SIMILAR PATTERNS OF AMINO ACIDS FOR 4QC6_B_KANB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 GLY A  70
HIS A 232
TYR A 233
ASP A  87
ASP A  19
 None
 1.16A 4qc6B-1azwA:
1.3		 4qc6B-1azwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 GLY A 177
GLU A  61
GLN A 249
ASP A 316
GLU A 179
 PQQ  A 701 (-3.7A)
PQQ  A 701 (-2.4A)
None
CA  A 751 (-3.3A)
CA  A 751 (-2.6A)
 1.50A 4qc6B-1flgA:
0.2		 4qc6B-1flgA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		5 GLY A 333
HIS A 294
GLU A 326
ARG A 403
GLU A 228
 None
None
None
GOL  A1451 (-4.1A)
None
 1.45A 4qc6B-1h4pA:
0.5		 4qc6B-1h4pA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 HIS A 181
GLU A 272
GLN A 257
ASP A 258
ASP A 149
 ZN  A 999 ( 3.1A)
GEM  A 801 (-3.0A)
None
None
None
 1.23A 4qc6B-1h8lA:
0.0		 4qc6B-1h8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 TYR A  29
GLY A  33
TYR A 217
GLU A 131
GLU A  64
 None
 1.25A 4qc6B-1pv9A:
0.0		 4qc6B-1pv9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 TYR A  54
GLY A  33
HIS A 232
TYR A 168
GLU A 262
 CL  A 290 (-4.8A)
None
CL  A 289 (-4.5A)
None
None
 1.32A 4qc6B-2p10A:
0.0		 4qc6B-2p10A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc8 GENE 22 PRODUCT

(Bacillus phage
SPP1) 		no annotation 5 TYR A  85
GLY A  84
GLN A  89
ASP A  87
GLU A  57
 None
 1.49A 4qc6B-2xc8A:
undetectable		 4qc6B-2xc8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A 504
GLY A 534
TYR A 562
GLU A 560
GLN A 110
 None
 1.47A 4qc6B-3bc9A:
undetectable		 4qc6B-3bc9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 GLY A 181
GLU A 217
TRP A 319
GLN A 156
ASP A 124
 None
 1.33A 4qc6B-3g77A:
0.0		 4qc6B-3g77A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 TYR B2356
GLY B2355
HIS B2342
HIS B2077
GLU B2352
 None
 1.16A 4qc6B-4bedB:
undetectable		 4qc6B-4bedB:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 GLY A 176
GLU A 212
TRP A 314
GLN A 151
ASP A 119
 None
17E  A 501 (-2.9A)
17E  A 501 (-3.4A)
17E  A 501 (-2.9A)
None
 1.29A 4qc6B-4r85A:
0.8		 4qc6B-4r85A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		5 GLY A 205
ARG A 253
ASP A 236
ASP A 344
GLU A 204
 None
 1.45A 4qc6B-5firA:
undetectable		 4qc6B-5firA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		5 GLY A 205
ASP A 234
ASP A 344
HIS A 207
GLU A 204
 None
 1.34A 4qc6B-5firA:
undetectable		 4qc6B-5firA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA

(Escherichia
coli) 		PF01544
(CorA) 		5 GLY A 127
TYR A 115
GLU A 138
ARG A 118
GLN A 122
 None
 1.22A 4qc6B-5n77A:
undetectable		 4qc6B-5n77A:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 7 TYR A  33
TYR A  49
GLU A  51
ARG A  59
GLN A  73
ASP A  98
ASP A 135
 None
None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.57A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 6 TYR A  33
TYR A  49
GLU A  51
ARG A  59
GLN A  73
HIS A 164
 None
 1.27A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 8 TYR A  33
TYR A  49
TRP A  53
ARG A  59
GLN A  73
ASP A  98
ASP A 135
GLU A 162
 None
None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
None
 0.83A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LEU A 580
ASP A 577
TYR A 576
 None
 0.67A 4qc6B-1b25A:
0.0		 4qc6B-1b25A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjl PROCATHEPSIN L

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 LEU A  69
ASP A  71
TYR A  72
 None
 0.59A 4qc6B-1cjlA:
0.0		 4qc6B-1cjlA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep8 THIOREDOXIN CH1,
H-TYPE

(Chlamydomonas
reinhardtii) 		PF00085
(Thioredoxin) 		3 LEU A  49
ASP A  52
TYR A  53
 None
 0.67A 4qc6B-1ep8A:
0.0		 4qc6B-1ep8A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9c GLUTAMATE MUTASE

