SIMILAR PATTERNS OF AMINO ACIDS FOR 4QB9_F_PARF500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN
WISKOTT-ALDRICH
SYNDROME PROTEIN
WASP

(Homo sapiens) 		PF00071
(Ras)
PF00786
(PBD) 		5 PHE B  42
THR A  58
SER A  71
GLU A 100
GLY A  60
 None
 1.49A 4qb9F-1ceeB:
undetectable		 4qb9F-1ceeB:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A 187
THR A 170
GLU A 174
ASP A  80
GLY A 178
 None
None
ZN  A 502 (-2.6A)
None
None
 1.47A 4qb9F-1fnoA:
0.9		 4qb9F-1fnoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		5 TYR A 220
GLU A 125
ASP A  87
ASP A 127
GLY A 138
 A2G  A 555 (-3.2A)
None
A2G  A 555 (-2.9A)
CA  A 500 (-2.2A)
None
 1.48A 4qb9F-1fnzA:
0.0		 4qb9F-1fnzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 SER A 704
SER A 674
GLU A 517
TYR A 390
GLY A 492
 None
None
CA  A 779 (-2.3A)
None
None
 1.31A 4qb9F-1j0nA:
0.0		 4qb9F-1j0nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 PHE A 422
SER A 373
THR A 397
GLU A 219
GLY A 399
 None
 1.42A 4qb9F-1rzvA:
0.0		 4qb9F-1rzvA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		5 PHE A 134
TYR A  42
GLU A 147
ASP A 179
GLY A 100
 None
 1.30A 4qb9F-1te5A:
undetectable		 4qb9F-1te5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 PHE A 195
SER A 241
GLU A 504
ASP A 327
ASP A 326
 None
 1.24A 4qb9F-1w6jA:
0.0		 4qb9F-1w6jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		5 SER A 205
SER A 199
GLU A 157
ASP A 151
GLY A 308
 None
 1.48A 4qb9F-1yt8A:
0.2		 4qb9F-1yt8A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE

(Sulfurisphaera
tokodaii) 		no annotation 5 THR A 180
SER A 151
ASP A  22
TYR A  72
GLY A  73
 None
 1.47A 4qb9F-2dgdA:
0.0		 4qb9F-2dgdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 PHE A 807
SER A 657
GLU A 522
TYR A 598
GLY A 625
 None
None
TDK  A 887 (-4.3A)
None
None
 1.20A 4qb9F-2g28A:
undetectable		 4qb9F-2g28A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae) 		PF00571
(CBS) 		5 SER C 125
THR C 123
SER C 142
GLU C 113
GLY C  77
 None
 1.40A 4qb9F-2qlvC:
undetectable		 4qb9F-2qlvC:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PHE A1256
SER A1194
GLU A1047
GLU A1043
ASP A1150
 None
None
None
PTR  A1163 ( 4.6A)
None
 1.47A 4qb9F-2z8cA:
undetectable		 4qb9F-2z8cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		5 SER A  92
SER A 153
GLU A  71
GLU A  58
GLY A  66
 None
 1.44A 4qb9F-3hp7A:
undetectable		 4qb9F-3hp7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A 190
THR A 173
GLU A 177
ASP A  81
GLY A 181
 None
None
ZN  A 412 (-2.2A)
None
None
 1.48A 4qb9F-3ifeA:
undetectable		 4qb9F-3ifeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 PHE X 174
ASP X 269
ASP X 327
TYR X 238
GLY X 224
 None
1BN  X 390 (-3.3A)
None
None
None
 1.45A 4qb9F-3pb9X:
0.8		 4qb9F-3pb9X:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		5 PHE A 183
GLU A 240
ASP A 104
ASP A 128
GLY A 269
 None
 1.33A 4qb9F-3qyjA:
undetectable		 4qb9F-3qyjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		5 PHE A 381
THR A 290
ASP A  46
ASP A  47
GLY A 293
 None
None
BXP  A 601 (-3.1A)
None
None
 1.48A 4qb9F-3vxcA:
undetectable		 4qb9F-3vxcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 SER A 456
GLU A 444
GLU A 313
ASP A 446
ASP A 445
 None
 1.35A 4qb9F-4bmaA:
undetectable		 4qb9F-4bmaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 SER A 159
TYR A 203
GLU A  81
ASP A 197
GLY A 119
 None
 1.40A 4qb9F-4dnhA:
0.4		 4qb9F-4dnhA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 SER A 114
THR A 119
SER A 121
TYR A 142
GLY A 144
 NO3  A 502 (-4.7A)
None
None
None
None
 1.41A 4qb9F-4e77A:
undetectable		 4qb9F-4e77A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 THR A 128
GLU A 173
ASP A 203
ASP A 204
GLY A 151
 FMT  A 501 (-3.6A)
None
None
None
None
 1.32A 4qb9F-4kv7A:
undetectable		 4qb9F-4kv7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		5 PHE A 110
GLU A 181
GLU A 179
ASP A 212
GLY A  17
 None
CA  A 403 ( 2.9A)
None
None
None
 1.36A 4qb9F-4lq0A:
undetectable		 4qb9F-4lq0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 SER A 279
SER A 143
TYR A 197
ASP A 148
GLY A 252
 None
EDO  A 408 (-3.6A)
EDO  A 408 ( 4.8A)
ZN  A 403 ( 2.6A)
None
 1.40A 4qb9F-4rgqA:
undetectable		 4qb9F-4rgqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 PHE A 146
ASP A 248
ASP A 306
TYR A 214
GLY A 200
 None
 1.44A 4qb9F-4yu9A:
0.5		 4qb9F-4yu9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		5 PHE A 105
SER A 136
GLU A 183
ASP A 174
GLY A 180
 None
 1.42A 4qb9F-5fa1A:
undetectable		 4qb9F-5fa1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

(Saccharomyces
cerevisiae) 		PF06870
(RNA_pol_I_A49) 		5 PHE M  30
GLU M  50
ASP M  39
TYR M  65
GLY M  64
 PHE  M  30 ( 1.3A)
GLU  M  50 ( 0.6A)
ASP  M  39 ( 0.5A)
TYR  M  65 ( 1.3A)
GLY  M  64 ( 0.0A)
 1.31A 4qb9F-5lmxM:
undetectable		 4qb9F-5lmxM:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 SER A 289
THR A 354
SER A 387
ASP A 211
GLY A 242
 ATP  A 700 (-2.4A)
ATP  A 700 (-4.3A)
ATP  A 700 ( 4.8A)
MG  A 701 (-3.4A)
ATP  A 700 (-3.5A)
 1.30A 4qb9F-5mb9A:
undetectable		 4qb9F-5mb9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 PHE A 441
TYR A 464
GLU A 307
GLU A 479
GLY A 471
 None
 1.35A 4qb9F-5n6uA:
undetectable		 4qb9F-5n6uA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		5 THR A  42
GLU A 155
ASP A  44
ASP A 134
TYR A 129
 FAD  A 401 (-3.3A)
None
None
FAD  A 401 (-3.9A)
None
 1.38A 4qb9F-5uwyA:
undetectable		 4qb9F-5uwyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 PHE A 193
SER A 177
SER A 169
TYR A 138
GLU A 374
 None
 1.15A 4qb9F-6ewjA:
undetectable		 4qb9F-6ewjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 5 SER A 303
GLU A 591
ASP A 633
TYR A  20
GLY A 630
 None
CA  A 802 (-2.7A)
CA  A 802 (-2.8A)
None
None
 1.43A 4qb9F-6f91A:
undetectable		 4qb9F-6f91A:
12.65