SIMILAR PATTERNS OF AMINO ACIDS FOR 4PXM_A_ESTA2000
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 5 | LEU A 278LEU A 281ALA A 282LEU A 2GLY A 40 | None | 1.02A | 4pxmA-1fobA:undetectable | 4pxmA-1fobA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3n | V-CYCLIN (Humangammaherpesvirus8) |
PF00134(Cyclin_N)PF09080(K-cyclin_vir_C) | 5 | LEU C 79LEU C 76ALA C 75LEU C 101LEU C 138 | None | 1.13A | 4pxmA-1g3nC:1.9 | 4pxmA-1g3nC:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h39 | SQUALENE--HOPENECYCLASE (Alicyclobacillusacidocaldarius) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 5 | LEU A 319LEU A 316ALA A 317GLY A 337LEU A 333 | None | 1.11A | 4pxmA-1h39A:undetectable | 4pxmA-1h39A:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i0a | DELTA CRYSTALLIN I (Meleagrisgallopavo) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | MET A 250LEU A 253LEU A 256ALA A 257LEU A 293 | None | 0.94A | 4pxmA-1i0aA:undetectable | 4pxmA-1i0aA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khy | CLPB PROTEIN (Escherichiacoli) |
PF02861(Clp_N) | 5 | LEU A 110LEU A 113ALA A 114GLU A 117LEU A 93 | None | 0.92A | 4pxmA-1khyA:undetectable | 4pxmA-1khyA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldd | ANAPHASE PROMOTINGCOMPLEX (Saccharomycescerevisiae) |
PF08672(ANAPC2) | 5 | LEU A 826LEU A 829ALA A 830LEU A 789GLY A 841 | None | 0.93A | 4pxmA-1lddA:undetectable | 4pxmA-1lddA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mn6 | POLYKETIDE SYNTHASEIV (Streptomycesvenezuelae) |
PF00975(Thioesterase) | 5 | ALA A 282LEU A 233LEU A 234GLY A 146HIS A 147 | None | 1.08A | 4pxmA-1mn6A:undetectable | 4pxmA-1mn6A:20.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | MET A 342LEU A 346LEU A 349GLU A 353LEU A 387LEU A 391ARG A 394 | NoneEST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 (-4.0A)EST A 1 ( 3.9A)EST A 1 (-3.7A) | 1.41A | 4pxmA-1pcgA:37.5 | 4pxmA-1pcgA:98.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 343LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394GLY A 521HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 ( 3.7A)EST A 1 (-2.8A)EST A 1 (-4.0A)NoneEST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.1A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.26A | 4pxmA-1pcgA:37.5 | 4pxmA-1pcgA:98.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOMEALPHA-TYPE SUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | MET A 13LEU A 19ALA A 20GLU A 119GLY A 108 | None | 0.98A | 4pxmA-1q5qA:undetectable | 4pxmA-1q5qA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sch | PEANUT PEROXIDASE,MAJOR CATIONICISOZYME (Arachishypogaea) |
PF00141(peroxidase) | 5 | LEU A 36ALA A 105LEU A 112GLY A 167HIS A 169 | NoneNoneNoneNoneHEM A 300 ( 3.3A) | 1.13A | 4pxmA-1schA:undetectable | 4pxmA-1schA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thx | THIOREDOXIN (Nostoc sp. PCC7120) |
PF00085(Thioredoxin) | 5 | MET A 38LEU A 41LEU A 44ALA A 45LEU A 78 | None | 0.81A | 4pxmA-1thxA:undetectable | 4pxmA-1thxA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugo | BCL2-ASSOCIATEDATHANOGENE 5 (Mus musculus) |
PF02179(BAG) | 5 | ALA A 79GLU A 83LEU A 57LEU A 53LEU A 20 | None | 1.07A | 4pxmA-1ugoA:undetectable | 4pxmA-1ugoA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzz | PROBABLEENDOGLUCANASE (Komagataeibacterxylinus) |