(Clostridium
cochlearium) 		PF02310
(B12-binding) 		3 LEU A  87
ASP A 114
TYR A  89
 None
 0.53A 4qc6B-1i9cA:
0.0		 4qc6B-1i9cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 LEU A  69
ASP A  71
TYR A  72
 None
 0.55A 4qc6B-1icfA:
0.0		 4qc6B-1icfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 LEU A 106
ASP A 140
TYR A 141
 None
 0.60A 4qc6B-1ii2A:
0.0		 4qc6B-1ii2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jig DLP-2

(Bacillus
anthracis) 		PF00210
(Ferritin) 		3 LEU A  98
ASP A 101
TYR A 102
 None
 0.24A 4qc6B-1jigA:
undetectable		 4qc6B-1jigA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		3 LEU A 301
ASP A 304
TYR A 305
 None
 0.45A 4qc6B-1krmA:
0.0		 4qc6B-1krmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orq POTASSIUM CHANNEL

(Aeropyrum
pernix) 		PF00520
(Ion_trans) 		3 LEU C  58
ASP C  62
TYR C  59
 None
 0.62A 4qc6B-1orqC:
undetectable		 4qc6B-1orqC:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4v CYSTEINE
ENDOPEPTIDASE

(Ricinus
communis) 		PF00112
(Peptidase_C1) 		3 LEU A  69
ASP A  71
TYR A  72
 None
 0.65A 4qc6B-1s4vA:
0.0		 4qc6B-1s4vA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6s CONSERVED
HYPOTHETICAL PROTEIN

(Chlorobaculum
tepidum) 		PF04079
(SMC_ScpB) 		3 LEU A  48
ASP A  51
TYR A  52
 None
 0.63A 4qc6B-1t6sA:
0.0		 4qc6B-1t6sA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t7s BAG-1 COCHAPERONE

(Caenorhabditis
elegans) 		PF02179
(BAG) 		3 LEU A 113
ASP A 110
TYR A 109
 None
 0.65A 4qc6B-1t7sA:
undetectable		 4qc6B-1t7sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		3 LEU A   4
ASP A   7
TYR A   8
 None
 0.35A 4qc6B-1tzbA:
undetectable		 4qc6B-1tzbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 LEU A 313
ASP A 316
TYR A 317
 None
 0.56A 4qc6B-1u8vA:
undetectable		 4qc6B-1u8vA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		3 LEU A 304
ASP A 307
TYR A 308
 None
 0.45A 4qc6B-1uioA:
undetectable		 4qc6B-1uioA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y71 KINASE-ASSOCIATED
PROTEIN B

(Bacillus cereus) 		PF08810
(KapB) 		3 LEU A 121
ASP A 124
TYR A 125
 None
 0.42A 4qc6B-1y71A:
undetectable		 4qc6B-1y71A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LEU A 274
ASP A 277
TYR A 278
 None
 0.64A 4qc6B-1zl6A:
undetectable		 4qc6B-1zl6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 LEU B  14
ASP B  17
TYR B  20
 None
 0.57A 4qc6B-2afhB:
undetectable		 4qc6B-2afhB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 LEU A 234
ASP A 237
TYR A 238
 None
 0.67A 4qc6B-2b81A:
undetectable		 4qc6B-2b81A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chp METALLOREGULATION
DNA-BINDING STRESS
PROTEIN

(Bacillus
subtilis) 		PF00210
(Ferritin) 		3 LEU A 104
ASP A 107
TYR A 108
 None
 0.39A 4qc6B-2chpA:
undetectable		 4qc6B-2chpA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		3 LEU A 117
ASP A 120
TYR A 121
 None
 0.61A 4qc6B-2gdzA:
undetectable		 4qc6B-2gdzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h09 TRANSCRIPTIONAL
REGULATOR MNTR

(Escherichia
coli) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 LEU A  37
ASP A  40
TYR A  41
 None
 0.48A 4qc6B-2h09A:
undetectable		 4qc6B-2h09A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3d LIN0334 PROTEIN

(Listeria
innocua) 		PF07252
(DUF1433) 		3 LEU A  91
ASP A  88
TYR A  87
 None
 0.52A 4qc6B-2k3dA:
undetectable		 4qc6B-2k3dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsw DISABLED HOMOLOG 2

