SIMILAR PATTERNS OF AMINO ACIDS FOR 4PTH_A_FOLA201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cz3 | DIHYDROFOLATEREDUCTASE (Thermotogamaritima) |
PF00186(DHFR_1) | 7 | ALA A 8THR A 47ILE A 51LEU A 55ARG A 58ILE A 100THR A 121 | NoneSO4 A 200 (-3.7A)NoneNoneNoneNoneNone | 0.40A | 4pthA-1cz3A:20.1 | 4pthA-1cz3A:29.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9THR A 56ILE A 60LEU A 67ARG A 70TYR A 121THR A 136 | HBI A 198 (-4.1A)HBI A 198 ( 3.6A)NAP A 191 (-3.5A)NoneNoneNoneNoneHBI A 198 ( 4.5A) | 0.65A | 4pthA-1dr6A:20.9 | 4pthA-1dr6A:33.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1geu | GLUTATHIONEREDUCTASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 135ALA A 9ILE A 285LEU A 272ILE A 298 | None | 1.03A | 4pthA-1geuA:undetectable | 4pthA-1geuA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1g | TRANSCRIPTIONALREGULATOR LRPA (Pyrococcusfuriosus) |
PF01037(AsnC_trans_reg)PF13412(HTH_24) | 5 | ILE A 125ALA A 81THR A 68ILE A 106ILE A 122 | None | 1.04A | 4pthA-1i1gA:undetectable | 4pthA-1i1gA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwa | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Galdieriapartita) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 252ILE A 267LEU A 291ILE A 265TYR A 218 | None | 0.99A | 4pthA-1iwaA:undetectable | 4pthA-1iwaA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME ALPHASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | ALA A 85THR A 151ILE A 138LEU A 112ILE A 116 | None | 1.11A | 4pthA-1j2qA:undetectable | 4pthA-1j2qA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lsh | LIPOVITELLIN (LV-1N,LV-1C) (Ichthyomyzonunicuspis) |
PF01347(Vitellogenin_N)PF09172(DUF1943) | 5 | MET A 291LEU A 46ILE A 815TYR A 281THR A 120 | NoneUPL A2014 ( 4.2A)UPL A2014 ( 4.6A)NoneUPL A2014 ( 3.9A) | 0.97A | 4pthA-1lshA:undetectable | 4pthA-1lshA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1npm | NEUROPSIN (Mus musculus) |
PF00089(Trypsin) | 5 | THR A 235ILE A 238LEU A 53ILE A 231THR A 177 | None | 1.04A | 4pthA-1npmA:undetectable | 4pthA-1npmA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tp7 | GENOME POLYPROTEIN (Rhinovirus A) |
PF00680(RdRP_1) | 5 | ILE A 304ALA A 324ILE A 242LEU A 351ILE A 303 | None | 1.11A | 4pthA-1tp7A:undetectable | 4pthA-1tp7A:16.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9THR A 56ILE A 60LEU A 67ARG A 70TYR A 121THR A 136 | MTX A 187 (-3.8A)NDP A 188 (-3.6A)NDP A 188 (-3.9A)MTX A 187 ( 4.2A)MTX A 187 ( 4.5A)MTX A 187 (-3.1A)NoneMTX A 187 (-4.4A) | 0.56A | 4pthA-1u70A:20.0 | 4pthA-1u70A:33.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9THR A 56ILE A 60LEU A 67ARG A 70TYR A 121THR A 136 | MXA A 187 (-4.5A)MXA A 187 (-3.6A)SO4 A 188 (-3.5A)MXA A 187 ( 4.7A)NoneNoneNoneMXA A 187 (-4.3A) | 0.51A | 4pthA-1u71A:20.7 | 4pthA-1u71A:32.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urj | MAJOR DNA-BINDINGPROTEIN (Humanalphaherpesvirus1) |
PF00747(Viral_DNA_bp) | 5 | ILE A 607THR A 864ILE A 868LEU A 819ILE A 826 | None | 0.89A | 4pthA-1urjA:undetectable | 4pthA-1urjA:8.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 9 | ILE A 5ALA A 7LYS A 32THR A 46ILE A 50LEU A 54ARG A 57ILE A 96THR A 115 | NoneNoneSO4 A3484 (-3.1A)SO4 A3483 (-3.5A)SO4 A3486 ( 4.8A)SO4 A3486 (-4.2A)SO4 A3484 (-3.3A)NoneNone | 0.64A | 4pthA-1zdrA:25.1 | 4pthA-1zdrA:40.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | ILE A 558ALA A 432ILE A 568LEU A 575THR A 469 | None | 1.07A | 4pthA-2b3xA:undetectable | 4pthA-2b3xA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkr | SENTRIN-SPECIFICPROTEASE 8 (Homo sapiens) |
PF02902(Peptidase_C48) | 5 | ILE A 32ILE A 206LEU A 13ILE A 31THR A 171 | None | 1.09A | 4pthA-2bkrA:undetectable | 4pthA-2bkrA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 8 | ILE A 13ALA A 15ILE A 121LEU A 128ARG A 131ILE A 173TYR A 179THR A 194 | CP7 A1240 (-4.1A)CP7 A1240 (-3.7A)MES A1241 ( 4.1A)MES A1241 (-4.5A)MES A1241 (-2.7A)CP7 A1240 ( 3.8A)NoneCP7 A1240 (-4.1A) | 0.71A | 4pthA-2blbA:20.4 | 4pthA-2blbA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzu | FIBER PROTEIN 2 (HumanmastadenovirusF) |
PF00541(Adeno_knob) | 5 | ILE A 267LYS A 365ILE A 244LEU A 284ILE A 269 | None | 0.77A | 4pthA-2bzuA:undetectable | 4pthA-2bzuA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4i | HYPOTHETICAL PROTEINTM0957 (Thermotogamaritima) |
PF10054(DUF2291) | 5 | ALA A 137ILE A 204LEU A 123ILE A 96THR A 138 | NoneMLY A 201 ( 4.6A)NoneNoneNone | 0.97A | 4pthA-2f4iA:undetectable | 4pthA-2f4iA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtr | CHROMODOMAIN Y-LIKEPROTEIN (Homo sapiens) |
PF00378(ECH_1) | 5 | ILE A 7ILE A 104LEU A 42ILE A 18THR A 22 | None | 1.05A | 4pthA-2gtrA:undetectable | 4pthA-2gtrA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ALA A 28THR A 80ILE A 84LEU A 91ARG A 94ILE A 154TYR A 160THR A 178 | NAP A 523 (-3.7A)NAP A 523 (-3.5A)NoneNoneNoneNoneNoneNone | 0.63A | 4pthA-2h2qA:19.7 | 4pthA-2h2qA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lv5 | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF10052(DUF2288) | 5 | ALA A 49TRP A 95ILE A 22LEU A 27ILE A 98 | None | 0.97A | 4pthA-2lv5A:undetectable | 4pthA-2lv5A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ALA A 11THR A 58ILE A 62LEU A 67ARG A 70TYR A 119THR A 134 | MTX A 605 ( 3.6A)NDP A 606 ( 3.5A)MTX A 605 ( 4.6A)MTX A 605 ( 4.4A)MTX A 605 ( 3.1A)NoneMTX A 605 ( 4.2A) | 0.59A | 4pthA-2oipA:21.4 | 4pthA-2oipA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 5 | ILE A 38THR A 81ARG A 69TYR A 199THR A 214 | EDO A 278 (-4.7A)EDO A 284 ( 3.5A)EDO A 275 (-2.8A)EDO A 280 (-4.3A)None | 1.05A | 4pthA-2p4gA:15.5 | 4pthA-2p4gA:21.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 7 | ALA A 8LYS A 33ILE A 51LEU A 55ARG A 58TYR A 102THR A 115 | MTX A 200 ( 3.4A)MTX A 200 ( 4.1A)MTX A 200 ( 4.2A)MTX A 200 ( 4.1A)MTX A 200 ( 2.8A)NoneMTX A 200 ( 4.4A) | 0.67A | 4pthA-2qk8A:25.4 | 4pthA-2qk8A:40.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfo | NUCLEOPORIN NIC96 (Saccharomycescerevisiae) |
