SIMILAR PATTERNS OF AMINO ACIDS FOR 4Q5M_A_ROCA1101_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1agx | GLUTAMINASE-ASPARAGINASE (Acinetobacterglutaminasificans) |
PF00710(Asparaginase) | 5 | GLY A 51ILE A 13ILE A 88VAL A 74ILE A 112 | None | 0.88A | 4q5mA-1agxA:undetectable | 4q5mA-1agxA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1guz | MALATE DEHYDROGENASE (Chlorobaculumtepidum;Prosthecochlorisvibrioformis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 141ILE A 74THR A 102ILE A 3THR A 15 | None | 1.03A | 4q5mA-1guzA:undetectable | 4q5mA-1guzA:23.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80PRO A 81VAL A 82ARG A 8VAL A 32ILE A 47THR A 80 | A79 A 800 (-3.0A)A79 A 800 (-2.7A)A79 A 800 ( 3.4A)A79 A 800 ( 4.0A)NoneA79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.4A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)None | 0.53A | 4q5mA-1hvcA:33.5 | 4q5mA-1hvcA:95.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80PRO A 81VAL A 82ARG A 8VAL A 32ILE A 47THR A 80 | A79 A 800 (-3.0A)A79 A 800 (-2.8A)A79 A 800 ( 3.2A)A79 A 800 (-3.8A)NoneA79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)None | 0.62A | 4q5mA-1hvcA:33.5 | 4q5mA-1hvcA:95.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1j | HEAT SHOCK PROTEASEHTRA (Thermotogamaritima) |
PF13365(Trypsin_2) | 5 | GLY A 207ASP A 127ILE A 131VAL A 107ILE A 133 | None | 0.98A | 4q5mA-1l1jA:undetectable | 4q5mA-1l1jA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpo | MALTOPORIN (Escherichiacoli) |
PF02264(LamB) | 5 | GLY A 190ASP A 173THR A 236ARG A 175ILE A 272 | None | 0.98A | 4q5mA-1mpoA:undetectable | 4q5mA-1mpoA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1muu | GDP-MANNOSE6-DEHYDROGENASE (Pseudomonasaeruginosa) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | GLY A 12ILE A 27ILE A 82VAL A 31ILE A 99 | NoneNoneNoneNAD A1001 (-4.4A)None | 1.01A | 4q5mA-1muuA:undetectable | 4q5mA-1muuA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNIT (Klebsiellapneumoniae) |
PF08841(DDR) | 5 | GLY A 170ASP A 168ILE A 164VAL A 201ILE A 134 | None | 0.90A | 4q5mA-1nbwA:undetectable | 4q5mA-1nbwA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4z | BETA-AGARASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 6 | GLY A 248ILE A 63ILE A 347VAL A 342VAL A 153ILE A 80 | None | 1.49A | 4q5mA-1o4zA:undetectable | 4q5mA-1o4zA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q9j | POLYKETIDE SYNTHASEASSOCIATED PROTEIN 5 (Mycobacteriumtuberculosis) |
PF00668(Condensation)PF16911(PapA_C) | 5 | GLY A 114ILE A 28THR A 355PRO A 356ARG A 112 | None | 1.02A | 4q5mA-1q9jA:undetectable | 4q5mA-1q9jA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qso | HPA2 HISTONEACETYLTRANSFERASE (Saccharomycescerevisiae) |
PF00583(Acetyltransf_1) | 5 | ASP A 18ILE A 73ARG A 12VAL A 112ILE A 90 | None | 1.01A | 4q5mA-1qsoA:undetectable | 4q5mA-1qsoA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 50THR A 80PRO A 81 | None | 0.37A | 4q5mA-1sivA:15.6 | 4q5mA-1sivA:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEALPHA CHAINTRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00290(Trp_syntA)PF00291(PALP) | 5 | GLY B 276ILE B 289VAL B 271VAL A 114ILE A 92 | None | 0.92A | 4q5mA-1wdwB:undetectable | 4q5mA-1wdwB:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc6 | BETA-GALACTOSIDASE (Penicillium sp.) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | GLY A 860ASN A 353ILE A 800VAL A 798ILE A 822 | None | 1.04A | 4q5mA-1xc6A:undetectable | 4q5mA-1xc6A:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhb | POLYPEPTIDEN-ACETYLGALACTOSAMINYLTRANSFERASE 1 (Mus musculus) |
