SIMILAR PATTERNS OF AMINO ACIDS FOR 4Q0B_A_NVPA901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LEU A  92
VAL A 282
VAL A 153
TYR A  72
 None
 1.18A 4q0bA-1b41A:
0.0		 4q0bA-1b41A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Micrococcus
luteus) 		PF01255
(Prenyltransf) 		4 LEU A 208
VAL A 143
TYR A  71
LEU A 195
 None
 1.13A 4q0bA-1f75A:
undetectable		 4q0bA-1f75A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  58
VAL A 112
VAL A  85
LEU A 103
 None
 1.17A 4q0bA-1fxlA:
3.1		 4q0bA-1fxlA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU B 274
VAL B 257
VAL B 347
LEU B 484
 None
 1.16A 4q0bA-1gl9B:
0.0		 4q0bA-1gl9B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imu HYPOTHETICAL PROTEIN
HI0257

(Haemophilus
influenzae) 		PF02482
(Ribosomal_S30AE) 		4 LEU A  20
VAL A  77
TYR A  71
LEU A  41
 None
 1.16A 4q0bA-1imuA:
undetectable		 4q0bA-1imuA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 VAL A 338
VAL A 292
TYR A 336
LEU A 315
 None
 0.94A 4q0bA-1lc7A:
undetectable		 4q0bA-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  24
VAL A  83
TRP A  76
LEU A  39
 None
 1.00A 4q0bA-1loxA:
undetectable		 4q0bA-1loxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 276
VAL A 285
VAL A 234
LEU A 290
 None
 1.02A 4q0bA-1muuA:
undetectable		 4q0bA-1muuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 0.97A 4q0bA-1o1yA:
undetectable		 4q0bA-1o1yA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		4 LEU A1028
VAL A1051
VAL A1116
TYR A1068
 None
 1.19A 4q0bA-1sfnA:
undetectable		 4q0bA-1sfnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		4 LEU A 315
VAL A 160
VAL A 199
LEU A 273
 None
 1.14A 4q0bA-1udxA:
undetectable		 4q0bA-1udxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS013

(Pyrococcus
horikoshii) 		PF05016
(ParE_toxin) 		4 LEU A  33
VAL A  45
VAL A  66
TYR A  57
 None
 0.88A 4q0bA-1wmiA:
undetectable		 4q0bA-1wmiA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  54
VAL A 120
VAL A  76
LEU A  68
 None
 1.17A 4q0bA-1x25A:
undetectable		 4q0bA-1x25A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		4 LEU A 174
VAL A 164
VAL A 218
LEU A 160
 None
 1.00A 4q0bA-1xipA:
undetectable		 4q0bA-1xipA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 LEU A  22
LYS A  39
TYR A  43
LEU A  60
 None
 1.08A 4q0bA-1y9jA:
undetectable		 4q0bA-1y9jA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 0.95A 4q0bA-1yhuA:
undetectable		 4q0bA-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 LEU A  85
VAL A   3
VAL A  15
LEU A  83
 None
 0.98A 4q0bA-2ag8A:
undetectable		 4q0bA-2ag8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		4 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.92A 4q0bA-2d2nA:
undetectable		 4q0bA-2d2nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 145
VAL A 256
TYR A 218
LEU A 179
 None
 1.08A 4q0bA-2ef0A:
undetectable		 4q0bA-2ef0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 172
LYS A 248
VAL A 251
LEU A 300
 None
 1.14A 4q0bA-2g17A:
undetectable		 4q0bA-2g17A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.15A 4q0bA-2hihA:
undetectable		 4q0bA-2hihA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TRP A 229
LEU A 234
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
 0.72A 4q0bA-2hnzA:
36.0		 4q0bA-2hnzA:
98.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
TRP A 229
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
 0.72A 4q0bA-2hnzA:
36.0		 4q0bA-2hnzA:
98.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 LEU A  53
VAL A  97
TYR A 338
LEU A  18
 None
 1.00A 4q0bA-2iuyA:
undetectable		 4q0bA-2iuyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbg NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  20
VAL A  37
TYR A  71
TYR A  39
 None
 0.96A 4q0bA-2kbgA:
undetectable		 4q0bA-2kbgA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khe TOXIN-LIKE PROTEIN

(Thermus
thermophilus) 		PF05016
(ParE_toxin) 		4 LEU A  65
VAL A  87
TYR A  63
LEU A  15
 None
 1.06A 4q0bA-2kheA:
undetectable		 4q0bA-2kheA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima) 		PF00403
(HMA) 		4 VAL A  61
VAL A  40
TYR A   3
TYR A  64
 None
 0.71A 4q0bA-2kyzA:
6.1		 4q0bA-2kyzA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpe KINASE SUPPRESSOR OF
RAS 1

