SIMILAR PATTERNS OF AMINO ACIDS FOR 4PTJ_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btn BETA-SPECTRIN

(Mus musculus) 		PF15410
(PH_9) 		3 ASP A  93
LYS A  91
LEU A   5
 None
 0.97A 4ptjA-1btnA:
undetectable		 4ptjA-1btnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ASP A 628
LYS A 632
LEU A 568
 None
 1.03A 4ptjA-1iv8A:
0.0		 4ptjA-1iv8A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		3 ASP A 613
LYS A 571
LEU A 515
 None
 0.82A 4ptjA-1kehA:
0.0		 4ptjA-1kehA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		3 ASP A 265
LYS A 224
LEU A 289
 None
 0.90A 4ptjA-1m2xA:
undetectable		 4ptjA-1m2xA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		3 ASP A  79
LYS A  83
LEU A 378
 None
 0.88A 4ptjA-1m7jA:
0.0		 4ptjA-1m7jA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 ASP A 194
LYS A 157
LEU A 103
 None
 1.03A 4ptjA-1r6mA:
undetectable		 4ptjA-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3g ADENYLATE KINASE

(Sporosarcina
globispora) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 ASP A  54
LYS A  48
LEU A  45
 None
 0.96A 4ptjA-1s3gA:
3.0		 4ptjA-1s3gA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		3 ASP 1  56
LYS 1  49
LEU 1  46
 None
 1.05A 4ptjA-1t6t1:
3.7		 4ptjA-1t6t1:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5i IA-1=SERINE
PROTEINASE INHIBITOR

(Pleurotus
ostreatus) 		no annotation 3 ASP B  23
LYS B  17
LEU B  63
 None
GOL  B2014 ( 3.4A)
GOL  B2002 (-3.6A)
 1.08A 4ptjA-1v5iB:
undetectable		 4ptjA-1v5iB:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 ASP A  27
LYS A  32
LEU A  54
 None
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
 0.64A 4ptjA-1zdrA:
25.3		 4ptjA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 ASP C 444
LYS C 402
LEU C 346
 None
 0.75A 4ptjA-2advC:
undetectable		 4ptjA-2advC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqq DNAJ HOMOLOG
SUBFAMILY C MEMBER 1

(Homo sapiens) 		no annotation 3 ASP A  57
LYS A  51
LEU A  19
 None
 0.97A 4ptjA-2cqqA:
undetectable		 4ptjA-2cqqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		3 ASP A  26
LYS A  23
LEU A 330
 None
 1.03A 4ptjA-2czcA:
undetectable		 4ptjA-2czcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A  76
LYS A  92
LEU A  97
 None
 1.01A 4ptjA-2d0iA:
undetectable		 4ptjA-2d0iA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 3 ASP A  25
LYS A  17
LEU A  59
 None
 0.95A 4ptjA-2d58A:
undetectable		 4ptjA-2d58A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 ASP A 260
LYS A  62
LEU A  69
 None
 1.05A 4ptjA-2douA:
undetectable		 4ptjA-2douA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyn ALPHA-ACTININ 1

(Homo sapiens) 		PF00307
(CH) 		3 ASP A 117
LYS A 110
LEU A  97
 None
 0.97A 4ptjA-2eynA:
undetectable		 4ptjA-2eynA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		3 ASP A 393
LYS A 343
LEU A 337
 None
 1.08A 4ptjA-2g5dA:
undetectable		 4ptjA-2g5dA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		3 ASP X 109
LYS X 244
LEU X  22
 None
 0.97A 4ptjA-2h3gX:
undetectable		 4ptjA-2h3gX:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ASP A 395
LYS A 390
LEU A 353
 None
 1.06A 4ptjA-2i4nA:
undetectable		 4ptjA-2i4nA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		3 ASP A 304
LYS A 233
LEU A 218
 None
 0.95A 4ptjA-2jg5A:
undetectable		 4ptjA-2jg5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6b NR1C

