SIMILAR PATTERNS OF AMINO ACIDS FOR 4PWJ_A_30ZA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis virus) 		no annotation 4 LYS C 198
LEU C 205
LEU C 196
SER C 193
 None
 0.92A 4pwjA-1b35C:
undetectable		 4pwjA-1b35C:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		4 LEU A 157
THR A 120
ALA A 118
SER A 162
 None
 1.05A 4pwjA-1dk5A:
undetectable		 4pwjA-1dk5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		4 LEU A  83
THR A  54
ALA A  52
LEU A  50
 None
FMN  A 165 (-4.0A)
None
None
 0.97A 4pwjA-1fueA:
undetectable		 4pwjA-1fueA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
 None
 0.48A 4pwjA-1gkeA:
22.1		 4pwjA-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LYS A 496
LEU A 492
THR A 499
ALA A 495
LEU A 322
 None
 1.45A 4pwjA-1gz4A:
undetectable		 4pwjA-1gz4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 0.99A 4pwjA-1gz6A:
0.0		 4pwjA-1gz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669

(Methanocaldococcus
jannaschii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 246
THR A 295
LEU A 315
SER A 340
 SO4  A 804 (-2.6A)
None
None
None
 1.04A 4pwjA-1hv8A:
undetectable		 4pwjA-1hv8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 651
THR A 606
LEU A 746
SER A 757
 None
 1.04A 4pwjA-1hwwA:
0.0		 4pwjA-1hwwA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LEU A1081
ALA A1098
LEU A1083
SER A1085
 None
 1.04A 4pwjA-1jl5A:
undetectable		 4pwjA-1jl5A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		4 THR A  31
ALA A  33
LEU A  35
SER A   8
 None
None
PNS  A1161 (-3.7A)
PNS  A1161 (-3.0A)
 0.77A 4pwjA-1od6A:
undetectable		 4pwjA-1od6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s78 PERTUZUMAB FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D 124
THR D 183
ALA D 137
SER D 127
 None
 1.02A 4pwjA-1s78D:
undetectable		 4pwjA-1s78D:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 LEU A  72
ALA A  69
LEU A  67
SER A  64
 None
 0.98A 4pwjA-1sa3A:
undetectable		 4pwjA-1sa3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.92A 4pwjA-1sb3B:
undetectable		 4pwjA-1sb3B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 LEU A 340
THR A 403
ALA A 406
LEU A 408
 None
 0.95A 4pwjA-1sc6A:
undetectable		 4pwjA-1sc6A:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
 None
 0.39A 4pwjA-1sn2A:
20.9		 4pwjA-1sn2A:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.83A 4pwjA-1tfpA:
19.4		 4pwjA-1tfpA:
72.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
 None
 0.46A 4pwjA-1tfpA:
19.4		 4pwjA-1tfpA:
72.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wha KIAA0147 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 THR A  89
ALA A  91
LEU A  93
SER A  65
 THR  A  89 ( 0.8A)
ALA  A  91 ( 0.0A)
LEU  A  93 ( 0.6A)
SER  A  65 ( 0.0A)
 0.76A 4pwjA-1whaA:
undetectable		 4pwjA-1whaA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 THR A 147
ALA A 143
LEU A 139
SER A 138
 None
 1.04A 4pwjA-1wydA:
undetectable		 4pwjA-1wydA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 166
THR A 260
ALA A 168
LEU A 189
 None
NAD  A 600 (-4.4A)
NAD  A 600 ( 4.3A)
None
 1.01A 4pwjA-1x87A:
undetectable		 4pwjA-1x87A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		4 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 1.02A 4pwjA-1ydoA:
undetectable		 4pwjA-1ydoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.66A 4pwjA-1yr2A:
undetectable		 4pwjA-1yr2A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.97A 4pwjA-2bg9E:
undetectable		 4pwjA-2bg9E:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 LEU A 128
THR A 124
LEU A 165
SER A 191
 None
 0.97A 4pwjA-2bx7A:
undetectable		 4pwjA-2bx7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A  44
THR A 101
ALA A  28
LEU A  41
 None
SAH  A 300 (-4.9A)
None
None
 0.96A 4pwjA-2cbfA:
undetectable		 4pwjA-2cbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chp METALLOREGULATION
DNA-BINDING STRESS
PROTEIN

