SIMILAR PATTERNS OF AMINO ACIDS FOR 4PWJ_B_30ZB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 LEU A   7
ALA A 111
SER A 102
THR A 104
 None
None
None
NA  A1255 (-3.8A)
 0.77A 4pwjB-1f80A:
undetectable		 4pwjB-1f80A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		4 LEU A  83
THR A  54
ALA A  52
LEU A  50
 None
FMN  A 165 (-4.0A)
None
None
 0.98A 4pwjB-1fueA:
undetectable		 4pwjB-1fueA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.41A 4pwjB-1gkeA:
21.7		 4pwjB-1gkeA:
82.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LYS A  15
THR A 106
ALA A 108
SER A 117
THR A 119
 None
 0.54A 4pwjB-1gkeA:
21.7		 4pwjB-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 651
THR A 606
LEU A 746
SER A 757
 None
 0.95A 4pwjB-1hwwA:
0.0		 4pwjB-1hwwA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LYS A 361
LEU A 357
ALA A 360
THR A 352
 None
 0.94A 4pwjB-1jmyA:
0.0		 4pwjB-1jmyA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 LEU A 108
THR A  41
LEU A  49
SER A  36
 None
 1.00A 4pwjB-1nsaA:
0.0		 4pwjB-1nsaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		4 THR A  31
ALA A  33
LEU A  35
SER A   8
 None
None
PNS  A1161 (-3.7A)
PNS  A1161 (-3.0A)
 0.79A 4pwjB-1od6A:
undetectable		 4pwjB-1od6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 430
THR A 437
ALA A 433
SER A 423
 None
 1.01A 4pwjB-1rzvA:
undetectable		 4pwjB-1rzvA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 LEU A 129
THR A 175
ALA A 154
THR A 219
 None
None
PMS  A1284 ( 3.8A)
PMS  A1284 (-4.6A)
 1.04A 4pwjB-1s2nA:
undetectable		 4pwjB-1s2nA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
 None
 0.40A 4pwjB-1sn2A:
21.2		 4pwjB-1sn2A:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.79A 4pwjB-1tfpA:
19.2		 4pwjB-1tfpA:
72.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
 None
 0.42A 4pwjB-1tfpA:
19.2		 4pwjB-1tfpA:
72.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.74A 4pwjB-1uunA:
undetectable		 4pwjB-1uunA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 THR A 179
ALA A 177
SER A 175
THR A 187
 None
 1.00A 4pwjB-1v6mA:
undetectable		 4pwjB-1v6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 THR A 147
ALA A 143
LEU A 139
SER A 138
 None
 1.01A 4pwjB-1wydA:
undetectable		 4pwjB-1wydA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.66A 4pwjB-1yr2A:
undetectable		 4pwjB-1yr2A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 THR A 305
ALA A 309
LEU A 313
SER A 314
 None
 1.03A 4pwjB-2bdwA:
undetectable		 4pwjB-2bdwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.91A 4pwjB-2bg9E:
undetectable		 4pwjB-2bg9E:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.00A 4pwjB-2csdA:
undetectable		 4pwjB-2csdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7b OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A  18
THR A  87
ALA A  89
LEU A  91
 None
 0.89A 4pwjB-2e7bA:
undetectable		 4pwjB-2e7bA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.00A 4pwjB-2eyqA:
undetectable		 4pwjB-2eyqA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 LEU A 149
THR A  73
ALA A  75
LEU A  77
 None
 0.81A 4pwjB-2f3jA:
undetectable		 4pwjB-2f3jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 0.82A 4pwjB-2ftpA:
undetectable		 4pwjB-2ftpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.84A 4pwjB-2jreA:
undetectable		 4pwjB-2jreA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 LEU A  89
THR A  77
ALA A  79
SER A 115
 None
 0.64A 4pwjB-2kfuA:
undetectable		 4pwjB-2kfuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkl UNCHARACTERIZED
PROTEIN MB1858

(Mycobacterium
bovis) 		PF00498
(FHA) 		4 LEU A  89
THR A  77
ALA A  79
SER A  95
 None
 0.86A 4pwjB-2kklA:
undetectable		 4pwjB-2kklA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfs UNCHARACTERIZED
PROTEIN, OSMOLARITY
SENSOR PROTEIN ENVZ
CHIMERA

(Archaeoglobus
fulgidus;
Shigella
flexneri) 		PF00512
(HisKA)
PF00672
(HAMP) 		4 THR A 334
ALA A 330
LEU A 326
SER A 325
 None
 1.04A 4pwjB-2lfsA:
undetectable		 4pwjB-2lfsA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2loj PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF10636
(hemP) 		4 LEU A  34
THR A  62
LEU A  33
SER A  30
 None
 1.04A 4pwjB-2lojA:
undetectable		 4pwjB-2lojA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mi6 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSG

(Mycobacterium
tuberculosis) 		no annotation 4 THR A  16
ALA A  27
LEU A  42
SER A  30
 None
 1.01A 4pwjB-2mi6A:
undetectable		 4pwjB-2mi6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 LEU A 208
ALA A  57
LEU A 142
SER A 141
 None
 1.03A 4pwjB-2nlzA:
undetectable		 4pwjB-2nlzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 0.93A 4pwjB-2pv7A:
undetectable		 4pwjB-2pv7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 171
THR A 265
ALA A 173
LEU A 194
 None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
 1.01A 4pwjB-2v7gA:
undetectable		 4pwjB-2v7gA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.84A 4pwjB-2v9tB:
undetectable		 4pwjB-2v9tB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.71A 4pwjB-2v9uA:
3.2		 4pwjB-2v9uA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		4 LEU A 269
THR A 293
ALA A 291
LEU A 289
 None
 0.89A 4pwjB-2wfdA:
undetectable		 4pwjB-2wfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.80A 4pwjB-2zygA:
undetectable		 4pwjB-2zygA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.75A 4pwjB-3b8kA:
undetectable		 4pwjB-3b8kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.97A 4pwjB-3bdwB:
undetectable		 4pwjB-3bdwB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A  46
ALA A  44
LEU A  40
SER A  41
 None
 0.74A 4pwjB-3bjlA:
3.7		 4pwjB-3bjlA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 LEU A 125
THR A 235
SER A 177
THR A 179
 None
 0.61A 4pwjB-3blwA:
undetectable		 4pwjB-3blwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C 237
THR C  60
LEU C 258
SER C 208
 None
 0.76A 4pwjB-3degC:
undetectable		 4pwjB-3degC:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
 IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
 0.38A 4pwjB-3fc8A:
23.5		 4pwjB-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.70A 4pwjB-3fc8A:
23.5		 4pwjB-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		4 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.01A 4pwjB-3g9hA:
undetectable		 4pwjB-3g9hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 LEU A 289
THR A 335
ALA A 314
THR A 385
 None
 1.04A 4pwjB-3gcwA:
undetectable		 4pwjB-3gcwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycolicibacterium
smegmatis) 		PF01648
(ACPS) 		4 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.79A 4pwjB-3gwmA:
undetectable		 4pwjB-3gwmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.81A 4pwjB-3iwkA:
undetectable		 4pwjB-3iwkA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 A223 PENTON BASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ALA Q 215
LEU Q 217
SER Q 165
THR Q 167
 None
 0.51A 4pwjB-3j31Q:
undetectable		 4pwjB-3j31Q:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.89A 4pwjB-3m7gA:
undetectable		 4pwjB-3m7gA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nps S4 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR C  76
ALA C  74
SER C  22
THR C  20
 None
 0.74A 4pwjB-3npsC:
undetectable		 4pwjB-3npsC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.60A 4pwjB-3prxB:
3.5		 4pwjB-3prxB:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 240
ALA A 243
LEU A 239
THR A 187
 None
 0.86A 4pwjB-3t6sA:
undetectable		 4pwjB-3t6sA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.85A 4pwjB-4aq9E:
undetectable		 4pwjB-4aq9E:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 THR A 548
ALA A 550
LEU A 552
SER A 483
 None
 0.81A 4pwjB-4cakA:
undetectable		 4pwjB-4cakA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		4 LEU B 187
LEU B 190
SER B 195
THR B 157
 None
 0.94A 4pwjB-4di4B:
undetectable		 4pwjB-4di4B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		4 LEU A 233
THR A 221
ALA A 226
LEU A 228
 None
 0.98A 4pwjB-4dmoA:
undetectable		 4pwjB-4dmoA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjB-4gfjA:
undetectable		 4pwjB-4gfjA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.56A 4pwjB-4ggaA:
undetectable		 4pwjB-4ggaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		4 THR A 120
ALA A 122
SER A 113
THR A 115
 None
None
CL  A 202 (-3.1A)
None
 0.86A 4pwjB-4hc6A:
undetectable		 4pwjB-4hc6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.79A 4pwjB-4i8qA:
undetectable		 4pwjB-4i8qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.65A 4pwjB-4n14A:
undetectable		 4pwjB-4n14A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  71
THR A 123
SER A 106
 None
 0.78A 4pwjB-4o38A:
undetectable		 4pwjB-4o38A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ALA A 485
LEU A 545
SER A 546
THR A 501
 None
 0.98A 4pwjB-4o9xA:
undetectable		 4pwjB-4o9xA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 THR A 835
ALA A 832
LEU A 828
THR A 831
 None
 0.89A 4pwjB-4qiwA:
undetectable		 4pwjB-4qiwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyb UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF10765
(DUF2591) 		4 LEU A  98
ALA A 102
SER A  94
THR A 105
 None
 0.81A 4pwjB-4qybA:
undetectable		 4pwjB-4qybA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.62A 4pwjB-4tr6A:
undetectable		 4pwjB-4tr6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 0.99A 4pwjB-4v1rA:
undetectable		 4pwjB-4v1rA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v23 MATRIX PROTEIN

(Respiratory
syncytial virus) 		PF03393
(Pneumo_matrix) 		4 THR A  15
ALA A  17
SER A 116
THR A 118
 None
 0.58A 4pwjB-4v23A:
undetectable		 4pwjB-4v23A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.99A 4pwjB-4w65A:
undetectable		 4pwjB-4w65A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B

