SIMILAR PATTERNS OF AMINO ACIDS FOR 4QMN_A_DB8A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.53A 4qmnA-1k9aA:
27.3		 4qmnA-1k9aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
GLU A 236
ILE A 264
TYR A 268
ASP A 332
 None
 0.80A 4qmnA-1k9aA:
27.3		 4qmnA-1k9aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
LYS A 608
TYR A 656
LEU A 731
ALA A 741
ASP A 742
 None
 0.74A 4qmnA-1lufA:
26.5		 4qmnA-1lufA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
LYS A 290
GLU A 305
ILE A 332
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.80A 4qmnA-1opkA:
26.0		 4qmnA-1opkA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 None
 0.76A 4qmnA-1u5qA:
36.5		 4qmnA-1u5qA:
39.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A 251
ALA A 272
LYS A 274
GLU A 293
TYR A 325
LEU A 376
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.85A 4qmnA-1zrzA:
28.6		 4qmnA-1zrzA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
GLU X  54
ILE X  80
TYR X  84
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.47A 4qmnA-2dq7X:
29.4		 4qmnA-2dq7X:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
LYS X  39
GLU X  54
TYR X  84
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.78A 4qmnA-2dq7X:
29.4		 4qmnA-2dq7X:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 184
LYS A 186
GLU A 201
ILE A 234
LEU A 290
ALA A 319
ASP A 320
 None
 0.69A 4qmnA-2eu9A:
26.6		 4qmnA-2eu9A:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.78A 4qmnA-2gcdA:
36.3		 4qmnA-2gcdA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
GLU A 286
ILE A 313
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.79A 4qmnA-2hz0A:
26.5		 4qmnA-2hz0A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ALA A 369
LYS A 371
GLU A 390
THR A 404
MET A 420
TYR A 422
ALA A 483
ASP A 484
 PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
PDS  A 901 (-3.2A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
PDS  A 901 (-3.6A)
 0.63A 4qmnA-2i0eA:
28.5		 4qmnA-2i0eA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
ALA A 452
LYS A 454
GLU A 471
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 4qmnA-2j0jA:
25.8		 4qmnA-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
GLU A  51
LEU A 134
ALA A 144
ASP A 145
 None
 0.77A 4qmnA-2jgzA:
28.6		 4qmnA-2jgzA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
GLU A 288
ILE A 314
TYR A 318
ALA A 381
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 1.01A 4qmnA-2og8A:
26.0		 4qmnA-2og8A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
GLU A 288
ILE A 314
TYR A 318
LEU A 371
ALA A 381
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.93A 4qmnA-2og8A:
26.0		 4qmnA-2og8A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
ALA B  67
GLU B  85
TYR B 116
LEU B 171
ASP B 182
 None
 0.83A 4qmnA-2qkwB:
25.9		 4qmnA-2qkwB:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
ALA A 705
GLU A 724
ILE A 751
TYR A 755
LEU A 807
ASP A 818
 None
 0.69A 4qmnA-2r2pA:
29.4		 4qmnA-2r2pA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 103
LYS A 105
GLU A 124
MET A 153
TYR A 155
LEU A 205
ASP A 216
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.08A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
GLU A 124
TYR A 155
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.92A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.88A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		10 ILE A  77
ALA A  98
LYS A 100
GLU A 119
THR A 132
MET A 148
TYR A 150
LEU A 202
ALA A 212
ASP A 213
 BI8  A1417 (-4.1A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-3.6A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
BI8  A1417 (-3.8A)
 0.65A 4qmnA-2vd5A:
28.3		 4qmnA-2vd5A:
26.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		9 ALA A  47
LYS A  49
GLU A  66
THR A  79
ILE A  93
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 4.2A)
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.62A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
LYS A  49
ILE A  93
MET A  95
LEU A 147
ALA A 157
LYS A 288
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
None
 1.40A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  47
LYS A  49
THR A  79
ILE A  93
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
J60  A1294 ( 4.2A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.65A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
ALA A 651
LYS A 653
ILE A 697
LEU A 753
ASP A 764
LYS A 713
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-4.3A)
None
None
 1.37A 4qmnA-2xyuA:
19.4		 4qmnA-2xyuA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
ALA A 651
LYS A 653
ILE A 697
TYR A 701
LEU A 753
LYS A 713
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
None
 1.23A 4qmnA-2xyuA:
19.4		 4qmnA-2xyuA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 305
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4qmnA-2z2wA:
28.7		 4qmnA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.89A 4qmnA-3c4fA:
25.0		 4qmnA-3c4fA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.53A 4qmnA-3d7uA:
28.0		 4qmnA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
ALA A 220
GLU A 236
ILE A 264
TYR A 268
ASP A 332
 None
 0.80A 4qmnA-3d7uA:
28.0		 4qmnA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 639
ALA A 663
LYS A 665
GLU A 682
ILE A 709
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 (-4.6A)
 0.81A 4qmnA-3dkoA:
25.5		 4qmnA-3dkoA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		9 ILE A  59
ALA A  80
LYS A  82
GLU A 100
MET A 129
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.71A 4qmnA-3iecA:
29.4		 4qmnA-3iecA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
GLU A 684
ILE A 711
TYR A 715
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-4.1A)
None
None
 0.76A 4qmnA-3kulA:
29.0		 4qmnA-3kulA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ILE A 210
ALA A 229
GLU A 244
TYR A 281
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.82A 4qmnA-3mdyA:
25.5		 4qmnA-3mdyA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ILE A 210
ALA A 229
LYS A 231
GLU A 244
TYR A 281
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.76A 4qmnA-3mdyA:
25.5		 4qmnA-3mdyA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 ILE A  34
ALA A  55
LYS A  57
GLU A  75
ILE A 107
LEU A 161
 GOL  A 434 ( 4.5A)
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
GOL  A 433 ( 4.8A)
None
GOL  A 434 (-4.2A)
 0.79A 4qmnA-3n9xA:
18.0		 4qmnA-3n9xA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ALA A 151
 None
 0.67A 4qmnA-3oz6A:
24.3		 4qmnA-3oz6A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ASP A 152
 None
 0.81A 4qmnA-3oz6A:
24.3		 4qmnA-3oz6A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 ALA A 369
GLU A 390
THR A 404
TYR A 422
ALA A 483
ASP A 484
 ANP  A 800 (-3.6A)
None
ANP  A 800 ( 3.8A)
ANP  A 800 (-4.2A)
ANP  A 800 ( 3.8A)
ANP  A 800 (-3.0A)
 0.59A 4qmnA-3pfqA:
28.5		 4qmnA-3pfqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 ALA A 369
LYS A 371
GLU A 390
THR A 404
MET A 420
TYR A 422
ASP A 484
 ANP  A 800 (-3.6A)
ANP  A 800 (-3.3A)
None
ANP  A 800 ( 3.8A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-3.0A)
 1.06A 4qmnA-3pfqA:
28.5		 4qmnA-3pfqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
GLU A 596
ILE A 623
TYR A 627
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.79A 4qmnA-3ppzA:
30.7		 4qmnA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A  82
ALA A 103
GLU A 124
THR A 137
MET A 153
TYR A 155
LEU A 207
ALA A 217
ASP A 218
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.97A 4qmnA-3qfvA:
26.7		 4qmnA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  82
ALA A 103
LYS A 105
GLU A 124
THR A 137
MET A 153
TYR A 155
LEU A 207
 None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-3.0A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.98A 4qmnA-3qfvA:
26.7		 4qmnA-3qfvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ALA A 640
ASP A 641
 07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
07J  A   1 (-4.7A)
 0.78A 4qmnA-3tt0A:
25.0		 4qmnA-3tt0A:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 382
GLU A 403
THR A 417
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.65A 4qmnA-3txoA:
18.5		 4qmnA-3txoA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
GLU A 125
THR A 138
MET A 154
TYR A 156
ALA A 218
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 (-4.9A)
None
None
 0.65A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
LYS A 106
GLU A 125
THR A 138
MET A 154
TYR A 156
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 (-4.9A)
None
 0.91A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
ALA A 104
GLU A 125
THR A 138
TYR A 156
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
None
 0.68A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
ALA A 104
LYS A 106
GLU A 125
THR A 138
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.82A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 ALA A 267
LYS A 269
GLU A 288
TYR A 320
LEU A 371
ASP A 382
 None
 0.72A 4qmnA-4c0tA:
28.4		 4qmnA-4c0tA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  43
