SIMILAR PATTERNS OF AMINO ACIDS FOR 4QDC_A_ASDA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 VAL A 353
HIS A 347
LEU A 339
ALA A 446
ASN A 378
 None
 1.50A 4qdcA-1lamA:
0.0		 4qdcA-1lamA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 VAL A  48
LEU A 224
SER A 225
LEU A 218
PHE A  30
 None
 1.46A 4qdcA-1sgvA:
0.0		 4qdcA-1sgvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 321
LEU A  94
ALA A  45
LEU A 111
ASN A 344
 None
 1.35A 4qdcA-2akzA:
undetectable		 4qdcA-2akzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		5 LEU A 229
SER A 233
ALA A 238
LEU A 142
PHE A 144
 None
 1.42A 4qdcA-2epjA:
0.0		 4qdcA-2epjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE

(Enterococcus
faecalis) 		PF02525
(Flavodoxin_2) 		5 VAL A  20
LEU A   4
ALA A 101
LEU A 144
PHE A 208
 None
 1.36A 4qdcA-2hpvA:
undetectable		 4qdcA-2hpvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 HIS A 217
GLN A 420
LEU A 222
LEU A 175
ASN A 273
 None
 1.38A 4qdcA-2i0kA:
0.0		 4qdcA-2i0kA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 VAL A  78
ALA A 154
LEU A 178
ASN A 179
PHE A 277
 None
TDP  A3001 (-3.6A)
None
None
None
 1.48A 4qdcA-2o1sA:
0.0		 4qdcA-2o1sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi8 PUTATIVE REGULATORY
PROTEIN SCO4313

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 HIS A  94
LEU A  79
ALA A 100
LEU A 183
PHE A 179
 None
 1.09A 4qdcA-2oi8A:
undetectable		 4qdcA-2oi8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 322
LEU A  93
ALA A  46
LEU A 110
ASN A 345
 None
 1.48A 4qdcA-2ptzA:
undetectable		 4qdcA-2ptzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 356
HIS A  13
ALA A 351
LEU A 349
PHE A 370
 None
 1.43A 4qdcA-2xd4A:
0.0		 4qdcA-2xd4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 HIS A  92
LEU A  12
SER A  40
LEU A  73
PHE A  77
 None
 1.17A 4qdcA-2yw9A:
undetectable		 4qdcA-2yw9A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		5 HIS A 181
LEU A 226
SER A 228
ALA A 230
MET A 238
 FE2  A 452 (-3.3A)
None
None
None
None
 0.89A 4qdcA-2zylA:
45.6		 4qdcA-2zylA:
61.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		9 VAL A 176
HIS A 186
GLN A 204
LEU A 226
SER A 228
ALA A 230
MET A 238
LEU A 255
ASN A 257
 None
FE2  A 452 (-3.3A)
None
None
None
None
None
None
None
 0.82A 4qdcA-2zylA:
45.6		 4qdcA-2zylA:
61.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3r CALCYPHOSIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 VAL A  97
MET A  90
SER A  91
ALA A  93
ASP A 176
 None
 1.37A 4qdcA-3e3rA:
undetectable		 4qdcA-3e3rA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		5 HIS A 147
MET A  93
SER A  92
LEU A  70
PHE A  85
 ERY  A 195 (-4.2A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.6A)
None
None
 1.14A 4qdcA-3frqA:
undetectable		 4qdcA-3frqA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		5 VAL A 333
GLN A  49
LEU A  89
LEU A 325
PHE A  72
 None
 1.46A 4qdcA-3ibgA:
undetectable		 4qdcA-3ibgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 146
SER A 143
ALA A  45
MET A  54
ASP A 159
 None
 1.41A 4qdcA-3il3A:
undetectable		 4qdcA-3il3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l51 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Mus musculus) 		PF06470
(SMC_hinge) 		5 VAL A 598
HIS A 604
ALA A 636
LEU A 652
ASN A 631
 None
 1.41A 4qdcA-3l51A:
undetectable		 4qdcA-3l51A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		5 VAL A  38
MET A 218
ALA A 293
MET A 313
ASN A 315
 None
2RH  A 410 ( 4.9A)
None
None
2RH  A 410 (-3.5A)
 1.45A 4qdcA-3o3oA:
undetectable		 4qdcA-3o3oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 VAL A  -2
GLN A  38
LEU A 188
SER A 175
ASP A 177
 None
None
None
PO4  A 354 ( 4.1A)
PO4  A 354 (-2.8A)
 1.40A 4qdcA-3oryA:
undetectable		 4qdcA-3oryA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 VAL B 749
GLN B 621
LEU B 628
SER B 625
ALA B 745
 None
 1.36A 4qdcA-3p8cB:
undetectable		 4qdcA-3p8cB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		5 HIS A  77
LEU A  71
LEU A 137
ASN A 139
PHE A 134
 None
 1.42A 4qdcA-3psqA:
undetectable		 4qdcA-3psqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		5 LEU A  58
SER A  81
ALA A 101
LEU A  86
PHE A  68
 None
 1.46A 4qdcA-3pssA:
undetectable		 4qdcA-3pssA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		5 MET A  15
LEU A  71
ALA A 113
ASP A 118
LEU A 120
 None
 1.37A 4qdcA-3qd8A:
undetectable		 4qdcA-3qd8A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)