PF00535(Glycos_transf_2)PF00652(Ricin_B_lectin) | 5 | GLY A 217ILE A 237PRO A 285ILE A 226THR A 206 | None | 1.04A | 4q5mA-1xhbA:undetectable | 4q5mA-1xhbA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzf | LIPASE/ACYLHYDROLASE (Enterococcusfaecalis) |
PF13472(Lipase_GDSL_2) | 5 | ASP A 79ILE A 128ILE A 110VAL A 72ILE A 182 | None | 1.01A | 4q5mA-1yzfA:undetectable | 4q5mA-1yzfA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zpu | IRON TRANSPORTMULTICOPPER OXIDASEFET3 (Saccharomycescerevisiae) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ASP A 146ILE A 142THR A 240VAL A 234THR A 58 | NoneNAG A2002 ( 4.8A)NoneNoneMAN A3008 ( 4.5A) | 0.87A | 4q5mA-1zpuA:undetectable | 4q5mA-1zpuA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zuw | GLUTAMATE RACEMASE 1 (Bacillussubtilis) |
PF01177(Asp_Glu_race) | 5 | ASP A 163ILE A 165ARG A 197VAL A 203ILE A 178 | None | 0.94A | 4q5mA-1zuwA:undetectable | 4q5mA-1zuwA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4a | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Plasmodiumyoelii) |
PF01791(DeoC) | 5 | GLY A 82ILE A 144VAL A 162ILE A 170THR A 158 | None | 1.01A | 4q5mA-2a4aA:undetectable | 4q5mA-2a4aA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2acv | TRITERPENEUDP-GLUCOSYLTRANSFERASE UGT71G1 (Medicagotruncatula) |
PF00201(UDPGT) | 5 | GLY A 178ASN A 181PRO A 189VAL A 217THR A 219 | None | 1.03A | 4q5mA-2acvA:undetectable | 4q5mA-2acvA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | GLY A 279ASP A 73VAL A 202ARG A 278ILE A 269 | None | 0.90A | 4q5mA-2aniA:undetectable | 4q5mA-2aniA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | GLY A 279ASP A 73VAL A 202ARG A 278ILE A 289 | None | 0.92A | 4q5mA-2aniA:undetectable | 4q5mA-2aniA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b24 | NAPHTHALENEDIOXYGENASE LARGESUBUNITNAPHTHALENEDIOXYGENASE SMALLSUBUNIT (Rhodococcus sp.NCIMB 12038) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A)PF00866(Ring_hydroxyl_B) | 5 | GLY B 643ILE B 670VAL B 567ILE A 364THR B 672 | None | 1.00A | 4q5mA-2b24B:undetectable | 4q5mA-2b24B:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b6n | PROTEINASE K (Serratia sp.GF96) |
PF00082(Peptidase_S8) | 5 | GLY A 181ILE A 13THR A 76VAL A 73THR A 249 | None | 1.00A | 4q5mA-2b6nA:undetectable | 4q5mA-2b6nA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e28 | PYRUVATE KINASE (Geobacillusstearothermophilus) |
PF00224(PK)PF00391(PEP-utilizers)PF02887(PK_C) | 5 | GLY A 536ILE A 531THR A 561VAL A 545ILE A 525 | None | 0.88A | 4q5mA-2e28A:undetectable | 4q5mA-2e28A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 53PRO A 86VAL A 87 | LP1 A 201 (-3.8A)LP1 A 201 (-3.6A)LP1 A 201 (-4.6A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A) | 0.62A | 4q5mA-2fmbA:12.7 | 4q5mA-2fmbA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gz6 | N-ACETYL-D-GLUCOSAMINE 2-EPIMERASE (Anabaena sp.CH1) |
