SIMILAR PATTERNS OF AMINO ACIDS FOR 4QMS_A_1N1A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.51A 4qmsA-1k9aA:
27.5		 4qmsA-1k9aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.80A 4qmsA-1k9aA:
27.5		 4qmsA-1k9aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A 185
LYS A 187
GLU A 202
LEU A 249
LEU A 301
ASP A 550
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.82A 4qmsA-1q8yA:
25.6		 4qmsA-1q8yA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
ALA A  55
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 None
 0.72A 4qmsA-1u5qA:
36.6		 4qmsA-1u5qA:
39.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
GLU A  55
TYR A  86
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.71A 4qmsA-1zltA:
27.5		 4qmsA-1zltA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  52
ALA A  73
LYS A  75
GLU A  89
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.6A)
None
 0.70A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  52
ALA A  73
LYS A  75
LEU A 122
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.2A)
5ID  A1300 (-4.6A)
None
 0.75A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		6 ILE A  18
ALA A  39
LYS A  41
GLU A  55
LEU A 138
ASP A 154
 CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 0.86A 4qmsA-2csnA:
25.6		 4qmsA-2csnA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
GLU X  54
ILE X  80
TYR X  84
LEU X 137
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.53A 4qmsA-2dq7X:
29.4		 4qmsA-2dq7X:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
LYS X  39
ILE X  80
TYR X  84
LEU X 137
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.81A 4qmsA-2dq7X:
29.4		 4qmsA-2dq7X:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
GLU A 201
ILE A 234
LEU A 239
LEU A 290
ASP A 320
 None
 0.57A 4qmsA-2eu9A:
26.6		 4qmsA-2eu9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
LYS A 186
ILE A 234
LEU A 239
LEU A 290
ASP A 320
 None
 0.69A 4qmsA-2eu9A:
26.6		 4qmsA-2eu9A:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.93A 4qmsA-2gcdA:
36.5		 4qmsA-2gcdA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
GLU A 471
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 4qmsA-2j0jA:
25.8		 4qmsA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
ALA A 452
LYS A 454
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 4qmsA-2j0jA:
25.8		 4qmsA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
GLU A 288
ILE A 314
TYR A 318
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
 0.76A 4qmsA-2og8A:
25.8		 4qmsA-2og8A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA X  53
LYS X  55
ILE X 115
TYR X 119
LEU X 179
ASP X 190
 HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
None
HMD  X 400 (-4.5A)
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
 0.76A 4qmsA-2pmoX:
30.0		 4qmsA-2pmoX:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 681
ALA A 705
ILE A 751
TYR A 755
LEU A 807
ASP A 818
 None
 0.78A 4qmsA-2r2pA:
29.1		 4qmsA-2r2pA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  77
ALA A  98
GLU A 119
MET A 148
TYR A 150
LEU A 202
ASP A 213
 BI8  A1417 (-4.1A)
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.60A 4qmsA-2vd5A:
28.4		 4qmsA-2vd5A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  77
ALA A  98
LYS A 100
MET A 148
TYR A 150
LEU A 202
ASP A 213
 BI8  A1417 (-4.1A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.89A 4qmsA-2vd5A:
28.4		 4qmsA-2vd5A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ILE A 490
ALA A 509
LYS A 511
GLU A 535
LEU A 656
ASP A 687
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.81A 4qmsA-2vuwA:
17.9		 4qmsA-2vuwA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.63A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  47
LYS A  49
ILE A  93
MET A  95
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
ALA A 651
LYS A 653
ILE A 697
TYR A 701
LEU A 753
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
 0.67A 4qmsA-2xyuA:
19.4		 4qmsA-2xyuA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 305
ALA A 326
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.68A 4qmsA-2z2wA:
28.6		 4qmsA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ASP A 641
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.86A 4qmsA-3c4fA:
25.0		 4qmsA-3c4fA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.51A 4qmsA-3d7uA:
28.2		 4qmsA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.81A 4qmsA-3d7uA:
28.2		 4qmsA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ILE A  59
ALA A  80
LYS A  82
GLU A 100
MET A 129
TYR A 131
LEU A 182
ASP A 193
 None
 0.86A 4qmsA-3iecA:
29.4		 4qmsA-3iecA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 453
GLU A 468
MET A 498
LEU A 501
LEU A 551
ASP A 565
 ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.0A)
ANP  A 400 (-4.7A)
None
 0.74A 4qmsA-3kn5A:
22.4		 4qmsA-3kn5A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 453
LYS A 455
GLU A 468
MET A 498
LEU A 501
ASP A 565
 ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.0A)
None
 0.81A 4qmsA-3kn5A:
22.4		 4qmsA-3kn5A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
GLU A 684
ILE A 711
TYR A 715
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
None
None
 0.91A 4qmsA-3kulA:
28.9		 4qmsA-3kulA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 700
LYS A 702
GLU A 715
ILE A 743
LEU A 804
ASP A 828
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.80A 4qmsA-3lj0A:
25.9		 4qmsA-3lj0A:
27.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ILE A 210
ALA A 229
LYS A 231
GLU A 244
TYR A 281
LEU A 339
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.98A 4qmsA-3mdyA:
25.7		 4qmsA-3mdyA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  70
LYS A  72
GLU A  91
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.97A 4qmsA-3mvjA:
29.9		 4qmsA-3mvjA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  36
ALA A  57
LYS A  59
GLU A  77
ILE A 109
ASP A 174
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 (-2.8A)
 0.85A 4qmsA-3nieA:
24.3		 4qmsA-3nieA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
GLU A 130
TYR A 161
LEU A 212
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.82A 4qmsA-3nuuA:
21.5		 4qmsA-3nuuA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
ILE A 623
TYR A 627
LEU A 628
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.75A 4qmsA-3ppzA:
31.0		 4qmsA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
ALA A 576
LYS A 578
GLU A 596
ILE A 623
TYR A 627
LEU A 628
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-3.5A)
 0.84A 4qmsA-3ppzA:
31.0		 4qmsA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA B 616
LYS B 618
GLU B 635
ILE B 884
MET B 886
ASP B 953
 None
 0.75A 4qmsA-3qd2B:
25.8		 4qmsA-3qd2B:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
GLU A 124
MET A 153
TYR A 155
LEU A 207
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 1.04A 4qmsA-3qfvA:
21.7		 4qmsA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.99A 4qmsA-3qfvA:
21.7		 4qmsA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ASP A 641
 07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.75A 4qmsA-3tt0A:
24.8		 4qmsA-3tt0A:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
ALA A 104
LYS A 106
GLU A 125
MET A 154
TYR A 156
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.93A 4qmsA-4aw2A:
27.5		 4qmsA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A  97
ALA A 121
LYS A 123
GLU A 140
ILE A 167
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.3A)
 0.81A 4qmsA-4aw5A:
26.6		 4qmsA-4aw5A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A  97
ALA A 121
LYS A 123
ILE A 167
LEU A 223
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.62A 4qmsA-4aw5A:
26.6		 4qmsA-4aw5A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 ALA A 267
LYS A 269
GLU A 288
TYR A 320
LEU A 371
ASP A 382
 None
 0.78A 4qmsA-4c0tA:
28.2		 4qmsA-4c0tA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  43
GLU A  64
MET A  93
TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.79A 4qmsA-4cfhA:
22.1		 4qmsA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  43
LYS A  45
GLU A  64
TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.71A 4qmsA-4cfhA:
22.1		 4qmsA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.81A 4qmsA-4crsA:
29.0		 4qmsA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 4qmsA-4e93A:
21.6		 4qmsA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A  64
ALA A  88
LYS A  90
GLU A 104
ILE A 132
TYR A 136
LEU A 137
LEU A 184
ASP A 196
 None
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
None
ADP  A 601 (-4.1A)
None
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.84A 4qmsA-4f99A:
17.2		 4qmsA-4f99A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
ALA A  50
GLU A  71
LEU A 103
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.70A 4qmsA-4fr4A:
28.9		 4qmsA-4fr4A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 429
GLU A 442
ILE A 469
LEU A 474
LEU A 524
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.9A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.64A 4qmsA-4g3fA:
27.9		 4qmsA-4g3fA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 429
LYS A 431
GLU A 442
ILE A 469
LEU A 474
LEU A 524
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.9A)
0WB  A 701 (-4.3A)
 0.74A 4qmsA-4g3fA:
27.9		 4qmsA-4g3fA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
GLU A 898
MET A 929
TYR A 931
LEU A 932
ASP A 994
 IZA  A2001 (-3.4A)
None
IZA  A2001 (-4.4A)
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.5A)
 0.76A 4qmsA-4gl9A:
26.6		 4qmsA-4gl9A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
GLU A 898
TYR A 931
LEU A 932
LEU A 983
ASP A 994
 IZA  A2001 (-3.4A)
None
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.73A 4qmsA-4gl9A:
26.6		 4qmsA-4gl9A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
LYS A 882
GLU A 898
LEU A 932
LEU A 983
ASP A 994
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.76A 4qmsA-4gl9A:
26.6		 4qmsA-4gl9A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
LYS A 882
GLU A 898
MET A 929
LEU A 932
ASP A 994
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.5A)
 0.81A 4qmsA-4gl9A:
26.6		 4qmsA-4gl9A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
MET A 902
TYR A 904
LEU A 905
ASP A 967
 19S  A1201 (-3.3A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
19S  A1201 ( 4.1A)
 0.78A 4qmsA-4hviA:
21.3		 4qmsA-4hviA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
TYR A 904
LEU A 905
LEU A 956
ASP A 967
 19S  A1201 (-3.3A)
None
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.57A 4qmsA-4hviA:
21.3		 4qmsA-4hviA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
LYS A 855
TYR A 904
LEU A 905
LEU A 956
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.75A 4qmsA-4hviA:
21.3		 4qmsA-4hviA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
GLU A 130
ILE A 157
TYR A 161
ASP A 223
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
None
1C7  A 401 (-3.5A)
None
 0.77A 4qmsA-4i6fA:
30.1		 4qmsA-4i6fA:
27.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 427
LYS A 429
GLU A 440
ILE A 467
LEU A 472
LEU A 522
ASP A 534
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-4.5A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 1.00A 4qmsA-4idtA:
28.1		 4qmsA-4idtA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
LYS A 508
GLU A 525
TYR A 557
LEU A 624
ASP A 635
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.85A 4qmsA-4k33A:
17.8		 4qmsA-4k33A:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
ALA A 434
LYS A 436
GLU A 452
MET A 481
LEU A 484
ASP A 544
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.6A)
 1.18A 4qmsA-4ks8A:
37.2		 4qmsA-4ks8A:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  61
LYS A  63
GLU A  77
TYR A 106
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.86A 4qmsA-4l52A:
25.7		 4qmsA-4l52A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
LEU B 102
LEU B 151
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.70A 4qmsA-4o27B:
33.7		 4qmsA-4o27B:
94.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 648
GLU A 669
MET A 701
TYR A 703
LEU A 753
ASP A 764
 None
 0.86A 4qmsA-4otdA:
29.5		 4qmsA-4otdA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.61A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.74A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 407
LYS A 409
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.82A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ILE A  27
ALA A  49
LYS A  51
GLU A  70
ILE A 102
LEU A 156
ASP A 167
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
None
ANP  A 402 (-4.6A)
ANP  A 402 ( 2.6A)
 0.82A 4qmsA-4qnyA:
25.8		 4qmsA-4qnyA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LYS A  37
ILE A  79
TYR A  83
LEU A 136
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
 0.67A 4qmsA-4ueuA:
28.4		 4qmsA-4ueuA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 ALA A 125
LYS A 127
GLU A 146
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.75A 4qmsA-4wb7A:
29.9		 4qmsA-4wb7A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
GLU A 509
ILE A 537
TYR A 541
LEU A 595
ASP A 606
 4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.69A 4qmsA-4yffA:
18.8		 4qmsA-4yffA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
ALA A 488
GLU A 509
ILE A 537
TYR A 541
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.75A 4qmsA-4yffA:
18.8		 4qmsA-4yffA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
ALA A 488
LYS A 490
ILE A 537
TYR A 541
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.66A 4qmsA-4yffA:
18.8		 4qmsA-4yffA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ILE A  62
ALA A  83
LYS A  85
GLU A 103
MET A 132
TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.80A 4qmsA-5es1A:
27.4		 4qmsA-5es1A:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
LYS A 930
GLU A 947
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 4qmsA-5f1zA:
27.2		 4qmsA-5f1zA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.68A 4qmsA-5grnA:
18.5		 4qmsA-5grnA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		7 ILE A  24
ALA A  45
LYS A  47
GLU A  65
TYR A  96
LEU A 147
ASP A 161
 None
None
None
None
PO4  A 401 (-4.8A)
None
None
 1.04A 4qmsA-5ig1A:
31.6		 4qmsA-5ig1A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  43
LYS A  45
GLU A  61
ILE A  88
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.74A 4qmsA-5j5tA:
30.2		 4qmsA-5j5tA:
38.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 4qmsA-5jznA:
29.4		 4qmsA-5jznA:
29.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A 276
ALA A 297
LYS A 299
GLU A 315
MET A 344
TYR A 346
LEU A 347
LEU A 396
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
None
 0.66A 4qmsA-5kbrA:
35.1		 4qmsA-5kbrA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
LYS A 911
GLU A 927
LEU A1016
ASP A1027
 None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.77A 4qmsA-5lpyA:
25.1		 4qmsA-5lpyA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 7 ILE C  15
ALA C  36
LYS C  38
GLU C  52
MET C  82
LEU C 135
ASP C 149
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
9XK  C 301 (-4.2A)
9XK  C 301 (-4.6A)
None
 0.88A 4qmsA-5oktC:
24.6		 4qmsA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
LEU A 139
ASP A 150
 7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.83A 4qmsA-5tvtA:
28.3		 4qmsA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
ASP A 232
 None
 0.88A 4qmsA-5u7qA:
27.6		 4qmsA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.78A 4qmsA-5u94A:
29.8		 4qmsA-5u94A:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 218
ALA A 239
GLU A 259
ILE A 287
TYR A 291
ASP A 380
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-4.8A)
 0.84A 4qmsA-5vdkA:
19.0		 4qmsA-5vdkA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 ALA A 707
GLU A 725
ILE A 752
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.5A)
None
None
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.84A 4qmsA-5vilA:
23.0		 4qmsA-5vilA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ILE A  75
ALA A  96
LYS A  98
GLU A 112
LEU A 195
ASP A 211
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 402 (-2.8A)
None
None
 0.76A 4qmsA-5x18A:
12.6		 4qmsA-5x18A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ILE A  75
ALA A  96
LYS A  98
LEU A 145
LEU A 195
ASP A 211
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 401 (-3.6A)
None
None
 0.61A 4qmsA-5x18A:
12.6		 4qmsA-5x18A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ILE A 215
ALA A 236
GLU A 253
LEU A 291
LEU A 342
ASP A 355
 None
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
None
HRM  A 601 (-4.7A)
 0.73A 4qmsA-5y86A:
25.4		 4qmsA-5y86A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ILE A 215
ALA A 236
LYS A 238
LEU A 291
LEU A 342
ASP A 355
 None
HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
None
None
HRM  A 601 (-4.7A)
 0.86A 4qmsA-5y86A:
25.4		 4qmsA-5y86A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ILE A 733
ALA A 754
LYS A 756
GLU A 774
TYR A 815
LEU A 866
ASP A 877
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
 0.90A 4qmsA-6b3eA:
29.7		 4qmsA-6b3eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
LYS A  89
GLU A 107
TYR A 138
LEU A 189
ASP A 200
 None
 0.79A 4qmsA-6c9dA:
21.7		 4qmsA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 134
ALA A 155
LYS A 157
LEU A 233
LEU A 282
ASP A 293
 H1N  A 501 (-4.3A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-4.6A)
H1N  A 501 (-4.8A)
H1N  A 501 (-3.5A)
 0.68A 4qmsA-6ccfA:
28.9		 4qmsA-6ccfA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.71A 4qmsA-6fyvA:
26.7		 4qmsA-6fyvA:
undetectable