(Escherichia
coli) 		PF12796
(Ank_2) 		3 ASP A  34
LYS A  64
LEU A  62
 None
 0.93A 4ptjA-2l6bA:
undetectable		 4ptjA-2l6bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		3 ASP A 379
LYS A 376
LEU A  29
 None
 0.96A 4ptjA-2o0rA:
undetectable		 4ptjA-2o0rA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ASP A  79
LYS A  73
LEU A 227
 None
 1.08A 4ptjA-2p0uA:
undetectable		 4ptjA-2p0uA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		3 ASP A 392
LYS A 452
LEU A 439
 None
 1.05A 4ptjA-2pbgA:
undetectable		 4ptjA-2pbgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 ASP C 285
LYS C  92
LEU C  95
 None
 1.04A 4ptjA-2v3cC:
3.9		 4ptjA-2v3cC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 ASP A  86
LYS A 194
LEU A 254
 None
 1.00A 4ptjA-2w9zA:
undetectable		 4ptjA-2w9zA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 ASP A 618
LYS A 620
LEU A 633
 None
 1.04A 4ptjA-2xqyA:
undetectable		 4ptjA-2xqyA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		no annotation 3 ASP A 306
LYS A 234
LEU A 346
 None
 1.07A 4ptjA-2xz8A:
undetectable		 4ptjA-2xz8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		3 ASP A  80
LYS A 255
LEU A 282
 None
 0.91A 4ptjA-2yjpA:
undetectable		 4ptjA-2yjpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP B 222
LYS B 225
LEU B 213
 None
 0.97A 4ptjA-3c60B:
undetectable		 4ptjA-3c60B:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 ASP A 331
LYS A 324
LEU A 359
 None
 1.08A 4ptjA-3cemA:
undetectable		 4ptjA-3cemA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE

(Escherichia
coli;
Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C)
PF04288
(MukE) 		3 ASP A 290
LYS A 283
LEU C 118
 None
 1.04A 4ptjA-3euhA:
undetectable		 4ptjA-3euhA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk9 MUTATOR MUTT PROTEIN

(Bacillus
halodurans) 		PF00293
(NUDIX) 		3 ASP A 107
LYS A 104
LEU A  17
 None
 0.86A 4ptjA-3fk9A:
undetectable		 4ptjA-3fk9A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 ASP A 179
LYS A 518
LEU A 255
 CA  A 736 ( 2.6A)
None
None
 1.06A 4ptjA-3hvdA:
undetectable		 4ptjA-3hvdA:
14.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		3 ASP X  27
LYS X  32
LEU X  54
 N22  X 219 (-2.8A)
None
None
 0.84A 4ptjA-3i8aX:
25.9		 4ptjA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 ASP A1260
LYS A1257
LEU A1319
 None
 1.05A 4ptjA-3k9bA:
1.4		 4ptjA-3k9bA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00903
(Glyoxalase) 		3 ASP A 124
LYS A  18
LEU A  61
 None
 0.90A 4ptjA-3l7tA:
undetectable		 4ptjA-3l7tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 ASP A 145
LYS A 107
LEU A 281
 None
 1.07A 4ptjA-3lp8A:
undetectable		 4ptjA-3lp8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		3 ASP A 197
LYS A 229
LEU A 307
 None
 0.78A 4ptjA-3m9xA:
2.1		 4ptjA-3m9xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 ASP A  93
LYS A  15
LEU A   3
 None
 0.93A 4ptjA-3oneA:
undetectable		 4ptjA-3oneA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyy ELONGATION FACTOR P

(Pseudomonas
aeruginosa) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		3 ASP A  66
LYS A 120
LEU A  45
 None
 1.01A 4ptjA-3oyyA:
undetectable		 4ptjA-3oyyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 198
LYS A 216
LEU A 244
 None
 1.06A 4ptjA-3pi7A:
undetectable		 4ptjA-3pi7A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 ASP A 259
LYS A 288
LEU A 281
 None
 0.98A 4ptjA-3rpkA:
undetectable		 4ptjA-3rpkA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		3 ASP A 176
LYS A 198
LEU A 196
 None
MLY  A 197 ( 3.6A)
MLY  A 197 ( 3.6A)
 1.01A 4ptjA-3rwxA:
undetectable		 4ptjA-3rwxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 ASP A 462
LYS A 457
LEU A 309
 None
None
HEM  A1500 (-4.0A)
 1.08A 4ptjA-3ut2A:
undetectable		 4ptjA-3ut2A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		3 ASP A  28
LYS A  33
LEU A  64
 None
 0.84A 4ptjA-3vcoA:
18.4		 4ptjA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 ASP A 467
LYS A 319
LEU A 292
 None
 0.91A 4ptjA-3w6qA:
undetectable		 4ptjA-3w6qA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd6 OMEGA-CLASS
GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ASP A 141
LYS A 135
LEU A 132
 None
 0.93A 4ptjA-3wd6A:
undetectable		 4ptjA-3wd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd6 OMEGA-CLASS
GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ASP A 171
LYS A 120
LEU A  93
 PEG  A 305 (-3.8A)
None
None
 1.04A 4ptjA-3wd6A:
undetectable		 4ptjA-3wd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ASP A 331
LYS A 305
LEU A 200
 None
 1.07A 4ptjA-3wfzA:
undetectable		 4ptjA-3wfzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 ASP A 872
LYS A 896
LEU A 893
 None
 1.02A 4ptjA-4b56A:
undetectable		 4ptjA-4b56A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		3 ASP A 157
LYS A 152
LEU A 132
 None
 1.05A 4ptjA-4cbvA:
undetectable		 4ptjA-4cbvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 300
LYS A 137
LEU A  75
 None
 1.00A 4ptjA-4cpdA:
3.2		 4ptjA-4cpdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqq PUTATIVE HOST CELL
SURFACE-EXPOSED
LIPOPROTEIN