PF07221(GlcNAc_2-epim) | 6 | GLY A 316ILE A 270ILE A 247ARG A 322ILE A 250THR A 259 | None | 1.40A | 4q5mA-2gz6A:undetectable | 4q5mA-2gz6A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iyo | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Lactococcuslactis) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | GLY A 180ASN A 102ILE A 98THR A 80ILE A 96 | None6PG A1471 (-2.9A)NoneNoneNone | 1.03A | 4q5mA-2iyoA:undetectable | 4q5mA-2iyoA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k3y | CHROMATINMODIFICATION-RELATEDPROTEIN EAF3 (Saccharomycescerevisiae) |
PF11717(Tudor-knot) | 5 | GLY A 83ILE A 79PRO A 46VAL A 14ILE A 27 | None | 1.01A | 4q5mA-2k3yA:undetectable | 4q5mA-2k3yA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgy | ENOLASE FROM THEENVIRONMENTAL GENOMESHOTGUN SEQUENCINGOF THE SARGASSO SEA (-) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASN A 293ILE A 262VAL A 247VAL A 315ILE A 274 | None | 1.01A | 4q5mA-2qgyA:undetectable | 4q5mA-2qgyA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgy | ENOLASE FROM THEENVIRONMENTAL GENOMESHOTGUN SEQUENCINGOF THE SARGASSO SEA (-) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 294ASN A 265ILE A 286VAL A 247ILE A 283 | None | 1.02A | 4q5mA-2qgyA:undetectable | 4q5mA-2qgyA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1d | NEUREXIN-1-BETA (Rattusnorvegicus) |
PF02210(Laminin_G_2) | 5 | GLY A 70ILE A 169VAL A 104VAL A 192ILE A 167 | None | 0.95A | 4q5mA-2r1dA:undetectable | 4q5mA-2r1dA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2raq | CONSERVED PROTEINMTH889 (Methanothermobacterthermautotrophicus) |
PF02680(DUF211) | 5 | ASP A 59ASN A 58ILE A 7VAL A 37ILE A 76 | None | 0.99A | 4q5mA-2raqA:undetectable | 4q5mA-2raqA:18.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 50THR A 80PRO A 81 | AB1 A 501 (-3.9A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)NoneAB1 A 501 (-4.2A) | 0.40A | 4q5mA-2rkfA:18.1 | 4q5mA-2rkfA:42.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8z | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Geobacillusstearothermophilus) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | GLY A 178ASN A 102ILE A 98THR A 80ILE A 96 | None6PG A1470 (-3.1A)NoneNoneNone | 1.01A | 4q5mA-2w8zA:undetectable | 4q5mA-2w8zA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xb6 | NEUREXIN-1-BETA (Rattusnorvegicus) |
PF02210(Laminin_G_2) | 5 | GLY C 116ILE C 245VAL C 150VAL C 268ILE C 243 | EDO C1295 ( 4.6A)NoneNoneNoneNone | 1.01A | 4q5mA-2xb6C:undetectable | 4q5mA-2xb6C:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdr | BETAINE ALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 5 | ASP A 399ILE A 395VAL A 420ARG A 296THR A 375 | None | 0.92A | 4q5mA-2xdrA:undetectable | 4q5mA-2xdrA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ILE A 104ILE A 148PRO A 98VAL A 274THR A 144 | None | 1.00A | 4q5mA-2xr1A:undetectable | 4q5mA-2xr1A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfq | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Peptoniphilusasaccharolyticus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ILE A 339PRO A 298VAL A 297VAL A 403ILE A 345 | None | 1.03A | 4q5mA-2yfqA:undetectable | 4q5mA-2yfqA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyg | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Klebsiellapneumoniae) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | GLY A 179ASN A 102ILE A 98THR A 80ILE A 96 | None | 0.96A | 4q5mA-2zygA:undetectable | 4q5mA-2zygA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asi | NEUREXIN-1-ALPHA (Bos taurus) |
