA A 236
LEU A 291
LEU A 342
 None
None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
None
None
 0.59A 4qmzA-5y86A:
25.4		 4qmzA-5y86A:
11.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 GLY A  34
VAL A  41
ALA A  54
TYR A 101
GLY A 103
LEU A 153
 ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.7A)
ANP  A 501 (-4.6A)
 0.53A 4qmzA-6ao5A:
30.3		 4qmzA-6ao5A:
49.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
GLY A 734
VAL A 741
ALA A 754
TYR A 815
LEU A 866
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
 0.67A 4qmzA-6b3eA:
30.0		 4qmzA-6b3eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 ILE A 531
GLY A 532
VAL A 539
ALA A 551
MET A 602
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.4A)
CQ7  A 801 (-4.5A)
 0.80A 4qmzA-6b4wA:
24.4		 4qmzA-6b4wA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 218
GLY A 219
VAL A 226
ALA A 237
LEU A 291
LEU A 347
 DL1  A 601 (-4.0A)
DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-4.4A)
DL1  A 601 (-3.9A)
 0.49A 4qmzA-6bfnA:
24.0		 4qmzA-6bfnA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
 EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
 0.74A 4qmzA-6bx6A:
14.1		 4qmzA-6bx6A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ILE A  66
GLY A  67
VAL A  74
ALA A  87
TYR A 138
LEU A 189
 None
 0.79A 4qmzA-6c9dA:
21.6		 4qmzA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 134
GLY A 135
VAL A 142
ALA A 155
LEU A 233
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.6A)
H1N  A 501 (-4.8A)
 0.35A 4qmzA-6ccfA:
28.6		 4qmzA-6ccfA:
14.05