SIMILAR PATTERNS OF AMINO ACIDS FOR 4QA0_A_SHHA404_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aur CARBOXYLESTERASE

(Pseudomonas
fluorescens) 		PF02230
(Abhydrolase_2) 		3 PRO A 196
MET A 197
TYR A 195
 None
 0.96A 4qa0B-1aurA:
1.1		 4qa0B-1aurA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 PRO A  90
MET A  92
TYR A  89
 None
 1.10A 4qa0B-1b8iA:
undetectable		 4qa0B-1b8iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE

(Escherichia
coli) 		PF00180
(Iso_dh) 		3 PRO A  30
MET A  66
TYR A  95
 None
 1.04A 4qa0B-1bl5A:
3.0		 4qa0B-1bl5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm0 P300/CBP ASSOCIATING
FACTOR

(Homo sapiens) 		no annotation 3 PRO B 530
MET B 529
TYR B 533
 None
 0.95A 4qa0B-1cm0B:
0.0		 4qa0B-1cm0B:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2 203
MET 2 202
TYR 2  35
 None
 1.03A 4qa0B-1ev12:
0.0		 4qa0B-1ev12:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 PRO A  61
MET A 131
TYR A  52
 None
 1.01A 4qa0B-1fpwA:
undetectable		 4qa0B-1fpwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 PRO A 400
MET A 401
TYR A 205
 None
 1.03A 4qa0B-1j3bA:
0.0		 4qa0B-1j3bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mov GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Montipora
efflorescens) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  82
 None
IOD  A 303 ( 4.8A)
None
 0.74A 4qa0B-1movA:
0.0		 4qa0B-1movA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO B 203
MET B 202
TYR B  35
 None
 1.08A 4qa0B-1mqtB:
undetectable		 4qa0B-1mqtB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PRO A  60
MET A  61
TYR A  59
 None
 1.06A 4qa0B-1tmoA:
2.6		 4qa0B-1tmoA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi7 HYPOTHETICAL PROTEIN
YIGZ

(Escherichia
coli) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		3 PRO A  85
MET A  86
TYR A 120
 None
 1.09A 4qa0B-1vi7A:
undetectable		 4qa0B-1vi7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		3 PRO A 119
MET A 120
TYR A 118
 None
 1.02A 4qa0B-1vz8A:
undetectable		 4qa0B-1vz8A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  79
 None
 0.74A 4qa0B-1xqmA:
undetectable		 4qa0B-1xqmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 135
MET A 134
TYR A 251
 None
 0.82A 4qa0B-1xrcA:
undetectable		 4qa0B-1xrcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4r GENERAL CONTROL OF
AMINO ACID SYNTHESIS
PROTEIN 5-LIKE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 PRO A 535
MET A 534
TYR A 538
 None
 1.08A 4qa0B-1z4rA:
undetectable		 4qa0B-1z4rA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zto POTASSIUM CHANNEL
PROTEIN RCK4

(Homo sapiens) 		PF07941
(K_channel_TID) 		3 PRO A  18
MET A  17
TYR A  21
 None
 1.11A 4qa0B-1ztoA:
undetectable		 4qa0B-1ztoA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a46 GFP-LIKE FLUORESCENT
CHROMOPROTEIN
AMFP486

(Anemonia majano) 		PF01353
(GFP) 		3 PRO A 192
MET A 191
TYR A  84
 None
 0.80A 4qa0B-2a46A:
undetectable		 4qa0B-2a46A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		3 PRO A 348
MET A 347
TYR A 357
 None
 1.07A 4qa0B-2bg5A:
undetectable		 4qa0B-2bg5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		3 PRO A 200
MET A 212
TYR A 199
 None
 1.13A 4qa0B-2cxiA:
undetectable		 4qa0B-2cxiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		3 PRO A  30
MET A  66
TYR A  95
 None
 1.04A 4qa0B-2d4vA:
undetectable		 4qa0B-2d4vA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8y EPLIN PROTEIN