PF02210(Laminin_G_2) | 5 | GLY A1118ILE A1217VAL A1152VAL A1240ILE A1215 | None | 0.97A | 4q5mA-3asiA:undetectable | 4q5mA-3asiA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgy | VIRULENCE SENSORHISTIDINE KINASEPHOQ (Salmonellaenterica) |
PF02518(HATPase_c) | 5 | GLY A 385ILE A 412VAL A 399VAL A 341ILE A 367 | None | 1.04A | 4q5mA-3cgyA:undetectable | 4q5mA-3cgyA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clq | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF06545(DUF1116) | 5 | GLY A 317ASP A 356ILE A 440ARG A 315VAL A 161 | None | 1.00A | 4q5mA-3clqA:undetectable | 4q5mA-3clqA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdu | PUTATIVE ENOYL-COAHYDRATASE/ISOMERASE (Acinetobacterbaumannii) |
PF00378(ECH_1) | 5 | GLY A 114ASN A 33ILE A 26VAL A 121VAL A 191 | None | 0.94A | 4q5mA-3fduA:undetectable | 4q5mA-3fduA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fs2 | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE (Brucellamelitensis) |
PF00793(DAHP_synth_1) | 5 | GLY A 75ASP A 61ILE A 98PRO A 109VAL A 110 | None | 0.88A | 4q5mA-3fs2A:undetectable | 4q5mA-3fs2A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyb | TRANSCRIPTIONALREGULATORS(LACI-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN) (Corynebacteriumglutamicum) |
PF13377(Peripla_BP_3) | 5 | GLY A 144ASN A 288ILE A 82PRO A 273VAL A 68 | None | 1.01A | 4q5mA-3gybA:undetectable | 4q5mA-3gybA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyl | VP1 (Aquareovirus C) |
PF06016(Reovirus_L2) | 5 | ILE W 842PRO W 741VAL W 740VAL W 852ILE W 846 | None | 0.87A | 4q5mA-3iylW:undetectable | 4q5mA-3iylW:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khj | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | GLY A 190ILE A 235VAL A 159ILE A 68THR A 36 | None | 0.97A | 4q5mA-3khjA:undetectable | 4q5mA-3khjA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqt | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 96ILE A 92ARG A 95ILE A 56THR A 89 | None | 1.04A | 4q5mA-3mqtA:undetectable | 4q5mA-3mqtA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mw2 | NEUREXIN-1-ALPHA (Mus musculus) |
PF02210(Laminin_G_2) | 5 | GLY A 116ILE A 245VAL A 150VAL A 268ILE A 243 | None | 0.88A | 4q5mA-3mw2A:undetectable | 4q5mA-3mw2A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mw3 | NEUREXIN-2-BETA (Rattusnorvegicus) |
PF02210(Laminin_G_2) | 5 | GLY A 118ILE A 247VAL A 152VAL A 270ILE A 245 | None | 1.00A | 4q5mA-3mw3A:undetectable | 4q5mA-3mw3A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mw4 | NEUREXIN-2-BETA (Mus musculus) |
PF02210(Laminin_G_2) | 5 | GLY A 114ILE A 213VAL A 148VAL A 236ILE A 211 | None | 1.00A | 4q5mA-3mw4A:undetectable | 4q5mA-3mw4A:23.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80PRO A 81VAL A 82 | None | 0.51A | 4q5mA-3mwsA:16.8 | 4q5mA-3mwsA:39.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfb | BETA-PEPTIDYLAMINOPEPTIDASE (Sphingosinicellaxenopeptidilytica) |
PF03576(Peptidase_S58) | 5 | GLY A 158ILE A 55VAL A 169VAL A 27ILE A 21 | None | 0.84A | 4q5mA-3nfbA:undetectable | 4q5mA-3nfbA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noy | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Aquifexaeolicus) |
PF04551(GcpE) | 5 | GLY A 96ILE A 79THR A 33VAL A 12ILE A 53 | None | 0.94A | 4q5mA-3noyA:undetectable | 4q5mA-3noyA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvn | PLEXIN-C1 (Homo sapiens) |