(Homo sapiens) 		no annotation 3 LEU A  39
ASP A  36
TYR A  38
 None
 0.66A 4qc6B-2lswA:
undetectable		 4qc6B-2lswA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 LEU A 404
ASP A 401
TYR A 400
 None
 0.64A 4qc6B-2o1sA:
undetectable		 4qc6B-2o1sA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 LEU A 407
ASP A 404
TYR A 403
 None
 0.33A 4qc6B-2o1xA:
undetectable		 4qc6B-2o1xA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohc TRNA-SPLICING
ENDONUCLEASE

(Thermoplasma
acidophilum) 		PF01974
(tRNA_int_endo) 		3 LEU A 102
ASP A 124
TYR A 125
 None
 0.66A 4qc6B-2ohcA:
undetectable		 4qc6B-2ohcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 LEU B  83
ASP B  86
TYR B  87
 None
 0.65A 4qc6B-2qtvB:
undetectable		 4qc6B-2qtvB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		3 LEU A 132
ASP A 135
TYR A 136
 None
 0.61A 4qc6B-2rfbA:
undetectable		 4qc6B-2rfbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhs CATHSILICATEIN

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 LEU A  69
ASP A  71
TYR A  72
 None
 0.63A 4qc6B-2vhsA:
undetectable		 4qc6B-2vhsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LEU A 479
ASP A 482
TYR A 483
 None
 0.54A 4qc6B-2vqrA:
undetectable		 4qc6B-2vqrA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LEU A 479
ASP A 482
TYR A 483
 None
 0.55A 4qc6B-2w8sA:
undetectable		 4qc6B-2w8sA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 LEU A 320
ASP A 317
TYR A 316
 None
 0.59A 4qc6B-2wjvA:
undetectable		 4qc6B-2wjvA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt9 NICOTINAMIDASE

(Acinetobacter
baumannii) 		PF00857
(Isochorismatase) 		3 LEU A  78
ASP A  79
TYR A  80
 None
 0.57A 4qc6B-2wt9A:
undetectable		 4qc6B-2wt9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 LEU A 638
ASP A 635
TYR A 634
 None
GOL  A1740 (-3.6A)
None
 0.46A 4qc6B-2xe4A:
1.2		 4qc6B-2xe4A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Geobacillus
kaustophilus) 		PF00215
(OMPdecase) 		3 LEU A 179
ASP A 210
TYR A 211
 None
 0.64A 4qc6B-2yytA:
undetectable		 4qc6B-2yytA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 LEU A   7
ASP A   9
TYR A  10
 None
 0.60A 4qc6B-2z1uA:
undetectable		 4qc6B-2z1uA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 LEU A 317
ASP A 320
TYR A 321
 None
 0.66A 4qc6B-3bdkA:
undetectable		 4qc6B-3bdkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		3 LEU X 107
ASP X 155
TYR X 156
 None
 0.63A 4qc6B-3dcmX:
undetectable		 4qc6B-3dcmX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		3 LEU A 241
ASP A 244
TYR A 245
 None
 0.64A 4qc6B-3ez6A:
undetectable		 4qc6B-3ez6A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwn CATHEPSIN L1

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 LEU A  69
ASP A  71
TYR A  72
 BD3  A 221 (-3.7A)
BD3  A 221 (-2.7A)
BD3  A 221 (-4.8A)
 0.55A 4qc6B-3hwnA:
undetectable		 4qc6B-3hwnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		3 LEU B 428
ASP B 431
TYR B 432
 None
 0.42A 4qc6B-3if8B:
undetectable		 4qc6B-3if8B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq1 DPS FAMILY PROTEIN

(Vibrio cholerae) 		PF00210
(Ferritin) 		3 LEU A 136
ASP A 139
TYR A 140
 None
 0.65A 4qc6B-3iq1A:
undetectable		 4qc6B-3iq1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 LEU X 386
ASP X 389
TYR X 390
 None
 0.60A 4qc6B-3jb9X:
undetectable		 4qc6B-3jb9X:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		3 LEU D 575
ASP D 578
TYR D 579
 None
 0.59A 4qc6B-3k8pD:
undetectable		 4qc6B-3k8pD:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LEU A 270
ASP A 273
TYR A 274
 None
 0.47A 4qc6B-3kdnA:
undetectable		 4qc6B-3kdnA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 LEU A  88
ASP A 404
TYR A  84
 None
 0.66A 4qc6B-3kzwA:
1.5		 4qc6B-3kzwA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l47 ODORANT BINDING
PROTEIN
(AGAP010409-PA)