(Homo sapiens) 		no annotation 4 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.90A 4pwjB-4xnzL:
undetectable		 4pwjB-4xnzL:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		4 LEU B 347
THR B 235
LEU B  91
SER B  90
 None
 1.03A 4pwjB-4ztuB:
undetectable		 4pwjB-4ztuB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 LEU A 850
THR A 827
LEU A 823
SER A 791
 None
 0.82A 4pwjB-5a42A:
5.8		 4pwjB-5a42A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 LEU L 446
ALA L 379
LEU L 374
SER L 370
 None
 0.92A 4pwjB-5a7dL:
undetectable		 4pwjB-5a7dL:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 LEU A 511
THR A 591
ALA A 589
SER A 578
 None
 0.64A 4pwjB-5ereA:
undetectable		 4pwjB-5ereA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 THR A 309
ALA A 305
LEU A 301
SER A 300
 None
 0.92A 4pwjB-5ggyA:
undetectable		 4pwjB-5ggyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU B 798
ALA B 741
SER B 791
THR B 765
 None
 1.03A 4pwjB-5gztB:
undetectable		 4pwjB-5gztB:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU A 798
ALA A 741
SER A 791
THR A 765
 None
 1.00A 4pwjB-5gzuA:
undetectable		 4pwjB-5gzuA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjB-5hm5A:
undetectable		 4pwjB-5hm5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR

(Acinetobacter
sp. ADP1) 		PF01614
(IclR) 		4 LEU A 260
ALA A 224
LEU A 238
THR A 161
 None
None
None
3HB  A 301 (-3.6A)
 0.98A 4pwjB-5hpiA:
undetectable		 4pwjB-5hpiA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 4 LEU B 841
THR B 848
ALA B 844
THR B 759
 None
 0.91A 4pwjB-5khnB:
undetectable		 4pwjB-5khnB:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 LEU B 165
ALA B 161
LEU B 167
THR B 159
 None
 1.02A 4pwjB-5kisB:
undetectable		 4pwjB-5kisB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 THR A 381
ALA A 377
LEU A 373
SER A 372
 FMN  A 901 (-4.6A)
None
None
None
 1.01A 4pwjB-5lq4A:
undetectable		 4pwjB-5lq4A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU O  83
THR O 174
LEU O  86
THR O 136
 None
 0.96A 4pwjB-5mpdO:
undetectable		 4pwjB-5mpdO:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.64A 4pwjB-5mq6A:
undetectable		 4pwjB-5mq6A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 342
THR A 370
LEU A 374
SER A 402
 None
 0.70A 4pwjB-5mzsA:
undetectable		 4pwjB-5mzsA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 THR A 428
ALA A 430
LEU A 432
THR A 423
 None
 0.69A 4pwjB-5n4aA:
undetectable		 4pwjB-5n4aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L10

(Mycolicibacterium
smegmatis) 		PF00466
(Ribosomal_L10) 		4 LEU I  56
THR I  50
ALA I  52
THR I  77
 None
 0.92A 4pwjB-5o60I:
undetectable		 4pwjB-5o60I:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 LEU B 147
THR B 124
LEU B 128
THR B 119
 None
 0.80A 4pwjB-5ofbB:
undetectable		 4pwjB-5ofbB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S25, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.93A 4pwjB-5opta:
undetectable		 4pwjB-5opta:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 THR A 853
ALA A 851
LEU A 847
SER A 846
 None
 1.01A 4pwjB-5tj6A:
undetectable		 4pwjB-5tj6A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		4 THR E 241
ALA E 239
SER E 184
THR E 182
 None
 0.75A 4pwjB-5u68E:
undetectable		 4pwjB-5u68E:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11

(Homo sapiens) 		no annotation 4 THR X 422
ALA X 418
LEU X 414
SER X 413
 None
 0.86A 4pwjB-5vfrX:
undetectable		 4pwjB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LYS J 230
LEU J 226
LEU J 277
THR J 282
 None
 0.98A 4pwjB-5vzjJ:
undetectable		 4pwjB-5vzjJ:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 THR A 383
ALA A 385
SER A 411
THR A 409
 None
 0.95A 4pwjB-5xhqA:
undetectable		 4pwjB-5xhqA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yax SCFV1 ANTIBODY

(Homo sapiens) 		no annotation 4 THR A1092
ALA A1090
SER A1022
THR A1020
 None
 0.94A 4pwjB-5yaxA:
undetectable		 4pwjB-5yaxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 LEU A 377
THR A 373
LEU A 364
SER A 355
 None
 0.85A 4pwjB-5yp3A:
undetectable		 4pwjB-5yp3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 THR A 142
ALA A 140
SER A 137
THR A 160
 None
 0.98A 4pwjB-6emsA:
undetectable		 4pwjB-6emsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1d COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 4 LYS A 218
LEU A 220
THR A 286
SER A 189
 None
 0.97A 4pwjB-6f1dA:
undetectable		 4pwjB-6f1dA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 4 LEU A 357
THR A 378
ALA A 368
THR A 367
 None
 0.92A 4pwjB-6fv4A:
undetectable		 4pwjB-6fv4A:
21.29