PF01437(PSI) | 5 | GLY B 56ILE B 49THR B 125VAL B 447ILE B 46 | None | 0.84A | 4q5mA-3nvnB:undetectable | 4q5mA-3nvnB:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohn | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher) | 5 | ASP A 274ILE A 303THR A 314VAL A 315VAL A 280 | None | 1.00A | 4q5mA-3ohnA:undetectable | 4q5mA-3ohnA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ox4 | ALCOHOLDEHYDROGENASE 2 (Zymomonasmobilis) |
PF00465(Fe-ADH) | 5 | GLY A 17ILE A 136VAL A 11VAL A 51ILE A 93 | None | 0.81A | 4q5mA-3ox4A:undetectable | 4q5mA-3ox4A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poy | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 5 | GLY A1178ILE A1307VAL A1212VAL A1330ILE A1305 | None | 0.86A | 4q5mA-3poyA:undetectable | 4q5mA-3poyA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qcw | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 5 | GLY A1162ILE A1291VAL A1196VAL A1314ILE A1289 | None | 0.97A | 4q5mA-3qcwA:undetectable | 4q5mA-3qcwA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qo6 | PROTEASE DO-LIKE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 237ILE A 300ILE A 296THR A 273VAL A 169 | None | 1.04A | 4q5mA-3qo6A:undetectable | 4q5mA-3qo6A:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80 | 017 A 201 (-3.4A)017 A 201 (-3.5A)None017 A 201 (-3.3A)None | 0.64A | 4q5mA-3t3cA:15.9 | 4q5mA-3t3cA:37.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 50THR A 80PRO A 81 | 017 A 201 (-3.6A)017 A 201 (-3.3A)017 A 201 (-3.3A)None017 A 201 (-4.1A) | 0.53A | 4q5mA-3ttpA:16.7 | 4q5mA-3ttpA:39.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ASP A 29ILE A 50THR A 80PRO A 81 | 017 A 201 ( 3.5A)017 A 201 (-3.2A)017 A 201 ( 3.5A)None017 A 202 (-4.0A) | 0.55A | 4q5mA-3u7sA:17.0 | 4q5mA-3u7sA:38.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ASP A 29ASN A 30THR A 80PRO A 81VAL A 82 | None | 0.58A | 4q5mA-3uhlA:13.8 | 4q5mA-3uhlA:39.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uve | CARVEOLDEHYDROGENASE((+)-TRANS-CARVEOLDEHYDROGENASE) (Mycobacteriumavium) |
PF13561(adh_short_C2) | 6 | GLY A 111ILE A 39VAL A 136VAL A 207ILE A 253THR A 209 | NoneNAD A 300 (-3.8A)NoneNAD A 300 (-4.1A)NoneNAD A 300 (-2.7A) | 1.10A | 4q5mA-3uveA:undetectable | 4q5mA-3uveA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atf | BETA-AGARASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 6 | GLY A 248ILE A 63ILE A 347VAL A 342VAL A 153ILE A 80 | None | 1.50A | 4q5mA-4atfA:undetectable | 4q5mA-4atfA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e09 | PLASMID PARTITIONINGPROTEIN PARF (Escherichiacoli) |
PF01656(CbiA) | 5 | GLY A 14ASN A 21ILE A 194ILE A 137ILE A 154 | ACP A 301 (-3.2A)NoneNoneNoneNone | 0.92A | 4q5mA-4e09A:undetectable | 4q5mA-4e09A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ehc | PE-PGRS FAMILYPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 6 | GLY A 249ILE A 216VAL A 172VAL A 210ILE A 176THR A 232 | NoneNoneNoneEDO A 326 (-4.9A)NoneNone | 1.37A | 4q5mA-4ehcA:11.2 | 4q5mA-4ehcA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gz8 | SEMAPHORIN-3A (Mus musculus) |
PF01403(Sema) | 6 | GLY A 337ASN A 428ILE A 451THR A 488VAL A 340ILE A 434 | None | 1.32A | 4q5mA-4gz8A:undetectable | 4q5mA-4gz8A:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7n | ALDEHYDEDEHYDROGENASE (Trichormusvariabilis) |
