SIMILAR PATTERNS OF AMINO ACIDS FOR 4QCK_A_ASDA404
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci9 | PROTEIN(CARBOXYLESTERASE) (Burkholderiagladioli) |
PF00144(Beta-lactamase) | 5 | ASN A 162LEU A 124ALA A 167LEU A 104GLY A 189 | None | 1.30A | 4qckA-1ci9A:undetectable | 4qckA-1ci9A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e4a | L-FUCULOSE1-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF00596(Aldolase_II) | 5 | ASN P 29VAL P 30MET P 17ASN P 23GLY P 156 | SO4 P 301 (-3.8A)BME P 303 ( 4.8A)NoneBME P 303 ( 4.4A)None | 1.04A | 4qckA-1e4aP:0.0 | 4qckA-1e4aP:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fs5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Escherichiacoli) |
PF01182(Glucosamine_iso) | 5 | ASN A 22LEU A 6ALA A 17MET A 55GLY A 265 | None | 1.31A | 4qckA-1fs5A:0.0 | 4qckA-1fs5A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1izo | CYTOCHROME P450152A1 (Bacillussubtilis) |
PF00067(p450) | 5 | ASN A 239LEU A 111ALA A 213MET A 217GLY A 365 | NoneNoneNoneNoneHEM A 501 ( 3.7A) | 1.29A | 4qckA-1izoA:undetectable | 4qckA-1izoA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1onf | GLUTATHIONEREDUCTASE (Plasmodiumfalciparum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ASN A 229ALA A 54ASN A 192GLY A 454ASP A 225 | None | 1.15A | 4qckA-1onfA:0.0 | 4qckA-1onfA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgu | ACTIN INTERACTINGPROTEIN 1 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | LEU A 590ALA A 579ASN A 581GLY A 586ASP A 562 | None | 1.12A | 4qckA-1pguA:0.0 | 4qckA-1pguA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgr | PROTEIN (IMPORTINBETA SUBUNIT) (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | ASN A 469VAL A 470MET A 417LEU A 413GLY A 391 | None | 1.02A | 4qckA-1qgrA:0.0 | 4qckA-1qgrA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qrr | SULFOLIPIDBIOSYNTHESIS (SQD1)PROTEIN (Arabidopsisthaliana) |
PF01370(Epimerase) | 5 | ASN A 362VAL A 365LEU A 240ALA A 247ASP A 358 | None | 1.30A | 4qckA-1qrrA:0.0 | 4qckA-1qrrA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4n | AMYLOID BETAPRECURSORPROTEIN-BINDINGPROTEIN 1 (Homo sapiens) |
PF00899(ThiF) | 5 | ASN A 37ALA A 40ASN A 73LEU A 76ASP A 61 | None | 1.20A | 4qckA-1r4nA:undetectable | 4qckA-1r4nA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4n | AMYLOID BETAPRECURSORPROTEIN-BINDINGPROTEIN 1 (Homo sapiens) |
PF00899(ThiF) | 5 | ASN A 37LEU A 93ALA A 40ASN A 73LEU A 76 | None | 1.20A | 4qckA-1r4nA:undetectable | 4qckA-1r4nA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s0p | ADENYLYLCYCLASE-ASSOCIATEDPROTEIN (Dictyosteliumdiscoideum) |
PF01213(CAP_N) | 5 | VAL A 191ALA A 141LEU A 139ASN A 138GLY A 78 | None | 1.17A | 4qckA-1s0pA:undetectable | 4qckA-1s0pA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6k | PHENAZINEBIOSYNTHESIS PROTEINPHZF (Pseudomonasfluorescens) |
PF02567(PhzC-PhzF) | 5 | GLN A 35LEU A 69ALA A 38ASN A 42GLY A 204 | None | 1.15A | 4qckA-1t6kA:undetectable | 4qckA-1t6kA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 5 | LEU A 231ALA A 234LEU A 275ASN A 277ASP A 211 | None | 1.28A | 4qckA-1t8wA:undetectable | 4qckA-1t8wA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tr1 | BETA-GLUCOSIDASE A (Paenibacilluspolymyxa) |
PF00232(Glyco_hydro_1) | 5 | ALA A 190ASN A 175LEU A 184ASN A 186GLY A 132 | None | 1.31A | 4qckA-1tr1A:undetectable | 4qckA-1tr1A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u6g | TIP120 PROTEIN (Homo sapiens) |