(Shewanella sp.
W3-18-1) 		PF01717
(Meth_synt_2) 		5 GLN A 186
LEU A 262
ALA A 219
LEU A 252
PHE A 249
 None
 1.41A 4qdcA-3rpdA:
undetectable		 4qdcA-3rpdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		5 MET A 436
LEU A 440
ALA A 254
LEU A 174
ASN A 248
 None
 1.49A 4qdcA-3rvaA:
undetectable		 4qdcA-3rvaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti2 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 MET A 179
LEU A  34
SER A 180
LEU A 106
PHE A  82
 None
 0.95A 4qdcA-3ti2A:
undetectable		 4qdcA-3ti2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 VAL A 232
LEU A 167
ALA A 164
LEU A 214
PHE A 205
 None
 1.26A 4qdcA-3vexA:
undetectable		 4qdcA-3vexA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 VAL A  65
LEU A 284
LEU A 145
ASN A 144
PHE A 147
 None
 1.49A 4qdcA-4a9aA:
undetectable		 4qdcA-4a9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 VAL A 139
LEU A 242
SER A 240
ALA A 122
PHE A 299
 None
 1.47A 4qdcA-4b8sA:
undetectable		 4qdcA-4b8sA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 VAL A1172
LEU A1180
ALA A 933
LEU A1127
PHE A1123
 None
 1.40A 4qdcA-4bocA:
undetectable		 4qdcA-4bocA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		5 VAL A 363
LEU A 439
ALA A 314
ASP A 315
LEU A 206
 None
 1.42A 4qdcA-4citA:
undetectable		 4qdcA-4citA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 VAL A 116
HIS A  80
GLN A 145
LEU A 157
ALA A 142
 None
ZN  A 504 (-3.1A)
None
None
None
 1.48A 4qdcA-4dzhA:
undetectable		 4qdcA-4dzhA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		5 VAL A 263
ALA A  75
MET A  79
LEU A 442
PHE A 299
 None
 1.28A 4qdcA-4ikvA:
undetectable		 4qdcA-4ikvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 GLN D 486
LEU D 352
LEU D 478
ASN D 481
PHE D 474
 None
 1.46A 4qdcA-4ngeD:
undetectable		 4qdcA-4ngeD:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		5 HIS A 187
MET A 212
SER A 235
ALA A 237
MET A 245
 FE2  A 402 (-3.5A)
None
30Q  A 403 (-3.6A)
30Q  A 403 ( 3.7A)
30Q  A 403 ( 3.8A)
 1.02A 4qdcA-4qddA:
50.5		 4qdcA-4qddA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		12 VAL A 182
HIS A 192
GLN A 210
MET A 212
LEU A 233
SER A 235
ALA A 237
MET A 245
ASP A 247
LEU A 262
ASN A 264
PHE A 300
 30Q  A 403 (-3.5A)
FE2  A 402 ( 3.5A)
30Q  A 403 (-3.6A)
None
None
30Q  A 403 (-3.6A)
30Q  A 403 ( 3.7A)
30Q  A 403 ( 3.8A)
30Q  A 403 (-3.7A)
None
None
30Q  A 403 (-3.6A)
 0.54A 4qdcA-4qddA:
50.5		 4qdcA-4qddA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		5 HIS B 181
MET B 206
SER B 229
ALA B 231
MET B 239
 FE2  B 401 (-3.4A)
30Q  B 403 ( 4.6A)
30Q  B 403 (-3.4A)
30Q  B 403 ( 3.7A)
30Q  B 403 (-3.6A)
 1.32A 4qdcA-4qdfB:
45.0		 4qdcA-4qdfB:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		5 HIS B 186
GLN B 204
ALA B 231
ASP B 241
LEU B 243
 FE2  B 401 ( 3.5A)
30Q  B 403 (-4.0A)
30Q  B 403 ( 3.7A)
30Q  B 403 (-3.5A)
30Q  B 403 (-4.8A)
 1.38A 4qdcA-4qdfB:
45.0		 4qdcA-4qdfB:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		9 HIS B 186
GLN B 204
MET B 206
SER B 229
ALA B 231
MET B 239
ASP B 241
LEU B 256
ASN B 258
 FE2  B 401 ( 3.5A)
30Q  B 403 (-4.0A)
30Q  B 403 ( 4.6A)
30Q  B 403 (-3.4A)
30Q  B 403 ( 3.7A)
30Q  B 403 (-3.6A)
30Q  B 403 (-3.5A)
None
30Q  B 403 ( 4.7A)
 0.85A 4qdcA-4qdfB:
45.0		 4qdcA-4qdfB:
62.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL A 298
ALA A 274
MET A 370
ASP A 277
LEU A 372
 None
 1.14A 4qdcA-4ux8A:
undetectable		 4qdcA-4ux8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euh PUTATIVE GGDEF
DOMAIN MEMBRANE
PROTEIN