PF04097(Nic96) | 5 | ILE A 723ILE A 767LEU A 716ILE A 720THR A 778 | None | 1.09A | 4pthA-2rfoA:undetectable | 4pthA-2rfoA:13.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 7 | ALA A 11THR A 50LEU A 61ARG A 64ILE A 102TYR A 108THR A 121 | VG9 A1168 ( 3.8A)NDP A1169 (-3.4A)VG9 A1168 ( 4.4A)VG9 A1168 ( 3.7A)VG9 A1168 ( 4.2A)NoneVG9 A1168 ( 4.7A) | 0.48A | 4pthA-2w3wA:24.8 | 4pthA-2w3wA:34.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 9 | ILE A 5ALA A 7LYS A 32THR A 46ILE A 50LEU A 54ARG A 57TYR A 98THR A 111 | TOP A1160 (-4.2A)TOP A1160 ( 3.6A)NoneNDP A1159 (-3.3A)TOP A1160 (-4.4A)NoneNoneNoneTOP A1160 ( 4.5A) | 0.56A | 4pthA-2w9sA:25.8 | 4pthA-2w9sA:38.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x24 | ACETYL-COACARBOXYLASE (Bos taurus) |
PF01039(Carboxyl_trans) | 5 | ILE A 147ILE A 253LEU A 335ARG A 111ILE A 113 | None | 1.07A | 4pthA-2x24A:undetectable | 4pthA-2x24A:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ada | SARCOSINE OXIDASEBETA SUBUNIT (Corynebacteriumsp. U-96) |
PF01266(DAO) | 5 | ILE B 338THR B 331ILE B 242LEU B 240ILE B 337 | None | 1.08A | 4pthA-3adaB:undetectable | 4pthA-3adaB:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au9 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | ILE A 228THR A 190ILE A 194LEU A 219ILE A 227 | None | 1.01A | 4pthA-3au9A:undetectable | 4pthA-3au9A:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3k | ALANINE RACEMASE (Actinobacillussuccinogenes) |
PF13377(Peripla_BP_3) | 5 | ILE A 130LYS A 172ILE A 210LEU A 203ILE A 188 | None | 1.06A | 4pthA-3c3kA:2.6 | 4pthA-3c3kA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 5 | ILE A 101THR A 91ILE A 90LEU A 337ARG A 332 | None | 1.00A | 4pthA-3c9fA:undetectable | 4pthA-3c9fA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfh | MANDELATE RACEMASE (VibrionalesbacteriumSWAT-3) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 66THR A 290ILE A 289LEU A 111THR A 6 | None | 1.02A | 4pthA-3dfhA:undetectable | 4pthA-3dfhA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfh | MANDELATE RACEMASE (VibrionalesbacteriumSWAT-3) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 276ILE A 286LEU A 295ILE A 279THR A 241 | None | 1.00A | 4pthA-3dfhA:undetectable | 4pthA-3dfhA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 5 | ALA A 6THR A 45LEU A 54ARG A 57THR A 116 | MTX A 164 (-3.8A)NDP A 163 (-3.4A)MTX A 164 ( 4.4A)MTX A 164 ( 2.9A)MTX A 164 ( 4.3A) | 0.55A | 4pthA-3dfrA:24.2 | 4pthA-3dfrA:29.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 7 | ILE A 14ALA A 16ILE A 112LEU A 119ARG A 122TYR A 170THR A 185 | RJ6 A 609 (-4.5A)RJ6 A 609 (-3.7A)RJ6 A 609 (-4.8A)RJ6 A 609 (-4.4A)NoneNDP A 610 ( 4.9A)RJ6 A 609 ( 4.5A) | 0.61A | 4pthA-3dg8A:20.5 | 4pthA-3dg8A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3foa | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N) | 5 | ILE A 474ALA A 472LEU A 505ILE A 499TYR A 74 | None | 1.09A | 4pthA-3foaA:undetectable | 4pthA-3foaA:14.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 8 | ALA X 7LYS X 32THR X 46ILE X 50LEU X 54ARG X 57TYR X 98THR X 111 | N22 X 219 ( 3.6A)NoneNDP X 207 (-3.2A)N22 X 219 (-4.6A)NoneNoneNoneN22 X 219 (-4.4A) | 0.72A | 4pthA-3i8aX:26.0 | 4pthA-3i8aX:37.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 10 | ILE A 6ALA A 8MET A 21LYS A 33THR A 47ILE A 51ARG A 58ILE A 96TYR A 102THR A 115 | MTX A 164 (-4.0A)MTX A 164 ( 3.7A)MTX A 164 (-3.3A)MTX A 164 (-3.2A)NDP A 163 (-3.4A)MTX A 164 (-4.1A)MTX A 164 (-2.9A)MTX A 164 ( 4.2A)NoneMTX A 164 (-4.3A) | 0.44A | 4pthA-3ia4A:28.3 | 4pthA-3ia4A:55.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 10 | ILE A 6ALA A 8MET A 21THR A 47ILE A 51LEU A 55ARG A 58ILE A 96TYR A 102THR A 115 | MTX A 164 (-4.0A)MTX A 164 ( 3.7A)MTX A 164 (-3.3A)NDP A 163 (-3.4A)MTX A 164 (-4.1A)MTX A 164 ( 4.4A)MTX A 164 (-2.9A)MTX A 164 ( 4.2A)NoneMTX A 164 (-4.3A) | 0.44A | 4pthA-3ia4A:28.3 | 4pthA-3ia4A:55.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix9 | DIHYDROFOLATEREDUCTASE (Streptococcuspneumoniae) |
PF00186(DHFR_1) | 7 | ILE A 8ALA A 10LYS A 35THR A 49LEU A 58ARG A 61THR A 119 | MTX A 200 (-4.1A)MTX A 200 (-3.8A)MTX A 200 (-4.1A)NDP A 193 (-3.4A)MTX A 200 ( 4.0A)MTX A 200 (-2.9A)MTX A 200 ( 4.5A) | 0.66A | 4pthA-3ix9A:25.3 | 4pthA-3ix9A:35.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2n | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N)PF17482(Phage_sheath_1C) | 5 | ILE U 474ALA U 472LEU U 505ILE U 499TYR U 74 | None | 1.09A | 4pthA-3j2nU:undetectable | 4pthA-3j2nU:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf8 | PROTEIN STN1 (Candidatropicalis) |
PF10451(Stn1) | 5 | ILE A 154THR A 46ILE A 47LEU A 49ILE A 85 | None | 1.07A | 4pthA-3kf8A:undetectable | 4pthA-3kf8A:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ALA A 16THR A 69ILE A 73LEU A 80ARG A 83TYR A 129THR A 144 | NAP A 512 (-3.7A)NAP A 512 (-3.6A)NoneNoneNoneNoneNone | 0.71A | 4pthA-3kjrA:20.9 | 4pthA-3kjrA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lx6 | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Shigellaflexneri) |
PF00145(DNA_methylase) | 6 | ILE A 213THR A 145ILE A 141LEU A 92ILE A 212THR A 244 | None | 1.20A | 4pthA-3lx6A:undetectable | 4pthA-3lx6A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3me5 | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Shigellaflexneri) |
PF00145(DNA_methylase) | 6 | ILE A 213THR A 145ILE A 141LEU A 92ILE A 212THR A 244 | None | 1.20A | 4pthA-3me5A:undetectable | 4pthA-3me5A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyi | FAT ACID-BINDINGPROTEIN (Eubacteriumventriosum) |