PF08623(TIP120) | 5 | ASN C 463VAL C 464LEU C 476ALA C 468ASN C 507 | None | 1.33A | 4qckA-1u6gC:undetectable | 4qckA-1u6gC:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x2g | LIPOATE-PROTEINLIGASE A (Escherichiacoli) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | HIS A 148LEU A 34ALA A 107LEU A 152GLY A 150 | None | 1.20A | 4qckA-1x2gA:undetectable | 4qckA-1x2gA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkd | ISOCITRATEDEHYDROGENASE (Aeropyrumpernix) |
PF00180(Iso_dh) | 5 | LEU A 290ALA A 305ASN A 309LEU A 308ASN A 307 | None | 1.33A | 4qckA-1xkdA:undetectable | 4qckA-1xkdA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7a | CONSERVEDHYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF01522(Polysacc_deac_1) | 5 | HIS A 126LEU A 54ASN A 216LEU A 213GLY A 166 | None | 1.21A | 4qckA-1z7aA:undetectable | 4qckA-1z7aA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akz | GAMMA ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | VAL A 321LEU A 94ALA A 45LEU A 111ASN A 344 | None | 1.26A | 4qckA-2akzA:undetectable | 4qckA-2akzA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b44 | GLYCYL-GLYCINEENDOPEPTIDASE LYTM (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 5 | HIS A 291ALA A 279ASN A 261ASN A 262GLY A 285 | PO4 A 500 (-3.9A)NoneNoneNonePO4 A 500 (-3.6A) | 1.29A | 4qckA-2b44A:undetectable | 4qckA-2b44A:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b6o | LENS FIBER MAJORINTRINSIC PROTEIN (Ovis aries) |
PF00230(MIP) | 5 | VAL A 90GLN A 93LEU A 52ALA A 186ASN A 184 | MC3 A 266 (-4.8A)NoneNoneNoneNone | 1.14A | 4qckA-2b6oA:undetectable | 4qckA-2b6oA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvt | BETA-1,4-MANNANASE (Cellulomonasfimi) |
PF02156(Glyco_hydro_26) | 5 | LEU A 21ALA A 279LEU A 243GLY A 275ASP A 272 | None | 1.22A | 4qckA-2bvtA:undetectable | 4qckA-2bvtA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dt4 | HYPOTHETICAL PROTEINPH0802 (Pyrococcushorikoshii) |
PF03479(DUF296) | 5 | ASN A 41LEU A 94ALA A 90LEU A 22GLY A 44 | None | 0.85A | 4qckA-2dt4A:undetectable | 4qckA-2dt4A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | VAL A 91GLN A 94LEU A 308MET A 103LEU A 98 | None | 1.33A | 4qckA-2fj0A:undetectable | 4qckA-2fj0A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iag | PROSTACYCLINSYNTHASE (Homo sapiens) |
PF00067(p450) | 5 | LEU A 384ALA A 354MET A 486GLY A 47ASP A 49 | None | 1.04A | 4qckA-2iagA:undetectable | 4qckA-2iagA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgd | 2-OXOGLUTARATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 5 | ASN A 423VAL A 422LEU A 229LEU A 207ASP A 425 | None | 1.17A | 4qckA-2jgdA:undetectable | 4qckA-2jgdA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzk | PUTATIVE NUCLEOTIDESUGAR EPIMERASE/DEHYDRATASE (Bordetellabronchiseptica) |
PF01370(Epimerase) | 5 | LEU A 28ALA A 102ASN A 98GLY A 52ASP A 56 | None | 1.23A | 4qckA-2pzkA:undetectable | 4qckA-2pzkA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qna | IMPORTIN SUBUNITBETA-1 (Homo sapiens) |
PF13513(HEAT_EZ) | 5 | ASN A 469VAL A 470MET A 417LEU A 413GLY A 391 | None | 1.13A | 4qckA-2qnaA:undetectable | 4qckA-2qnaA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 5 | ASN A 139VAL A 140GLN A 109LEU A 76GLY A 135 | None | 1.31A | 4qckA-2qzwA:0.0 | 4qckA-2qzwA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vjh | PHYCOERYTHRIN BETASUBUNIT (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | ASN B 143LEU B 90ALA B 43LEU B 97GLY B 166 | None | 1.28A | 4qckA-2vjhB:undetectable | 4qckA-2vjhB:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y30 | PUTATIVE REPRESSORSIMREG2 (Streptomycesantibioticus) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | GLN A 136LEU A 88LEU A 110GLY A 84ASP A 80 | None | 1.14A | 4qckA-2y30A:undetectable | 4qckA-2y30A:21.