SIMILAR PATTERNS OF AMINO ACIDS FOR 4QB9_D_PARD500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		4 THR A  89
GLU A  55
ASP A  56
ASP A  54
 None
 1.15A 4qb9D-1bxcA:
0.0		 4qb9D-1bxcA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 PHE 1 115
ASP 3  18
ASP 3  17
TYR 1 239
 None
 1.20A 4qb9D-1ev11:
undetectable		 4qb9D-1ev11:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		4 SER A 444
THR A 387
SER A 385
GLU A 396
 None
 1.40A 4qb9D-1gxnA:
0.0		 4qb9D-1gxnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 SER A 492
SER A 227
GLU A 376
ASP A 342
 FAD  A1031 (-3.2A)
FAD  A1031 ( 4.6A)
None
FAD  A1031 (-4.3A)
 1.31A 4qb9D-1h7wA:
0.0		 4qb9D-1h7wA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		4 SER A  62
SER A  12
GLU A  36
ASP A  37
 None
 1.05A 4qb9D-1hnoA:
0.9		 4qb9D-1hnoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 SER A 171
THR A 423
SER A 420
GLU A 392
 None
None
CD  A 596 (-2.1A)
None
 1.12A 4qb9D-1ii0A:
0.1		 4qb9D-1ii0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		4 PHE A 164
THR A 114
GLU A 134
ASP A 128
 None
 1.33A 4qb9D-1mivA:
0.0		 4qb9D-1mivA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 PHE A 114
ASP C  18
ASP C  17
TYR A 238
 SPL  A 284 (-4.9A)
None
None
None
 1.21A 4qb9D-1mqtA:
0.0		 4qb9D-1mqtA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 SER A 256
THR A 208
SER A 195
ASP A 211
 None
 1.35A 4qb9D-1nr0A:
undetectable		 4qb9D-1nr0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 SER A 185
THR A 134
SER A 141
GLU A 114
 None
 1.25A 4qb9D-1pojA:
undetectable		 4qb9D-1pojA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 THR A 332
SER A 344
ASP A 328
ASP A 329
 None
 1.35A 4qb9D-1q2eA:
undetectable		 4qb9D-1q2eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		4 PHE 1 121
ASP 3  18
ASP 3  17
TYR 1 240
 None
 1.29A 4qb9D-1r1a1:
undetectable		 4qb9D-1r1a1:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rms RIBONUCLEASE MS

(Aspergillus
phoenicis) 		PF00545
(Ribonuclease) 		4 SER A  30
THR A  33
ASP A  35
ASP A  36
 None
 1.35A 4qb9D-1rmsA:
undetectable		 4qb9D-1rmsA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 SER A 189
THR A 179
SER A 202
ASP A 183
 None
 1.37A 4qb9D-1s2nA:
undetectable		 4qb9D-1s2nA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlg POLYANDROCARPA
LECTIN

(Polyandrocarpa
misakiensis) 		PF00059
(Lectin_C) 		4 PHE A  67
SER A  88
ASP A  52
TYR A 103
 None
GAL  A 126 ( 3.1A)
None
None
 1.10A 4qb9D-1tlgA:
undetectable		 4qb9D-1tlgA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 305
THR A 319
ASP A 315
ASP A 316
 None
 1.29A 4qb9D-1xapA:
undetectable		 4qb9D-1xapA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		4 PHE B 305
THR B 319
ASP B 315
ASP B 316
 None
 1.38A 4qb9D-1xdkB:
undetectable		 4qb9D-1xdkB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1z MINOR TAIL PROTEIN U

(Escherichia
virus Lambda) 		PF06141
(Phage_tail_U) 		4 THR A 124
SER A 105
ASP A 122
TYR A  42
 None
 1.41A 4qb9D-1z1zA:
undetectable		 4qb9D-1z1zA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		4 SER A 363
SER A 322
GLU A 413
TYR A 388
 None
 1.18A 4qb9D-1zefA:
undetectable		 4qb9D-1zefA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		4 SER A 193
THR A 183
SER A 206
ASP A 187
 None
None
SO4  A 301 (-2.5A)
None
 1.40A 4qb9D-2b6nA:
undetectable		 4qb9D-2b6nA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
CO-CHAPERONE PROTEIN
SBA1

