SIMILAR PATTERNS OF AMINO ACIDS FOR 4Q15_A_HFGA803_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fse GERE

(Bacillus
subtilis) 		PF00196
(GerE) 		3 GLU A  18
THR A  42
HIS A  46
 None
 0.71A 4q15A-1fseA:
undetectable		 4q15A-1fseA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLU A 108
THR A  34
HIS A  35
 None
 0.76A 4q15A-1gvhA:
undetectable		 4q15A-1gvhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 GLU A 152
THR A 416
HIS A 153
 None
 0.78A 4q15A-1h0hA:
0.0		 4q15A-1h0hA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		3 GLU A 326
THR A 141
HIS A 367
 HSO  A1001 ( 4.1A)
NAD  A1201 ( 4.1A)
HSO  A1001 (-3.5A)
 0.84A 4q15A-1kaeA:
3.0		 4q15A-1kaeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		3 GLU A 683
THR A 653
HIS A 654
 None
 0.78A 4q15A-1kehA:
undetectable		 4q15A-1kehA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbz FRUCTOSE
1,6-BISPHOSPHATASE/I
NOSITOL
MONOPHOSPHATASE

(Archaeoglobus
fulgidus) 		PF00459
(Inositol_P) 		3 GLU A 241
THR A 216
HIS A 244
 None
 0.72A 4q15A-1lbzA:
0.0		 4q15A-1lbzA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 119
THR A 235
HIS A 237
 5CA  A 512 (-3.0A)
5CA  A 512 (-3.0A)
5CA  A 512 (-4.4A)
 0.40A 4q15A-1nj1A:
43.8		 4q15A-1nj1A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		3 GLU A 103
THR A 219
HIS A 221
 None
 0.75A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 GLU A 171
THR A 208
HIS A 205
 None
 0.84A 4q15A-1pk9A:
0.0		 4q15A-1pk9A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		3 GLU A 287
THR A 248
HIS A 247
 None
 0.75A 4q15A-1qd1A:
0.9		 4q15A-1qd1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlh CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF04008
(Adenosine_kin) 		3 GLU A  96
THR A  29
HIS A  30
 None
 0.82A 4q15A-1rlhA:
undetectable		 4q15A-1rlhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF03921
(ICAM_N) 		3 GLU A 269
THR B  38
HIS A 264
 None
 0.82A 4q15A-1t0pA:
3.7		 4q15A-1t0pA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 161
THR A  48
HIS A  46
 None
 0.78A 4q15A-1v26A:
undetectable		 4q15A-1v26A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 GLU A 327
THR A 261
HIS A 281
 None
 0.87A 4q15A-1vftA:
undetectable		 4q15A-1vftA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		3 GLU A  79
THR A  42
HIS A  85
 None
ACT  A 135 (-3.1A)
None
 0.70A 4q15A-1vmfA:
undetectable		 4q15A-1vmfA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbf CLOSTRIDIUM
ACETOBUTYLICUM
Q97KL0

(Clostridium
acetobutylicum) 		PF01894
(UPF0047) 		3 GLU A  81
THR A  45
HIS A  87
 None
SO4  A 201 (-3.1A)
None
 0.74A 4q15A-1xbfA:
undetectable		 4q15A-1xbfA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		3 GLU A 420
THR A 204
HIS A 296
 None
 0.60A 4q15A-1ya0A:
undetectable		 4q15A-1ya0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7y HYPOTHETICAL PROTEIN
RV2302/MT2359

(Mycobacterium
tuberculosis) 		PF08940
(DUF1918) 		3 GLU A  63
THR A  16
HIS A  19
 None
 0.77A 4q15A-2a7yA:
undetectable		 4q15A-2a7yA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 GLU C 514
THR C 484
HIS C 485
 None
 0.81A 4q15A-2advC:
undetectable		 4q15A-2advC:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aym U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 GLU A  19
THR A  73
HIS A  74
 None
 0.81A 4q15A-2aymA:
undetectable		 4q15A-2aymA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 GLU A 811
THR A 860
HIS A 805
 None
 0.83A 4q15A-2b5mA:
undetectable		 4q15A-2b5mA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		3 GLU A 172
THR A 262
HIS A 268
 None
CU  A 500 ( 4.9A)
CU  A 500 (-3.1A)
 0.80A 4q15A-2dv6A:
undetectable		 4q15A-2dv6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		3 GLU A 161
THR A 172
HIS A 118
 None
 0.83A 4q15A-2fj0A:
undetectable		 4q15A-2fj0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A  53
THR A 354
HIS A 307
 None
 0.86A 4q15A-2ggjA:
undetectable		 4q15A-2ggjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 GLU A 157
THR A 219
HIS A 221
 None
 0.71A 4q15A-2o1vA:
undetectable		 4q15A-2o1vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		3 GLU A  68
THR A 278
HIS A  59
 None
None
GOL  A 501 (-3.8A)
 0.82A 4q15A-2p76A:
undetectable		 4q15A-2p76A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 GLU A 268
THR A 473
HIS A 469
 None
 0.84A 4q15A-2qr4A:
undetectable		 4q15A-2qr4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		3 GLU A  20
THR A 332
HIS A 290
 None
 0.71A 4q15A-2r8aA:
undetectable		 4q15A-2r8aA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w57 FERRIC UPTAKE
REGULATION PROTEIN

