SIMILAR PATTERNS OF AMINO ACIDS FOR 4QB9_B_PARB500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A 187
THR A 170
GLU A 174
ASP A  80
GLY A 178
 None
None
ZN  A 502 (-2.6A)
None
None
 1.46A 4qb9B-1fnoA:
0.0		 4qb9B-1fnoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 THR A 137
GLU A  27
ARG A  95
ASP A  25
GLY A 135
 None
 1.47A 4qb9B-2hq6A:
0.0		 4qb9B-2hq6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PHE A 180
SER A 168
SER A 146
GLU A  96
ASP A 123
 None
 1.50A 4qb9B-3pdwA:
0.0		 4qb9B-3pdwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0q LIPID BINDING
PROTEIN

(Grifola
frondosa) 		no annotation 5 SER A  80
THR A 105
SER A 107
GLU A  54
GLY A  86
 None
 1.16A 4qb9B-5h0qA:
0.0		 4qb9B-5h0qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Bacillus
subtilis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		5 PHE A 185
SER A 127
THR A 125
ASP A 123
GLY A  19
 None
7C5  A 302 ( 3.1A)
None
None
None
 1.43A 4qb9B-5th5A:
0.5		 4qb9B-5th5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 722
SER A 720
THR A 235
TYR A 325
GLY A 263
 None
None
None
GLA  A 801 (-4.7A)
None
 1.38A 4qb9B-6eonA:
0.0		 4qb9B-6eonA:
20.00