PF02645(DegV) | 5 | ILE A 287ALA A 129ILE A 119LEU A 152THR A 265 | None | 1.03A | 4pthA-3nyiA:undetectable | 4pthA-3nyiA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogj | PRKG1 PROTEIN (Homo sapiens) |
PF00027(cNMP_binding) | 5 | ILE A 146ALA A 194LEU A 204ILE A 145THR A 193 | CMP A 250 ( 4.2A)CMP A 250 (-3.6A)NoneNoneCMP A 250 (-2.9A) | 1.10A | 4pthA-3ogjA:undetectable | 4pthA-3ogjA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 5 | ALA A 48ILE A 247LEU A 258ILE A 262TYR A 131 | None | 1.09A | 4pthA-3ppoA:undetectable | 4pthA-3ppoA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfs | NADPH--CYTOCHROMEP450 REDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | ILE A 532ILE A 665LEU A 668ARG A 673ILE A 629 | None | 1.10A | 4pthA-3qfsA:2.8 | 4pthA-3qfsA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 7 | ALA A 34THR A 86LEU A 97ARG A 100ILE A 160TYR A 166THR A 184 | WRA A 602 (-3.9A)NDP A 601 ( 3.2A)NoneNoneWRA A 602 ( 3.9A)NoneWRA A 602 (-4.2A) | 0.32A | 4pthA-3rg9A:19.8 | 4pthA-3rg9A:27.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s47 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Clostridiumbeijerinckii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 66THR A 290ILE A 289LEU A 111THR A 6 | None | 0.95A | 4pthA-3s47A:undetectable | 4pthA-3s47A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thw | DNA MISMATCH REPAIRPROTEIN MSH3 (Homo sapiens) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05192(MutS_III) | 5 | ILE B 381THR B 427ILE B 431LEU B 417ILE B 362 | None | 1.03A | 4pthA-3thwB:undetectable | 4pthA-3thwB:10.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 5 | ALA A 7THR A 47ILE A 51LEU A 55ARG A 58 | NDP A1001 ( 4.1A)NDP A1001 (-3.1A)MTX A2001 (-4.3A)MTX A2001 ( 4.5A)MTX A2001 (-2.8A) | 0.96A | 4pthA-3tq9A:25.7 | 4pthA-3tq9A:43.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 9 | ILE A 6ALA A 8LYS A 33THR A 47ILE A 51LEU A 55ARG A 58ILE A 96THR A 115 | MTX A2001 (-4.0A)MTX A2001 ( 3.4A)NoneNDP A1001 (-3.1A)MTX A2001 (-4.3A)MTX A2001 ( 4.5A)MTX A2001 (-2.8A)MTX A2001 ( 4.2A)MTX A2001 (-4.3A) | 0.24A | 4pthA-3tq9A:25.7 | 4pthA-3tq9A:43.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 5 | ILE A 94LYS A 33ILE A 51LEU A 55ILE A 41 | NoneNoneMTX A2001 (-4.3A)MTX A2001 ( 4.5A)None | 1.09A | 4pthA-3tq9A:25.7 | 4pthA-3tq9A:43.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 6 | ILE A 94LYS A 33THR A 47ILE A 51LEU A 55ILE A 96 | NoneNoneNDP A1001 (-3.1A)MTX A2001 (-4.3A)MTX A2001 ( 4.5A)MTX A2001 ( 4.2A) | 1.36A | 4pthA-3tq9A:25.7 | 4pthA-3tq9A:43.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ILE A 14THR A 108LEU A 119ARG A 122ILE A 164TYR A 170THR A 185 | 1CY A 609 (-4.3A)NDP A 610 ( 3.4A)NoneNone1CY A 609 ( 4.0A)None1CY A 609 (-4.3A) | 0.39A | 4pthA-3um6A:20.4 | 4pthA-3um6A:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | THR A 108ILE A 112LEU A 119ARG A 122ILE A 164THR A 185 | NDP A 610 ( 3.4A)1CY A 609 (-4.4A)NoneNone1CY A 609 ( 4.0A)1CY A 609 (-4.3A) | 0.79A | 4pthA-3um6A:20.4 | 4pthA-3um6A:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwc | NUCLEOTIDE-SUGARAMINOTRANSFERASE (Coxiellaburnetii) |
PF01041(DegT_DnrJ_EryC1) | 5 | ILE A 152LYS A 143THR A 123ILE A 119ILE A 126 | None | 1.04A | 4pthA-3uwcA:undetectable | 4pthA-3uwcA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 6 | ALA A 8LYS A 33THR A 53ILE A 111TYR A 117THR A 133 | NoneNoneSO4 A 201 (-3.7A)NoneNoneNone | 0.84A | 4pthA-3vcoA:18.4 | 4pthA-3vcoA:29.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 8 | ALA A 8THR A 53ILE A 57LEU A 64ARG A 67ILE A 111TYR A 117THR A 133 | NoneSO4 A 201 (-3.7A)NoneNoneNoneNoneNoneNone | 0.70A | 4pthA-3vcoA:18.4 | 4pthA-3vcoA:29.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxy | SUBTILISIN-LIKEPROTEIN (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | ALA A 150THR A 124LEU A 133TYR A 190THR A 221 | None | 1.07A | 4pthA-3zxyA:undetectable | 4pthA-3zxyA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyp | CIP1 (Trichodermareesei) |
no annotation | 5 | ILE A 87THR A 153ILE A 151LEU A 145THR A 85 | NoneNoneNoneNonePEG A1224 (-3.2A) | 1.09A | 4pthA-3zypA:undetectable | 4pthA-3zypA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bru | ATP-DEPENDENT RNAHELICASE DHH1 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ILE A 356ALA A 286ILE A 413ILE A 384THR A 336 | None | 0.89A | 4pthA-4bruA:undetectable | 4pthA-4bruA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 5 | ALA A 610THR A 423ILE A 425LEU A 593ILE A 607 | None | 1.07A | 4pthA-4btpA:undetectable | 4pthA-4btpA:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c23 | L-FUCULOSE KINASEFUCK (Streptococcuspneumoniae) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ILE A 298THR A 333ILE A 331LEU A 348ILE A 297 | None | 0.86A | 4pthA-4c23A:undetectable | 4pthA-4c23A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g3h | ARGINASE (ROCF) (Helicobacterpylori) |
PF00491(Arginase) | 5 | ILE A 305THR A 41ILE A 42LEU A 28ILE A 306 | None | 1.04A | 4pthA-4g3hA:undetectable | 4pthA-4g3hA:19.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 9 | ILE X 10ALA X 12THR X 61ILE X 65LEU X 72ARG X 75ILE X 123TYR X 129THR X 144 | TOP X 301 (-4.2A)NDP X 302 ( 3.8A)NDP X 302 (-3.4A)TOP X 301 ( 4.3A)NoneNoneTOP X 301 ( 4.0A)NoneTOP X 301 (-4.5A) | 0.52A | 4pthA-4g8zX:20.3 | 4pthA-4g8zX:30.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6w | N-TERMINALCYANOBACTIN PROTEASE (Planktothrixagardhii) |