(Mus musculus) 		PF13543
(KSR1-SAM) 		4 LEU A 133
VAL A 121
VAL A 116
LEU A 128
 None
 1.05A 4q0bA-2lpeA:
undetectable		 4q0bA-2lpeA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 LEU A 390
VAL A 413
TYR A 408
LEU A 619
 None
 0.94A 4q0bA-2o0aA:
undetectable		 4q0bA-2o0aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okf FDXN ELEMENT
EXCISION CONTROLLING
FACTOR PROTEIN

(Trichormus
variabilis) 		PF08814
(XisH) 		4 LEU A  86
LYS A  88
VAL A  31
TYR A  82
 None
 1.15A 4q0bA-2okfA:
2.6		 4q0bA-2okfA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owy RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Pseudomonas
aeruginosa) 		PF04381
(RdgC) 		4 VAL A 250
VAL A   8
TRP A 236
LEU A 240
 None
 1.07A 4q0bA-2owyA:
undetectable		 4q0bA-2owyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		4 LEU A   8
VAL A  73
TYR A  49
LEU A  56
 None
 0.89A 4q0bA-2p1rA:
1.4		 4q0bA-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 VAL A 562
TYR A 564
TYR A 578
TRP A 576
 None
 1.18A 4q0bA-2pb7A:
undetectable		 4q0bA-2pb7A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 LEU A 335
VAL A 201
VAL A  15
LEU A 370
 None
None
FAD  A 401 ( 3.8A)
None
 1.08A 4q0bA-2q6uA:
undetectable		 4q0bA-2q6uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		4 LEU B 130
VAL B 176
VAL B 137
LEU B 165
 None
 1.16A 4q0bA-2xa7B:
undetectable		 4q0bA-2xa7B:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 LEU F 314
VAL F 297
TYR F 284
LEU F 248
 None
 1.17A 4q0bA-2xwbF:
2.3		 4q0bA-2xwbF:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		4 LEU A 128
VAL A 166
VAL A 140
LEU A 155
 None
 1.11A 4q0bA-2z06A:
undetectable		 4q0bA-2z06A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Mus musculus) 		PF02182
(SAD_SRA) 		4 VAL A 566
TYR A 568
TYR A 582
TRP A 580
 None
 1.16A 4q0bA-2zkgA:
undetectable		 4q0bA-2zkgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)

(Verrillofungia
concinna) 		PF01353
(GFP) 		4 LEU A  57
VAL A 199
VAL A 206
LEU A  50
 None
None
GYS  A  63 ( 4.9A)
None
 0.94A 4q0bA-2zo6A:
undetectable		 4q0bA-2zo6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 LEU A 114
VAL A 394
VAL A 143
LEU A 401
 None
 1.18A 4q0bA-2zy2A:
undetectable		 4q0bA-2zy2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 LEU A 819
VAL A 837
TYR A 839
LEU A 898
 None
 0.90A 4q0bA-3av6A:
undetectable		 4q0bA-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 VAL A 562
TYR A 564
TYR A 578
TRP A 576
 None
 1.16A 4q0bA-3dwhA:
undetectable		 4q0bA-3dwhA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3v REGULATORY PROTEIN
RECX

(Lactobacillus
salivarius) 		PF02631
(RecX) 		4 LEU A  67
VAL A  80
TYR A  63
LEU A 106
 None
 1.13A 4q0bA-3e3vA:
undetectable		 4q0bA-3e3vA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 196
VAL A  24
VAL A  17
LEU A  99
 None
 1.12A 4q0bA-3eoqA:
4.7		 4q0bA-3eoqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF09165
(Ubiq-Cytc-red_N) 		4 VAL B 314
VAL B 258
TYR B 325
LEU I  64
 None
 0.88A 4q0bA-3h1lB:
3.0		 4q0bA-3h1lB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 LEU W1250
VAL W1271
VAL W1237
TYR W1287
 None
 0.85A 4q0bA-3iylW:
undetectable		 4q0bA-3iylW:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knb OBSCURIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF07679
(I-set) 		4 LEU B  73
VAL B  23
VAL B 103
LEU B  71
 None
 0.83A 4q0bA-3knbB:
undetectable		 4q0bA-3knbB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A  29
VAL A 123
TYR A 421
LEU A   5
 None
 0.92A 4q0bA-3l01A:
undetectable		 4q0bA-3l01A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 LEU A 160
VAL A  98
VAL A  72
LEU A 156
 None
 1.11A 4q0bA-3l6dA:
undetectable		 4q0bA-3l6dA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m94 TRANSLATION
INITIATION FACTOR 4E