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c)
no annotation 		4 THR X  19
SER X  17
GLU A 316
TYR X  72
 None
 1.40A 4qb9D-2cg9X:
undetectable		 4qb9D-2cg9X:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 SER A 393
GLU A 559
ASP A 557
ASP A 556
 None
 1.31A 4qb9D-2dw4A:
0.9		 4qb9D-2dw4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLU B 262
ASP B 266
ASP B 265
TYR B  83
 None
 1.33A 4qb9D-2f2aB:
undetectable		 4qb9D-2f2aB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PHE A 299
THR A 346
SER A 344
TYR A 268
 None
 1.10A 4qb9D-2f43A:
undetectable		 4qb9D-2f43A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 PHE A   5
THR A 472
SER A 470
ASP A  70
 None
None
None
ACR  A 995 (-3.0A)
 1.39A 4qb9D-2f6dA:
undetectable		 4qb9D-2f6dA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 SER A 256
GLU A 340
ASP A 291
ASP A 294
 None
 1.19A 4qb9D-2gfiA:
undetectable		 4qb9D-2gfiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 487
SER A 425
GLU A 288
ASP A 382
 None
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 1.40A 4qb9D-2hk5A:
undetectable		 4qb9D-2hk5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  73
THR A 102
GLU A 126
ASP A 125
 None
 1.29A 4qb9D-2i6uA:
undetectable		 4qb9D-2i6uA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mim CD3 EPSILON PROTEIN,
LINKER, CD3
GLYCOPROTEIN

(Gallus gallus;
synthetic
construct) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		4 SER A 170
THR A  58
SER A  24
ASP A  28
 None
 1.41A 4qb9D-2mimA:
undetectable		 4qb9D-2mimA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7b ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
agalactiae) 		PF00583
(Acetyltransf_1) 		4 SER A 110
ASP A  74
ASP A  73
TYR A 147
 None
None
None
FLC  A 164 (-4.7A)
 1.26A 4qb9D-2q7bA:
10.6		 4qb9D-2q7bA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 871
SER A 809
GLU A 670
ASP A 764
 None
 1.41A 4qb9D-2qobA:
undetectable		 4qb9D-2qobA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PHE A 292
THR A 339
SER A 337
TYR A 261
 None
 1.19A 4qb9D-2r9vA:
undetectable		 4qb9D-2r9vA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		4 SER A  63
GLU A 147
ASP A 145
ASP A 146
 None
 1.41A 4qb9D-2w2sA:
undetectable		 4qb9D-2w2sA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A1256
SER A1194
GLU A1047
ASP A1150
 None
 1.39A 4qb9D-2z8cA:
undetectable		 4qb9D-2z8cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens) 		PF01398
(JAB) 		4 THR A 363
SER A 366
ASP A 360
TYR A 322
 None
EDO  A   2 (-3.4A)
None
None
 1.43A 4qb9D-2znvA:
undetectable		 4qb9D-2znvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 THR A  12
SER A  85
ASP A 129
TYR A 132
 None
None
CA  A 623 (-2.9A)
None
 1.15A 4qb9D-2zuyA:
undetectable		 4qb9D-2zuyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 PHE A 490
SER A 428
GLU A 290
ASP A 385
 None
 1.38A 4qb9D-2zv7A:
undetectable		 4qb9D-2zv7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 SER A  40
GLU A 100
ASP A 104
TYR A  28
 None
 1.07A 4qb9D-3ce2A:
undetectable		 4qb9D-3ce2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 PHE A  45
SER A  48
THR A  52
ASP A  75
 GDP  A 302 (-4.4A)
None
None
MG  A 301 ( 4.1A)
 1.11A 4qb9D-3cphA:
undetectable		 4qb9D-3cphA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz8 PUTATIVE
SPORULATION-SPECIFIC
GLYCOSYLASE YDHD