PF01270(Glyco_hydro_8) | 5 | LEU A 300ALA A 301GLU A 304LEU A 314LEU A 317 | None | 1.09A | 4pxmA-1wzzA:undetectable | 4pxmA-1wzzA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9s | DNA POLYMERASE (Escherichiavirus T7) |
PF00476(DNA_pol_A) | 5 | LEU A 481LEU A 484ALA A 485GLY A 503LEU A 501 | None | 0.79A | 4pxmA-1x9sA:undetectable | 4pxmA-1x9sA:15.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 324LEU A 327GLU A 331LEU A 365ARG A 372HIS A 494 | None | 0.55A | 4pxmA-1xb7A:28.5 | 4pxmA-1xb7A:32.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw5 | PEPTIDYL PROLYLCIS/TRANS ISOMERASE (Candidaalbicans) |
PF00397(WW)PF00639(Rotamase) | 5 | LEU A 107LEU A 103LEU A 120LEU A 117GLY A 113 | None | 1.04A | 4pxmA-1yw5A:undetectable | 4pxmA-1yw5A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh8 | OXIDOREDUCTASE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | LEU A 305LEU A 308ALA A 309GLU A 312LEU A 327 | None | 1.11A | 4pxmA-1zh8A:undetectable | 4pxmA-1zh8A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dby | GTP-BINDING PROTEIN (Thermusthermophilus) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 5 | LEU A 137LEU A 140ALA A 141GLU A 144GLY A 86 | None | 0.80A | 4pxmA-2dbyA:undetectable | 4pxmA-2dbyA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5f | HYPOTHETICAL PROTEINPH0510 (Pyrococcushorikoshii) |
PF01380(SIS) | 5 | MET A 51LEU A 48LEU A 45LEU A 295GLY A 194 | None | 1.10A | 4pxmA-2e5fA:undetectable | 4pxmA-2e5fA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef4 | ARGINASE (Thermusthermophilus) |
PF00491(Arginase) | 5 | LEU A 278LEU A 281ALA A 282LEU A 259LEU A 93 | None | 1.11A | 4pxmA-2ef4A:undetectable | 4pxmA-2ef4A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fe1 | CONSERVEDHYPOTHETICAL PROTEINPAE0151 (Pyrobaculumaerophilum) |
PF01850(PIN) | 5 | LEU A 36LEU A 38ALA A 39GLU A 42LEU A 75 | None | 1.10A | 4pxmA-2fe1A:undetectable | 4pxmA-2fe1A:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 268LEU A 271ALA A 272GLU A 275LEU A 309ARG A 316HIS A 434 | OHT A 500 (-4.1A)OHT A 500 ( 4.4A)OHT A 500 (-3.5A)OHT A 500 (-2.6A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.57A | 4pxmA-2gpvA:27.2 | 4pxmA-2gpvA:34.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jug | TUBC PROTEIN (Archangiumdisciforme) |
no annotation | 5 | LEU A 52ALA A 54LEU A 11LEU A 10GLY A 18 | None | 0.98A | 4pxmA-2jugA:undetectable | 4pxmA-2jugA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lky | UNCHARACTERIZEDPROTEIN (Mycolicibacteriumsmegmatis) |
PF11829(DUF3349) | 5 | LEU A 33LEU A 36ALA A 35LEU A 41GLY A 65 | None | 0.92A | 4pxmA-2lkyA:undetectable | 4pxmA-2lkyA:18.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 342LEU A 346LEU A 349GLU A 353LEU A 391ARG A 394 | NoneEST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.6A)EST A 596 (-4.0A) | 1.50A | 4pxmA-2ocfA:37.5 | 4pxmA-2ocfA:93.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 343LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387MET A 388LEU A 391ARG A 394GLY A 521HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 ( 3.9A)EST A 596 (-2.7A)EST A 596 ( 4.2A)NoneEST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 ( 4.0A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.39A | 4pxmA-2ocfA:37.5 | 4pxmA-2ocfA:93.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmp | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Arabidopsisthaliana) |