(Homo sapiens) 		PF00412
(LIM) 		3 PRO A  27
MET A  28
TYR A  26
 None
 1.09A 4qa0B-2d8yA:
undetectable		 4qa0B-2d8yA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 PRO A 567
MET A 566
TYR A 573
 None
 0.58A 4qa0B-2db3A:
5.2		 4qa0B-2db3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfx COLICIN-E5 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF11480
(ImmE5) 		3 PRO I  73
MET I  72
TYR I  76
 None
 0.98A 4qa0B-2dfxI:
undetectable		 4qa0B-2dfxI:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.76A 4qa0B-2fl1A:
undetectable		 4qa0B-2fl1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 PRO A 391
MET A 390
TYR A 360
 None
 0.98A 4qa0B-2hv2A:
undetectable		 4qa0B-2hv2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		3 PRO A 217
MET A 218
TYR A  27
 None
 1.07A 4qa0B-2i34A:
1.8		 4qa0B-2i34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  79
 None
 0.69A 4qa0B-2ib5A:
undetectable		 4qa0B-2ib5A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 PRO B  46
MET B  47
TYR B  45
 None
 0.91A 4qa0B-2iwgB:
undetectable		 4qa0B-2iwgB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 271
 None
 0.81A 4qa0B-2obvA:
undetectable		 4qa0B-2obvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.78A 4qa0B-2ogrA:
undetectable		 4qa0B-2ogrA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p64 F-BOX/WD REPEAT
PROTEIN 1A

(Homo sapiens) 		PF12125
(Beta-TrCP_D) 		3 PRO A 174
MET A 175
TYR A 171
 None
 0.68A 4qa0B-2p64A:
undetectable		 4qa0B-2p64A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 PRO A 195
MET A 194
TYR A  82
 None
 0.82A 4qa0B-2pxsA:
undetectable		 4qa0B-2pxsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3p UNCHARACTERIZED
PROTEIN AT3G17210

(Arabidopsis
thaliana) 		PF07876
(Dabb) 		3 PRO A  44
MET A  45
TYR A  80
 None
 0.90A 4qa0B-2q3pA:
undetectable		 4qa0B-2q3pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		3 PRO A 317
MET A 318
TYR A 316
 None
 1.09A 4qa0B-2rgjA:
undetectable		 4qa0B-2rgjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh7 GREEN FLUORESCENT
PROTEIN

(Renilla
reniformis) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  82
 None
 0.71A 4qa0B-2rh7A:
undetectable		 4qa0B-2rh7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		3 PRO A 119
MET A 120
TYR A 118
 None
 0.98A 4qa0B-2v4iA:
undetectable		 4qa0B-2v4iA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB

(Escherichia
coli) 		PF00271
(Helicase_C) 		3 PRO D 326
MET D 325
TYR D 332
 None
 0.85A 4qa0B-2yjtD:
3.8		 4qa0B-2yjtD:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 277
MET A 278
TYR A 276
 None
 1.01A 4qa0B-2yv3A:
undetectable		 4qa0B-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  82
 None
 0.78A 4qa0B-3cglA:
undetectable		 4qa0B-3cglA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		3 PRO A 573
MET A 575
TYR A 572
 None
 1.02A 4qa0B-3ciaA:
undetectable		 4qa0B-3ciaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		3 PRO A 194
MET A 195
TYR A 193
 None
 0.95A 4qa0B-3cn7A:
2.6		 4qa0B-3cn7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Methanosarcina
acetivorans) 		PF00528
(BPD_transp_1) 		3 PRO C 222
MET C 223
TYR C 221
 None
 1.12A 4qa0B-3d31C:
undetectable		 4qa0B-3d31C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		3 PRO A  32
MET A  68
TYR A  97
 None
 0.94A 4qa0B-3dmsA:
3.0		 4qa0B-3dmsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 PRO A 230
MET A 229
TYR A 233
 None
 1.02A 4qa0B-3du4A:
3.5		 4qa0B-3du4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		3 PRO A 301
MET A 302
TYR A 300
 None
 1.02A 4qa0B-3eafA:
3.1		 4qa0B-3eafA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 PRO A1058
MET A1061
TYR A 822
 None
 0.68A 4qa0B-3f2bA:
undetectable		 4qa0B-3f2bA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3h UNCHARACTERIZED
SNOAL-LIKE PROTEIN

(Burkholderia
thailandensis) 		PF12680
(SnoaL_2) 		3 PRO A  41
MET A  42
TYR A 119
 None
 1.08A 4qa0B-3h3hA:
undetectable		 4qa0B-3h3hA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 139
MET A 138
TYR A 255
 None
 0.80A 4qa0B-3imlA:
undetectable		 4qa0B-3imlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir8 LARGE STOKES SHIFT
FLUORESCENT PROTEIN