(Streptococcus
phage TP-J34) 		PF07553
(Lipoprotein_Ltp) 		3 ASP A 110
LYS A 104
LEU A 123
 None
SO4  A 202 (-2.5A)
None
 0.87A 4ptjA-4eqqA:
undetectable		 4ptjA-4eqqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 ASP A 710
LYS A 270
LEU A 246
 None
 1.06A 4ptjA-4f1nA:
undetectable		 4ptjA-4f1nA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 ASP A 506
LYS A 771
LEU A 654
 None
 1.07A 4ptjA-4hsuA:
undetectable		 4ptjA-4hsuA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		3 ASP A 178
LYS A 172
LEU A 101
 None
 1.07A 4ptjA-4hyjA:
undetectable		 4ptjA-4hyjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz2 SUPEROXIDE DISMUTASE

(Clostridioides
difficile) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASP A  49
LYS A  54
LEU A  37
 None
 1.02A 4ptjA-4jz2A:
undetectable		 4ptjA-4jz2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		3 ASP A 266
LYS A  63
LEU A  70
 None
 0.94A 4ptjA-4le6A:
undetectable		 4ptjA-4le6A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		3 ASP B 178
LYS B 175
LEU A 536
 None
 1.05A 4ptjA-4oy2B:
undetectable		 4ptjA-4oy2B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 ASP A 299
LYS A 294
LEU A 329
 None
 1.00A 4ptjA-4p7hA:
undetectable		 4ptjA-4p7hA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		3 ASP A 134
LYS A  66
LEU A  63
 None
 1.04A 4ptjA-4txkA:
undetectable		 4ptjA-4txkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		3 ASP A 346
LYS A 361
LEU A 353
 None
 0.99A 4ptjA-4u3tA:
undetectable		 4ptjA-4u3tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9z CYTOCHROME C OXIDASE
SUBUNIT 2

(Bradyrhizobium
diazoefficiens) 		PF00116
(COX2) 		3 ASP A 150
LYS A 136
LEU A 212
 None
 0.94A 4ptjA-4w9zA:
undetectable		 4ptjA-4w9zA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 ASP A 278
LYS A 289
LEU A 257
 None
 0.98A 4ptjA-4xaeA:
undetectable		 4ptjA-4xaeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		3 ASP A 226
LYS A 258
LEU A 338
 None
 0.93A 4ptjA-4ys6A:
undetectable		 4ptjA-4ys6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ASP A  74
LYS A  65
LEU A 135
 None
 1.06A 4ptjA-4z1pA:
undetectable		 4ptjA-4z1pA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ASP A  74
LYS A  65
LEU A 135
 None
 0.98A 4ptjA-4z23A:
undetectable		 4ptjA-4z23A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASP A 107
LYS A 103
LEU A  88
 None
 0.99A 4ptjA-4ztxA:
undetectable		 4ptjA-4ztxA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zys EXOTOXIN 6

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 ASP A  94
LYS A  60
LEU A  82
 None
 1.07A 4ptjA-4zysA:
undetectable		 4ptjA-4zysA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0o ADHIRON

(synthetic
construct) 		PF16845
(SQAPI) 		3 ASP B  48
LYS B  85
LEU B  11
 None
 0.85A 4ptjA-5a0oB:
undetectable		 4ptjA-5a0oB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b39 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 3DL1