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		3 LEU A 128
ASP A 131
TYR A 132
 None
 0.29A 4qc6B-3l47A:
undetectable		 4qc6B-3l47A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		3 LEU A 299
ASP A 302
TYR A 303
 None
 0.42A 4qc6B-3oyrA:
undetectable		 4qc6B-3oyrA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 LEU A 289
ASP A 292
TYR A 293
 None
 0.53A 4qc6B-3pkoA:
undetectable		 4qc6B-3pkoA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		3 LEU A  62
ASP A  65
TYR A  66
 None
 0.35A 4qc6B-3q15A:
undetectable		 4qc6B-3q15A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID

(Staphylococcus
aureus) 		PF02441
(Flavoprotein) 		3 LEU A 132
ASP A 135
TYR A 136
 None
 0.54A 4qc6B-3qjgA:
undetectable		 4qc6B-3qjgA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		3 LEU A 109
ASP A 112
TYR A 113
 None
 0.54A 4qc6B-3rc3A:
undetectable		 4qc6B-3rc3A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		3 LEU A 170
ASP A 201
TYR A 202
 None
 0.66A 4qc6B-3ru6A:
undetectable		 4qc6B-3ru6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 3 LEU A  23
ASP A  78
TYR A  79
 None
 0.55A 4qc6B-3slrA:
undetectable		 4qc6B-3slrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		3 LEU A 177
ASP A 208
TYR A 209
 None
 0.61A 4qc6B-3tr2A:
undetectable		 4qc6B-3tr2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 LEU A  42
ASP A  56
TYR A  55
 None
 0.60A 4qc6B-3u0oA:
undetectable		 4qc6B-3u0oA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 176
ASP A 175
TYR A 389
 None
 0.56A 4qc6B-3vcnA:
undetectable		 4qc6B-3vcnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 LEU A 150
ASP A 153
TYR A 154
 None
 0.56A 4qc6B-4a3uA:
undetectable		 4qc6B-4a3uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 LEU A  11
ASP A  14
TYR A  15
 None
 0.56A 4qc6B-4a6eA:
2.1		 4qc6B-4a6eA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  25
ASP A  28
TYR A  29
 None
 0.53A 4qc6B-4b09A:
undetectable		 4qc6B-4b09A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		3 LEU A 610
ASP A 613
TYR A 614
 None
 0.62A 4qc6B-4bq4A:
undetectable		 4qc6B-4bq4A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 LEU B  83
ASP B  86
TYR B  87
 None
 0.65A 4qc6B-4bziB:
undetectable		 4qc6B-4bziB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 LEU A 503
ASP A 506
TYR A 507
 None
 0.57A 4qc6B-4cmrA:
undetectable		 4qc6B-4cmrA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LEU A 345
ASP A 348
TYR A 349
 None
 0.67A 4qc6B-4di5A:
undetectable		 4qc6B-4di5A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		3 LEU A 212
ASP A 233
TYR A 234
 None
 0.67A 4qc6B-4f48A:
undetectable		 4qc6B-4f48A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fle ESTERASE

(Yersinia
enterocolitica) 		PF05728
(UPF0227) 		3 LEU A  99
ASP A 102
TYR A 103
 None
 0.57A 4qc6B-4fleA:
undetectable		 4qc6B-4fleA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		3 LEU C 230
ASP C 233
TYR C 234
 None
 0.66A 4qc6B-4fzwC:
undetectable		 4qc6B-4fzwC:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzb PUTATIVE PERIPLASMIC
PROTEIN