(Bacillus
subtilis) 		PF00704
(Glyco_hydro_18) 		4 SER A 127
SER A 104
GLU A 212
ASP A 210
 GOL  A 501 (-2.9A)
GOL  A 506 ( 4.7A)
GOL  A 502 (-3.4A)
GOL  A 502 (-3.4A)
 1.15A 4qb9D-3cz8A:
undetectable		 4qb9D-3cz8A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 SER A 405
GLU A 114
ASP A 424
TYR A 189
 None
 1.16A 4qb9D-3d8kA:
undetectable		 4qb9D-3d8kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 244
SER A 236
GLU A 380
ASP A 226
 None
 1.21A 4qb9D-3dh9A:
undetectable		 4qb9D-3dh9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 SER A 383
THR A 167
SER A 153
ASP A 170
 None
BGC  A   3 (-3.3A)
None
None
 1.15A 4qb9D-3gd9A:
undetectable		 4qb9D-3gd9A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 SER A  11
SER A  45
ASP A 255
ASP A 254
 None
 1.44A 4qb9D-3h74A:
undetectable		 4qb9D-3h74A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 PHE A 234
THR A 219
GLU A  97
ASP A  78
 None
 0.93A 4qb9D-3ihgA:
undetectable		 4qb9D-3ihgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 SER A  82
SER A 109
GLU A 164
ASP A 165
 None
 1.34A 4qb9D-3ilvA:
undetectable		 4qb9D-3ilvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 4 PHE B 449
THR B 331
SER B 334
GLU B 223
 None
 1.43A 4qb9D-3jruB:
undetectable		 4qb9D-3jruB:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr0 SENSORY BOX
HISTIDINE
KINASE/RESPONSE
REGULATOR

(Burkholderia
thailandensis) 		PF08447
(PAS_3) 		4 SER A  16
SER A  32
GLU A  45
ASP A  43
 None
 0.93A 4qb9D-3mr0A:
undetectable		 4qb9D-3mr0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		4 PHE A 104
SER A  94
THR A 101
ASP A  70
 None
 1.37A 4qb9D-3nk4A:
undetectable		 4qb9D-3nk4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A   7
SER A  88
GLU A 352
TYR A 405
 None
 1.26A 4qb9D-3oytA:
undetectable		 4qb9D-3oytA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 PHE B 234
SER B 276
SER B 225
ASP B 183
 None
 1.31A 4qb9D-3q75B:
undetectable		 4qb9D-3q75B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 597
SER A 534
GLU A 384
ASP A 478
 None
None
STU  A   1 (-3.7A)
STU  A   1 ( 4.2A)
 1.31A 4qb9D-3s95A:
undetectable		 4qb9D-3s95A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 SER A 180
SER A 249
ASP A 274
TYR A  77
 None
 1.20A 4qb9D-3smtA:
undetectable		 4qb9D-3smtA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua0 FIBROIN HEAVY CHAIN