(Bacillus
subtilis) 		PF00210
(Ferritin) 		4 LYS A  49
LEU A  53
THR A  45
LEU A  31
 None
 1.04A 4pwjA-2chpA:
undetectable		 4pwjA-2chpA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.04A 4pwjA-2csdA:
undetectable		 4pwjA-2csdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 LEU A 161
THR A 105
LEU A 163
SER A 164
 None
 1.05A 4pwjA-2cwoA:
undetectable		 4pwjA-2cwoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7b OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A  18
THR A  87
ALA A  89
LEU A  91
 None
 0.91A 4pwjA-2e7bA:
1.8		 4pwjA-2e7bA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 LEU A 939
THR A 882
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
None
EPE  A1152 (-2.8A)
 1.36A 4pwjA-2eyqA:
undetectable		 4pwjA-2eyqA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 LEU A 149
THR A  73
ALA A  75
LEU A  77
 None
 0.86A 4pwjA-2f3jA:
undetectable		 4pwjA-2f3jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 0.84A 4pwjA-2ftpA:
undetectable		 4pwjA-2ftpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
LEU A 297
THR A 338
SER A 330
 H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
None
 0.84A 4pwjA-2h8hA:
undetectable		 4pwjA-2h8hA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 LEU A  17
THR A 227
LEU A 251
SER A 262
 None
 0.98A 4pwjA-2hypA:
undetectable		 4pwjA-2hypA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 LYS A  10
LEU A  12
THR A  27
SER A  75
 None
 1.02A 4pwjA-2idcA:
2.6		 4pwjA-2idcA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A 205
THR A 236
LEU A 211
SER A 212
 None
 1.04A 4pwjA-2iyoA:
undetectable		 4pwjA-2iyoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.82A 4pwjA-2jreA:
undetectable		 4pwjA-2jreA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 LEU A  89
THR A  77
ALA A  79
SER A 115
 None
 0.65A 4pwjA-2kfuA:
undetectable		 4pwjA-2kfuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkl UNCHARACTERIZED
PROTEIN MB1858

(Mycobacterium
bovis) 		PF00498
(FHA) 		4 LEU A  89
THR A  77
ALA A  79
SER A  95
 None
 0.86A 4pwjA-2kklA:
undetectable		 4pwjA-2kklA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2loj PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF10636
(hemP) 		4 LEU A  34
THR A  62
LEU A  33
SER A  30
 None
 1.05A 4pwjA-2lojA:
undetectable		 4pwjA-2lojA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mi6 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSG

(Mycobacterium
tuberculosis) 		no annotation 4 THR A  16
ALA A  27
LEU A  42
SER A  30
 None
 1.03A 4pwjA-2mi6A:
undetectable		 4pwjA-2mi6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 LEU A 208
ALA A  57
LEU A 142
SER A 141
 None
 1.01A 4pwjA-2nlzA:
undetectable		 4pwjA-2nlzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.03A 4pwjA-2o3jA:
undetectable		 4pwjA-2o3jA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 1.03A 4pwjA-2pv7A:
undetectable		 4pwjA-2pv7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 305
THR A  31
ALA A 335
LEU A 337
 None
 1.03A 4pwjA-2q6zA:
undetectable		 4pwjA-2q6zA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 171
THR A 265
ALA A 173
LEU A 194
 None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
 0.99A 4pwjA-2v7gA:
1.3		 4pwjA-2v7gA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.89A 4pwjA-2v9tB:
undetectable		 4pwjA-2v9tB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		4 LEU A 269
THR A 293
ALA A 291
LEU A 289
 None
 0.95A 4pwjA-2wfdA:
undetectable		 4pwjA-2wfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB

(Escherichia
coli) 		PF01381
(HTH_3) 		4 LEU B  64
THR B  56
LEU B  66
SER B  67
 None
 0.91A 4pwjA-2wiuB:
undetectable		 4pwjA-2wiuB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 LEU A 367
THR A  61
ALA A  65
LEU A  69
 None
 1.03A 4pwjA-2x98A:
undetectable		 4pwjA-2x98A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.81A 4pwjA-2zygA:
undetectable		 4pwjA-2zygA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		4 LEU B  75
THR A  96
ALA B 117
LEU B 115
 None
 0.93A 4pwjA-3aqcB:
undetectable		 4pwjA-3aqcB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.94A 4pwjA-3aqpA:
undetectable		 4pwjA-3aqpA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		4 LEU A 308
THR A 315
ALA A 311
LEU A 307
 None
 1.02A 4pwjA-3asaA:
undetectable		 4pwjA-3asaA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.97A 4pwjA-3bdwB:
undetectable		 4pwjA-3bdwB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A  46
ALA A  44
LEU A  40
SER A  41
 None
 0.78A 4pwjA-3bjlA:
3.7		 4pwjA-3bjlA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C 237
THR C  60
LEU C 258
SER C 208
 None
 0.66A 4pwjA-3degC:
undetectable		 4pwjA-3degC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.96A 4pwjA-3epd1:
undetectable		 4pwjA-3epd1:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.66A 4pwjA-3fc8A:
23.7		 4pwjA-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LYS A 179
LEU A 175
THR A 209
ALA A 178
LEU A 174
 None
 1.37A 4pwjA-3gd5A:
undetectable		 4pwjA-3gd5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01402
(RHH_1) 		4 LEU C  24
ALA C  22
LEU C  26
SER C  27
 GOL  C  74 (-4.3A)
None
None
None
 1.04A 4pwjA-3h87C:
undetectable		 4pwjA-3h87C:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 239
THR A 302
ALA A 300
SER A 285
 None
 0.88A 4pwjA-3hdiA:
undetectable		 4pwjA-3hdiA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 LEU A  17
THR A 227
LEU A 251
SER A 262
 None
 1.03A 4pwjA-3ib7A:
undetectable		 4pwjA-3ib7A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 LEU A 621
THR A 589
LEU A 624
SER A 625
 None
 0.96A 4pwjA-3j0aA:
undetectable		 4pwjA-3j0aA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 THR A1080
ALA A1104
LEU A1112
SER A1111
 None
 1.02A 4pwjA-3kg7A:
undetectable		 4pwjA-3kg7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 409
ALA A 411
LEU A 413
SER A 401
 None
 1.05A 4pwjA-3kzuA:
undetectable		 4pwjA-3kzuA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.03A 4pwjA-3m7dA:
undetectable		 4pwjA-3m7dA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjA-3m7gA:
undetectable		 4pwjA-3m7gA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 LEU A 481
ALA A 497
LEU A 495
SER A 492
 None
 1.05A 4pwjA-3oeeA:
undetectable		 4pwjA-3oeeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
LEU A 580
THR A 625
LEU A 621
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
 0.90A 4pwjA-3ppzA:
undetectable		 4pwjA-3ppzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 LYS A 140
LEU A  91
THR A 114
LEU A 146
 None
 1.06A 4pwjA-3rftA:
undetectable		 4pwjA-3rftA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 LEU A 223
THR A 175
LEU A 219
SER A 218
 None
 1.00A 4pwjA-3wo8A:
undetectable		 4pwjA-3wo8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 THR E 468
ALA E 464
LEU E 460
SER E 459
 None
 0.89A 4pwjA-4aq9E:
undetectable		 4pwjA-4aq9E:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 LYS A 613
LEU A 617
LEU A 619
SER A 620
 None
 1.04A 4pwjA-4c51A:
undetectable		 4pwjA-4c51A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 THR A 548
ALA A 550
LEU A 552
SER A 483
 None
 0.84A 4pwjA-4cakA:
undetectable		 4pwjA-4cakA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 LEU A 448
THR A 463
ALA A 461
LEU A 459
 None
 0.99A 4pwjA-4dg8A:
undetectable		 4pwjA-4dg8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		4 LEU A 190
THR A 157
ALA A 159
SER A 129
 None
 0.72A 4pwjA-4e69A:
undetectable		 4pwjA-4e69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A 382
THR A 368
LEU A 376
SER A 377
 None
 1.05A 4pwjA-4f4fA:
undetectable		 4pwjA-4f4fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.99A 4pwjA-4gfjA:
undetectable		 4pwjA-4gfjA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU D 255
THR D 163
LEU D 275
SER A  45
 None
 1.03A 4pwjA-4gipD:
undetectable		 4pwjA-4gipD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gri GLUTAMATE--TRNA
LIGASE