(Montipora sp.
20) 		PF01353
(GFP) 		3 PRO A 186
MET A 185
TYR A  78
 None
 0.75A 4qa0B-3ir8A:
undetectable		 4qa0B-3ir8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO C 194
MET C 193
TYR C  26
 None
 1.09A 4qa0B-3j2jC:
undetectable		 4qa0B-3j2jC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		3 PRO A 235
MET A 108
TYR A 103
 None
 0.83A 4qa0B-3kcxA:
undetectable		 4qa0B-3kcxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		3 PRO B 221
MET B 233
TYR B 220
 None
 1.11A 4qa0B-3l4gB:
undetectable		 4qa0B-3l4gB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 3 PRO B 340
MET B 339
TYR B 343
 None
 0.99A 4qa0B-3l82B:
undetectable		 4qa0B-3l82B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 PRO A 190
MET A 189
TYR A  81
 None
 0.77A 4qa0B-3mgfA:
undetectable		 4qa0B-3mgfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 272
 None
 0.85A 4qa0B-3rv2A:
undetectable		 4qa0B-3rv2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 138
MET A 137
TYR A 258
 None
 0.87A 4qa0B-3so4A:
undetectable		 4qa0B-3so4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		3 PRO B 914
MET B 913
TYR B 917
 SO4  B   4 (-4.1A)
None
None
 1.04A 4qa0B-3tacB:
undetectable		 4qa0B-3tacB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		3 PRO A 914
MET A 913
TYR A 917
 None
 1.07A 4qa0B-3tadA:
undetectable		 4qa0B-3tadA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 PRO A3717
MET A3761
TYR A3689
 None
 1.06A 4qa0B-3vkgA:
undetectable		 4qa0B-3vkgA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		3 PRO A 190
MET A 189
TYR A 220
 None
 0.98A 4qa0B-3vsmA:
undetectable		 4qa0B-3vsmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		3 PRO B  51
MET B  52
TYR B  50
 None
 0.91A 4qa0B-3zo0B:
undetectable		 4qa0B-3zo0B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 PRO A  43
MET A  42
TYR A  46
 None
GSH  A1450 (-4.2A)
None
 0.87A 4qa0B-4agsA:
undetectable		 4qa0B-4agsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 PRO A 673
MET A 672
TYR A 573
 None
 0.90A 4qa0B-4b9yA:
undetectable		 4qa0B-4b9yA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by4 FI18190P1

(Drosophila
melanogaster) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 PRO A  61
MET A 131
TYR A  52
 None
 0.72A 4qa0B-4by4A:
undetectable		 4qa0B-4by4A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		3 PRO C 626
MET C 625
TYR A2036
 None
 1.11A 4qa0B-4c0dC:
undetectable		 4qa0B-4c0dC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 PRO A 407
MET A 406
TYR A 352
 None
 1.00A 4qa0B-4d4lA:
undetectable		 4qa0B-4d4lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgc NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Bacillus
subtilis) 		PF14489
(QueF) 		3 PRO A 113
MET A 111
TYR A  70
 None
 0.95A 4qa0B-4fgcA:
undetectable		 4qa0B-4fgcA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		3 PRO 2 205
MET 2 204
TYR 2  35
 None
 0.95A 4qa0B-4gb32:
undetectable		 4qa0B-4gb32:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		3 PRO A  24
MET A  21
TYR A 130
 None
 0.82A 4qa0B-4j9uA:
undetectable		 4qa0B-4j9uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 PRO A3133
MET A3132
TYR A3136
 None
 1.13A 4qa0B-4kc5A:
undetectable		 4qa0B-4kc5A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrd CD44 ANTIGEN

(Mus musculus) 		PF00193
(Xlink) 		3 PRO A  65
MET A  70
TYR A 122
 None
 0.87A 4qa0B-4mrdA:
undetectable		 4qa0B-4mrdA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsq HISTONE
ACETYLTRANSFERASE
KAT2B

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 PRO A 530
MET A 529
TYR A 533
 None
 0.90A 4qa0B-4nsqA:
undetectable		 4qa0B-4nsqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 156
MET A 155
TYR A 279
 None
 0.77A 4qa0B-4odjA:
undetectable		 4qa0B-4odjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 PRO B  45
MET B  46
TYR B  87
 None
 1.13A 4qa0B-4ritB:
3.1		 4qa0B-4ritB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9r UNCHARACTERIZED
PROTEIN

