SIMILAR PATTERNS OF AMINO ACIDS FOR 4POO_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 THR A  71
GLY A  83
HIS A  67
LEU A  82
SER A 216
 None
 1.22A 4pooA-1bh6A:
1.1		 4pooA-1bh6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ASP A 131
HIS A 102
ASN A 130
THR A 115
SER A  79
 None
 1.29A 4pooA-1c1dA:
6.1		 4pooA-1c1dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 THR A1043
GLY A1047
ASN A1045
LEU A 960
SER A1018
 ORN  A4010 ( 4.9A)
None
None
None
None
 1.36A 4pooA-1c30A:
3.5		 4pooA-1c30A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 GLY A  67
ASN A  80
ASP A  11
SER A  58
ASN A  85
 None
 1.18A 4pooA-1cpyA:
0.0		 4pooA-1cpyA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 ASN A 203
ASP A 195
ILE A 130
HIS A 113
SER A  72
 None
 1.32A 4pooA-1icpA:
0.3		 4pooA-1icpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		5 GLY A  30
ASN A  27
HIS A  58
LEU A  31
THR A  37
 None
 1.29A 4pooA-1iduA:
undetectable		 4pooA-1iduA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpt M-PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 THR A  71
GLY A  83
HIS A  67
LEU A  82
SER A 216
 None
 1.20A 4pooA-1mptA:
undetectable		 4pooA-1mptA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 THR A 171
GLY A 166
ASN A 151
HIS A 194
ASN A 170
 None
 1.36A 4pooA-1nr0A:
undetectable		 4pooA-1nr0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 THR A 302
GLY A 300
ASN A 174
HIS A 186
LEU A  46
 None
 1.32A 4pooA-1nsvA:
undetectable		 4pooA-1nsvA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  73
ASP A 186
ILE A 136
HIS A 108
ASN A 191
 STU  A 401 (-3.6A)
None
None
None
STU  A 401 (-4.5A)
 1.32A 4pooA-1nxkA:
undetectable		 4pooA-1nxkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 THR A  44
GLY A  48
ASN A 201
HIS A 282
SER A 315
 None
 1.09A 4pooA-1pieA:
undetectable		 4pooA-1pieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 703
ASN A 700
SER A 748
LEU A 755
SER A 789
 None
 1.34A 4pooA-1tmoA:
2.1		 4pooA-1tmoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 GLY A 216
ILE A  22
SER A 262
LEU A 214
THR A  20
 HH2  A 282 (-3.3A)
None
None
HH2  A 282 ( 4.9A)
None
 1.34A 4pooA-1twwA:
undetectable		 4pooA-1twwA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 ASP A 360
ILE A 442
SER A 443
HIS A 340
LEU A 367
 None
 1.36A 4pooA-1ua4A:
4.0		 4pooA-1ua4A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		5 GLY A 115
ILE A  86
SER A 207
THR A 105
SER A 209
 None
 1.36A 4pooA-1v6mA:
undetectable		 4pooA-1v6mA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 GLY A 288
ILE A  16
SER A  15
LEU A 274
THR A   8
 None
 1.32A 4pooA-1xi8A:
undetectable		 4pooA-1xi8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 THR A 545
GLY A 617
ILE A 612
SER A 607
LEU A 552
 None
PGR  A 805 ( 4.9A)
None
None
PGR  A 805 (-4.6A)
 1.27A 4pooA-1yiqA:
undetectable		 4pooA-1yiqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 GLY A 258
ASN A  44
ILE A  99
SER A 254
HIS A 255
 None
ACT  A 321 (-3.9A)
None
None
None
 1.27A 4pooA-2ajrA:
4.9		 4pooA-2ajrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cui TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		5 THR A  21
ASP A  19
SER A  79
LEU A  74
SER A 110
 None
 1.17A 4pooA-2cuiA:
undetectable		 4pooA-2cuiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		5 GLY A 159
HIS A 157
ASP A 194
ILE A 166
LEU A  65
 None
 1.34A 4pooA-2d5rA:
undetectable		 4pooA-2d5rA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		5 GLY A 222
ASP A 219
ILE A 102
ASN A  40
SER A  74
 None
 1.25A 4pooA-2hykA:
undetectable		 4pooA-2hykA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 HIS A 186
SER A 173
LEU A 390
THR A 361
SER A 167
 None
FAD  A 501 ( 3.9A)
None
None
FAD  A 501 ( 4.5A)
 1.17A 4pooA-2i0zA:
2.2		 4pooA-2i0zA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOUB PROTEIN