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zyl | POSSIBLEOXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF00355(Rieske) | 12 | ASN A 175VAL A 176HIS A 186GLN A 204LEU A 226ALA A 230MET A 238ASN A 240LEU A 255ASN A 257GLY A 300ASP A 304 | NoneNoneFE2 A 452 (-3.3A)NoneNoneNoneNoneNoneNoneNoneNoneFE2 A 452 (-2.0A) | 0.25A | 4qckA-2zylA:53.2 | 4qckA-2zylA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zyl | POSSIBLEOXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF00355(Rieske) | 7 | ASN A 175VAL A 176HIS A 186GLN A 204LEU A 242GLY A 300ASP A 304 | NoneNoneFE2 A 452 (-3.3A)NoneNoneNoneFE2 A 452 (-2.0A) | 1.21A | 4qckA-2zylA:53.2 | 4qckA-2zylA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zyl | POSSIBLEOXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF00355(Rieske) | 6 | HIS A 181ALA A 230MET A 238ASN A 240ASN A 257ASP A 304 | FE2 A 452 (-3.3A)NoneNoneNoneNoneFE2 A 452 (-2.0A) | 1.30A | 4qckA-2zylA:53.2 | 4qckA-2zylA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cit | SENSOR HISTIDINEKINASE (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 5 | VAL A 58HIS A 80LEU A 110ASN A 133GLY A 81 | NoneNoneNoneGOL A 176 (-3.2A)None | 1.21A | 4qckA-3citA:undetectable | 4qckA-3citA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cl6 | PUUE ALLANTOINASE (Pseudomonasfluorescens) |
PF01522(Polysacc_deac_1) | 5 | HIS A 126LEU A 54ASN A 216LEU A 213GLY A 166 | None | 1.24A | 4qckA-3cl6A:undetectable | 4qckA-3cl6A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnc | FIBER PROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 5 | LEU A 225MET A 252LEU A 163ASN A 245GLY A 231 | None | 1.01A | 4qckA-3cncA:undetectable | 4qckA-3cncA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4i | GLYCOSYLTRANSFERASEGTFA,GLYCOSYLTRANSFERASE (Actinoplanesteichomyceticus;Amycolatopsisorientalis) |
PF03033(Glyco_transf_28)PF04101(Glyco_tran_28_C) | 5 | VAL A 123ALA A 181LEU A 185GLY A 292ASP A 315 | NoneNoneNoneNoneU2F A 547 (-2.7A) | 1.31A | 4qckA-3h4iA:undetectable | 4qckA-3h4iA:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igh | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcushorikoshii) |
PF07969(Amidohydro_3) | 5 | VAL X 376HIS X 330GLN X 377LEU X 285GLY X 283 | NoneSO4 X 1 (-3.9A)NoneNoneNone | 1.10A | 4qckA-3ighX:undetectable | 4qckA-3ighX:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilv | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Cytophagahutchinsonii) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | ASN A 219VAL A 234LEU A 83ALA A 9GLY A 49 | None | 1.33A | 4qckA-3ilvA:undetectable | 4qckA-3ilvA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyl | VP1 (Aquareovirus C) |
PF06016(Reovirus_L2) | 5 | ASN W 502VAL W 501HIS W1193LEU W1276GLY W1150 | None | 1.30A | 4qckA-3iylW:undetectable | 4qckA-3iylW:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kiz | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Cytophagahutchinsonii) |
PF02769(AIRS_C) | 5 | ASN A 183VAL A 184ALA A 351GLY A 280ASP A 283 | NoneNoneNoneEDO A 397 (-3.3A)None | 1.19A | 4qckA-3kizA:undetectable | 4qckA-3kizA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kom | TRANSKETOLASE (Francisellatularensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ASN A 187VAL A 248LEU A 267ALA A 257GLY A 264 | None | 1.33A | 4qckA-3komA:undetectable | 4qckA-3komA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9i | LENS FIBER MAJORINTRINSIC PROTEIN (Ovis aries) |
