SIMILAR PATTERNS OF AMINO ACIDS FOR 4QA2_A_SHHA404_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aur CARBOXYLESTERASE

(Pseudomonas
fluorescens) 		PF02230
(Abhydrolase_2) 		3 PRO A 196
MET A 197
TYR A 195
 None
 0.89A 4qa2B-1aurA:
2.8		 4qa2B-1aurA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 PRO A  90
MET A  92
TYR A  89
 None
 0.95A 4qa2B-1b8iA:
undetectable		 4qa2B-1b8iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm0 P300/CBP ASSOCIATING
FACTOR

(Homo sapiens) 		no annotation 3 PRO B 530
MET B 529
TYR B 533
 None
 1.03A 4qa2B-1cm0B:
undetectable		 4qa2B-1cm0B:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PRO A  58
MET A  59
TYR A  57
 None
 1.05A 4qa2B-1dmsA:
undetectable		 4qa2B-1dmsA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2 203
MET 2 202
TYR 2  35
 None
 1.05A 4qa2B-1ev12:
undetectable		 4qa2B-1ev12:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 PRO 1  94
MET 1  96
TYR 1  93
 None
 0.89A 4qa2B-1g291:
undetectable		 4qa2B-1g291:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 PRO A 152
MET A 153
TYR A 149
 None
 0.90A 4qa2B-1gwiA:
undetectable		 4qa2B-1gwiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		3 PRO A 128
MET A 130
TYR A 127
 None
 1.01A 4qa2B-1j32A:
2.4		 4qa2B-1j32A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		3 PRO A  87
MET A  89
TYR A  86
 None
 0.85A 4qa2B-1js6A:
4.1		 4qa2B-1js6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mov GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Montipora
efflorescens) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  82
 None
IOD  A 303 ( 4.8A)
None
 0.79A 4qa2B-1movA:
undetectable		 4qa2B-1movA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		3 PRO A 158
MET A 159
TYR A 157
 None
 1.04A 4qa2B-1ohfA:
undetectable		 4qa2B-1ohfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 PRO A 524
MET A 525
TYR A 521
 None
 0.95A 4qa2B-1qlbA:
undetectable		 4qa2B-1qlbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PRO A  60
MET A  61
TYR A  59
 None
 0.90A 4qa2B-1tmoA:
2.8		 4qa2B-1tmoA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi7 HYPOTHETICAL PROTEIN
YIGZ

(Escherichia
coli) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		3 PRO A  85
MET A  86
TYR A 120
 None
 1.00A 4qa2B-1vi7A:
undetectable		 4qa2B-1vi7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		3 PRO A 119
MET A 120
TYR A 118
 None
 0.99A 4qa2B-1vz8A:
undetectable		 4qa2B-1vz8A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  79
 None
 0.82A 4qa2B-1xqmA:
undetectable		 4qa2B-1xqmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 135
MET A 134
TYR A 251
 None
 0.89A 4qa2B-1xrcA:
undetectable		 4qa2B-1xrcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y97 THREE PRIME REPAIR
EXONUCLEASE 2

(Homo sapiens) 		no annotation 3 PRO A 125
MET A 225
TYR A 122
 None
 1.01A 4qa2B-1y97A:
undetectable		 4qa2B-1y97A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a46 GFP-LIKE FLUORESCENT
CHROMOPROTEIN
AMFP486