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF06234
(TmoB) 		5 THR C  78
ASP C  80
HIS A 427
ASN C   9
THR A 395
 None
 1.34A 4pooA-2incC:
undetectable		 4pooA-2incC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		5 GLY A 396
ILE A 366
LEU A 399
THR A 482
SER A 213
 None
HEM  A 500 ( 4.1A)
None
None
None
 1.29A 4pooA-2pg6A:
undetectable		 4pooA-2pg6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		5 THR A 262
HIS A 299
ASP A 173
ILE A 235
LEU A 268
 None
 1.32A 4pooA-2r44A:
undetectable		 4pooA-2r44A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 THR A 198
ASP A 193
ASN A 197
LEU A 203
SER A 230
 None
 1.09A 4pooA-2rfaA:
undetectable		 4pooA-2rfaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		5 THR A 172
GLY A 197
ASP A 193
ASN A 194
THR A  11
 PO4  A1506 (-2.9A)
None
None
None
PO4  A1506 ( 3.4A)
 1.31A 4pooA-2v7yA:
undetectable		 4pooA-2v7yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 GLY A2025
ASN A1458
SER A2108
ASN A2028
THR A2083
 None
 1.32A 4pooA-2vz9A:
undetectable		 4pooA-2vz9A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY B 279
HIS B 283
ASN B 254
LEU B 124
SER B 221
 None
 1.30A 4pooA-2w2kB:
2.0		 4pooA-2w2kB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 THR A 435
ASP A 437
ASN A 436
LEU A 328
THR A  92
 None
 1.23A 4pooA-2xijA:
undetectable		 4pooA-2xijA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 THR A 772
GLY A 745
ASP A 774
ILE A 740
LEU A 746
 None
 1.27A 4pooA-3bg9A:
undetectable		 4pooA-3bg9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		5 GLY A 208
HIS A 205
ASP A 206
ILE A 108
LEU A  36
 None
 1.32A 4pooA-3cn7A:
3.7		 4pooA-3cn7A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czc RMPB

(Streptococcus
mutans) 		PF02302
(PTS_IIB) 		5 GLY A  74
ASN A  58
HIS A  59
ILE A  53
SER A  36
 None
 1.21A 4pooA-3czcA:
undetectable		 4pooA-3czcA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		5 THR A 438
ASP A 432
ILE A 477
ASN A 433
LEU A 379
 None
 1.27A 4pooA-3djaA:
undetectable		 4pooA-3djaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		5 GLY A  95
ASP A   9
HIS A  91
ASN A  49
LEU A 101
 None
 1.26A 4pooA-3eefA:
4.3		 4pooA-3eefA:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		5 THR A  28
ASN A  31
ASP A  26
LEU A 102
THR A 111
 SAM  A 300 (-4.1A)
SAM  A 300 (-4.7A)
SAM  A 300 ( 4.5A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
 1.34A 4pooA-3eeyA:
29.6		 4pooA-3eeyA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		9 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  81
ASN A  98
LEU A 102
THR A 111
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
 0.34A 4pooA-3eeyA:
29.6		 4pooA-3eeyA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		5 GLY A 174
ILE A 150
SER A 151
LEU A 173
THR A 167
 None
 1.35A 4pooA-3hocA:
undetectable		 4pooA-3hocA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		5 GLY A 118
ASN A 120
ILE A  25
ASN A 113
THR A 103
 None
 1.31A 4pooA-3jr7A:
2.0		 4pooA-3jr7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		5 ASN A 303
HIS A 304
ILE A  71
HIS A  58
THR A  66
 None
 0.92A 4pooA-3jugA:
undetectable		 4pooA-3jugA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		5 GLY A 302
ASN A 303
HIS A 304
HIS A  58
THR A  66
 None
 0.91A 4pooA-3jugA:
undetectable		 4pooA-3jugA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 THR A 185
GLY A 212
HIS A 320
ILE A 203
SER A 160
 None
 1.17A 4pooA-3kveA:
undetectable		 4pooA-3kveA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 THR A 442
GLY A 468
HIS A 409
ASN A 517
SER A 634
 KCX  A 490 ( 3.4A)
None
NI  A 841 ( 3.3A)
None
None
 1.31A 4pooA-3la4A:
2.3		 4pooA-3la4A:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		8 THR A  27
GLY A  29
ASN A  30
ASP A  33
HIS A  76
ASN A  93
LEU A  97
THR A 106
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-3.1A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
 0.64A 4pooA-3lbyA:
28.4		 4pooA-3lbyA:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		5 THR A  27
GLY A  29
ASN A  30
HIS A  76
ASN A  93
 None
 1.13A 4pooA-3mtiA:
24.9		 4pooA-3mtiA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		5 THR A  27
GLY A  29
ASP A  33
HIS A  76
ASN A  93
 None
 0.78A 4pooA-3mtiA:
24.9		 4pooA-3mtiA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 54

