SIMILAR PATTERNS OF AMINO ACIDS FOR 4PO0_A_NPSA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 ALA A  72
GLY A  10
LEU A  68
LEU A  22
 None
 0.80A 4po0A-1c1kA:
0.3		 4po0A-1c1kA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 ALA A  82
GLY A 274
LEU A 185
LEU A 125
 None
 0.85A 4po0A-1ci9A:
undetectable		 4po0A-1ci9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		5 LYS A 162
ALA A 163
GLY A 140
LEU A 142
LEU A 218
 None
 1.46A 4po0A-1dl2A:
2.4		 4po0A-1dl2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LYS A 112
GLY A 154
LEU A 155
LEU A 192
 None
 0.83A 4po0A-1ee0A:
undetectable		 4po0A-1ee0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggq OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 LYS A 188
ALA A 187
LEU A 183
LEU A 120
 None
 0.72A 4po0A-1ggqA:
3.7		 4po0A-1ggqA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 LYS A 370
ALA A 371
GLY A 376
LEU A 377
 SO4  A1462 (-2.7A)
None
None
None
 0.86A 4po0A-1gkpA:
undetectable		 4po0A-1gkpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gp1 GLUTATHIONE
PEROXIDASE

(Bos taurus) 		PF00255
(GSHPx) 		5 ARG A  61
GLY A  63
LEU A  67
LEU A  37
GLU A 189
 None
 1.38A 4po0A-1gp1A:
undetectable		 4po0A-1gp1A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ALA A 367
GLY A 354
LEU A 382
LEU A 394
 None
 0.72A 4po0A-1gz5A:
0.0		 4po0A-1gz5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ALA A 397
GLY A 388
LEU A 387
LEU A 347
 None
 0.85A 4po0A-1httA:
0.0		 4po0A-1httA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 GLY A 236
LEU A 277
LEU A 540
GLU A 500
 ADP  A 590 (-3.3A)
ADP  A 590 ( 4.5A)
None
TAS  A 701 (-3.2A)
 0.78A 4po0A-1ii0A:
0.0		 4po0A-1ii0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 ALA A 376
GLY A 416
LEU A 433
LEU A 387
 None
 0.83A 4po0A-1k32A:
undetectable		 4po0A-1k32A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 LYS A 270
ALA A 271
GLY A 276
LEU A 275
LEU A 166
 None
 1.46A 4po0A-1kgpA:
undetectable		 4po0A-1kgpA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		4 LYS A 153
ALA A 152
LEU A 148
LEU A   7
 None
 0.83A 4po0A-1l7pA:
undetectable		 4po0A-1l7pA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 LYS A 263
ALA A 264
LEU A 268
LEU A 325
 None
 0.82A 4po0A-1ldkA:
2.3		 4po0A-1ldkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LYS A 313
ALA A 312
LEU A 308
LEU A 244
 None
 0.81A 4po0A-1m66A:
2.6		 4po0A-1m66A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LYS X 423
ALA X 424
GLY X 426
LEU X 450
LEU X 234
 None
 1.41A 4po0A-1mw9X:
undetectable		 4po0A-1mw9X:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ALA A 618
GLY A 626
LEU A 622
LEU A 653
 None
 0.88A 4po0A-1n11A:
undetectable		 4po0A-1n11A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ

(Escherichia
coli) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		5 LYS A 361
ALA A 362
GLY A 364
LEU A 366
LEU A 403
 None
 1.32A 4po0A-1ni5A:
2.8		 4po0A-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		4 LYS A  53
ALA A  52
LEU A  42
GLU A  70
 None
 0.85A 4po0A-1nxzA:
undetectable		 4po0A-1nxzA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 GLY A  86
LEU A  85
LEU A 220
GLU A 175
 None
 0.75A 4po0A-1o1yA:
undetectable		 4po0A-1o1yA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF14681
(UPRTase) 		4 LYS A 142
ALA A 143
LEU A 147
LEU A 129
 None
 0.87A 4po0A-1o5oA:
undetectable		 4po0A-1o5oA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqv TOXIN-COREGULATED
PILUS SUBUNIT