PF02542(YgbB) | 5 | LEU A 86ALA A 83GLU A 82GLY A 124LEU A 123 | None | 1.12A | 4pxmA-2pmpA:undetectable | 4pxmA-2pmpA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35ALA A 36LEU A 77ARG A 80 | 1CA A 247 (-4.0A)1CA A 247 ( 4.4A)1CA A 247 (-3.6A)1CA A 247 ( 3.9A)1CA A 247 (-3.8A) | 0.34A | 4pxmA-2q3yA:28.3 | 4pxmA-2q3yA:26.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrk | ALPHA-L-ARABINOFURANOSIDASE (Thermobacillusxylanilyticus) |
PF06964(Alpha-L-AF_C) | 5 | MET A 63LEU A 60LEU A 57LEU A 38LEU A 365 | None | 1.12A | 4pxmA-2vrkA:undetectable | 4pxmA-2vrkA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w55 | XANTHINEDEHYDROGENASE (Rhodobactercapsulatus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | MET B 255LEU B 35LEU B 33ALA B 103GLY B 38 | None | 1.01A | 4pxmA-2w55B:undetectable | 4pxmA-2w55B:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y0e | UDP-GLUCOSEDEHYDROGENASE (Burkholderiacepacia) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | MET A 228LEU A 231LEU A 234ALA A 235GLY A 248 | None | 0.74A | 4pxmA-2y0eA:undetectable | 4pxmA-2y0eA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzm | D-ALANINE--D-ALANINELIGASE (Thermusthermophilus) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 5 | LEU A 53LEU A 50ALA A 49LEU A 5GLY A 9 | None | 0.98A | 4pxmA-2yzmA:undetectable | 4pxmA-2yzmA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhq | TRANSCRIPTIONALREGULATOR (Mesorhizobiumjaponicum) |
PF00440(TetR_N)PF14246(TetR_C_7) | 5 | LEU A 91LEU A 94ALA A 95LEU A 169MET A 168 | None | 0.93A | 4pxmA-3bhqA:undetectable | 4pxmA-3bhqA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e02 | UNCHARACTERIZEDPROTEIN DUF849 (Paraburkholderiaxenovorans) |
PF05853(BKACE) | 5 | ALA A 99LEU A 94ARG A 156GLY A 89HIS A 51 | NoneEDO A 320 (-4.5A)EDO A 320 (-4.5A)None ZN A 311 (-3.4A) | 1.10A | 4pxmA-3e02A:undetectable | 4pxmA-3e02A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee4 | PROBABLERIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | MET A 231LEU A 234LEU A 237ALA A 238LEU A 170 | NoneNoneNoneNoneMYR A 315 ( 4.7A) | 1.08A | 4pxmA-3ee4A:3.0 | 4pxmA-3ee4A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eno | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Thermoplasmaacidophilum) |
PF00814(Peptidase_M22) | 5 | LEU A 295LEU A 296ALA A 293GLU A 113GLY A 16 | None | 1.01A | 4pxmA-3enoA:undetectable | 4pxmA-3enoA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | ALA A 462LEU A 473LEU A 442GLY A 493HIS A 455 | None | 1.02A | 4pxmA-3epmA:undetectable | 4pxmA-3epmA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f7c | PROTEIN OF UNKNOWNFUNCTION (DUF416) (Marinobacterhydrocarbonoclasticus) |
PF04222(DUF416) | 5 | LEU A 22LEU A 23ALA A 20HIS A 113LEU A 13 | None | 1.05A | 4pxmA-3f7cA:undetectable | 4pxmA-3f7cA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fh2 | PROBABLEATP-DEPENDENTPROTEASE (HEAT SHOCKPROTEIN) (Corynebacteriumglutamicum) |
PF02861(Clp_N) | 5 | ALA A 9LEU A 108LEU A 109GLY A 95HIS A 100 | None | 0.94A | 4pxmA-3fh2A:undetectable | 4pxmA-3fh2A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkb | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 5 | LEU A 138LEU A 175GLU A 269GLY A 153LEU A 157 | None | 1.09A | 4pxmA-3gkbA:undetectable | 4pxmA-3gkbA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rde | ARACHIDONATE12-LIPOXYGENASE,12S-TYPE (Sus scrofa) |