(Pseudomonas
fluorescens) 		PF00990
(GGDEF) 		5 LEU A 397
ALA A 343
ASP A 342
ASN A 349
PHE A 423
 None
 1.41A 4qdcA-5euhA:
undetectable		 4qdcA-5euhA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		5 LEU A 171
ALA A 136
MET A 158
LEU A 164
PHE A 220
 None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
None
 1.04A 4qdcA-5gm2A:
undetectable		 4qdcA-5gm2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 GLN A 215
LEU A 261
SER A 260
ASN A 253
PHE A  26
 None
 1.38A 4qdcA-5hmqA:
undetectable		 4qdcA-5hmqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN

(Mojiang
henipavirus) 		PF00423
(HN) 		5 VAL A 273
GLN A 252
LEU A 249
SER A 250
ALA A 275
 None
 1.42A 4qdcA-5nopA:
undetectable		 4qdcA-5nopA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 GLN A  56
LEU A  43
ALA A  18
LEU A  75
ASN A  76
 None
 1.39A 4qdcA-5w7zA:
undetectable		 4qdcA-5w7zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 5 VAL A 399
HIS A 278
GLN A 327
LEU A 569
ALA A 286
 None
 1.40A 4qdcA-5zq6A:
undetectable		 4qdcA-5zq6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 LEU A 208
SER A 212
MET A 150
LEU A 146
PHE A 142
 None
 1.34A 4qdcA-6b07A:
undetectable		 4qdcA-6b07A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 VAL g  72
LEU C 403
ALA g  68
MET g 320
LEU g  66
 None
 1.44A 4qdcA-6fkhg:
undetectable		 4qdcA-6fkhg:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 5 VAL A 152
LEU A 532
SER A 406
ALA A 148
MET A 565
 None
 1.32A 4qdcA-6g3uA:
undetectable		 4qdcA-6g3uA:
undetectable