(Vibrio cholerae) 		PF05946
(TcpA) 		4 LYS A  35
ALA A  36
LEU A  40
LEU A 123
 None
 0.84A 4po0A-1oqvA:
undetectable		 4po0A-1oqvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		4 ALA A 245
GLY A 249
LEU A 277
LEU A 257
 None
 0.89A 4po0A-1oyzA:
2.5		 4po0A-1oyzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LYS A 357
ALA A 358
LEU A 342
LEU A 344
 None
 0.88A 4po0A-1p43A:
undetectable		 4po0A-1p43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 LYS A 129
ALA A 128
GLY A 123
LEU A 549
 None
 0.79A 4po0A-1q50A:
2.2		 4po0A-1q50A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 LYS A 258
ALA A 259
GLY A 222
LEU A 221
LEU A 138
 None
 1.38A 4po0A-1qo8A:
2.6		 4po0A-1qo8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxe TRANSCRIPTIONAL
REGULATOR ERG

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 ALA A 146
GLY A 151
LEU A 152
LEU A 188
 None
 0.80A 4po0A-1sxeA:
undetectable		 4po0A-1sxeA:
10.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 209
ALA A 213
GLY A 328
LEU A 331
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1001 ( 4.1A)
None
 0.68A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LYS A  20
ALA A  21
LEU A 139
LEU A 155
 None
 0.61A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LYS A 212
ALA A 213
GLY A 328
LEU A 331
LEU A 347
GLU A 354
 None
DKA  A1001 ( 4.0A)
DKA  A1001 ( 4.1A)
None
DKA  A1002 ( 4.3A)
DKA  A1002 ( 4.4A)
 0.90A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5w HYPOTHETICAL UPF0244
PROTEIN YJJX

(Escherichia
coli) 		PF01931
(NTPase_I-T) 		5 LYS A 140
ALA A 142
GLY A 124
LEU A 123
LEU A 109
 None
 1.43A 4po0A-1u5wA:
undetectable		 4po0A-1u5wA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ALA A 435
GLY A 440
LEU A 441
LEU A 421
 None
 0.87A 4po0A-1uaaA:
undetectable		 4po0A-1uaaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		5 ALA A 141
GLY A 175
LEU A 172
LEU A 162
GLU A 154
 None
 1.20A 4po0A-1ub0A:
2.0		 4po0A-1ub0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 171
LEU A 180
LEU A 214
GLU A 157
 None
 0.78A 4po0A-1ukwA:
2.4		 4po0A-1ukwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		4 ALA A  85
LEU A  89
LEU A  26
GLU A  50
 None
 0.76A 4po0A-1v2xA:
undetectable		 4po0A-1v2xA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LYS A 282
ALA A 283
LEU A 287
LEU A 127
 None
 0.65A 4po0A-1v3tA:
undetectable		 4po0A-1v3tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		5 LYS A 140
ALA A 139
GLY A 107
LEU A 105
LEU A 123
 None
 1.41A 4po0A-1v5xA:
undetectable		 4po0A-1v5xA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		4 ALA C 300
GLY C 298
LEU C 294
LEU C 289
 None
None
None
HEM  C 402 ( 4.4A)
 0.76A 4po0A-1vrnC:
undetectable		 4po0A-1vrnC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ARG A  12
LYS A 267
GLY A 231
LEU A 232
LEU A 281
 None
 1.46A 4po0A-1w5tA:
2.0		 4po0A-1w5tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfm SYNAPTOTAGMIN XIII