PF00171(Aldedh) | 5 | GLY A 190ASN A 195ILE A 19VAL A 156VAL A 7 | None | 1.03A | 4q5mA-4h7nA:undetectable | 4q5mA-4h7nA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 5 | GLY A 195ILE A 188THR A 39VAL A 233ILE A 201 | NoneNoneIMD A 509 ( 3.8A)NoneNone | 0.96A | 4q5mA-4hvlA:undetectable | 4q5mA-4hvlA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hw6 | HYPOTHETICALPROTEIN, IPT/TIGDOMAIN PROTEIN (Bacteroidesovatus) |
PF01833(TIG) | 5 | GLY A 62ILE A 104VAL A 114ARG A 63ILE A 94 | None | 1.04A | 4q5mA-4hw6A:undetectable | 4q5mA-4hw6A:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6m | ACTIN-LIKE PROTEINARP9 (Saccharomycescerevisiae) |
PF00022(Actin) | 5 | ILE B 335VAL B 329VAL B 164ILE B 309THR B 340 | None | 0.90A | 4q5mA-4i6mB:undetectable | 4q5mA-4i6mB:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4if2 | PHOSPHOTRIESTERASEHOMOLOGY PROTEIN (Mycobacteriumtuberculosis) |
PF02126(PTE) | 5 | GLY A 96ILE A 27VAL A 66ILE A 205THR A 148 | KCX A 145 ( 3.4A)NoneNoneNoneNone | 1.03A | 4q5mA-4if2A:undetectable | 4q5mA-4if2A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iug | BETA-GALACTOSIDASE A (Aspergillusoryzae) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | GLY A 857ASN A 352ILE A 797VAL A 795ILE A 819 | None | 1.03A | 4q5mA-4iugA:undetectable | 4q5mA-4iugA:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix2 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH) | 5 | GLY A 278ILE A 323VAL A 246ILE A 69THR A 37 | None | 1.02A | 4q5mA-4ix2A:undetectable | 4q5mA-4ix2A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jen | CMP N-GLYCOSIDASE (Clostridiumbotulinum) |
no annotation | 5 | ASP A 45ILE A 71ILE A 104THR A 89ILE A 130 | None | 0.96A | 4q5mA-4jenA:undetectable | 4q5mA-4jenA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k8l | PROLINE RACEMASE (Ochrobactrumanthropi) |
PF05544(Pro_racemase) | 5 | ILE A 245ILE A 201THR A 242VAL A 157ILE A 163 | None | 0.94A | 4q5mA-4k8lA:undetectable | 4q5mA-4k8lA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld6 | PWWPDOMAIN-CONTAININGPROTEIN 2B (Homo sapiens) |
PF00855(PWWP) | 6 | GLY A 496ILE A 541ARG A 554VAL A 488ILE A 511THR A 482 | None | 1.01A | 4q5mA-4ld6A:undetectable | 4q5mA-4ld6A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwa | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Bacillusanthracis) |
PF04551(GcpE) | 5 | GLY D 98ILE D 73VAL D 59ILE D 46THR D 36 | None | 1.01A | 4q5mA-4mwaD:undetectable | 4q5mA-4mwaD:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6e | THIS/MOAD FAMILYPROTEIN (Amycolatopsisorientalis) |
PF02597(ThiS) | 6 | ASP B 64ILE B 83THR B 80VAL B 3ARG B 66ILE B 42 | None | 1.46A | 4q5mA-4n6eB:undetectable | 4q5mA-4n6eB:18.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80PRO A 81 | RIT A 500 (-3.9A)RIT A 500 (-3.2A)RIT A 500 ( 4.5A)RIT A 500 (-4.3A)NoneRIT A 500 (-3.9A) | 0.48A | 4q5mA-4njvA:17.6 | 4q5mA-4njvA:43.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 5 | GLY A 94ILE A 3ILE A 43VAL A 65ILE A 9 | None | 0.98A | 4q5mA-4o1eA:undetectable | 4q5mA-4o1eA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6v | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella suis) |
PF13561(adh_short_C2) | 5 | GLY A 228ILE A 204VAL A 175ILE A 132THR A 207 | None | 0.97A | 4q5mA-4o6vA:undetectable | 4q5mA-4o6vA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj5 | TAILSPIKE PROTEIN (Escherichiavirus CBA120) |