PF00230(MIP) | 5 | VAL A 90GLN A 93LEU A 52ALA A 186ASN A 184 | None | 1.23A | 4qckA-3m9iA:undetectable | 4qckA-3m9iA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3o | ALPHA-SUBUNIT2-HYDROXYISOCAPROYL-COA DEHYDRATASE (Clostridioidesdifficile) |
PF06050(HGD-D) | 6 | VAL A 38LEU A 214ALA A 293MET A 313ASN A 315GLY A 264 | NoneNoneNoneNone2RH A 410 (-3.5A)None | 1.43A | 4qckA-3o3oA:undetectable | 4qckA-3o3oA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ow2 | 50S RIBOSOMALPROTEIN L2P (Haloarculamarismortui) |
PF00181(Ribosomal_L2)PF03947(Ribosomal_L2_C) | 5 | ASN A 107VAL A 108ALA A 126ASN A 125GLY A 160 | None | 1.25A | 4qckA-3ow2A:2.4 | 4qckA-3ow2A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3quf | EXTRACELLULARSOLUTE-BINDINGPROTEIN, FAMILY 1 (Bifidobacteriumlongum) |
PF13416(SBP_bac_8) | 5 | ASN A 374LEU A 339ALA A 145GLY A 123ASP A 125 | NoneNoneNoneSO4 A 3 (-3.5A)None | 1.32A | 4qckA-3qufA:undetectable | 4qckA-3qufA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r6y | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1) | 5 | ASN A 136VAL A 135LEU A 250ALA A 57GLY A 228 | ASN A 136 ( 0.6A)VAL A 135 ( 0.6A)LEU A 250 ( 0.6A)ALA A 57 ( 0.0A)GLY A 228 ( 0.0A) | 1.22A | 4qckA-3r6yA:undetectable | 4qckA-3r6yA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASN A 132VAL A 131LEU A 247ALA A 60GLY A 225 | None | 1.28A | 4qckA-3rd8A:undetectable | 4qckA-3rd8A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrp | PROBABLE FUMARATEHYDRATASE FUM (Mycobacteroidesabscessus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASN A 133VAL A 132LEU A 248ALA A 59GLY A 226 | None | 1.30A | 4qckA-3rrpA:undetectable | 4qckA-3rrpA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5s | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Sorangiumcellulosum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASN A 269VAL A 268ALA A 265LEU A 221GLY A 195 | None | 1.21A | 4qckA-3s5sA:undetectable | 4qckA-3s5sA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6o | POLYSACCHARIDEDEACETYLASE FAMILYPROTEIN (Burkholderiapseudomallei) |
PF01522(Polysacc_deac_1) | 5 | HIS A 127LEU A 56ASN A 220LEU A 217GLY A 167 | None | 1.20A | 4qckA-3s6oA:undetectable | 4qckA-3s6oA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stt | METHYLKETONESYNTHASE I (Solanumhabrochaites) |
PF12697(Abhydrolase_6) | 5 | ASN A 163LEU A 88LEU A 153ASN A 138GLY A 129 | NoneDKA A 266 (-4.2A)NoneNoneDKA A 266 ( 3.7A) | 1.12A | 4qckA-3sttA:undetectable | 4qckA-3sttA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tej | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00550(PP-binding)PF00975(Thioesterase) | 5 | ASN A1216HIS A1072ALA A1109LEU A1112GLY A1140 | None | 1.28A | 4qckA-3tejA:undetectable | 4qckA-3tejA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zhr | MULTIFUNCTIONAL2-OXOGLUTARATEMETABOLISM ENZYME (Mycolicibacteriumsmegmatis) |
PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 5 | ASN A 710VAL A 709LEU A 508LEU A 486ASP A 712 | None | 1.16A | 4qckA-3zhrA:undetectable | 4qckA-3zhrA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5q | CHI1 (Yersiniaentomophaga) |