(Vibrio cholerae) 		PF01475
(FUR) 		3 GLU A 101
THR A  69
HIS A  71
 ZN  A 202 ( 4.6A)
None
ZN  A 202 ( 4.9A)
 0.79A 4q15A-2w57A:
undetectable		 4q15A-2w57A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 GLU A 507
THR A 539
HIS A 542
 None
 0.86A 4q15A-2w9mA:
undetectable		 4q15A-2w9mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		3 GLU A 306
THR A 164
HIS A 212
 None
 0.82A 4q15A-2wamA:
undetectable		 4q15A-2wamA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 GLU A 105
THR A 210
HIS A 206
 None
 0.84A 4q15A-2x5fA:
undetectable		 4q15A-2x5fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 GLU A  37
THR A 127
HIS A 133
 None
CU  A 500 ( 4.6A)
CU  A 500 (-3.1A)
 0.85A 4q15A-2zooA:
undetectable		 4q15A-2zooA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		3 GLU A 276
THR A 199
HIS A 201
 None
 0.84A 4q15A-2zwvA:
undetectable		 4q15A-2zwvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpk NITRILOTRIACETATE
MONOOXYGENASE
COMPONENT B

(Bacillus cereus) 		PF01613
(Flavin_Reduct) 		3 GLU A 128
THR A  31
HIS A  84
 None
 0.65A 4q15A-3bpkA:
undetectable		 4q15A-3bpkA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		3 GLU A  42
THR A 251
HIS A 250
 None
 0.85A 4q15A-3cerA:
undetectable		 4q15A-3cerA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		3 GLU A  26
THR A 315
HIS A 317
 None
 0.80A 4q15A-3g7tA:
undetectable		 4q15A-3g7tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm5 LACTOYLGLUTATHIONE
LYASE AND RELATED
LYASES

(Caldanaerobacter
subterraneus) 		PF13669
(Glyoxalase_4) 		3 GLU A  74
THR A  84
HIS A  97
 CIT  A 379 (-2.9A)
None
None
 0.57A 4q15A-3gm5A:
undetectable		 4q15A-3gm5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A 181
THR A 379
HIS A 377
 None
 0.81A 4q15A-3hn7A:
undetectable		 4q15A-3hn7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 GLU A 288
THR A 216
HIS A 283
 None
 0.83A 4q15A-3hriA:
8.9		 4q15A-3hriA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 GLU A 370
THR A 354
HIS A 350
 None
 0.81A 4q15A-3iu1A:
undetectable		 4q15A-3iu1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		3 GLU A  14
THR A 160
HIS A 162
 IMD  A 496 (-3.3A)
None
ZN  A 495 ( 3.3A)
 0.75A 4q15A-3iuuA:
3.8		 4q15A-3iuuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 GLU A 314
THR A  20
HIS A  75
 None
 0.83A 4q15A-3nvaA:
3.7		 4q15A-3nvaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 GLU A 346
THR A  20
HIS A  39
 None
 0.84A 4q15A-3nz4A:
undetectable		 4q15A-3nz4A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		3 GLU A 169
THR A 193
HIS A 197
 None
 0.82A 4q15A-3p7nA:
undetectable		 4q15A-3p7nA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		3 GLU A  20
THR A 204
HIS A 206
 None
 0.83A 4q15A-3px2A:
undetectable		 4q15A-3px2A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzd MYOSIN-X