(Anemonia majano) 		PF01353
(GFP) 		3 PRO A 192
MET A 191
TYR A  84
 None
 0.89A 4qa2B-2a46A:
undetectable		 4qa2B-2a46A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 PRO A  97
MET A  99
TYR A  96
 None
SO4  A1005 ( 3.8A)
None
 0.99A 4qa2B-2d62A:
2.8		 4qa2B-2d62A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 PRO A 567
MET A 566
TYR A 573
 None
 0.69A 4qa2B-2db3A:
6.5		 4qa2B-2db3A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfx COLICIN-E5 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF11480
(ImmE5) 		3 PRO I  73
MET I  72
TYR I  76
 None
 0.97A 4qa2B-2dfxI:
undetectable		 4qa2B-2dfxI:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.86A 4qa2B-2fl1A:
undetectable		 4qa2B-2fl1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 PRO A 391
MET A 390
TYR A 360
 None
 0.97A 4qa2B-2hv2A:
undetectable		 4qa2B-2hv2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  79
 None
 0.74A 4qa2B-2ib5A:
undetectable		 4qa2B-2ib5A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		3 PRO 1 110
MET 1 112
TYR 1 109
 None
 0.99A 4qa2B-2ijd1:
undetectable		 4qa2B-2ijd1:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		3 PRO A  88
MET A  90
TYR A  87
 None
 0.95A 4qa2B-2it1A:
undetectable		 4qa2B-2it1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 PRO B  46
MET B  47
TYR B  45
 None
 0.82A 4qa2B-2iwgB:
undetectable		 4qa2B-2iwgB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 271
 None
 0.89A 4qa2B-2obvA:
undetectable		 4qa2B-2obvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.86A 4qa2B-2ogrA:
undetectable		 4qa2B-2ogrA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Archaeoglobus
fulgidus) 		PF00528
(BPD_transp_1) 		3 PRO C 210
MET C 211
TYR C 209
 None
 0.92A 4qa2B-2onkC:
undetectable		 4qa2B-2onkC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p64 F-BOX/WD REPEAT
PROTEIN 1A

(Homo sapiens) 		PF12125
(Beta-TrCP_D) 		3 PRO A 174
MET A 175
TYR A 171
 None
 0.73A 4qa2B-2p64A:
undetectable		 4qa2B-2p64A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		3 PRO A 393
MET A 394
TYR A 392
 None
 1.03A 4qa2B-2pg6A:
undetectable		 4qa2B-2pg6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.90A 4qa2B-2pxsA:
undetectable		 4qa2B-2pxsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3p UNCHARACTERIZED
PROTEIN AT3G17210

(Arabidopsis
thaliana) 		PF07876
(Dabb) 		3 PRO A  44
MET A  45
TYR A  80
 None
 0.85A 4qa2B-2q3pA:
undetectable		 4qa2B-2q3pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5y HOMEOTIC PROTEIN SEX
COMBS REDUCED

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 PRO A  83
MET A  85
TYR A  82
 None
 1.04A 4qa2B-2r5yA:
undetectable		 4qa2B-2r5yA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		3 PRO A 317
MET A 318
TYR A 316
 None
 1.01A 4qa2B-2rgjA:
undetectable		 4qa2B-2rgjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh7 GREEN FLUORESCENT
PROTEIN

(Renilla
reniformis) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  82
 None
 0.81A 4qa2B-2rh7A:
undetectable		 4qa2B-2rh7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		3 PRO A 119
MET A 120
TYR A 118
 None
 0.93A 4qa2B-2v4iA:
undetectable		 4qa2B-2v4iA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB

(Escherichia
coli) 		PF00271
(Helicase_C) 		3 PRO D 326
MET D 325
TYR D 332
 None
 0.96A 4qa2B-2yjtD:
3.7		 4qa2B-2yjtD:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 277
MET A 278
TYR A 276
 None
 0.82A 4qa2B-2yv3A:
undetectable		 4qa2B-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 PRO A  88
MET A  90
TYR A  87
 None
PEG  A2001 ( 4.7A)
PEG  A2001 ( 4.6A)
 1.03A 4qa2B-2yyzA:
3.1		 4qa2B-2yyzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  82
 None
 0.85A 4qa2B-3cglA:
undetectable		 4qa2B-3cglA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		3 PRO A 573
MET A 575
TYR A 572
 None
 0.80A 4qa2B-3ciaA:
undetectable		 4qa2B-3ciaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		3 PRO A 194
MET A 195
TYR A 193
 None
 0.89A 4qa2B-3cn7A:
3.0		 4qa2B-3cn7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Methanosarcina
acetivorans) 		PF00528
(BPD_transp_1) 		3 PRO C 222
MET C 223
TYR C 221
 None
 0.92A 4qa2B-3d31C:
undetectable		 4qa2B-3d31C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		3 PRO A 210
MET A 211
TYR A 207
 None
SXN  A1401 (-3.8A)
RET  A1301 (-3.8A)
 0.83A 4qa2B-3ddlA:
undetectable		 4qa2B-3ddlA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		3 PRO A  32
MET A  68
TYR A  97
 None
 1.05A 4qa2B-3dmsA:
2.9		 4qa2B-3dmsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 PRO A 230
MET A 229
TYR A 233
 None
 1.03A 4qa2B-3du4A:
undetectable		 4qa2B-3du4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		3 PRO A 301
MET A 302
TYR A 300
 None
 0.91A 4qa2B-3eafA:
2.7		 4qa2B-3eafA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 PRO A1058
MET A1061
TYR A 822
 None
 0.67A 4qa2B-3f2bA:
undetectable		 4qa2B-3f2bA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 PRO A 394
MET A 396
TYR A 393
 None
 0.95A 4qa2B-3fr8A:
2.0		 4qa2B-3fr8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 PRO A 166
MET A 168
TYR A 165
 None
None
GOL  A 504 ( 4.9A)
 1.03A 4qa2B-3i1iA:
undetectable		 4qa2B-3i1iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 139
MET A 138
TYR A 255
 None
 0.90A 4qa2B-3imlA:
undetectable		 4qa2B-3imlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir8 LARGE STOKES SHIFT
FLUORESCENT PROTEIN