PF00082(Peptidase_S8) | 5 | ALA A 153THR A 127LEU A 136TYR A 193THR A 224 | None | 1.10A | 4pthA-4h6wA:undetectable | 4pthA-4h6wA:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 11 | ILE A 9ALA A 11MET A 25LYS A 37THR A 58ILE A 62LEU A 69ARG A 72ILE A 112TYR A 118THR A 133 | 14Q A 202 (-4.3A)14Q A 202 ( 3.7A)NDP A 201 (-3.9A)NoneNDP A 201 (-3.7A)14Q A 202 ( 4.8A)NoneNone14Q A 202 ( 4.2A)None14Q A 202 ( 4.6A) | 0.89A | 4pthA-4h96A:17.9 | 4pthA-4h96A:32.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 9 | ILE A 9ALA A 11THR A 58ILE A 62LEU A 69ARG A 72ILE A 121TYR A 127THR A 140 | 14Q A 302 (-4.1A)14Q A 302 ( 3.4A)NDP A 301 (-3.5A)14Q A 302 (-4.2A)NoneNone14Q A 302 ( 4.0A)None14Q A 302 (-4.2A) | 0.45A | 4pthA-4h98A:19.1 | 4pthA-4h98A:27.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnl | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Enterococcusgallinarum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 64THR A 288ILE A 287LEU A 109THR A 4 | None | 0.95A | 4pthA-4hnlA:undetectable | 4pthA-4hnlA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfe | GERANYLGERANYLDIPHOSPHATE SYNTHASE (Streptococcusuberis) |
PF00348(polyprenyl_synt) | 5 | ILE A 204ALA A 208ILE A 278LEU A 264ILE A 201 | None | 1.05A | 4pthA-4lfeA:undetectable | 4pthA-4lfeA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 237ALA A 88ILE A 146ILE A 236THR A 8 | None | 1.04A | 4pthA-4ls5A:undetectable | 4pthA-4ls5A:17.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 8 | ILE A 5ALA A 7THR A 46LEU A 57ARG A 60ILE A 94TYR A 100THR A 113 | TMQ A 202 (-4.0A)TMQ A 202 ( 3.5A)NDP A 201 (-3.4A)NoneNoneTMQ A 202 ( 3.8A)NoneTMQ A 202 (-4.2A) | 0.26A | 4pthA-4m2xA:23.5 | 4pthA-4m2xA:35.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7THR A 46LEU A 55ARG A 58THR A 116 | RAR A 200 (-4.0A)RAR A 200 ( 3.6A)NAP A 201 (-3.0A)RAR A 200 (-4.2A)RAR A 200 ( 3.2A)RAR A 200 (-4.4A) | 0.75A | 4pthA-4m7vA:11.8 | 4pthA-4m7vA:37.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mr0 | PLASMIN ANDFIBRONECTIN-BINDINGPROTEIN A (Streptococcuspneumoniae) |
PF12708(Pectate_lyase_3)PF13229(Beta_helix) | 5 | ILE A 306ALA A 281THR A 232ILE A 250ILE A 284 | None | 1.11A | 4pthA-4mr0A:undetectable | 4pthA-4mr0A:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 121ALA A 198ILE A 367ILE A 123THR A 119 | None | 1.05A | 4pthA-4na3A:undetectable | 4pthA-4na3A:13.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nx8 | PROTEIN-TYROSINEPHOSPHATASE 2 (Bdellovibriobacteriovorus) |
PF14566(PTPlike_phytase) | 5 | ILE A 156THR A 151ILE A 148LEU A 48ILE A 108 | NoneGOL A 302 (-3.9A)NoneNoneNone | 1.05A | 4pthA-4nx8A:undetectable | 4pthA-4nx8A:19.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 6 | ALA A 6TRP A 30LYS A 32THR A 46ILE A 50ARG A 57 | NAP A 202 ( 4.2A)NoneMTX A 201 ( 3.9A)NAP A 202 (-3.2A)MTX A 201 (-4.7A)MTX A 201 (-3.0A) | 1.47A | 4pthA-4p68A:30.0 | 4pthA-4p68A:98.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 11 | ILE A 5ALA A 7MET A 20TRP A 30LYS A 32THR A 46ILE A 50ARG A 57ILE A 94TYR A 100THR A 113 | MTX A 201 (-4.1A)MTX A 201 ( 4.0A)MTX A 201 ( 3.6A)NoneMTX A 201 ( 3.9A)NAP A 202 (-3.2A)MTX A 201 (-4.7A)MTX A 201 (-3.0A)MTX A 201 ( 4.3A)NoneMTX A 201 ( 4.5A) | 0.50A | 4pthA-4p68A:30.0 | 4pthA-4p68A:98.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | ALA A 221THR A 8ILE A 9LEU A 236THR A 218 | None | 1.01A | 4pthA-4twiA:undetectable | 4pthA-4twiA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj0 | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pyrococcushorikoshii) |
PF01867(Cas_Cas1) | 5 | ILE A 61ILE A 48LEU A 14ILE A 56THR A 199 | None | 1.01A | 4pthA-4wj0A:undetectable | 4pthA-4wj0A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y67 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE,APICOPLAST (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | ILE A 228THR A 190ILE A 194LEU A 219ILE A 227 | None | 0.97A | 4pthA-4y67A:2.2 | 4pthA-4y67A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b71 | COMPLEMENT C5 BETACHAIN (Homo sapiens) |
no annotation | 5 | ILE E 87ALA E 35ILE E 39LEU E 104ILE E 56 | None | 1.06A | 4pthA-5b71E:undetectable | 4pthA-5b71E:16.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 6 | ALA A 6TRP A 47THR A 63ILE A 67LEU A 71ARG A 74 | NAP A 201 (-3.7A)NoneNAP A 201 (-3.7A)PEG A 202 ( 4.9A)NoneNone | 1.42A | 4pthA-5dxvA:17.1 | 4pthA-5dxvA:69.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 10 | ILE A 5ALA A 7TRP A 47THR A 63ILE A 67LEU A 71ARG A 74ILE A 111TYR A 117THR A 130 | NoneNAP A 201 (-3.7A)NoneNAP A 201 (-3.7A)PEG A 202 ( 4.9A)NoneNoneNoneNoneCME A 140 ( 4.5A) | 0.42A | 4pthA-5dxvA:17.1 | 4pthA-5dxvA:69.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eve | PROFILIN (Ambrosiaartemisiifolia) |
PF00235(Profilin) | 5 | ILE A 107ALA A 26ILE A 85LEU A 67ILE A 94 | None | 1.05A | 4pthA-5eveA:undetectable | 4pthA-5eveA:20.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fda | DIHYDROFOLATEREDUCTASE (Yersinia pestis) |
PF00186(DHFR_1) | 7 | ILE A 6ALA A 8THR A 47ILE A 51LEU A 55TYR A 101THR A 114 | None | 0.57A | 4pthA-5fdaA:19.9 | 4pthA-5fdaA:80.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fef | PROFILIN-5 (Zea mays) |
PF00235(Profilin) | 5 | ILE A 105ALA A 24ILE A 83LEU A 65ILE A 92 | NoneNoneGOL A 201 ( 4.9A)NoneNone | 1.02A | 4pthA-5fefA:undetectable | 4pthA-5fefA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kc8 | GLUTAMATE RECEPTORIONOTROPIC, DELTA-2 (Homo sapiens) |
PF01094(ANF_receptor) | 5 | ILE A 259ALA A 230ILE A 181LEU A 152ILE A 156 | None | 1.07A | 4pthA-5kc8A:undetectable | 4pthA-5kc8A:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5no8 | BACCELL_00875 (Bacteroidescellulosilyticus) |
no annotation | 5 | ILE A 217THR A 165LEU A 220ILE A 218THR A 58 | None | 1.07A | 4pthA-5no8A:undetectable | 4pthA-5no8A:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nzb | PROFILIN-2 (Betula pendula) |