(Bombyx mori) 		no annotation 4 SER A  40
THR A  42
GLU A  56
ASP A  44
 None
 1.38A 4qb9D-3ua0A:
undetectable		 4qb9D-3ua0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 PHE A  30
THR A 210
GLU A 150
ASP A 183
 None
None
FUD  A 301 ( 2.4A)
MN  A 302 ( 3.2A)
 1.41A 4qb9D-3vnkA:
undetectable		 4qb9D-3vnkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 PHE A  43
SER A  77
GLU A  90
ASP A  86
 None
 1.05A 4qb9D-3vvjA:
undetectable		 4qb9D-3vvjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 PHE A  43
SER A 270
GLU A 159
ASP A 192
 None
None
MN  A1002 (-2.4A)
MN  A1001 ( 4.5A)
 0.99A 4qb9D-3wqoA:
undetectable		 4qb9D-3wqoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 SER A 115
THR A  84
SER A  82
TYR A 262
 None
 1.30A 4qb9D-3zfvA:
undetectable		 4qb9D-3zfvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PHE A 200
SER A 192
GLU A 287
ASP A  44
 None
None
None
ZN  A1596 (-3.0A)
 1.31A 4qb9D-3zu0A:
undetectable		 4qb9D-3zu0A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 PHE A 476
GLU A 504
ASP A 499
TYR A  91
 None
 1.34A 4qb9D-4aefA:
undetectable		 4qb9D-4aefA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 PHE A 475
THR A 403
GLU A 194
ASP A 292
 None
CA  A1593 ( 4.5A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 3.1A)
 1.13A 4qb9D-4amfA:
undetectable		 4qb9D-4amfA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 PHE A  19
SER A  50
THR A 278
TYR A 247
 None
 1.39A 4qb9D-4bg2A:
0.7		 4qb9D-4bg2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 4 GLU A 642
ASP A 644
ASP A 643
TYR A 421
 None
 1.41A 4qb9D-4btgA:
undetectable		 4qb9D-4btgA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 SER A  95
SER A   2
GLU A 195
TYR A 141
 None
 1.18A 4qb9D-4d51A:
undetectable		 4qb9D-4d51A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 PHE A 238
SER A 362
ASP A 223
ASP A 224
 APR  A 501 (-4.7A)
None
None
None
 1.32A 4qb9D-4eppA:
undetectable		 4qb9D-4eppA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 283
THR A 319
GLU A 143
ASP A 141
 PHE  A 283 ( 1.3A)
THR  A 319 ( 0.8A)
GLU  A 143 (-0.6A)
ASP  A 141 (-0.5A)
 0.94A 4qb9D-4flxA:
undetectable		 4qb9D-4flxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 PHE A 174
THR A 189
SER A 170
ASP A 216
 None
 1.11A 4qb9D-4immA:
undetectable		 4qb9D-4immA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 SER A 369
SER A 375
GLU A 382
TYR A 388
 None
 1.35A 4qb9D-4k51A:
undetectable		 4qb9D-4k51A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfz ANTI-LMO2 VH
LMO-2