(Montipora sp.
20) 		PF01353
(GFP) 		3 PRO A 186
MET A 185
TYR A  78
 None
 0.81A 4qa2B-3ir8A:
undetectable		 4qa2B-3ir8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		3 PRO A 235
MET A 108
TYR A 103
 None
 0.91A 4qa2B-3kcxA:
undetectable		 4qa2B-3kcxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 3 PRO B 340
MET B 339
TYR B 343
 None
 1.00A 4qa2B-3l82B:
undetectable		 4qa2B-3l82B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  81
 None
 0.84A 4qa2B-3mgfA:
undetectable		 4qa2B-3mgfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 PRO A 125
MET A 127
TYR A 124
 None
 1.01A 4qa2B-3pfiA:
undetectable		 4qa2B-3pfiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 PRO A  87
MET A  89
TYR A  86
 None
 0.77A 4qa2B-3rblA:
4.8		 4qa2B-3rblA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 272
 None
 0.92A 4qa2B-3rv2A:
undetectable		 4qa2B-3rv2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 138
MET A 137
TYR A 258
 None
 0.95A 4qa2B-3so4A:
undetectable		 4qa2B-3so4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3y THREE PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 3 PRO B 132
MET B 232
TYR B 129
 None
 1.02A 4qa2B-3u3yB:
undetectable		 4qa2B-3u3yB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		3 PRO A 190
MET A 189
TYR A 220
 None
 0.98A 4qa2B-3vsmA:
undetectable		 4qa2B-3vsmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		3 PRO B  51
MET B  52
TYR B  50
 None
 0.79A 4qa2B-3zo0B:
undetectable		 4qa2B-3zo0B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 PRO A  43
MET A  42
TYR A  46
 None
GSH  A1450 (-4.2A)
None
 0.84A 4qa2B-4agsA:
undetectable		 4qa2B-4agsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 PRO A 673
MET A 672
TYR A 573
 None
 0.93A 4qa2B-4b9yA:
undetectable		 4qa2B-4b9yA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 PRO A 370
MET A 372
TYR A 369
 None
 0.82A 4qa2B-4bl3A:
undetectable		 4qa2B-4bl3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 3 PRO A 455
MET A 456
TYR A 449
 None
 0.94A 4qa2B-4btgA:
undetectable		 4qa2B-4btgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by4 FI18190P1

(Drosophila
melanogaster) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 PRO A  61
MET A 131
TYR A  52
 None
 0.81A 4qa2B-4by4A:
undetectable		 4qa2B-4by4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		3 PRO A 121
MET A 123
TYR A 120
 None
 1.04A 4qa2B-4g3jA:
undetectable		 4qa2B-4g3jA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2 205
MET 2 204
TYR 2  35
 None
 1.02A 4qa2B-4gb32:
undetectable		 4qa2B-4gb32:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 PRO L 125
MET L 127
TYR L 124
 None
 0.94A 4qa2B-4heaL:
undetectable		 4qa2B-4heaL:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		3 PRO A  24
MET A  21
TYR A 130
 None
 0.97A 4qa2B-4j9uA:
undetectable		 4qa2B-4j9uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 PRO A 275
MET A 276
TYR A 272
 None
 0.84A 4qa2B-4k5yA:
undetectable		 4qa2B-4k5yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		3 PRO A 453
MET A 455
TYR A 452
 None
 1.04A 4qa2B-4kqbA:
undetectable		 4qa2B-4kqbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrd CD44 ANTIGEN