no annotation | 5 | ILE A 107ALA A 26ILE A 85LEU A 67ILE A 94 | None | 1.05A | 4pthA-5nzbA:undetectable | 4pthA-5nzbA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | ALA A 10THR A 83LEU A 94ARG A 97TYR A 157THR A 172 | 73X A 704 (-4.0A)NDP A 702 (-3.2A)NoneNoneNone73X A 704 (-4.2A) | 0.29A | 4pthA-5t0lA:21.3 | 4pthA-5t0lA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5win | - (-) |
no annotation | 5 | MET A 661TRP A 718ILE A 670LEU A 730THR A 742 | None | 1.02A | 4pthA-5winA:undetectable | 4pthA-5winA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9w | POLLEN RECEPTOR-LIKEKINASE 6 (Arabidopsisthaliana) |
no annotation | 5 | ILE B 160MET B 191ILE B 212LEU B 222ILE B 184 | None | 1.10A | 4pthA-5y9wB:undetectable | 4pthA-5y9wB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 9 | ILE A 6ALA A 8LYS A 33THR A 47LEU A 58ARG A 61ILE A 92TYR A 98THR A 111 | MMV A 202 (-4.0A)NAP A 201 (-3.9A)MMV A 202 ( 4.6A)NAP A 201 (-3.3A)MMV A 202 (-4.2A)MMV A 202 (-2.8A)MMV A 202 ( 4.2A)NoneMMV A 202 (-4.4A) | 0.53A | 4pthA-6cxmA:21.8 | 4pthA-6cxmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 6 | ALA A 7THR A 46ILE A 50LEU A 54ARG A 57THR A 111 | MMV A 202 ( 3.5A)NAP A 201 ( 3.3A)MMV A 202 ( 4.9A)NoneNoneMMV A 202 (-4.3A) | 0.45A | 4pthA-6e4eA:25.9 | 4pthA-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ft1 | FLAVODOXIN (Bacillus cereus) |
no annotation | 5 | ILE A 38ALA A 57ILE A 53LEU A 47ILE A 7 | None | 0.91A | 4pthA-6ft1A:2.2 | 4pthA-6ft1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea9 | CYCLOMALTODEXTRINASE (Bacillus sp.(in: Bacteria)) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 3 | ASP C 482LEU C 483PHE C 486 | None | 0.74A | 4pthA-1ea9C:undetectable | 4pthA-1ea9C:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eqk | ORYZACYSTATIN-I (Oryza sativa) |
PF16845(SQAPI) | 3 | ASP A 25LEU A 26PHE A 29 | None | 0.55A | 4pthA-1eqkA:undetectable | 4pthA-1eqkA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ewk | METABOTROPICGLUTAMATE RECEPTORSUBTYPE 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 3 | ASP A 351LEU A 355PHE A 354 | None | 0.73A | 4pthA-1ewkA:3.2 | 4pthA-1ewkA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezr | NUCLEOSIDE HYDROLASE (Leishmaniamajor) |
PF01156(IU_nuc_hydro) | 3 | ASP A 295LEU A 294PHE A 296 | None | 0.74A | 4pthA-1ezrA:0.2 | 4pthA-1ezrA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f7u | ARGINYL-TRNASYNTHETASE (Saccharomycescerevisiae) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 3 | ASP A 419LEU A 418PHE A 158 | None | 0.53A | 4pthA-1f7uA:0.0 | 4pthA-1f7uA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ith | HEMOGLOBIN (CYANOMET) (Urechis caupo) |
PF00042(Globin) | 3 | ASP A 12LEU A 16PHE A 15 | None | 0.75A | 4pthA-1ithA:undetectable | 4pthA-1ithA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1juv | DIHYDROFOLATEREDUCTASE (Escherichiavirus T4) |
PF00186(DHFR_1) | 3 | ASP A 36LEU A 37PHE A 40 | None | 0.45A | 4pthA-1juvA:18.0 | 4pthA-1juvA:27.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llp | LIGNIN PEROXIDASE (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ASP A 22LEU A 21PHE A 18 | None | 0.52A | 4pthA-1llpA:0.0 | 4pthA-1llpA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 3 | ASP A 253LEU A 254PHE A 255 | None | 0.65A | 4pthA-1lrwA:undetectable | 4pthA-1lrwA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhy | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 3 | ASP B 188LEU B 187PHE B 184 | None | 0.44A | 4pthA-1mhyB:undetectable | 4pthA-1mhyB:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfd | H57 FABH57 FAB (Mus musculus;Mus musculus) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 3 | ASP F 101LEU E 46PHE F 100 | None | 0.66A | 4pthA-1nfdF:undetectable | 4pthA-1nfdF:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 3 | ASP A 426LEU A 429PHE A 425 | None | 0.75A | 4pthA-1pcgA:undetectable | 4pthA-1pcgA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfw | ANTIBODY (ANTI ALPHASUBUNIT) (HEAVYCHAIN)ANTIBODY (ANTI ALPHASUBUNIT) (LIGHTCHAIN) (Mus musculus;Mus musculus) |
PF07686(V-set)PF07686(V-set) | 3 | ASP H 105LEU L 50PHE H 104 | None | 0.71A | 4pthA-1qfwH:undetectable | 4pthA-1qfwH:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpa | LIGNIN PEROXIDASE (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ASP A 22LEU A 21PHE A 18 | None | 0.39A | 4pthA-1qpaA:undetectable | 4pthA-1qpaA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qsd | PROTEIN(BETA-TUBULINBINDINGPOST-CHAPERONINCOFACTOR) (Saccharomycescerevisiae) |
PF02970(TBCA) | 3 | ASP A 75LEU A 76PHE A 79 | None | 0.63A | 4pthA-1qsdA:undetectable | 4pthA-1qsdA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkp | IRON-RICHDPSA-HOMOLOG PROTEIN (Halobacteriumsalinarum) |
PF00210(Ferritin) | 3 | ASP A 62LEU A 63PHE A 66 | None | 0.18A | 4pthA-1tkpA:undetectable | 4pthA-1tkpA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v93 | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (Thermusthermophilus) |
PF02219(MTHFR) | 3 | ASP A 162LEU A 163PHE A 166 | FAD A 300 ( 4.9A)DIO A 304 ( 4.5A)None | 0.54A | 4pthA-1v93A:undetectable | 4pthA-1v93A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1b | CRTF-RELATED PROTEIN (Chlorobaculumtepidum) |
PF00891(Methyltransf_2) | 3 | ASP A 114LEU A 111PHE A 115 | None | 0.63A | 4pthA-1x1bA:undetectable | 4pthA-1x1bA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yln | HYPOTHETICAL PROTEINVCA0042 (Vibrio cholerae) |
PF07238(PilZ)PF12945(YcgR_2) | 3 | ASP A 162LEU A 163PHE A 141 | None | 0.74A | 4pthA-1ylnA:undetectable | 4pthA-1ylnA:18.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 3 | ASP A 27LEU A 28PHE A 31 | NoneSO4 A3486 ( 4.8A)SO4 A3486 (-4.1A) | 0.41A | 4pthA-1zdrA:25.1 | 4pthA-1zdrA:40.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btv | PROTEIN (VP7 COREPROTEIN) (Bluetonguevirus) |