PF00305(Lipoxygenase) | 5 | LEU A 358ALA A 433LEU A 281LEU A 282HIS A 356 | None | 1.05A | 4pxmA-3rdeA:undetectable | 4pxmA-3rdeA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u07 | UNCHARACTERIZEDPROTEIN VPA0106 (Vibrioparahaemolyticus) |
PF06742(DUF1214)PF06863(DUF1254) | 5 | MET A 267LEU A 270LEU A 273ALA A 274LEU A 304 | None | 0.71A | 4pxmA-3u07A:undetectable | 4pxmA-3u07A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | LEU A 300LEU A 303ALA A 304LEU A 320GLY A 73 | None | 0.82A | 4pxmA-3uboA:undetectable | 4pxmA-3uboA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3un6 | HYPOTHETICAL PROTEINSAOUHSC_00137 (Staphylococcusaureus) |
PF13379(NMT1_2) | 5 | LEU A 93LEU A 96ALA A 97LEU A 78HIS A 114 | NoneNoneNoneNone ZN A 325 ( 4.9A) | 1.11A | 4pxmA-3un6A:undetectable | 4pxmA-3un6A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7n | THREONINE SYNTHASE (Burkholderiathailandensis) |
PF00291(PALP)PF14821(Thr_synth_N) | 5 | LEU A 123ALA A 430GLU A 428ARG A 91GLY A 436 | None | 1.10A | 4pxmA-3v7nA:undetectable | 4pxmA-3v7nA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf7 | ARABINOGALACTANENDO-1,4-BETA-GALACTOSIDASE A (Aspergillusnidulans) |
PF07745(Glyco_hydro_53) | 5 | LEU A 278LEU A 281ALA A 282LEU A 2GLY A 40 | NoneNone ZN A 413 ( 4.7A)NoneNone | 0.90A | 4pxmA-4bf7A:undetectable | 4pxmA-4bf7A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf7 | ARABINOGALACTANENDO-1,4-BETA-GALACTOSIDASE A (Aspergillusnidulans) |
PF07745(Glyco_hydro_53) | 5 | LEU A 278LEU A 281ALA A 282LEU A 2GLY A 331 | NoneNone ZN A 413 ( 4.7A)NoneNone | 0.78A | 4pxmA-4bf7A:undetectable | 4pxmA-4bf7A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cad | RAS AND A-FACTORCONVERTING ENZYME 1,RCE1 (Methanococcusmaripaludis) |
PF02517(Abi) | 5 | LEU C 132LEU C 135ALA C 136LEU C 48LEU C 45 | None | 0.87A | 4pxmA-4cadC:undetectable | 4pxmA-4cadC:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccd | GALACTOCEREBROSIDASE (Mus musculus) |
PF02057(Glyco_hydro_59)PF17387(Glyco_hydro_59M) | 5 | LEU A 357ALA A 356LEU A 35GLY A 399LEU A 397 | None | 0.90A | 4pxmA-4ccdA:undetectable | 4pxmA-4ccdA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqd | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | MET A 114LEU A 102ALA A 106LEU A 82LEU A 81 | None | 1.13A | 4pxmA-4dqdA:undetectable | 4pxmA-4dqdA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 5 | LEU A 298LEU A 301ALA A 302LEU A 318GLY A 71 | None | 0.80A | 4pxmA-4e3aA:undetectable | 4pxmA-4e3aA:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8d | GLYCOSYL HYDROLASE,FAMILY 35 (Streptococcuspneumoniae) |
PF01301(Glyco_hydro_35) | 5 | LEU A 41LEU A 44ALA A 43GLY A 84LEU A 83 | NoneNoneNoneGOL A 602 (-3.8A)None | 1.08A | 4pxmA-4e8dA:undetectable | 4pxmA-4e8dA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hfv | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
PF16848(SoDot-IcmSS) | 5 | LEU A 76LEU A 79ALA A 78LEU A 105LEU A 5 | None | 1.09A | 4pxmA-4hfvA:undetectable | 4pxmA-4hfvA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i96 | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF01365(RYDR_ITPR)PF02815(MIR) | 5 | MET A 403LEU A 410LEU A 445LEU A 443GLY A 450 | None | 1.00A | 4pxmA-4i96A:undetectable | 4pxmA-4i96A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 5 | LEU A 187LEU A 217ALA A 216LEU A 168GLY A 171 | None | 0.96A | 4pxmA-4issA:undetectable | 4pxmA-4issA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | LEU A 286LEU A 289ALA A 290LEU A 276LEU A 275 | None | 1.08A | 4pxmA-4iuwA:undetectable | 4pxmA-4iuwA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j34 | KYNURENINE3-MONOOXYGENASE (Saccharomycescerevisiae) |