(Homo sapiens) 		PF00412
(LIM)
PF07686
(V-set) 		4 PHE C  27
SER C  32
GLU A  52
ASP A  53
 None
 1.13A 4qb9D-4kfzC:
undetectable		 4qb9D-4kfzC:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 PHE A  83
THR A 204
GLU A 264
ASP A 136
 None
 1.39A 4qb9D-4km3A:
undetectable		 4qb9D-4km3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 SER A 423
SER A 431
GLU A 139
TYR A 390
 None
 1.00A 4qb9D-4l8nA:
undetectable		 4qb9D-4l8nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 PHE A 275
SER A  21
THR A 279
ASP A 306
 None
FDA  A 801 ( 4.3A)
None
None
 1.38A 4qb9D-4mifA:
undetectable		 4qb9D-4mifA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 PHE A 191
THR A 263
SER A 268
ASP A 265
 None
 1.07A 4qb9D-4mk0A:
undetectable		 4qb9D-4mk0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		4 PHE B  62
SER B  47
GLU B 153
ASP B 114
 None
 1.40A 4qb9D-4ol0B:
0.4		 4qb9D-4ol0B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 SER A  45
SER A 307
ASP A 304
ASP A 303
 None
None
None
GOL  A 622 (-2.6A)
 1.29A 4qb9D-4pspA:
undetectable		 4qb9D-4pspA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 PHE 1 132
ASP 3  18
ASP 3  17
TYR 1 262
 None
 1.24A 4qb9D-4q4y1:
undetectable		 4qb9D-4q4y1:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 PHE A 423
GLU A 528
ASP A 485
TYR A 468
 None
COA  A 602 (-2.8A)
COA  A 602 ( 2.7A)
None
 1.43A 4qb9D-4qvhA:
undetectable		 4qb9D-4qvhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 PHE B 198
SER B 329
SER B 222
ASP B 650
 None
 1.36A 4qb9D-4r3zB:
0.3		 4qb9D-4r3zB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		4 SER A 133
SER A 358
GLU A 372
ASP A 369
 None
 1.39A 4qb9D-4r6iA:
undetectable		 4qb9D-4r6iA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 SER A 269
GLU A 157
ASP A 264
TYR A 133
 None
None
None
P3G  A 501 ( 3.9A)
 1.17A 4qb9D-4ru0A:
undetectable		 4qb9D-4ru0A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 PHE A 478
THR A 221
ASP A 223
TYR A 254
 None
 1.35A 4qb9D-4tz5A:
undetectable		 4qb9D-4tz5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 454
GLU A  51
ASP A  44
TYR A 444
 None
 1.42A 4qb9D-4xzeA:
undetectable		 4qb9D-4xzeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		4 SER A  53
SER A  75
ASP A  80
ASP A  79
 None
 1.36A 4qb9D-5b0sA:
undetectable		 4qb9D-5b0sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 SER A 216
GLU A 224
ASP A 227
ASP A 185
 None
 1.41A 4qb9D-5egwA:
undetectable		 4qb9D-5egwA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE A 119
SER A 110
ASP A 114
TYR A 400
 None
 1.32A 4qb9D-5eufA:
undetectable		 4qb9D-5eufA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 SER B  56
ASP B 100
ASP B 101
TYR B  72
 None
 1.31A 4qb9D-5fozB:
undetectable		 4qb9D-5fozB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		4 THR A 561
SER A 563
ASP A  15
ASP A 437
 None
 1.29A 4qb9D-5fqeA:
undetectable		 4qb9D-5fqeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 PHE A 291
THR A 338
SER A 336
TYR A 260
 None
 1.21A 4qb9D-5ik2A:
undetectable		 4qb9D-5ik2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd6 MGS-MCHE2

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		4 THR A 114
SER A 116
GLU A 236
ASP A 203
 None
 1.21A 4qb9D-5jd6A:
undetectable		 4qb9D-5jd6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 312
THR A 326
ASP A 322
ASP A 323
 None
 1.37A 4qb9D-5k13A:
undetectable		 4qb9D-5k13A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		4 SER A 219
THR A 179
ASP A 176
ASP A 177
 None
None
CL  A 313 (-3.4A)
None
 1.20A 4qb9D-5n05A:
undetectable		 4qb9D-5n05A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 SER A 489
THR A  44
SER A 486
ASP A  51
 None
 1.31A 4qb9D-5ngkA:
undetectable		 4qb9D-5ngkA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 PHE A 110
ASP C  18
ASP C  17
TYR A 231
 None
 1.20A 4qb9D-5osnA:
undetectable		 4qb9D-5osnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 4 PHE B 305
THR B 319
ASP B 315
ASP B 316
 None
 1.30A 4qb9D-5uanB:
undetectable		 4qb9D-5uanB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 THR D 801
SER D 805
ASP D 795
ASP D 796
 None
 1.36A 4qb9D-5uheD:
undetectable		 4qb9D-5uheD:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 4 PHE A 114
THR A 229
ASP A 227
ASP A 226
 None
 0.85A 4qb9D-5wm4A:
undetectable		 4qb9D-5wm4A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 SER A 191
THR A 181
SER A 204
ASP A 185
 None
None
SO4  A 306 (-2.6A)
None
 1.34A 4qb9D-5wslA:
undetectable		 4qb9D-5wslA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 SER A  78
GLU A  64
ASP A  68
ASP A  65
 None
 1.01A 4qb9D-5yknA:
undetectable		 4qb9D-5yknA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 PHE A 741
SER A 507
SER A 743
ASP A 471
 None
 1.40A 4qb9D-6en4A:
undetectable		 4qb9D-6en4A:
11.27