no annotation | 3 | ASP P 67LEU P 66PHE P 63 | None | 0.34A | 4pthA-2btvP:undetectable | 4pthA-2btvP:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d81 | PHB DEPOLYMERASE (Talaromycesfuniculosus) |
PF10503(Esterase_phd) | 3 | ASP A 140LEU A 108PHE A 139 | None | 0.73A | 4pthA-2d81A:undetectable | 4pthA-2d81A:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dla | 397AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF04104(DNA_primase_lrg) | 3 | ASP A 62LEU A 63PHE A 66 | None | 0.55A | 4pthA-2dlaA:undetectable | 4pthA-2dlaA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqh | HYPOTHETICAL PROTEINTA0938 (Thermoplasmaacidophilum) |
PF11494(Ta0938) | 3 | ASP A 38LEU A 39PHE A 40 | None | 0.58A | 4pthA-2fqhA:undetectable | 4pthA-2fqhA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jpo | PHEROMONE-BINDINGPROTEIN (Antheraeapolyphemus) |
PF01395(PBP_GOBP) | 3 | ASP A 32LEU A 33PHE A 36 | None | 0.53A | 4pthA-2jpoA:undetectable | 4pthA-2jpoA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jqq | CONSERVED OLIGOMERICGOLGI COMPLEXSUBUNIT 2 (Saccharomycescerevisiae) |
no annotation | 3 | ASP A 113LEU A 114PHE A 117 | None | 0.74A | 4pthA-2jqqA:undetectable | 4pthA-2jqqA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lgd | UBIQUITIN-LIKEDOMAIN-CONTAININGCTD PHOSPHATASE 1 (Homo sapiens) |
PF00240(ubiquitin) | 3 | ASP A 27LEU A 28PHE A 31 | None | 0.60A | 4pthA-2lgdA:undetectable | 4pthA-2lgdA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m5w | LUPUS LA PROTEIN (Dictyosteliumdiscoideum) |
PF05383(La) | 3 | ASP A 25LEU A 28PHE A 27 | None | 0.62A | 4pthA-2m5wA:undetectable | 4pthA-2m5wA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mas | INOSINE-URIDINENUCLEOSIDEN-RIBOHYDROLASE (Crithidiafasciculata) |
PF01156(IU_nuc_hydro) | 3 | ASP A 296LEU A 295PHE A 297 | None | 0.68A | 4pthA-2masA:undetectable | 4pthA-2masA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2myi | EXODEOXYRIBONUCLEASEIII (Pseudomonas sp.Lz4W) |
PF03372(Exo_endo_phos) | 3 | ASP A 128LEU A 125PHE A 129 | None | 0.71A | 4pthA-2myiA:undetectable | 4pthA-2myiA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyu | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 (Homo sapiens) |
PF01728(FtsJ) | 3 | ASP A 116LEU A 115PHE A 112 | None | 0.47A | 4pthA-2nyuA:2.4 | 4pthA-2nyuA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 3 | ASP A 32LEU A 33PHE A 36 | MTX A 605 ( 3.0A)MTX A 605 ( 4.0A)MTX A 605 ( 4.1A) | 0.11A | 4pthA-2oipA:21.4 | 4pthA-2oipA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q6t | DNAB REPLICATIONFORK HELICASE (Thermusaquaticus) |
PF00772(DnaB)PF03796(DnaB_C) | 3 | ASP A 191LEU A 190PHE A 187 | None | 0.48A | 4pthA-2q6tA:1.5 | 4pthA-2q6tA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qco | CMER (Campylobacterjejuni) |
PF00440(TetR_N) | 3 | ASP A 66LEU A 65PHE A 62 | None | 0.75A | 4pthA-2qcoA:undetectable | 4pthA-2qcoA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqh | COMPLEMENT COMPONENTC8 ALPHA CHAIN (Homo sapiens) |
PF01823(MACPF) | 3 | ASP A 242LEU A 246PHE A 245 | None | 0.74A | 4pthA-2qqhA:undetectable | 4pthA-2qqhA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 3 | ASP A 483LEU A 484PHE A 487 | None | 0.63A | 4pthA-2vwbA:undetectable | 4pthA-2vwbA:16.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 3 | ASP A 31LEU A 32PHE A 35 | VG9 A1168 (-3.0A)VG9 A1168 (-4.7A)VG9 A1168 (-3.9A) | 0.26A | 4pthA-2w3wA:24.8 | 4pthA-2w3wA:34.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8s | PHOSPHONATEMONOESTER HYDROLASE (Paraburkholderiacaryophylli) |
PF00884(Sulfatase)PF16347(DUF4976) | 3 | ASP A 309LEU A 308PHE A 305 | None | 0.71A | 4pthA-2w8sA:undetectable | 4pthA-2w8sA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xay | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT BETA (unidentified) |
no annotation | 3 | ASP D 369LEU D 370PHE D 373 | None | 0.67A | 4pthA-2xayD:undetectable | 4pthA-2xayD:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbm | PROTEIN-TYROSINE-PHOSPHATASE (Shewanella sp.) |
PF00149(Metallophos) | 3 | ASP A 243LEU A 244PHE A 247 | None | 0.65A | 4pthA-2zbmA:undetectable | 4pthA-2zbmA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyi | LIPASE, PUTATIVE (Archaeoglobusfulgidus) |
PF00561(Abhydrolase_1) | 3 | ASP A 115LEU A 114PHE A 111 | None | 0.33A | 4pthA-2zyiA:undetectable | 4pthA-2zyiA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aje | PUTATIVEUNCHARACTERIZEDPROTEIN ST1526 (Sulfurisphaeratokodaii) |
PF01300(Sua5_yciO_yrdC)PF03481(SUA5) | 3 | ASP A 306LEU A 305PHE A 302 | None | 0.66A | 4pthA-3ajeA:3.6 | 4pthA-3ajeA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgw | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF00772(DnaB)PF03796(DnaB_C) | 3 | ASP A 186LEU A 185PHE A 182 | None | 0.53A | 4pthA-3bgwA:undetectable | 4pthA-3bgwA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bh0 | DNAB-LIKEREPLICATIVE HELICASE (Bacillus phageSPP1) |
PF03796(DnaB_C) | 3 | ASP A 186LEU A 185PHE A 182 | None | 0.43A | 4pthA-3bh0A:undetectable | 4pthA-3bh0A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bks | STEROL CARRIERPROTEIN-2 LIKE-3 (Aedes aegypti) |
PF02036(SCP2) | 3 | ASP A 114LEU A 113PHE A 110 | None | 0.59A | 4pthA-3bksA:undetectable | 4pthA-3bksA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7v | BETA-LACTAMASEINHIBITORY PROTEIN (Streptomycesclavuligerus) |
PF07467(BLIP) | 3 | ASP B 133LEU B 83PHE B 132 | None | 0.65A | 4pthA-3c7vB:undetectable | 4pthA-3c7vB:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3db2 | PUTATIVENADPH-DEPENDENTOXIDOREDUCTASE (Desulfitobacteriumhafniense) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | ASP A 256LEU A 255PHE A 257 | None | 0.69A | 4pthA-3db2A:2.1 | 4pthA-3db2A:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 3 | ASP A 26LEU A 27PHE A 30 | MTX A 164 ( 2.9A)MTX A 164 ( 4.5A)MTX A 164 ( 4.0A) | 0.18A | 4pthA-3dfrA:24.2 | 4pthA-3dfrA:29.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7d | COBH, PRECORRIN-8XMETHYLMUTASE (Brucellaabortus) |