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF00788
(RA) 		3 GLU A1690
THR A1679
HIS A1719
 None
 0.81A 4q15A-3pzdA:
undetectable		 4q15A-3pzdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		3 GLU A 213
THR A 184
HIS A 186
 None
 0.44A 4q15A-3qtdA:
undetectable		 4q15A-3qtdA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		3 GLU A  38
THR A  61
HIS A  52
 None
 0.87A 4q15A-3tfzA:
undetectable		 4q15A-3tfzA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		3 GLU A 147
THR A 256
HIS A 111
 MN  A1001 (-2.5A)
None
None
 0.86A 4q15A-3vylA:
undetectable		 4q15A-3vylA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		3 GLU A  47
THR A 137
HIS A 143
 None
CU  A1460 ( 4.6A)
CU  A1460 (-3.1A)
 0.83A 4q15A-3zbmA:
undetectable		 4q15A-3zbmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 GLU A 349
THR A 200
HIS A  42
 None
CUO  A9001 ( 4.9A)
CUO  A9001 (-3.4A)
 0.82A 4q15A-4bedA:
undetectable		 4q15A-4bedA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		3 GLU A 641
THR A 545
HIS A 549
 None
 0.83A 4q15A-4blaA:
undetectable		 4q15A-4blaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		3 GLU A 311
THR A 121
HIS A 318
 None
 0.67A 4q15A-4bweA:
undetectable		 4q15A-4bweA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 GLU A 359
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.82A 4q15A-4cnsA:
undetectable		 4q15A-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 GLU A 360
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.56A 4q15A-4cnsA:
undetectable		 4q15A-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 GLU A 360
THR A 335
HIS A 333
 None
 0.65A 4q15A-4cntA:
undetectable		 4q15A-4cntA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 223
THR A 300
HIS A 298
 None
 0.85A 4q15A-4dwdA:
undetectable		 4q15A-4dwdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 267
THR A 243
HIS A 240
 None
 0.82A 4q15A-4hnlA:
undetectable		 4q15A-4hnlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 GLU A 117
THR A 231
HIS A 232
 None
 0.80A 4q15A-4j7qA:
undetectable		 4q15A-4j7qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 GLU A 296
THR A  85
HIS A 168
 None
 0.86A 4q15A-4jklA:
undetectable		 4q15A-4jklA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		3 GLU A 178
THR A 442
HIS A 452
 None
 0.85A 4q15A-4mifA:
2.8		 4q15A-4mifA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 GLU A  32
THR A 115
HIS A  70
 None
 0.84A 4q15A-4nreA:
undetectable		 4q15A-4nreA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		3 GLU A 150
THR A  85
HIS A  89
 None
 0.84A 4q15A-4ojzA:
undetectable		 4q15A-4ojzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		3 GLU A 134
THR A 237
HIS A  92
 None
 0.87A 4q15A-4p56A:
undetectable		 4q15A-4p56A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.78A 4q15A-4ppuA:
undetectable		 4q15A-4ppuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 GLU A 400
THR A 485
HIS A 496
 None
 0.87A 4q15A-4q1vA:
undetectable		 4q15A-4q1vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 GLU A 119
THR A   4
HIS A   6
 None
 0.84A 4q15A-4qmeA:
undetectable		 4q15A-4qmeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 GLU A 573
THR A 651
HIS A 581
 None
 0.72A 4q15A-4r04A:
2.3		 4q15A-4r04A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		3 GLU A  52
THR A 281
HIS A  43
 None
None
GOL  A 405 (-3.8A)
 0.85A 4q15A-4r7oA:
undetectable		 4q15A-4r7oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN

(Citrobacter
koseri) 		PF03480
(DctP) 		3 GLU A  74
THR A 217
HIS A  36
 BDP  A 401 ( 2.9A)
BDP  A 401 (-3.8A)
BDP  A 401 (-4.1A)
 0.86A 4q15A-4x04A:
undetectable		 4q15A-4x04A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 361
THR A 478
HIS A 480
 HFG  A 802 (-2.9A)
HFG  A 802 ( 4.0A)
HFG  A 802 (-4.0A)
 0.30A 4q15A-4ydqA:
52.1		 4q15A-4ydqA:
97.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		3 GLU I 232
THR I 204
HIS I 231
 None
 0.84A 4q15A-4zoqI:
undetectable		 4q15A-4zoqI:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 GLU A 377
THR A 350
HIS A 387
 None
 0.85A 4q15A-5bs5A:
undetectable		 4q15A-5bs5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		3 GLU A 236
THR A 150
HIS A 267
 None
 0.84A 4q15A-5f7vA:
undetectable		 4q15A-5f7vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 GLU A 361
THR A 157
HIS A 286
 None
 0.64A 4q15A-5gndA:
undetectable		 4q15A-5gndA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 GLU A 935
THR A1005
HIS A1009
 None
 0.79A 4q15A-5i6eA:
undetectable		 4q15A-5i6eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		3 GLU A 687
THR A 643
HIS A 645
 None
 0.63A 4q15A-5j44A:
undetectable		 4q15A-5j44A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jiu RAN-BINDING PROTEIN
9