PF01494(FAD_binding_3) | 5 | LEU A 19ALA A 20LEU A 62GLY A 330LEU A 312 | None | 1.05A | 4pxmA-4j34A:undetectable | 4pxmA-4j34A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4log | MALTOSE ABCTRANSPORTERPERIPLASMIC PROTEINAND NR2E3 PROTEINCHIMERIC CONSTRUCT (Escherichiacoli;Homo sapiens) |
PF00104(Hormone_recep)PF13416(SBP_bac_8) | 5 | LEU A1295ALA A1296GLU A1299LEU A1389LEU A1388 | None | 0.97A | 4pxmA-4logA:14.0 | 4pxmA-4logA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lu1 | MAF-LIKE PROTEINYCEF (Escherichiacoli) |
PF02545(Maf) | 5 | LEU A 108ALA A 53GLY A 114HIS A 115LEU A 116 | None | 0.92A | 4pxmA-4lu1A:undetectable | 4pxmA-4lu1A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4md8 | CASEIN KINASE IISUBUNIT ALPHA (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA E 318GLU E 317LEU E 313ARG E 10GLY E 219 | None | 1.12A | 4pxmA-4md8E:undetectable | 4pxmA-4md8E:19.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 7 | LEU A 283LEU A 286ALA A 287GLU A 290LEU A 324ARG A 331GLY A 447 | None | 0.52A | 4pxmA-4n1yA:31.5 | 4pxmA-4n1yA:38.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 6 | LEU A 286ALA A 287GLU A 290LEU A 324ARG A 331GLY A 444 | None | 1.11A | 4pxmA-4n1yA:31.5 | 4pxmA-4n1yA:38.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nte | DEPH (Chromobacteriumviolaceum) |
PF07992(Pyr_redox_2) | 5 | MET A 256LEU A 109ALA A 110LEU A 229GLY A 273 | NoneNoneNoneNone NA A 302 (-3.5A) | 1.08A | 4pxmA-4nteA:undetectable | 4pxmA-4nteA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw0 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Chitinophagapinensis) |
PF00561(Abhydrolase_1) | 5 | LEU A 153GLU A 157LEU A 160GLY A 260HIS A 259 | NoneNoneNoneNone CL A 301 (-4.2A) | 1.13A | 4pxmA-4pw0A:undetectable | 4pxmA-4pw0A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Pisum sativum) |
PF00223(PsaA_PsaB) | 5 | LEU B 631LEU B 643GLY B 653HIS B 654LEU B 651 | NoneNoneNoneCLA B9022 ( 4.0A)CLA B9022 (-3.5A) | 1.09A | 4pxmA-4rkuB:undetectable | 4pxmA-4rkuB:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rm9 | EZRIN (Homo sapiens) |
PF00373(FERM_M)PF00769(ERM)PF09379(FERM_N)PF09380(FERM_C) | 5 | LEU A 125ALA A 129LEU A 192GLY A 109LEU A 111 | None | 1.12A | 4pxmA-4rm9A:3.5 | 4pxmA-4rm9A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s15 | NUCLEAR RECEPTORROR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | MET A 270LEU A 273LEU A 276ALA A 277LEU A 422 | None | 0.65A | 4pxmA-4s15A:22.0 | 4pxmA-4s15A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx2 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Actinoplanesteichomyceticus) |
PF00668(Condensation) | 5 | MET B 259LEU B 262ALA B 265LEU B 319LEU B 441 | None | 1.01A | 4pxmA-4tx2B:undetectable | 4pxmA-4tx2B:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u98 | MALTOKINASE (Mycolicibacteriumvanbaalenii) |