PF02570(CbiC) | 3 | ASP A 148LEU A 147PHE A 144 | None | 0.74A | 4pthA-3e7dA:undetectable | 4pthA-3e7dA:26.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epj | TRNAISOPENTENYLTRANSFERASE (Saccharomycescerevisiae) |
PF01715(IPPT) | 3 | ASP A 218LEU A 217PHE A 214 | None | 0.66A | 4pthA-3epjA:3.3 | 4pthA-3epjA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2i | ALR0221 PROTEIN (Nostoc sp. PCC7120) |
PF00300(His_Phos_1) | 3 | ASP A 91LEU A 90PHE A 87 | None | 0.72A | 4pthA-3f2iA:undetectable | 4pthA-3f2iA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4s | 50S RIBOSOMALPROTEIN L6P (Haloarculamarismortui) |
PF00347(Ribosomal_L6) | 3 | ASP E 164LEU E 108PHE E 91 | NoneNone A 02694 ( 4.5A) | 0.61A | 4pthA-3g4sE:undetectable | 4pthA-3g4sE:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lby | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1697C (Streptococcusmutans) |
PF06962(rRNA_methylase) | 3 | ASP A 11LEU A 8PHE A 12 | None | 0.72A | 4pthA-3lbyA:2.6 | 4pthA-3lbyA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljn | HYPOTHETICAL PROTEIN (Leishmaniamajor) |
PF00023(Ank)PF12796(Ank_2) | 3 | ASP A 264LEU A 267PHE A 266 | None | 0.65A | 4pthA-3ljnA:undetectable | 4pthA-3ljnA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd0 | SLL0855 PROTEIN (Synechocystissp. PCC 6803) |
PF00654(Voltage_CLC) | 3 | ASP A 273LEU A 272PHE A 269 | None | 0.71A | 4pthA-3nd0A:undetectable | 4pthA-3nd0A:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nrb | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Pseudomonasputida) |
PF00551(Formyl_trans_N)PF01842(ACT) | 3 | ASP A 180LEU A 181PHE A 184 | None | 0.68A | 4pthA-3nrbA:undetectable | 4pthA-3nrbA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwg | MICROCOMPARTMENTSPROTEIN (Desulfitobacteriumhafniense) |
PF00936(BMC) | 3 | ASP A 69LEU A 6PHE A 71 | None | 0.74A | 4pthA-3nwgA:undetectable | 4pthA-3nwgA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o90 | NICOTINAMIDASE (Streptococcuspneumoniae) |
PF00857(Isochorismatase) | 3 | ASP A 84LEU A 85PHE A 88 | None | 0.69A | 4pthA-3o90A:2.5 | 4pthA-3o90A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogz | UDP-SUGARPYROPHOSPHORYLASE (Leishmaniamajor) |
PF01704(UDPGP) | 3 | ASP A 47LEU A 48PHE A 51 | None | 0.69A | 4pthA-3ogzA:undetectable | 4pthA-3ogzA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pz9 | MANNANENDO-1,4-BETA-MANNOSIDASE. GLYCOSYLHYDROLASE FAMILY 5 (Thermotogapetrophila) |
PF00150(Cellulase) | 3 | ASP A 113LEU A 112PHE A 109 | None | 0.49A | 4pthA-3pz9A:undetectable | 4pthA-3pz9A:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ASP A 22LEU A 21PHE A 18 | None | 0.72A | 4pthA-3q3uA:undetectable | 4pthA-3q3uA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r38 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Listeriamonocytogenes) |
PF00275(EPSP_synthase) | 3 | ASP A 194LEU A 195PHE A 198 | None | 0.68A | 4pthA-3r38A:undetectable | 4pthA-3r38A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5x | D-ALANINE--D-ALANINELIGASE (Bacillusanthracis) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 3 | ASP A 127LEU A 126PHE A 123 | None | 0.71A | 4pthA-3r5xA:3.2 | 4pthA-3r5xA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT M (Escherichiacoli) |
no annotation | 3 | ASP M 135LEU M 138PHE M 137 | None | 0.66A | 4pthA-3rkoM:undetectable | 4pthA-3rkoM:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 3 | ASP A 241LEU A 240PHE A 237 | None | 0.70A | 4pthA-3s51A:undetectable | 4pthA-3s51A:7.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgh | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12741(SusD-like) | 3 | ASP A 174LEU A 173PHE A 170 | None | 0.45A | 4pthA-3sghA:undetectable | 4pthA-3sghA:16.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 3 | ASP A 28LEU A 29PHE A 32 | MTX A2001 (-2.7A)MTX A2001 (-3.9A)MTX A2001 (-4.3A) | 0.30A | 4pthA-3tq9A:25.7 | 4pthA-3tq9A:43.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tts | BETA-GALACTOSIDASE (Bacilluscirculans) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | ASP A 63LEU A 62PHE A 59 | None | 0.44A | 4pthA-3ttsA:undetectable | 4pthA-3ttsA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7v | BETA-GALACTOSIDASE (Caulobactervibrioides) |
PF02449(Glyco_hydro_42) | 3 | ASP A 109LEU A 108PHE A 105 | None | 0.47A | 4pthA-3u7vA:undetectable | 4pthA-3u7vA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh9 | ENDO-BETA-1,4-MANNANASE (Aspergillusniger) |
PF00150(Cellulase) | 3 | ASP A 303LEU A 304PHE A 305 | None | 0.61A | 4pthA-3wh9A:undetectable | 4pthA-3wh9A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wt2 | PROTEINDISULFIDE-ISOMERASE (Humicolainsolens) |
PF00085(Thioredoxin)PF13848(Thioredoxin_6) | 3 | ASP A 435LEU A 436PHE A 439 | None | 0.37A | 4pthA-3wt2A:undetectable | 4pthA-3wt2A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zc4 | SSO1398 (Sulfolobussolfataricus) |
no annotation | 3 | ASP A 145LEU A 144PHE A 141 | None | 0.38A | 4pthA-3zc4A:undetectable | 4pthA-3zc4A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ziz | GH5ENDO-BETA-1,4-MANNANASE (Podosporaanserina) |
PF00150(Cellulase) | 3 | ASP A 305LEU A 306PHE A 307 | None | 0.63A | 4pthA-3zizA:undetectable | 4pthA-3zizA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ac3 | BIFUNCTIONAL PROTEINGLMU (Streptococcuspneumoniae) |