(Mus musculus) 		PF07928
(Vps54) 		5 ASN A 955
ILE A 901
ASN A 918
LEU A 959
SER A 858
 None
 1.30A 4pooA-3n1bA:
2.1		 4pooA-3n1bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr PBICP-C

(Plasmodium
berghei) 		PF09394
(Inhibitor_I42)
PF12628
(Inhibitor_I71) 		5 GLY B 201
ASN B 202
ILE B 224
SER B 318
ASN B 345
 None
 1.19A 4pooA-3pnrB:
undetectable		 4pooA-3pnrB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ASN A 192
ASP A 218
ILE A 122
ASN A 220
SER A 312
 None
 1.13A 4pooA-3rjyA:
2.1		 4pooA-3rjyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		5 THR A  86
GLY A  88
HIS A  18
SER A  70
THR A  99
 None
 1.30A 4pooA-3tr5A:
undetectable		 4pooA-3tr5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		5 GLY A  71
ASN A 155
ASP A  73
ILE A  39
ASN A  84
 None
 1.17A 4pooA-3tx2A:
undetectable		 4pooA-3tx2A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 5 GLY A 119
HIS A 127
ASP A 115
THR A 248
SER A  68
 None
None
CBI  A 301 (-3.7A)
None
None
 1.21A 4pooA-3wdyA:
undetectable		 4pooA-3wdyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a20 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin) 		5 THR A  97
HIS A 127
ASP A 128
SER A  93
ASN A 129
 None
SO4  A1152 (-3.8A)
SO4  A1152 (-3.4A)
None
None
 1.36A 4pooA-4a20A:
undetectable		 4pooA-4a20A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bcx AP-1 COMPLEX SUBUNIT
GAMMA-LIKE 2