PF00704(Glyco_hydro_18) | 5 | ASN A 69VAL A 70HIS A 250ASN A 321GLY A 292 | None | 1.17A | 4qckA-4a5qA:undetectable | 4qckA-4a5qA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amc | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | ASN A1549VAL A1548ALA A1598ASN A 983GLY A1553 | None | 1.16A | 4qckA-4amcA:undetectable | 4qckA-4amcA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apb | FUMARATE HYDRATASECLASS II (Mycobacteriumtuberculosis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ASN A 134VAL A 133LEU A 249ALA A 62GLY A 227 | None | 1.27A | 4qckA-4apbA:undetectable | 4qckA-4apbA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 5 | VAL A 458ALA A 392LEU A 446GLY A 687ASP A 691 | None | 1.19A | 4qckA-4btpA:undetectable | 4qckA-4btpA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIBINTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF01839(FG-GAP)PF07965(Integrin_B_tail)PF07974(EGF_2)PF08441(Integrin_alpha2)PF17205(PSI_integrin) | 5 | LEU B 343ALA A 323LEU B 245ASN B 305GLY B 349 | None | 1.14A | 4qckA-4cakB:undetectable | 4qckA-4cakB:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnx | SULFATEADENYLYLTRANSFERASE (Allochromatiumvinosum) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 5 | GLN A 152LEU A 270ALA A 40ASN A 43LEU A 83 | None | 1.29A | 4qckA-4dnxA:undetectable | 4qckA-4dnxA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 5 | ASN A 14VAL A 176ALA A 139ASN A 179GLY A 255 | None | 1.32A | 4qckA-4fr2A:undetectable | 4qckA-4fr2A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4s | PROTEASOME CHAPERONE1 (Saccharomycescerevisiae) |
PF10450(POC1) | 5 | ALA O 219MET O 177LEU O 217GLY O 243ASP O 240 | None | 1.15A | 4qckA-4g4sO:undetectable | 4qckA-4g4sO:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h41 | PUTATIVEALPHA-L-FUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF14488(DUF4434)PF17134(DUF5109) | 5 | ALA A 202MET A 206ASN A 165GLY A 150ASP A 148 | None | 1.24A | 4qckA-4h41A:undetectable | 4qckA-4h41A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnn | DIHYDRODIPICOLINATESYNTHASE (Vitis vinifera) |
PF00701(DHDPS) | 5 | VAL A 315GLN A 272LEU A 229ASN A 297GLY A 303 | None | 1.18A | 4qckA-4hnnA:undetectable | 4qckA-4hnnA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ica | MATRIX PROTEIN P15 (Felineimmunodeficiencyvirus) |
no annotation | 5 | VAL A 85LEU A 96ALA A 106GLY A 114ASP A 116 | None | 1.21A | 4qckA-4icaA:undetectable | 4qckA-4icaA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 5 | HIS A 133LEU A 107ALA A 115ASN A 204GLY A 131 | LMS A 401 (-3.9A)NoneNoneNoneNone | 1.22A | 4qckA-4injA:undetectable | 4qckA-4injA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jg3 | CATABOLITEREPRESSION CONTROLPROTEIN (Pseudomonasaeruginosa) |
PF03372(Exo_endo_phos) | 5 | VAL A 9LEU A 46ALA A 17ASN A 12GLY A 69 | None | 1.32A | 4qckA-4jg3A:undetectable | 4qckA-4jg3A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdc | PUTATIVE GLUTATHIONES-TRANSFERASE (Sinorhizobiummeliloti) |
PF13417(GST_N_3)PF14497(GST_C_3) | 5 | HIS A 224ALA A 192MET A 149GLY A 185ASP A 182 | None | 1.26A | 4qckA-4mdcA:undetectable | 4qckA-4mdcA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pju | COHESIN SUBUNIT SA-2 (Homo sapiens) |
PF08514(STAG) | 5 | VAL A 376HIS A 337ALA A 390LEU A 351GLY A 333 | None | 1.29A | 4qckA-4pjuA:undetectable | 4qckA-4pjuA:16.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdd | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 8 | ASN A 181VAL A 182GLN A 210LEU A 233ALA A 237MET A 245LEU A 262ASN A 264 | FE2 A 402 (-4.2A)30Q A 403 (-3.5A)30Q A 403 (-3.6A)None30Q A 403 ( 3.7A)30Q A 403 ( 3.8A)NoneNone | 0.57A | 4qckA-4qddA:44.1 | 4qckA-4qddA:61.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdd | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 8 | ASN A 181VAL A 182HIS A 192GLN A 210ALA A 237MET A 245LEU A 262ASN A 264 | FE2 A 402 (-4.2A)30Q A 403 (-3.5A)FE2 A 402 ( 3.5A)30Q A 403 (-3.6A)30Q A 403 ( 3.7A)30Q A 403 ( 3.8A)NoneNone | 0.63A | 4qckA-4qddA:44.1 | 4qckA-4qddA:61.