PF00132(Hexapep)PF00483(NTP_transferase)PF14602(Hexapep_2) | 3 | ASP A 219LEU A 217PHE A 220 | None | 0.64A | 4pthA-4ac3A:undetectable | 4pthA-4ac3A:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bm1 | MANGANESE PEROXIDASE4 (Pleurotusostreatus) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ASP A 23LEU A 22PHE A 19 | None | 0.42A | 4pthA-4bm1A:undetectable | 4pthA-4bm1A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cc9 | PROTEIN VPX (Simianimmunodeficiencyvirus) |
PF00522(VPR) | 3 | ASP B 26LEU B 25PHE B 22 | None | 0.39A | 4pthA-4cc9B:undetectable | 4pthA-4cc9B:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvz | CYTOTOXICITY-ASSOCIATED IMMUNODOMINANTANTIGEN (Helicobacterpylori) |
no annotation | 3 | ASP A 814LEU A 815PHE A 818 | None | 0.44A | 4pthA-4dvzA:undetectable | 4pthA-4dvzA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcs | VERSATILE PEROXIDASEVPL2 (Pleurotuseryngii) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ASP A 22LEU A 21PHE A 18 | None | 0.49A | 4pthA-4fcsA:undetectable | 4pthA-4fcsA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3v | OXIDOREDUCTASEDOMAIN PROTEIN (Kribbellaflavida) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | ASP A 198LEU A 199PHE A 202 | None | 0.59A | 4pthA-4h3vA:undetectable | 4pthA-4h3vA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzc | CYSE, SERINEACETYLTRANSFERASE (Brucellaabortus) |
PF00132(Hexapep)PF06426(SATase_N) | 3 | ASP A 78LEU A 81PHE A 77 | None | 0.75A | 4pthA-4hzcA:undetectable | 4pthA-4hzcA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kmo | PUTATIVE VACUOLARPROTEINSORTING-ASSOCIATEDPROTEIN (Chaetomiumthermophilum) |
PF04840(Vps16_C) | 3 | ASP B 559LEU B 560PHE B 563 | None | 0.36A | 4pthA-4kmoB:undetectable | 4pthA-4kmoB:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8o | BILE ACID7A-DEHYDRATASE, BAIE ([Clostridium]hylemonae) |
PF13577(SnoaL_4) | 3 | ASP A 35LEU A 34PHE A 31 | None | 0.61A | 4pthA-4l8oA:undetectable | 4pthA-4l8oA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8p | BILE ACID7A-DEHYDRATASE, BAIE ([Clostridium]hiranonis) |
PF13577(SnoaL_4) | 3 | ASP A 35LEU A 34PHE A 31 | None | 0.61A | 4pthA-4l8pA:undetectable | 4pthA-4l8pA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldp | NDP-FOROSAMYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 3 | ASP A 114LEU A 115PHE A 118 | None | 0.67A | 4pthA-4ldpA:undetectable | 4pthA-4ldpA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4leh | BILE ACID 7-ALPHADEHYDRATASE, BAIE ([Clostridium]scindens) |
PF13577(SnoaL_4) | 3 | ASP A 38LEU A 37PHE A 34 | None | 0.67A | 4pthA-4lehA:undetectable | 4pthA-4lehA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lzi | MULTICYSTATIN (Solanumtuberosum) |
PF00031(Cystatin) | 3 | ASP A 21LEU A 22PHE A 25 | None | 0.66A | 4pthA-4lziA:undetectable | 4pthA-4lziA:19.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 3 | ASP A 27LEU A 28PHE A 31 | RAR A 200 (-2.6A)RAR A 200 (-3.8A)RAR A 200 (-3.8A) | 0.35A | 4pthA-4m7vA:11.8 | 4pthA-4m7vA:37.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn7 | PUTATIVEUNCHARACTERIZEDPROTEIN TA0848 (Thermoplasmaacidophilum) |
PF13185(GAF_2) | 3 | ASP A 2LEU A 3PHE A 6 | None | 0.62A | 4pthA-4mn7A:undetectable | 4pthA-4mn7A:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5c | CARGO-TRANSPORTPROTEIN YPP1 (Saccharomycescerevisiae) |
no annotation | 3 | ASP A 42LEU A 41PHE A 38 | None | 0.63A | 4pthA-4n5cA:undetectable | 4pthA-4n5cA:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmn | REPLICATIVE DNAHELICASE (Aquifexaeolicus) |
PF00772(DnaB)PF03796(DnaB_C) | 3 | ASP A 190LEU A 189PHE A 186 | None | 0.62A | 4pthA-4nmnA:undetectable | 4pthA-4nmnA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmy | ABC-TYPE TRANSPORTSYSTEM,EXTRACELLULARSOLUTE-BINDINGPROTEIN (Clostridioidesdifficile) |
PF09084(NMT1) | 3 | ASP A 26LEU A 25PHE A 22 | None | 0.46A | 4pthA-4nmyA:undetectable | 4pthA-4nmyA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obs | ALPHA-L-IDURONIDASE (Homo sapiens) |
PF01229(Glyco_hydro_39) | 3 | ASP A 115LEU A 114PHE A 111 | None | 0.69A | 4pthA-4obsA:undetectable | 4pthA-4obsA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4on9 | PROBABLEATP-DEPENDENT RNAHELICASE DDX58 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | ASP A 392LEU A 391PHE A 388 | None | 0.75A | 4pthA-4on9A:undetectable | 4pthA-4on9A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcq | POSSIBLETRANSCRIPTIONALREGULATORY PROTEIN(PROBABLYLRP/ASNC-FAMILY) (Mycobacteriumtuberculosis) |
PF01037(AsnC_trans_reg)PF13412(HTH_24) | 3 | ASP A 146LEU A 147PHE A 150 | None | 0.68A | 4pthA-4pcqA:undetectable | 4pthA-4pcqA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qa9 | EPOXIDE HYDROLASE (Streptomycescarzinostaticus) |
PF06441(EHN) | 3 | ASP A 374LEU A 375PHE A 378 | None | 0.51A | 4pthA-4qa9A:undetectable | 4pthA-4qa9A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uom | FAB FRAGMENT HEAVYCHAINFAB FRAGMENT LIGHTCHAIN (Homo sapiens;Homo sapiens) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 3 | ASP H 104LEU L 47PHE H 103 | None | 0.72A | 4pthA-4uomH:undetectable | 4pthA-4uomH:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoz | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | ASP A 77LEU A 76PHE A 73 | None | 0.65A | 4pthA-4uozA:undetectable | 4pthA-4uozA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8p | TALIN-1 (Mus musculus) |
no annotation | 3 | ASP A1394LEU A1393PHE A1390 | None | 0.74A | 4pthA-4w8pA:undetectable | 4pthA-4w8pA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd1 | ACETOACETATE-COALIGASE (Streptomyceslividans) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 3 | ASP A 645LEU A 646PHE A 649 | None | 0.75A | 4pthA-4wd1A:2.1 | 4pthA-4wd1A:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvm | STONUSTOXIN SUBUNITBETA (Synanceiahorrida) |
PF00622(SPRY)PF13765(PRY) | 3 | ASP B 415LEU B 418PHE B 417 | None | 0.73A | 4pthA-4wvmB:undetectable | 4pthA-4wvmB:11.71 |