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 THR A 701
GLY A 738
ILE A 741
LEU A 739
THR A 699
 None
 1.21A 4pooA-4bcxA:
undetectable		 4pooA-4bcxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 GLY A 314
ASN A 274
ILE A 354
ASN A 310
THR A 350
 None
 1.36A 4pooA-4bplA:
undetectable		 4pooA-4bplA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		5 GLY A 409
HIS A 405
SER A 448
HIS A 596
LEU A 412
 None
 1.20A 4pooA-4c0aA:
undetectable		 4pooA-4c0aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 HIS A 185
SER A 172
LEU A 364
THR A 335
SER A 166
 None
FAD  A1392 ( 4.1A)
None
None
FAD  A1392 ( 4.3A)
 1.20A 4pooA-4cnkA:
undetectable		 4pooA-4cnkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 THR A  29
ILE A 159
LEU A  32
THR A  19
SER A  21
 None
 1.35A 4pooA-4cnkA:
undetectable		 4pooA-4cnkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		5 THR A 391
SER A 425
HIS A  71
LEU A  81
THR A  69
 None
 1.26A 4pooA-4dweA:
undetectable		 4pooA-4dweA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		5 GLY A  35
HIS A  45
ASP A  88
SER A  93
ASN A  37
 None
 1.26A 4pooA-4e5vA:
undetectable		 4pooA-4e5vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 5 GLY B 132
ASN B 133
HIS B 134
ILE B 186
THR B 220
 None
MN  B 502 (-2.4A)
None
None
None
 1.31A 4pooA-4fcxB:
undetectable		 4pooA-4fcxB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 THR B 442
GLY B 468
HIS B 409
ASN B 517
SER B 634
 KCX  B 490 ( 3.5A)
KCX  B 490 ( 4.9A)
NI  B 901 (-3.3A)
None
None
 1.31A 4pooA-4g7eB:
2.0		 4pooA-4g7eB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		5 GLY B 159
HIS B 157
ASP B 194
ILE B 166
LEU B  65
 None
 1.23A 4pooA-4gmjB:
undetectable		 4pooA-4gmjB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 293
ASN A 169
ILE A 230
SER A 129
ASN A 291
 None
 1.04A 4pooA-4ic6A:
undetectable		 4pooA-4ic6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A3273
GLY A3289
ILE A3114
ASN A3271
THR A3112
 None
None
GOL  A4001 (-4.7A)
None
None
 1.32A 4pooA-4kc5A:
undetectable		 4pooA-4kc5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 GLY A 133
ASN A 136
ILE A 179
SER A 157
THR A 175
 None
 1.21A 4pooA-4nbrA:
5.5		 4pooA-4nbrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		5 THR A4157
GLY A4159
ASN A4173
SER A4140
THR A4198
 None
 1.06A 4pooA-4o2wA:
undetectable		 4pooA-4o2wA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		5 THR A  28
ASN A  31
ASP A  26
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 1.34A 4pooA-4pooA:
38.7		 4pooA-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
HIS A  33
ASP A  34
ILE A  53
SER A  79
HIS A  80
ASN A 101
LEU A 105
THR A 114
SER A 118
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
SAM  A 301 ( 3.8A)
 0.00A 4pooA-4pooA:
38.7		 4pooA-4pooA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		5 THR A  68
GLY A  66
ILE A 118
SER A 117
LEU A  73
 None
 1.34A 4pooA-4q6tA:
undetectable		 4pooA-4q6tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE

(Staphylococcus
aureus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 THR A  72
GLY A 100
HIS A  73
ASN A  97
LEU A  94
 NAP  A 500 ( 4.9A)
None
None
NAP  A 500 (-3.6A)
None
 1.19A 4pooA-4s3mA:
undetectable		 4pooA-4s3mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 GLY A 324
ASN A 284
ILE A 363
ASN A 320
THR A 359
 None
 1.35A 4pooA-4uadA:
undetectable		 4pooA-4uadA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 GLY A  88
HIS A  90
SER A  39
LEU A 329
SER A 261
 None
 1.32A 4pooA-4xnuA:
undetectable		 4pooA-4xnuA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		5 THR A 795
GLY A 793
ILE A 773
SER A 772
SER A 846
 None
 1.34A 4pooA-4zgvA:
undetectable		 4pooA-4zgvA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 390
ASN A  55
SER A 368
ASN A 392
LEU A 425
 None
 1.17A 4pooA-4zoxA:
undetectable		 4pooA-4zoxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLY A 731
ILE A 711
SER A 369
ASN A 360
THR A 282
 K  A2007 ( 4.8A)
None
None
None
None
 0.78A 4pooA-5aw4A:
undetectable		 4pooA-5aw4A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 THR A 350
GLY A 539
SER A 375
HIS A 387
THR A 385
 None
 1.17A 4pooA-5bs5A:
3.6		 4pooA-5bs5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 225
ASN A 226
ASP A  52
ILE A 184
SER A 183
 GLY  A 225 ( 0.0A)
ASN  A 226 ( 0.6A)
ASP  A  52 ( 0.6A)
ILE  A 184 ( 0.4A)
SER  A 183 ( 0.0A)
 1.28A 4pooA-5ep8A:
undetectable		 4pooA-5ep8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 GLY A  85
ILE A  50
SER A  17
ASN A  36
THR A  20
 None
 1.30A 4pooA-5fo1A:
undetectable		 4pooA-5fo1A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 THR B 274
GLY B  27
ILE B 278
SER B 277
LEU B  30
 None
 1.32A 4pooA-5grhB:
undetectable		 4pooA-5grhB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		6 GLY A 298
HIS A 270
ASP A 292
HIS A  12
ASN A 296
LEU A  43
 None
 1.43A 4pooA-5gvaA:
undetectable		 4pooA-5gvaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.03A 4pooA-5j0aA:
undetectable		 4pooA-5j0aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 GLY A 242
ILE A  94
HIS A 101
LEU A 241
THR A 235
 None
 1.36A 4pooA-5k0tA:
2.5		 4pooA-5k0tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 THR A 373
ASN A 252
ASP A 357
ILE A 371
THR A 383
 None
 1.34A 4pooA-5kufA:
2.2		 4pooA-5kufA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kza VIRUS MATRIX PROTEIN