(Homo sapiens) 		PF00622
(SPRY) 		3 GLU A 160
THR A 205
HIS A 206
 None
 0.70A 4q15A-5jiuA:
undetectable		 4q15A-5jiuA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 GLU A 511
THR A 426
HIS A 429
 None
 0.75A 4q15A-5jo7A:
undetectable		 4q15A-5jo7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 3 GLU A1225
THR A 940
HIS A 922
 None
 0.75A 4q15A-5ng6A:
undetectable		 4q15A-5ng6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 3 GLU A 360
THR A 335
HIS A 333
 GLU  A 360 ( 0.6A)
THR  A 335 ( 0.8A)
HIS  A 333 ( 1.0A)
 0.51A 4q15A-5nksA:
undetectable		 4q15A-5nksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 GLU A 359
THR A 335
HIS A 333
 None
 0.85A 4q15A-5uqcA:
undetectable		 4q15A-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 GLU A 360
THR A 335
HIS A 333
 None
 0.58A 4q15A-5uqcA:
undetectable		 4q15A-5uqcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v52 T-CELL
IMMUNORECEPTOR WITH
IG AND ITIM DOMAINS

(Homo sapiens) 		PF07686
(V-set) 		3 GLU A  60
THR A 117
HIS A 111
 None
 0.82A 4q15A-5v52A:
undetectable		 4q15A-5v52A:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.45A 4q15A-5vadA:
48.5		 4q15A-5vadA:
50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		3 GLU A  19
THR A 338
HIS A  26
 None
 0.77A 4q15A-5vc2A:
undetectable		 4q15A-5vc2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		3 GLU A 367
THR A 177
HIS A 408
 HIS  A 501 ( 2.7A)
None
HIS  A 501 ( 3.4A)
 0.86A 4q15A-5vldA:
3.0		 4q15A-5vldA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		3 GLU A 224
THR A 248
HIS A 225
 None
 0.75A 4q15A-5w70A:
undetectable		 4q15A-5w70A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 3 GLU A 423
THR A 164
HIS A 175
 GOL  A 501 (-3.2A)
None
None
 0.86A 4q15A-5wkaA:
undetectable		 4q15A-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 3 GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.36A 4q15A-5xiiA:
50.4		 4q15A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 3 GLU A 333
THR A 450
HIS A 452
 HFG  A 801 (-3.0A)
ANP  A 803 (-3.9A)
HFG  A 801 (-4.2A)
 0.58A 4q15A-5xioA:
31.6		 4q15A-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 3 GLU A 361
THR A 478
HIS A 480
 HFG  A1003 (-2.9A)
ANP  A1001 ( 3.7A)
HFG  A1003 (-3.5A)
 0.23A 4q15A-5xipA:
35.6		 4q15A-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		3 GLU A1420
THR A1630
HIS A 551
 None
 0.78A 4q15A-5xjyA:
undetectable		 4q15A-5xjyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 3 GLU A 284
THR A 332
HIS A 336
 None
 0.82A 4q15A-5xwwA:
undetectable		 4q15A-5xwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 3 GLU A 366
THR A 224
HIS A 226
 None
FMT  A 422 ( 2.8A)
FMT  A 420 (-3.5A)
 0.82A 4q15A-6b3pA:
undetectable		 4q15A-6b3pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 3 GLU A 115
THR A 297
HIS A 296
 None
 0.87A 4q15A-6blbA:
undetectable		 4q15A-6blbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 3 GLU A 714
THR A 569
HIS A 653
 None
 0.63A 4q15A-6byiA:
undetectable		 4q15A-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 GLU A 648
THR A 322
HIS A 323
 None
 0.82A 4q15A-6czaA:
undetectable		 4q15A-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 3 GLU A 106
THR A  58
HIS A 142
 None
 0.62A 4q15A-6gruA:
undetectable		 4q15A-6gruA:
undetectable