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdd | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 7 | ASN A 181VAL A 182HIS A 192GLN A 210MET A 245ASN A 264GLY A 307 | FE2 A 402 (-4.2A)30Q A 403 (-3.5A)FE2 A 402 ( 3.5A)30Q A 403 (-3.6A)30Q A 403 ( 3.8A)NoneNone | 1.00A | 4qckA-4qddA:44.1 | 4qckA-4qddA:61.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdd | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 5 | ASN A 181VAL A 182HIS A 192GLY A 307ASP A 311 | FE2 A 402 (-4.2A)30Q A 403 (-3.5A)FE2 A 402 ( 3.5A)NoneFE2 A 402 (-2.3A) | 0.99A | 4qckA-4qddA:44.1 | 4qckA-4qddA:61.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdd | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 5 | HIS A 187GLN A 210ALA A 237MET A 245ASN A 264 | FE2 A 402 (-3.5A)30Q A 403 (-3.6A)30Q A 403 ( 3.7A)30Q A 403 ( 3.8A)None | 1.13A | 4qckA-4qddA:44.1 | 4qckA-4qddA:61.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdf | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 9 | ASN B 175HIS B 186GLN B 204ALA B 231MET B 239LEU B 256ASN B 258GLY B 301ASP B 305 | FE2 B 401 (-4.9A)FE2 B 401 ( 3.5A)30Q B 403 (-4.0A)30Q B 403 ( 3.7A)30Q B 403 (-3.6A)None30Q B 403 ( 4.7A)30Q B 403 ( 4.3A)FE2 B 401 ( 2.1A) | 0.33A | 4qckA-4qdfB:48.2 | 4qckA-4qdfB:58.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qdf | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 6 | ASN B 175HIS B 186GLN B 204LEU B 243GLY B 301ASP B 305 | FE2 B 401 (-4.9A)FE2 B 401 ( 3.5A)30Q B 403 (-4.0A)30Q B 403 (-4.8A)30Q B 403 ( 4.3A)FE2 B 401 ( 2.1A) | 1.26A | 4qckA-4qdfB:48.2 | 4qckA-4qdfB:58.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rih | GLYCOSYL TRANSFERASEHOMOLOG,GLYCOSYLTRANSFERASE (Streptomycescyanogenus;Streptomycesfradiae) |
PF06722(DUF1205) | 5 | HIS A 283GLN A 299ALA A 292LEU A 270GLY A 218 | 3R2 A 401 (-4.3A)NoneNone3R2 A 401 (-3.7A)3R2 A 401 (-3.5A) | 1.26A | 4qckA-4rihA:undetectable | 4qckA-4rihA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zyj | DNMZ (Streptomycespeucetius) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 259HIS A 120ALA A 255MET A 336ASP A 323 | TYD A 501 (-4.3A)NoneTYD A 501 ( 3.8A)NoneNone | 1.27A | 4qckA-4zyjA:undetectable | 4qckA-4zyjA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c08 | 1E6 TCR BETA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | ASN E 50MET E 69ASN E 52GLY E 28ASP E 30 | GOL E 306 (-3.5A)NoneNoneNoneGOL E 306 (-2.7A) | 1.30A | 4qckA-5c08E:undetectable | 4qckA-5c08E:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c70 | GLUCURONIDASE (Aspergillusoryzae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | GLN A 527LEU A 514ALA A 508ASN A 567ASP A 554 | None | 1.32A | 4qckA-5c70A:undetectable | 4qckA-5c70A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cio | PYRROLOQUINOLINEQUINONE BIOSYNTHESISPROTEIN PQQF (Serratia sp.FS14) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | GLN A 174LEU A 49ALA A 116GLY A 167ASP A 169 | None | 1.16A | 4qckA-5cioA:undetectable | 4qckA-5cioA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjh | 4-ALPHA-GLUCANOTRANSFERASE (Corynebacteriumglutamicum) |
PF02446(Glyco_hydro_77) | 5 | GLN A 423ALA A 413LEU A 468GLY A 390ASP A 460 | NoneNoneNoneGOL A 801 ( 4.3A)None | 1.17A | 4qckA-5jjhA:undetectable | 4qckA-5jjhA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxf | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Flavobacteriumpsychrophilum) |