GLU A  64
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.55A 4qmnA-4cfhA:
30.3		 4qmnA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 ALA A  43
LYS A  45
GLU A  64
MET A  93
TYR A  95
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.93A 4qmnA-4cfhA:
30.3		 4qmnA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
TYR A 703
LEU A 773
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 0.82A 4qmnA-4ckrA:
24.7		 4qmnA-4ckrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 684
GLU A 705
TYR A 739
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.47A 4qmnA-4crsA:
28.8		 4qmnA-4crsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.66A 4qmnA-4e93A:
21.6		 4qmnA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  64
ALA A  88
GLU A 104
ILE A 132
TYR A 136
LEU A 184
ASP A 196
 None
ADP  A 601 (-3.5A)
None
None
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.69A 4qmnA-4f99A:
17.1		 4qmnA-4f99A:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
THR B  83
ILE B  97
MET B  99
TYR B 101
LEU B 151
ALA B 161
 GOL  B1000 ( 4.3A)
None
None
None
None
GOL  B1000 (-4.0A)
GOL  B1000 ( 4.4A)
None
 0.97A 4qmnA-4fzdB:
37.0		 4qmnA-4fzdB:
82.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
MET A 902
TYR A 904
ALA A 966
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.95A 4qmnA-4hviA:
27.9		 4qmnA-4hviA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
TYR A 904
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.75A 4qmnA-4hviA:
27.9		 4qmnA-4hviA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
TYR A 557
LEU A 624
ALA A 634
ASP A 635
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.4A)
None
MG  A 802 ( 3.0A)
 0.53A 4qmnA-4k33A:
13.4		 4qmnA-4k33A:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  61
LYS A  63
GLU A  77
TYR A 106
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.73A 4qmnA-4l52A:
25.4		 4qmnA-4l52A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  54
GLU A  70
ILE A  97
MET A  99
TYR A 101
LEU A 153
ALA A 163
 GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.04A 4qmnA-4lg4A:
33.2		 4qmnA-4lg4A:
50.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  54
LYS A  56
GLU A  70
ILE A  97
TYR A 101
LEU A 153
ALA A 163
 GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.76A 4qmnA-4lg4A:
33.2		 4qmnA-4lg4A:
50.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
LYS B  53
GLU B  70
THR B  83
ILE B  97
MET B  99
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.9A)
None
ADP  B 500 ( 4.1A)
None
ADP  B 500 ( 3.4A)
 0.96A 4qmnA-4o27B:
33.8		 4qmnA-4o27B:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		9 ALA B  51
LYS B  53
GLU B  70
THR B  83
ILE B  97
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.9A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.67A 4qmnA-4o27B:
33.8		 4qmnA-4o27B:
94.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
LYS A 930
GLU A 947
TYR A 980
LEU A1030
ASP A1041
 2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.82A 4qmnA-4oliA:
26.7		 4qmnA-4oliA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
ALA A 644
GLU A 663
ILE A 690
TYR A 694
LEU A 746
ASP A 757
 None
 0.97A 4qmnA-4p2kA:
21.7		 4qmnA-4p2kA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 407
GLU A 428
THR A 442
MET A 458
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-3.5A)
None
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.57A 4qmnA-4q9zA:
29.2		 4qmnA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 407
GLU A 428
THR A 442
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.5A)
None
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.74A 4qmnA-4q9zA:
29.2		 4qmnA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
ALA A  49
GLU A  70
ILE A 102
LEU A 156
ASP A 167
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.0A)
None
ANP  A 402 (-4.6A)
ANP  A 402 ( 2.6A)
 0.69A 4qmnA-4qnyA:
25.9		 4qmnA-4qnyA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
ALA A  49
LYS A  51
GLU A  70
ILE A 102
ASP A 167
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
None
ANP  A 402 ( 2.6A)
 0.74A 4qmnA-4qnyA:
25.9		 4qmnA-4qnyA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 366
GLU A 387
THR A 401
MET A 417
TYR A 419
ALA A 480
 3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 ( 4.8A)
 0.58A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 366
GLU A 387
THR A 401
MET A 417
TYR A 419
ASP A 481
 3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-2.9A)