(Capnocytophaga
ochracea) 		PF00756
(Esterase) 		3 PRO A 331
MET A 330
TYR A 325
 None
None
GOL  A 502 ( 4.5A)
 0.82A 4qa0B-4w9rA:
undetectable		 4qa0B-4w9rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 3 PRO E 249
MET E 204
TYR E 401
 None
 1.01A 4qa0B-4whbE:
undetectable		 4qa0B-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP

(Stichodactyla
gigantea) 		PF01353
(GFP) 		3 PRO A 189
MET A 188
TYR A  78
 None
 0.77A 4qa0B-4zb1A:
undetectable		 4qa0B-4zb1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 151
MET A 150
TYR A 271
 None
 0.80A 4qa0B-5a1iA:
undetectable		 4qa0B-5a1iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 3 PRO A 419
MET A 418
TYR A 406
 None
 1.09A 4qa0B-5ah1A:
undetectable		 4qa0B-5ah1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 PRO A 407
MET A 406
TYR A 352
 None
 1.01A 4qa0B-5ajzA:
undetectable		 4qa0B-5ajzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		3 PRO B 191
MET B 193
TYR B  35
 None
 1.05A 4qa0B-5bnnB:
undetectable		 4qa0B-5bnnB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli) 		PF01353
(GFP) 		3 PRO A 194
MET A 193
TYR A  83
 None
 0.78A 4qa0B-5bqlA:
undetectable		 4qa0B-5bqlA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 PRO A 627
MET A 626
TYR A 633
 None
 1.11A 4qa0B-5dtuA:
4.2		 4qa0B-5dtuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PEPTIDOGLYCAN
HYDROLASE GP4

(Salmonella
virus P22) 		PF11650
(P22_Tail-4) 		3 PRO K 138
MET K 141
TYR K 137
 None
 1.13A 4qa0B-5gaiK:
undetectable		 4qa0B-5gaiK:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 PRO C 147
MET C 146
TYR C 264
 None
 0.84A 4qa0B-5h9uC:
undetectable		 4qa0B-5h9uC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		3 PRO A 401
MET A 400
TYR A 442
 None
 1.00A 4qa0B-5iv9A:
undetectable		 4qa0B-5iv9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 PRO B 837
MET B 840
TYR B 778
 None
 1.08A 4qa0B-5kyuB:
undetectable		 4qa0B-5kyuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.77A 4qa0B-5lk4A:
undetectable		 4qa0B-5lk4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 PRO A1776
MET A1777
TYR A1773
 None
 0.95A 4qa0B-5lkiA:
undetectable		 4qa0B-5lkiA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nt7 ATP-DEPENDENT RNA
HELICASE VASA,
ISOFORM A

(Drosophila
melanogaster) 		PF00271
(Helicase_C) 		3 PRO B 567
MET B 566
TYR B 573
 None
 0.89A 4qa0B-5nt7B:
3.9		 4qa0B-5nt7B:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 PRO A 446
MET A 445
TYR A 340
 None
 1.13A 4qa0B-5oriA:
undetectable		 4qa0B-5oriA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		3 PRO A 118
MET A 117
TYR A 121
 None
ILE  A 300 (-3.5A)
ILE  A 300 (-4.6A)
 1.10A 4qa0B-5t65A:
undetectable		 4qa0B-5t65A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 PRO A 138
MET A 137
TYR A 256
 None
 0.83A 4qa0B-5t8tA:
undetectable		 4qa0B-5t8tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 PRO A 159
MET A 160
TYR A 156
 None
 0.90A 4qa0B-5ub6A:
undetectable		 4qa0B-5ub6A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udg NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Bacillus
subtilis) 		PF14489
(QueF) 		3 PRO A 113
MET A 111
TYR A  70
 None
 0.99A 4qa0B-5udgA:
undetectable		 4qa0B-5udgA:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 PRO A 273
MET A 274
TYR A 306
 EDO  A 407 ( 3.6A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.48A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		3 PRO A 159
MET A 164
TYR A 189
 None
None
LLP  A 211 ( 4.6A)
 1.09A 4qa0B-5x2vA:
3.6		 4qa0B-5x2vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		3 PRO A 568
MET A 569
TYR A 358
 None
 0.99A 4qa0B-5xmcA:
undetectable		 4qa0B-5xmcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 3 PRO A 727
MET A 725
TYR A 713
 None
 1.09A 4qa0B-5znnA:
undetectable		 4qa0B-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 3 PRO A  36
MET A  72
TYR A 101
 None
 1.05A 4qa0B-6c0eA:
2.7		 4qa0B-6c0eA:
12.89