(Ascaris suum) 		PF01652
(IF4E) 		4 LEU A 147
VAL A 176
TYR A 104
LEU A  58
 None
 1.15A 4q0bA-3m94A:
3.6		 4q0bA-3m94A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00553
(CBM_2) 		4 LYS E 404
TYR E 387
TRP E 418
LEU E 416
 None
 1.12A 4q0bA-3ndyE:
undetectable		 4q0bA-3ndyE:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		4 LEU A 204
VAL A 297
VAL A 288
LEU A 202
 None
 1.05A 4q0bA-3ot5A:
undetectable		 4q0bA-3ot5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 LEU A 226
VAL A 296
VAL A 254
LEU A 196
 None
 1.05A 4q0bA-3phfA:
undetectable		 4q0bA-3phfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqb UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF13622
(4HBT_3) 		4 LEU A  46
VAL A  64
VAL A 210
LEU A  93
 None
 1.01A 4q0bA-3rqbA:
undetectable		 4q0bA-3rqbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A  38
VAL A  24
TYR A 121
LEU A 338
 None
 1.18A 4q0bA-3tqpA:
undetectable		 4q0bA-3tqpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 VAL A  89
VAL A 171
TYR A 173
TYR A 184
 None
 0.48A 4q0bA-3vsvA:
undetectable		 4q0bA-3vsvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 LEU A 156
VAL A 308
VAL A 145
LEU A 303
 None
 0.79A 4q0bA-3vvlA:
undetectable		 4q0bA-3vvlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.85A 4q0bA-3wctA:
undetectable		 4q0bA-3wctA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		4 LEU A  37
VAL A 103
VAL A  42
LEU A  62
 None
 1.16A 4q0bA-4b96A:
1.4		 4q0bA-4b96A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 319
LYS A 218
TRP A 232
LEU A 323
 None
 1.08A 4q0bA-4bfcA:
undetectable		 4q0bA-4bfcA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 VAL A 121
VAL A 143
TYR A 319
LEU A 113
 None
 1.10A 4q0bA-4c1tA:
undetectable		 4q0bA-4c1tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		4 LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.07A 4q0bA-4cg1A:
1.8		 4q0bA-4cg1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		4 VAL A 121
TYR A 123
TRP A  87
LEU A  57
 None
UN9  A1391 ( 4.8A)
None
None
 0.90A 4q0bA-4cswA:
undetectable		 4q0bA-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlq LATROPHILIN-1

(Rattus
norvegicus) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.12A 4q0bA-4dlqA:
undetectable		 4q0bA-4dlqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 LYS A 197
VAL A 236
TRP A 185
LEU A 188
 None
 1.02A 4q0bA-4fcyA:
undetectable		 4q0bA-4fcyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 LEU B 449
VAL B 382
TYR B 409
TYR B 367
 None
 1.12A 4q0bA-4hxeB:
undetectable		 4q0bA-4hxeB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.06A 4q0bA-4jggA:
undetectable		 4q0bA-4jggA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A  69
VAL A 100
VAL A  49
LEU A  61
 None
 1.04A 4q0bA-4le5A:
undetectable		 4q0bA-4le5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU C 117
VAL C 100
VAL C 128
LEU C  78
 None
 1.02A 4q0bA-4leoC:
undetectable		 4q0bA-4leoC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE

(Amycolatopsis
mediterranei) 		PF14765
(PS-DH) 		4 LEU A 219
VAL A 262
VAL A 284
LEU A 223
 None
 0.90A 4q0bA-4ln9A:
undetectable		 4q0bA-4ln9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 LEU A 399
VAL A 414
VAL A 435
LEU A 367
 None
 1.15A 4q0bA-4nk6A:
undetectable		 4q0bA-4nk6A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwy PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 LEU A 279
VAL A 328
TYR A 325
LEU A 339
 None
 1.12A 4q0bA-4nwyA:
2.2		 4q0bA-4nwyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 LEU A 399
VAL A 414
VAL A 435
LEU A 367
 None
 1.18A 4q0bA-4ozyA:
undetectable		 4q0bA-4ozyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		4 LEU A 363
VAL A 302
TYR A 373
LEU A 312
 None
 1.14A 4q0bA-4r5oA:
undetectable		 4q0bA-4r5oA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rct RESTRICTION
ENDONUCLEASE
R.NGOVII