 0.74A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 366
LYS A 368
GLU A 387
THR A 401
MET A 417
TYR A 419
 3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
 0.78A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
ILE A  79
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.91A 4qmnA-4ueuA:
28.7		 4qmnA-4ueuA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  29
ALA A  50
GLU A  69
ILE A 101
LEU A 154
ASP A 165
 42A  A 402 ( 4.7A)
42A  A 402 (-3.2A)
None
None
42A  A 402 ( 4.9A)
None
 0.81A 4qmnA-4xrlA:
26.7		 4qmnA-4xrlA:
27.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 469
ALA A 488
LYS A 490
GLU A 509
ILE A 537
TYR A 541
LEU A 595
ALA A 605
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.93A 4qmnA-4yffA:
25.8		 4qmnA-4yffA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLU A 531
TYR A 563
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.73A 4qmnA-5a46A:
25.2		 4qmnA-5a46A:
29.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A  69
ALA A  90
LYS A  92
GLU A 110
ILE A 142
ASP A 207
 None
 0.79A 4qmnA-5ci6A:
23.5		 4qmnA-5ci6A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  83
GLU A 103
MET A 132
TYR A 134
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.76A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  62
ALA A  83
GLU A 103
MET A 132
TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.78A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  62
ALA A  83
LYS A  85
GLU A 103
MET A 132
TYR A 134
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
 0.89A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.80A 4qmnA-5grnA:
18.5		 4qmnA-5grnA:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  43
GLU A  61
ILE A  88
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.70A 4qmnA-5j5tA:
30.1		 4qmnA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  43
LYS A  45
GLU A  61
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.79A 4qmnA-5j5tA:
30.1		 4qmnA-5j5tA:
38.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.78A 4qmnA-5jznA:
29.3		 4qmnA-5jznA:
29.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A 276
ALA A 297
LYS A 299
GLU A 315
MET A 344
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.98A 4qmnA-5kbrA:
34.9		 4qmnA-5kbrA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 7 ILE C  15
ALA C  36
LYS C  38
GLU C  52
MET C  82
LEU C 135
ASP C 149
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
9XK  C 301 (-4.2A)
9XK  C 301 (-4.6A)
None
 0.76A 4qmnA-5oktC:
24.5		 4qmnA-5oktC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
LEU A 139
ASP A 150
 7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.74A 4qmnA-5tvtA:
28.3		 4qmnA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
ALA A 119
GLU A 140
TYR A 171
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 4qmnA-5u7qA:
27.9		 4qmnA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
 None
 0.66A 4qmnA-5u7qA:
27.9		 4qmnA-5u7qA:
28.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 218
ALA A 239
LYS A 241
GLU A 259
ILE A 287
TYR A 291
ASP A 380
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-4.8A)
 0.80A 4qmnA-5vdkA:
26.9		 4qmnA-5vdkA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 ALA A  49
LYS A  51
GLU A  69
TYR A  98
LEU A 150
ASP A 161
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 0.69A 4qmnA-5wnmA:
26.4		 4qmnA-5wnmA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ILE A 733
ALA A 754
GLU A 774
TYR A 815
LEU A 866
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 0.78A 4qmnA-6b3eA:
29.6		 4qmnA-6b3eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
ALA A 754
LYS A 756
GLU A 774
TYR A 815
LEU A 866
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
 0.81A 4qmnA-6b3eA:
29.6		 4qmnA-6b3eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
GLU A 107
TYR A 138
LEU A 189
ALA A 199
ASP A 200
 None
 0.54A 4qmnA-6c9dA:
29.3		 4qmnA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
ALA A 192
LYS A 194
GLU A 236
LEU A 319
ALA A 329
ASP A 330
 F6J  A 501 (-4.3A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
F6J  A 501 (-3.8A)
 0.85A 4qmnA-6cmjA:
21.4		 4qmnA-6cmjA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 ALA U  42
GLU U  62
MET U  91
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.81A 4qmnA-6fdyU:
29.1		 4qmnA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 ALA A 191
LYS A 193
GLU A 208
ILE A 241
LEU A 297
ASP A 327
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
3NG  A 501 (-4.5A)
 0.75A 4qmnA-6fylA:
26.6		 4qmnA-6fylA:
undetectable