no annotation | 6 | GLY A 647ILE A 675ILE A 589PRO A 641VAL A 643ILE A 607 | None | 1.29A | 4q5mA-4oj5A:undetectable | 4q5mA-4oj5A:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p22 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 1 (Homo sapiens) |
PF00899(ThiF)PF16190(E1_FCCH)PF16191(E1_4HB) | 6 | ASP A 393ILE A 397ILE A 87ARG A 81VAL A 77ILE A 91 | None | 1.29A | 4q5mA-4p22A:undetectable | 4q5mA-4p22A:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3m | MGS-M4 (unidentified) |
PF00248(Aldo_ket_red) | 5 | GLY A 37ILE A 68ILE A 15VAL A 243ILE A 217 | None | 0.97A | 4q5mA-4q3mA:undetectable | 4q5mA-4q3mA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qc8 | VP2 (Ungulatebocaparvovirus1) |
PF00740(Parvo_coat) | 5 | GLY A 158ILE A 70ILE A 453VAL A 133ILE A 451 | None | 1.00A | 4q5mA-4qc8A:undetectable | 4q5mA-4qc8A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yhg | GH5 (Bacteroidetesbacterium AC2a) |
PF00150(Cellulase) | 5 | ASP A 227ASN A 225ILE A 334VAL A 219ARG A 287 | None | 1.04A | 4q5mA-4yhgA:undetectable | 4q5mA-4yhgA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 5 | GLY A 106ILE A 159ILE A 81VAL A 69ILE A 83 | None | 1.00A | 4q5mA-5cjuA:undetectable | 4q5mA-5cjuA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 252VAL A 510ARG A 249VAL A 234ILE A 32 | None | 1.01A | 4q5mA-5eb5A:undetectable | 4q5mA-5eb5A:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eft | P9-1 (Southern riceblack-streakeddwarf virus) |
PF06043(Reo_P9) | 5 | GLY B 208ASN B 212ILE B 14VAL B 220THR B 8 | None | 0.94A | 4q5mA-5eftB:undetectable | 4q5mA-5eftB:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej2 | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 6 | GLY A 115ILE A 47VAL A 140VAL A 211ILE A 257THR A 213 | NoneNAD A 300 (-3.8A)NoneNAD A 300 (-4.2A)NoneNAD A 300 (-2.6A) | 1.10A | 4q5mA-5ej2A:undetectable | 4q5mA-5ej2A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwm | HEAT SHOCK PROTEINHSP 90 BETA (Homo sapiens) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | ILE A 182ILE A 75THR A 179VAL A 202ILE A 213 | NoneNoneATP A1691 (-4.4A)NoneNone | 0.99A | 4q5mA-5fwmA:undetectable | 4q5mA-5fwmA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1q | METHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT BETAMETHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT GAMMA (Methanothermococcusthermolithotrophicus) |
PF02240(MCR_gamma)PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | GLY B 346ILE B 331VAL B 267ARG C 245THR B 355 | None | 1.04A | 4q5mA-5n1qB:undetectable | 4q5mA-5n1qB:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6y | NITROGENASEVANADIUM-IRONPROTEIN BETA CHAIN (Azotobactervinelandii) |
no annotation | 6 | ASN E 260ILE E 293THR E 279PRO E 280VAL E 210THR E 297 | None | 1.20A | 4q5mA-5n6yE:undetectable | 4q5mA-5n6yE:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngy | DSR-M GLUCANSUCRASEINACTIVE MUTANTE715Q (Leuconostoccitreum) |
no annotation | 6 | GLY A 631ASP A 633ASN A1274ILE A 581ILE A1278ILE A 565 | None CA A1501 (-2.3A)NoneNoneNoneNone | 1.46A | 4q5mA-5ngyA:undetectable | 4q5mA-5ngyA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osn | CAPSID PROTEIN (Enterovirus E) |
PF00073(Rhv) | 5 | GLY A 84ASP A 220VAL A 121VAL A 136ILE A 116 | None | 0.98A | 4q5mA-5osnA:undetectable | 4q5mA-5osnA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ASP A 29ILE A 47ILE A 50THR A 80PRO A 81 | None | 0.53A | 4q5mA-5t2zA:17.5 | 4q5mA-5t2zA:40.39 |