PF10459(Peptidase_S46) | 5 | LEU A 100ALA A 321ASN A 210GLY A 202ASP A 219 | NoneARG A 801 (-3.7A)ARG A 801 (-2.9A)NoneNone | 1.31A | 4qckA-5jxfA:undetectable | 4qckA-5jxfA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kuf | GLUTAMATE RECEPTORIONOTROPIC, KAINATE2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | HIS A 297ALA A 289MET A 285LEU A 251GLY A 339 | None | 1.26A | 4qckA-5kufA:undetectable | 4qckA-5kufA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kuf | GLUTAMATE RECEPTORIONOTROPIC, KAINATE2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | HIS A 297LEU A 118ALA A 289LEU A 251GLY A 339 | None | 1.33A | 4qckA-5kufA:undetectable | 4qckA-5kufA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | LEU A 386ALA A 539ASN A 540LEU A 547GLY A 409 | None | 1.33A | 4qckA-5l3dA:undetectable | 4qckA-5l3dA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0k | BETA-XYLANASE (Cellulomonasflavigena) |
no annotation | 5 | ASN A 278GLN A 242LEU A 234ALA A 291GLY A 266 | None | 1.19A | 4qckA-5m0kA:undetectable | 4qckA-5m0kA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5min | QUINOPROTEIN GLUCOSEDEHYDROGENASE B (Acinetobactercalcoaceticus) |
no annotation | 5 | ASN A 212LEU A 149LEU A 204ASN A 203GLY A 152 | None | 1.23A | 4qckA-5minA:0.0 | 4qckA-5minA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzs | FERRIC ENTEROBACTINRECEPTOR (Pseudomonasaeruginosa) |
no annotation | 5 | GLN A 150ALA A 151ASN A 182GLY A 195ASP A 236 | None | 1.16A | 4qckA-5mzsA:3.4 | 4qckA-5mzsA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n40 | PUTATIVE INVASIN (Yersiniapseudotuberculosis) |
PF05689(DUF823)PF09134(Invasin_D3) | 5 | ASN A2583VAL A2584ALA A2547ASN A2467GLY A2498 | None | 1.26A | 4qckA-5n40A:undetectable | 4qckA-5n40A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngk | GLUCOSYLCERAMIDASE (Bacteroidesthetaiotaomicron) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | VAL A 376LEU A 96ALA A 399LEU A 381GLY A 90 | None | 1.30A | 4qckA-5ngkA:undetectable | 4qckA-5ngkA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3w | PEPTIDE CYCLASE 1 (Gypsophilavaccaria) |
no annotation | 5 | ASN A 355GLN A 380LEU A 359ALA A 378LEU A 337 | None | 1.29A | 4qckA-5o3wA:0.0 | 4qckA-5o3wA:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 5 | ASN T1287VAL T1284LEU T1311LEU T1242ASN T1239 | None | 1.24A | 4qckA-5ojsT:undetectable | 4qckA-5ojsT:7.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 5 | ASN A 237GLN A 186LEU A 178ALA A 185LEU A 220 | None | 1.29A | 4qckA-5ve8A:undetectable | 4qckA-5ve8A:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtp | OMPA FAMILY PROTEIN (Capnocytophagagingivalis) |
no annotation | 5 | ASN A 369VAL A 367LEU A 423ASN A 373GLY A 417 | None | 1.11A | 4qckA-5wtpA:undetectable | 4qckA-5wtpA:11.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zm4 | DIOXYGENASE ANDA (Aspergillusstellatus) |
no annotation | 5 | LEU A 123ALA A 230MET A 156ASN A 158GLY A 214 | AKG A 302 ( 3.6A)9FU A 303 (-3.5A)9FU A 303 ( 4.0A)9FU A 303 (-4.3A)AKG A 302 ( 3.9A) | 1.09A | 4qckA-5zm4A:undetectable | 4qckA-5zm4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5f | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Yersiniaenterocolitica) |
no annotation | 5 | VAL A 243LEU A 284ALA A 272MET A 185GLY A 263 | None | 1.32A | 4qckA-6b5fA:undetectable | 4qckA-6b5fA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 5 | VAL A 31LEU A 309ALA A 6LEU A 281ASP A 159 | None | 1.26A | 4qckA-6dllA:undetectable | 4qckA-6dllA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evg | MULTI-COPPER OXIDASECUEO (Ochrobactrum) |
no annotation | 5 | HIS A 234LEU A 298ALA A 228GLY A 288ASP A 290 | None | 1.18A | 4qckA-6evgA:undetectable | 4qckA-6evgA:11.23 |