(Rous sarcoma
virus) 		PF02813
(Retro_M) 		5 GLY A  79
ILE A   8
SER A   9
LEU A  78
THR A  73
 None
 1.33A 4pooA-5kzaA:
undetectable		 4pooA-5kzaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 GLY b 229
ASN b 230
ILE b   6
THR b   8
SER b  38
 None
 1.33A 4pooA-5l9wb:
2.1		 4pooA-5l9wb:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlq CDPS

(Nocardia
brasiliensis) 		no annotation 5 ASN A  96
ASP A 101
ILE A 193
LEU A  45
SER A  55
 None
 1.25A 4pooA-5mlqA:
undetectable		 4pooA-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 5 THR A 337
GLY A 335
ASN A 185
ILE A 326
ASN A 338
 None
 1.32A 4pooA-5nhbA:
undetectable		 4pooA-5nhbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A 363
ILE A 445
SER A 446
HIS A 343
LEU A 370
 None
 1.36A 4pooA-5o0jA:
undetectable		 4pooA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 5 GLY A  69
ASN A  70
HIS A  73
HIS A  90
LEU A  68
 None
 1.33A 4pooA-5utiA:
undetectable		 4pooA-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 THR A 322
HIS A 380
ASN A 321
LEU A 294
THR A 384
 None
 1.34A 4pooA-5wayA:
undetectable		 4pooA-5wayA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5g BETA-LACTAMASE

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 THR A  57
ILE A 152
HIS A  61
ASN A 240
THR A 171
 None
 1.27A 4pooA-5x5gA:
undetectable		 4pooA-5x5gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 GLY A 298
ASP A 337
ASN A 335
LEU A 347
SER A 137
 None
 1.34A 4pooA-5xevA:
undetectable		 4pooA-5xevA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 THR A 319
ASP A 314
ASN A 318
LEU A 324
SER A 357
 None
 1.30A 4pooA-6bbjA:
undetectable		 4pooA-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN

(Marburg
marburgvirus) 		no annotation 5 THR A 161
GLY A 163
ASN A 164
LEU A  54
THR A  91
 None
None
NAG  B 704 (-2.9A)
None
None
 1.35A 4pooA-6bp2A:
undetectable		 4pooA-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PROTEIN FAM126A

(Homo sapiens) 		no annotation 5 GLY C 107
ASN C 110
ILE C 101
HIS C  58
LEU C 106
 None
 1.24A 4pooA-6bq1C:
undetectable		 4pooA-6bq1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 THR A 319
ASP A 314
ASN A 318
LEU A 324
SER A 357
 None
 1.31A 4pooA-6c8gA:
undetectable		 4pooA-6c8gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 5 GLY C 451
ILE C 284
SER C 274
ASN C 478
LEU C 452
 None
 1.32A 4pooA-6ccbC:
undetectable		 4pooA-6ccbC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 5 GLY B 393
ASP B 396
SER B 349
ASN B 395
THR B 335
 None
 1.02A 4pooA-6dnhB:
undetectable		 4pooA-6dnhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 5 GLY A 409
HIS A 405
SER A 448
HIS A 596
LEU A 412
 None
 1.33A 4pooA-6faeA:
undetectable		 4pooA-6faeA:
undetectable