(Neisseria
gonorrhoeae) 		PF09565
(RE_NgoFVII) 		4 LEU A  47
VAL A  32
TYR A 108
LEU A  62
 None
 1.17A 4q0bA-4rctA:
undetectable		 4q0bA-4rctA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 LEU A  51
VAL A  68
TYR A 223
LEU A  64
 None
 1.15A 4q0bA-4rvhA:
undetectable		 4q0bA-4rvhA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 4 LEU a 286
LYS a 288
VAL a 248
TYR a 257
 None
 1.07A 4q0bA-4uera:
undetectable		 4q0bA-4uera:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		4 LEU A 699
VAL A 619
TYR A 621
LEU A 744
 None
 0.89A 4q0bA-4zcsA:
undetectable		 4q0bA-4zcsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		4 LEU H 134
VAL H 149
TYR H 167
LEU H 169
 None
 1.06A 4q0bA-5a5tH:
undetectable		 4q0bA-5a5tH:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 1.10A 4q0bA-5aeeA:
undetectable		 4q0bA-5aeeA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
 None
 0.78A 4q0bA-5c24B:
10.9		 4q0bA-5c24B:
96.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2

(Clostridioides
difficile) 		PF08020
(DUF1706) 		4 LEU A  68
VAL A  82
TRP A 100
LEU A  97
 None
 0.94A 4q0bA-5comA:
undetectable		 4q0bA-5comA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezb CHICKEN PRESTIN STAS
DOMAIN,CHICKEN
PRESTIN STAS DOMAIN

(Gallus gallus) 		PF01740
(STAS) 		4 LEU A 675
VAL A 712
VAL A 689
LEU A 702
 None
 1.03A 4q0bA-5ezbA:
undetectable		 4q0bA-5ezbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		4 LEU H 154
VAL H   4
TYR H 124
LEU H 146
 None
 0.75A 4q0bA-5fg9H:
undetectable		 4q0bA-5fg9H:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		4 LEU H 154
VAL H  13
VAL H   4
LEU H 146
 None
 0.99A 4q0bA-5fg9H:
undetectable		 4q0bA-5fg9H:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 LEU B1539
VAL B1596
VAL B1646
LEU B1535
 None
 1.11A 4q0bA-5hb4B:
undetectable		 4q0bA-5hb4B:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 LEU A  41
VAL A  96
VAL A 101
LEU A  32
 None
 0.80A 4q0bA-5hctA:
undetectable		 4q0bA-5hctA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 LYS B 102
VAL B 105
TYR B 180
TYR B 187
 None
 0.58A 4q0bA-5ovnB:
10.1		 4q0bA-5ovnB:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 LEU A  41
VAL A  96
VAL A 101
LEU A  32
 None
 0.80A 4q0bA-5p60A:
undetectable		 4q0bA-5p60A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF13420
(Acetyltransf_4) 		4 LEU A 110
VAL A 180
TYR A  57
LEU A 114
 None
 0.94A 4q0bA-5t7dA:
undetectable		 4q0bA-5t7dA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		4 LEU A 238
VAL A 407
TRP A 228
LEU A 418
 None
 0.81A 4q0bA-5u2pA:
undetectable		 4q0bA-5u2pA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 LEU A 360
VAL A 408
VAL A 398
LEU A 355
 None
 1.08A 4q0bA-5u70A:
undetectable		 4q0bA-5u70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 LEU E  45
VAL E  84
TYR E 121
LEU E 258
 None
 0.87A 4q0bA-5u8sE:
2.4		 4q0bA-5u8sE:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		4 LEU A 155
VAL A 165
VAL A  95
LEU A 206
 None
 1.13A 4q0bA-5vipA:
undetectable		 4q0bA-5vipA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 VAL A 255
TYR A 293
TRP A 272
LEU A 328
 None
 1.19A 4q0bA-5vk4A:
undetectable		 4q0bA-5vk4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1316
VAL A1120
TYR A1331
LEU A1342
 None
 1.13A 4q0bA-5xogA:
4.1		 4q0bA-5xogA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 4 LEU I  27
VAL I  64
TYR I  66
LEU I  81
 None
 1.00A 4q0bA-6az1I:
2.3		 4q0bA-6az1I:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 4 LEU I  27
VAL I  94
VAL I  49
LEU I  81
 None
 0.96A 4q0bA-6az1I:
2.3		 4q0bA-6az1I:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN

(Mus musculus) 		no annotation 4 LEU G  46
VAL F  90
TYR F  41
TRP G 110
 None
 1.18A 4q0bA-6cnkG:
undetectable		 4q0bA-6cnkG:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 LEU A 147
VAL A 192
VAL A 133
LEU A 165
 None
 1.17A 4q0bA-6etzA:
undetectable		 4q0bA-6etzA:
9.13