(Borreliella
burgdorferi) 		PF00749
(tRNA-synt_1c) 		4 LEU A 227
THR A 175
LEU A 224
SER A 221
 None
 0.89A 4pwjA-4griA:
undetectable		 4pwjA-4griA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 161
THR A  73
LEU A 175
SER A 176
 None
None
None
MLY  A 359 ( 4.2A)
 0.99A 4pwjA-4gxrA:
undetectable		 4pwjA-4gxrA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 LEU A 309
THR A 235
LEU A 277
SER A 276
 None
 1.04A 4pwjA-4m46A:
undetectable		 4pwjA-4m46A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 LEU A 204
THR A 211
ALA A 207
SER A 202
 None
 0.94A 4pwjA-4mm0A:
undetectable		 4pwjA-4mm0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 LEU A 179
ALA A 171
LEU A   7
SER A   5
 None
 1.02A 4pwjA-4n2xA:
undetectable		 4pwjA-4n2xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  71
THR A 123
SER A 106
 None
 0.78A 4pwjA-4o38A:
undetectable		 4pwjA-4o38A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 LEU A 669
THR A 677
LEU A 672
SER A 673
 None
 0.93A 4pwjA-4oj5A:
undetectable		 4pwjA-4oj5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pt1 ODORANT-BINDING
PROTEIN 1D

(Locusta
migratoria) 		PF01395
(PBP_GOBP) 		4 THR A 128
ALA A 124
LEU A 120
SER A 119
 None
 1.05A 4pwjA-4pt1A:
undetectable		 4pwjA-4pt1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU B 485
THR B 438
LEU B 492
SER B 493
 None
 0.96A 4pwjA-4q4aB:
undetectable		 4pwjA-4q4aB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd9 THIOESTERASE PA1618

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 LEU A  10
THR A 101
ALA A  39
LEU A  13
 None
 0.96A 4pwjA-4qd9A:
undetectable		 4pwjA-4qd9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 LEU A  85
THR A  77
LEU A  87
SER A  89
 None
 1.03A 4pwjA-4r9iA:
undetectable		 4pwjA-4r9iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 LEU A 842
THR A 819
LEU A 815
SER A 783
 None
 0.94A 4pwjA-4u48A:
3.5		 4pwjA-4u48A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 LEU A 853
THR A 626
LEU A 855
SER A1005
 None
 0.99A 4pwjA-4u48A:
3.5		 4pwjA-4u48A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5

(Kluyveromyces
lactis) 		PF10392
(COG5) 		4 THR B 230
ALA B 234
LEU B 238
SER B 239
 None
 0.97A 4pwjA-4u6uB:
undetectable		 4pwjA-4u6uB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 1.03A 4pwjA-4v1rA:
undetectable		 4pwjA-4v1rA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzn GENOME POLYPROTEIN

(Hepatovirus A) 		no annotation 4 LEU A 969
THR A 861
LEU A 971
SER A 972
 None
 0.97A 4pwjA-4wznA:
undetectable		 4pwjA-4wznA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.03A 4pwjA-4xvxA:
undetectable		 4pwjA-4xvxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 LEU A 207
THR A 214
ALA A 210
LEU A 206
 None
 1.05A 4pwjA-4yhbA:
undetectable		 4pwjA-4yhbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00497
(SBP_bac_3) 		4 LYS A 170
LEU A 172
THR A 148
SER A 157
 None
None
None
ARG  A 301 ( 4.7A)
 0.93A 4pwjA-4ymxA:
undetectable		 4pwjA-4ymxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zey NUCLEAR
RECEPTOR-BINDING
FACTOR 2

(Homo sapiens) 		PF17169
(NRBF2_MIT) 		4 LYS A  35
LEU A  68
ALA A  38
SER A  63
 None
 1.05A 4pwjA-4zeyA:
undetectable		 4pwjA-4zeyA:
19.38