SIMILAR PATTERNS OF AMINO ACIDS FOR 4Q36_A_GCSA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 MET A 147
TRP A 131
HIS A 353
PHE A 280
 None
 1.45A 4q36A-2fjaA:
0.0		 4q36A-2fjaA:
20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 MET A 161
TRP A 163
TRP A 164
PHE A 277
 None
None
None
MFK  A 401 (-4.5A)
 1.12A 4q36A-4mfzA:
43.5		 4q36A-4mfzA:
71.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 MET A 161
TRP A 163
TRP A 164
HIS A 196
PHE A 281
 TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
TEC  A 404 (-4.1A)
COA  A 403 (-3.4A)
 0.13A 4q36A-4q38A:
50.9		 4q36A-4q38A:
100.00