PF01636(APH) | 5 | LEU A 406ALA A 407GLU A 410HIS A 449LEU A 447 | None | 1.06A | 4pxmA-4u98A:undetectable | 4pxmA-4u98A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 769LEU A 772ALA A 773LEU A 810LEU A 814ARG A 817 | CV7 A1987 (-4.1A)CV7 A1987 ( 4.5A)CV7 A1987 (-3.5A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.28A | 4pxmA-4udbA:27.8 | 4pxmA-4udbA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uhi | STEROL 14-ALPHADEMETHYLASE (Homo sapiens) |
PF00067(p450) | 5 | LEU A 305LEU A 286ARG A 272GLY A 162LEU A 159 | NoneNoneNoneNoneVFV A 580 (-4.5A) | 1.06A | 4pxmA-4uhiA:2.3 | 4pxmA-4uhiA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uvk | ZYRO0D15994P (Zygosaccharomycesrouxii) |
PF08514(STAG) | 5 | LEU A 773LEU A 776ALA A 777LEU A 825LEU A 826 | None | 0.97A | 4pxmA-4uvkA:undetectable | 4pxmA-4uvkA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwa | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF00622(SPRY)PF01365(RYDR_ITPR)PF02026(RyR)PF02815(MIR)PF08709(Ins145_P3_rec) | 5 | MET A 403LEU A 410LEU A 445LEU A 443GLY A 450 | None | 0.95A | 4pxmA-4uwaA:undetectable | 4pxmA-4uwaA:5.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb6 | ALPHA-D-RIBOSE1-METHYLPHOSPHONATE5-TRIPHOSPHATESYNTHASE SUBUNITPHNI (Escherichiacoli) |
PF05861(PhnI) | 5 | LEU C 204LEU C 207ALA C 208LEU C 294GLY C 274 | None | 0.82A | 4pxmA-4xb6C:undetectable | 4pxmA-4xb6C:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 5 | LEU A 247LEU A 137ALA A 138LEU A 244LEU A 318 | None | 1.12A | 4pxmA-4yu9A:undetectable | 4pxmA-4yu9A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yub | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | LEU A 56LEU A 114ALA A 115LEU A 109GLY A 59 | None | 0.99A | 4pxmA-4yubA:undetectable | 4pxmA-4yubA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zk6 | QUINOLINATE SYNTHASEA (Pyrococcushorikoshii) |
PF02445(NadA) | 5 | MET A 61LEU A 68ALA A 45GLY A 36HIS A 21 | NTM A 402 (-3.5A)NoneNoneNoneNTM A 402 ( 3.9A) | 1.13A | 4pxmA-4zk6A:undetectable | 4pxmA-4zk6A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 5 (Homo sapiens) |
PF12862(ANAPC5) | 5 | LEU O 473LEU O 470ALA O 469LEU O 445MET O 444 | None | 1.12A | 4pxmA-5a31O:undetectable | 4pxmA-5a31O:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | MET A 416LEU A 490LEU A 489MET A 514GLY A 344 | None | 0.99A | 4pxmA-5bs5A:undetectable | 4pxmA-5bs5A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cec | BD3460 (Bdellovibriobacteriovorus) |
PF12796(Ank_2) | 5 | LEU B 82LEU B 83LEU B 76GLY B 40LEU B 42 | NoneNoneSO4 B 301 (-4.4A)NoneNone | 0.98A | 4pxmA-5cecB:undetectable | 4pxmA-5cecB:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5et1 | ESPIN (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5) | 5 | LEU A 89LEU A 90LEU A 83GLY A 47LEU A 49 | None | 1.02A | 4pxmA-5et1A:undetectable | 4pxmA-5et1A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gk9 | BRD1 PROTEINHISTONEACETYLTRANSFERASEKAT7 (Homo sapiens) |
PF01853(MOZ_SAS)no annotation | 5 | MET A 564LEU A 575LEU A 573GLU B 58LEU A 531 | None | 1.07A | 4pxmA-5gk9A:undetectable | 4pxmA-5gk9A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | LEU A 187LEU A 217ALA A 216LEU A 168GLY A 171 | None | 0.97A | 4pxmA-5i8iA:undetectable | 4pxmA-5i8iA:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6s | ENDOPLASMICRETICULUMAMINOPEPTIDASE 2 (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | LEU A 757LEU A 754ALA A 753LEU A 697HIS A 708 | None | 1.04A | 4pxmA-5j6sA:undetectable | 4pxmA-5j6sA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 5 | LEU A 303LEU A 304ALA A 301LEU A 281LEU A 428 | NoneNoneEDO A 505 ( 3.7A)NoneEDO A 504 (-4.5A) | 1.08A | 4pxmA-5jijA:undetectable | 4pxmA-5jijA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdx | METALLOPEPTIDASE (Pseudomonasaeruginosa) |