(Homo sapiens) 		PF00047
(ig) 		3 ASP G 142
LYS G 136
LEU G 168
 None
 1.03A 4ptjA-5b39G:
undetectable		 4ptjA-5b39G:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 ASP A 312
LYS A 250
LEU A 241
 None
 0.94A 4ptjA-5d4kA:
undetectable		 4ptjA-5d4kA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 ASP A  42
LYS A  87
LEU A 152
 None
None
FAD  A 600 (-4.7A)
 0.97A 4ptjA-5fxeA:
undetectable		 4ptjA-5fxeA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 ASP A 531
LYS A 526
LEU A 254
 None
 1.06A 4ptjA-5g5zA:
undetectable		 4ptjA-5g5zA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		3 ASP A1270
LYS B 357
LEU B 359
 None
 1.08A 4ptjA-5ikfA:
undetectable		 4ptjA-5ikfA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 ASP A 189
LYS A 194
LEU A 131
 None
 0.95A 4ptjA-5ipwA:
undetectable		 4ptjA-5ipwA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 ASP B 445
LYS B 483
LEU B 712
 None
 1.06A 4ptjA-5l9wB:
undetectable		 4ptjA-5l9wB:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 ASP A 570
LYS A 402
LEU A 528
 None
 1.00A 4ptjA-5n4lA:
undetectable		 4ptjA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP W 401
LYS W 599
LEU W 606
 None
 1.04A 4ptjA-5o9gW:
undetectable		 4ptjA-5o9gW:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 ASP A 429
LYS A 375
LEU A 371
 None
 1.07A 4ptjA-5ot4A:
undetectable		 4ptjA-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2x UNCHARACTERIZED
PROTEIN LPG1670

(Legionella
pneumophila) 		no annotation 3 ASP A 238
LYS A 235
LEU A 226
 None
 0.99A 4ptjA-5t2xA:
undetectable		 4ptjA-5t2xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASP D 889
LYS D 893
LEU D 905
 None
 0.91A 4ptjA-5t4yD:
undetectable		 4ptjA-5t4yD:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t51 KLLA0F02343P
KLLA0E05809P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05859
(Mis12)
PF03980
(Nnf1) 		3 ASP B  94
LYS B  89
LEU A  16
 None
 1.05A 4ptjA-5t51B:
undetectable		 4ptjA-5t51B:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF02272
(DHHA1) 		3 ASP A  94
LYS A  88
LEU A 104
 None
 1.03A 4ptjA-5t76A:
undetectable		 4ptjA-5t76A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 3 ASP A 437
LYS A 435
LEU A  69
 None
 1.02A 4ptjA-5verA:
undetectable		 4ptjA-5verA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO
FIBROBLAST GROWTH
FACTOR 23

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 ASP A 426
LYS A 429
LEU B 193
 ZN  A1008 (-2.2A)
None
None
 1.00A 4ptjA-5w21A:
undetectable		 4ptjA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E

(Leishmania
major) 		no annotation 3 ASP A  27
LYS A 166
LEU A  63
 None
 1.02A 4ptjA-5wb5A:
undetectable		 4ptjA-5wb5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		3 ASP A 524
LYS A 458
LEU A 100
 None
 0.95A 4ptjA-5wrrA:
undetectable		 4ptjA-5wrrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		3 ASP A1116
LYS A1083
LEU A 899
 None
 1.06A 4ptjA-5wvrA:
undetectable		 4ptjA-5wvrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 ASP C3587
LYS C4019
LEU C3758
 None
 0.83A 4ptjA-5y3rC:
undetectable		 4ptjA-5y3rC:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 3 ASP A  26
LYS A 120
LEU A 131
 None
OCS  A 119 ( 3.1A)
None
 1.08A 4ptjA-5yhhA:
undetectable		 4ptjA-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 ASP A1713
LYS A1718
LEU A1571
 None
 1.07A 4ptjA-5zalA:
undetectable		 4ptjA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER
RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 ASP A 349
LYS A 354
LEU B 359
 None
 0.89A 4ptjA-5zalA:
undetectable		 4ptjA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT N

(Zea mays) 		no annotation 3 ASP N 124
LYS N  79
LEU N  76
 None
 0.75A 4ptjA-5zjiN:
undetectable		 4ptjA-5zjiN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 3 ASP A 743
LYS A 804
LEU A 998
 None
 1.01A 4ptjA-6cnhA:
undetectable		 4ptjA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A  28
LYS A  33
LEU A  58
 MMV  A 202 (-2.9A)
MMV  A 202 ( 4.6A)
MMV  A 202 (-4.2A)
 0.67A 4ptjA-6cxmA:
21.8		 4ptjA-6cxmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ASP A1971
LYS I 654
LEU I 728
 None
 1.06A 4ptjA-6emkA:
undetectable		 4ptjA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 3 ASP A 314
LYS A 332
LEU A 335
 None
 0.97A 4ptjA-6fi2A:
undetectable		 4ptjA-6fi2A:
undetectable