(Mus musculus) 		PF00193
(Xlink) 		3 PRO A  65
MET A  70
TYR A 122
 None
 0.95A 4qa2B-4mrdA:
undetectable		 4qa2B-4mrdA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsq HISTONE
ACETYLTRANSFERASE
KAT2B

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 PRO A 530
MET A 529
TYR A 533
 None
 0.99A 4qa2B-4nsqA:
undetectable		 4qa2B-4nsqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 156
MET A 155
TYR A 279
 None
 0.86A 4qa2B-4odjA:
undetectable		 4qa2B-4odjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		3 PRO A 111
MET A 113
TYR A 110
 None
 0.98A 4qa2B-4q3lA:
undetectable		 4qa2B-4q3lA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		3 PRO A 180
MET A 182
TYR A 179
 None
 1.02A 4qa2B-4ry0A:
undetectable		 4qa2B-4ry0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		3 PRO A 220
MET A 222
TYR A 219
 None
 0.96A 4qa2B-4s0vA:
undetectable		 4qa2B-4s0vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9r UNCHARACTERIZED
PROTEIN

(Capnocytophaga
ochracea) 		PF00756
(Esterase) 		3 PRO A 331
MET A 330
TYR A 325
 None
None
GOL  A 502 ( 4.5A)
 0.84A 4qa2B-4w9rA:
2.4		 4qa2B-4w9rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yru NEURONAL CALCIUM
SENSOR 1

(Rattus
norvegicus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 PRO A  61
MET A 131
TYR A  52
 None
 1.04A 4qa2B-4yruA:
undetectable		 4qa2B-4yruA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP

(Stichodactyla
gigantea) 		PF01353
(GFP) 		3 PRO A 189
MET A 188
TYR A  78
 None
 0.80A 4qa2B-4zb1A:
undetectable		 4qa2B-4zb1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 271
 None
 0.87A 4qa2B-5a1iA:
undetectable		 4qa2B-5a1iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli) 		PF01353
(GFP) 		3 PRO A 194
MET A 193
TYR A  83
 None
 0.82A 4qa2B-5bqlA:
undetectable		 4qa2B-5bqlA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m NANOBODY 39

(Lama glama) 		PF07686
(V-set) 		3 PRO B  33
MET B  34
TYR B  32
 None
 1.01A 4qa2B-5c1mB:
undetectable		 4qa2B-5c1mB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 PRO A 122
MET A 124
TYR A 121
 None
 1.03A 4qa2B-5eawA:
4.9		 4qa2B-5eawA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcy RED CAROTENOID
PROTEIN (RCP)

(Nostoc sp. PCC
7120) 		PF09150
(Carot_N) 		3 PRO A 152
MET A 153
TYR A 149
 None
 0.85A 4qa2B-5fcyA:
undetectable		 4qa2B-5fcyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 PRO C 147
MET C 146
TYR C 264
 None
 0.97A 4qa2B-5h9uC:
undetectable		 4qa2B-5h9uC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.83A 4qa2B-5lk4A:
undetectable		 4qa2B-5lk4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 PRO A1776
MET A1777
TYR A1773
 None
 0.87A 4qa2B-5lkiA:
undetectable		 4qa2B-5lkiA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nt7 ATP-DEPENDENT RNA
HELICASE VASA,
ISOFORM A

(Drosophila
melanogaster) 		PF00271
(Helicase_C) 		3 PRO B 567
MET B 566
TYR B 573
 None
 1.04A 4qa2B-5nt7B:
4.2		 4qa2B-5nt7B:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 138
MET A 137
TYR A 256
 None
 0.94A 4qa2B-5t8tA:
undetectable		 4qa2B-5t8tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 PRO A 159
MET A 160
TYR A 156
 None
 0.89A 4qa2B-5ub6A:
undetectable		 4qa2B-5ub6A:
10.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 PRO A 273
MET A 274
TYR A 306
 EDO  A 407 ( 3.6A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.46A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		3 PRO A 568
MET A 569
TYR A 358
 None
 0.99A 4qa2B-5xmcA:
undetectable		 4qa2B-5xmcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 3 PRO A 208
MET A 209
TYR A 206
 None
None
MLI  A 703 (-4.3A)
 0.91A 4qa2B-6b3bA:
2.3		 4qa2B-6b3bA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 3 PRO B 152
MET B 154
TYR B 151
 None
 1.02A 4qa2B-6f3mB:
2.4		 4qa2B-6f3mB:
undetectable