(Ralstonia
pickettii) 		PF12883
(DUF3828) 		3 LEU B  71
ASP B  74
TYR B  75
 None
 0.27A 4qc6B-4hzbB:
undetectable		 4qc6B-4hzbB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		3 LEU A  33
ASP A  36
TYR A  37
 None
 0.39A 4qc6B-4iu4A:
undetectable		 4qc6B-4iu4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 LEU A 331
ASP A 334
TYR A 335
 None
 0.65A 4qc6B-4jc8A:
undetectable		 4qc6B-4jc8A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		3 LEU A  89
ASP A  92
TYR A  93
 None
 0.61A 4qc6B-4kkjA:
undetectable		 4qc6B-4kkjA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll7 SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		PF17078
(SHE3) 		3 LEU A 112
ASP A 115
TYR A 116
 SO4  A 209 (-3.5A)
DY  A 204 (-2.8A)
None
 0.27A 4qc6B-4ll7A:
undetectable		 4qc6B-4ll7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		3 LEU A 118
ASP A 121
TYR A 122
 None
 0.42A 4qc6B-4ltmA:
undetectable		 4qc6B-4ltmA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LEU A 344
ASP A 346
TYR A 347
 None
 0.65A 4qc6B-4m9aA:
undetectable		 4qc6B-4m9aA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 3 LEU C 114
ASP C 117
TYR C 118
 None
 0.50A 4qc6B-4ptzC:
undetectable		 4qc6B-4ptzC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		3 LEU A  88
ASP A  91
TYR A  92
 None
 0.45A 4qc6B-4q0cA:
undetectable		 4qc6B-4q0cA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		3 LEU A  39
ASP A  67
TYR A  68
 None
 0.45A 4qc6B-4r7oA:
undetectable		 4qc6B-4r7oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		PF01207
(Dus) 		3 LEU A  30
ASP A  33
TYR A  34
 None
 0.62A 4qc6B-4wfsA:
undetectable		 4qc6B-4wfsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlh LIPOPOLYSACCHARIDE
ASSEMBLY PROTEIN B

(Escherichia
coli) 		PF14559
(TPR_19) 		3 LEU A 113
ASP A 116
TYR A 117
 None
 0.54A 4qc6B-4zlhA:
undetectable		 4qc6B-4zlhA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		3 LEU A 208
ASP A 211
TYR A 212
 None
 0.53A 4qc6B-4zowA:
undetectable		 4qc6B-4zowA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 LEU A 356
ASP A 359
TYR A 360
 None
 0.54A 4qc6B-5aorA:
undetectable		 4qc6B-5aorA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		3 LEU A 381
ASP A 384
TYR A 385
 None
 0.63A 4qc6B-5diyA:
undetectable		 4qc6B-5diyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		3 LEU A 177
ASP A 180
TYR A 181
 None
 0.56A 4qc6B-5frdA:
undetectable		 4qc6B-5frdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		3 LEU A 476
ASP A 477
TYR A 478
 None
 0.64A 4qc6B-5hz7A:
undetectable		 4qc6B-5hz7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4h CATHEPSIN L1

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 LEU A  69
ASP A  71
TYR A  72
 None
 0.56A 4qc6B-5i4hA:
undetectable		 4qc6B-5i4hA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		3 LEU A 147
ASP A 151
TYR A  98
 None
 0.35A 4qc6B-5j6qA:
undetectable		 4qc6B-5j6qA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		3 LEU A 174
ASP A 177
TYR A 178
 None
 0.67A 4qc6B-5koiA:
undetectable		 4qc6B-5koiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		3 LEU A  19
ASP B 331
TYR A  35
 None
 0.64A 4qc6B-5l1xA:
undetectable		 4qc6B-5l1xA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		3 LEU A 307
ASP A 311
TYR A 308
 None
 0.60A 4qc6B-5l25A:
undetectable		 4qc6B-5l25A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LEU Q 343
ASP Q 340
TYR Q 339
 None
 0.54A 4qc6B-5mpdQ:
undetectable		 4qc6B-5mpdQ:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 3 LEU B  42
ASP B  45
TYR B  46
 None
 0.46A 4qc6B-5thzB:
undetectable		 4qc6B-5thzB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		3 LEU A 410
ASP A 413
TYR A 414
 None
 0.57A 4qc6B-5wzrA:
undetectable		 4qc6B-5wzrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 3 LEU A 344
ASP A 316
TYR A 346
 None
 0.63A 4qc6B-5yf0A:
2.0		 4qc6B-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 3 LEU C 418
ASP C 421
TYR C 422
 None
 0.61A 4qc6B-5yfpC:
undetectable		 4qc6B-5yfpC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 3 LEU A 891
ASP A 894
TYR A 895
 None
 0.63A 4qc6B-6a91A:
undetectable		 4qc6B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 LEU A  85
ASP A  88
TYR A  89
 None
 0.66A 4qc6B-6apeA:
undetectable		 4qc6B-6apeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 3 LEU C 285
ASP C 288
TYR C 289
 None
 0.57A 4qc6B-6c4mC:
undetectable		 4qc6B-6c4mC:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 3 LEU E 271
ASP E 268
TYR E 267
 None
 0.65A 4qc6B-6d04E:
undetectable		 4qc6B-6d04E:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 3 LEU A 135
ASP A 138
TYR A 139
 None
 0.62A 4qc6B-6dk2A:
undetectable		 4qc6B-6dk2A:
undetectable