PF13402(Peptidase_M60) | 5 | LEU A 130LEU A 128LEU A 165GLY A 243LEU A 240 | None | 0.93A | 4pxmA-5kdxA:undetectable | 4pxmA-5kdxA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlv | - (-) |
no annotation | 5 | MET G 202LEU G 219ALA G 223LEU G 177MET G 176 | None | 0.96A | 4pxmA-5mlvG:undetectable | 4pxmA-5mlvG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 5 | LEU A 769LEU A 772ALA A 773LEU A 814ARG A 817 | ECV A1101 (-4.7A)ECV A1101 ( 3.9A)ECV A1101 (-3.8A)ECV A1101 (-4.1A)ECV A1101 (-4.0A) | 0.21A | 4pxmA-5mwpA:27.9 | 4pxmA-5mwpA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Synechocystissp. PCC 6803) |
no annotation | 5 | LEU b 628LEU b 640GLY b 650HIS b 651LEU b 648 | NoneNoneNoneCLA b1806 ( 4.0A)None | 1.01A | 4pxmA-5oy0b:undetectable | 4pxmA-5oy0b:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcb | PELA (Pseudomonasaeruginosa) |
PF03537(Glyco_hydro_114) | 5 | LEU A 142LEU A 143ALA A 140GLY A 117LEU A 114 | None | 0.86A | 4pxmA-5tcbA:undetectable | 4pxmA-5tcbA:22.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 294LEU A 298LEU A 301GLU A 305LEU A 343ARG A 346 | NoneEST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.4A)EST A 601 (-4.1A) | 1.44A | 4pxmA-5toaA:31.7 | 4pxmA-5toaA:57.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 298LEU A 301ALA A 302GLU A 305LEU A 339MET A 340LEU A 343ARG A 346GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 ( 3.9A)EST A 601 (-2.4A)EST A 601 (-3.9A)EST A 601 ( 4.8A)EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.35A | 4pxmA-5toaA:31.7 | 4pxmA-5toaA:57.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 295LEU A 298LEU A 354GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)NoneEST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 1.29A | 4pxmA-5toaA:31.7 | 4pxmA-5toaA:57.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4n | FRUCTOSE-1 (Neisseriagonorrhoeae) |
PF01116(F_bP_aldolase) | 5 | ALA A 193GLU A 142LEU A 146GLY A 152LEU A 149 | None | 0.99A | 4pxmA-5u4nA:undetectable | 4pxmA-5u4nA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 5 | LEU E 458LEU E 457GLY E 463HIS E 464LEU E 465 | None | 1.02A | 4pxmA-6d04E:undetectable | 4pxmA-6d04E:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6es9 | ACYL-COADEHYDROGENASE (Paracoccusdenitrificans) |
no annotation | 5 | LEU A 65LEU A 62ALA A 61LEU A 126GLY A 109 | None | 1.13A | 4pxmA-6es9A:undetectable | 4pxmA-6es9A:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN1NADH-UBIQUINONEOXIDOREDUCTASE CHAIN3 (Mus musculus) |
no annotation | 5 | LEU A 72LEU A 94ALA A 91LEU H 298LEU H 155 | None | 1.13A | 4pxmA-6g72A:undetectable | 4pxmA-6g72A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbg | OUTER MEMBRANEPROTEIN (Helicobacterpylori) |
no annotation | 5 | LEU A 84ALA A 82LEU A 394GLY A 73LEU A 185 | NoneNoneNone BR A 503 ( 4.0A)None | 0.95A | 4pxmA-6gbgA:undetectable | 4pxmA-6gbgA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbg | OUTER MEMBRANEPROTEIN (Helicobacterpylori) |
no annotation | 5 | LEU A 84LEU A 85ALA A 82GLY A 73LEU A 185 | NoneNoneNone BR A 503 ( 4.0A)None | 0.81A | 4pxmA-6gbgA:undetectable | 4pxmA-6gbgA:18.18 |