(Homo sapiens) 		PF00168
(C2) 		4 ALA A  90
GLY A 114
LEU A 115
LEU A  82
 None
 0.75A 4po0A-1wfmA:
undetectable		 4po0A-1wfmA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkq GUANINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		4 LYS A  61
ALA A  62
LEU A  66
LEU A  71
 None
 0.82A 4po0A-1wkqA:
undetectable		 4po0A-1wkqA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 ALA A 125
GLY A 128
LEU A 129
LEU A  72
 PO4  A1506 ( 4.5A)
PO4  A1506 ( 4.4A)
None
None
 0.89A 4po0A-1wxxA:
undetectable		 4po0A-1wxxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 LYS A 137
ALA A 138
GLY A 106
LEU A 219
 None
 0.86A 4po0A-1x1nA:
undetectable		 4po0A-1x1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		4 LYS A  46
ALA A  47
LEU A  51
LEU A  33
 None
 0.50A 4po0A-1zaoA:
undetectable		 4po0A-1zaoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		4 ALA A 231
GLY A 244
LEU A 247
LEU A 220
 None
 0.85A 4po0A-1zelA:
undetectable		 4po0A-1zelA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zi7 KES1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		4 LYS A 262
ALA A 263
LYS A 247
GLU A 232
 None
None
SO4  A1103 (-3.3A)
SO4  A1103 ( 4.9A)
 0.77A 4po0A-1zi7A:
undetectable		 4po0A-1zi7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS B 304
ALA B 305
GLY B 434
LEU B 362
 TPO  B 446 ( 3.2A)
None
None
None
 0.87A 4po0A-2a1aB:
undetectable		 4po0A-2a1aB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2o HYPOTHETICAL PROTEIN
BT3146

(Bacteroides
thetaiotaomicron) 		no annotation 4 LYS A 217
ALA A 218
LEU A  42
LEU A  38
 None
 0.86A 4po0A-2a2oA:
undetectable		 4po0A-2a2oA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		5 LYS A 182
ALA A 181
GLY A  38
LEU A  37
LEU A 145
 None
 1.36A 4po0A-2a33A:
undetectable		 4po0A-2a33A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6c HELIX-TURN-HELIX
MOTIF

(Nitrosomonas
europaea) 		PF13744
(HTH_37) 		5 LYS A  24
ALA A  25
GLY A  30
LEU A  29
LEU A  15
 None
 1.40A 4po0A-2a6cA:
undetectable		 4po0A-2a6cA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 ALA A  43
GLY A  48
LEU A  47
LEU A  11
 None
 0.87A 4po0A-2a6pA:
undetectable		 4po0A-2a6pA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LYS L 106
ALA L  13
GLY L  16
LEU L  78
LEU L 103
 None
 1.44A 4po0A-2adfL:
undetectable		 4po0A-2adfL:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ALA A  58
GLY A 147
LEU A 148
LEU A  97
 None
 0.81A 4po0A-2b42A:
undetectable		 4po0A-2b42A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9e PERIDININ-CHLOROPHYL
L A PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		4 ALA A  45
GLY A 198
LEU A 257
LEU A 252
 PID  A1335 (-3.6A)
None
PID  A1335 (-4.2A)
None
 0.78A 4po0A-2c9eA:
undetectable		 4po0A-2c9eA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctq DNAJ HOMOLOG
SUBFAMILY C MEMBER
12

(Homo sapiens) 		PF00226
(DnaJ) 		4 LYS A  68
ALA A  69
LEU A  73
LEU A  26
 None
 0.70A 4po0A-2ctqA:
undetectable		 4po0A-2ctqA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwy HYPOTHETICAL PROTEIN
TTHA0068

(Thermus
thermophilus) 		PF03745
(DUF309) 		4 LYS A  64
ALA A  65
LEU A  69
LEU A  85
 None
 0.89A 4po0A-2cwyA:
2.8		 4po0A-2cwyA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkl TRINUCLEOTIDE REPEAT
CONTAINING 6C
PROTEIN

(Homo sapiens) 		PF00627
(UBA) 		4 ALA A  52
LEU A  56
LEU A  28
GLU A  40
 None
 0.88A 4po0A-2dklA:
1.8		 4po0A-2dklA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 LYS A  30
ALA A  31
LEU A  35
LEU B  95
 None
 0.86A 4po0A-2dppA:
undetectable		 4po0A-2dppA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 LYS L 107
ALA L  13
GLY L  17
LEU L  78
LEU L 104
 None
 1.45A 4po0A-2e27L:
undetectable		 4po0A-2e27L:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo0 HYPOTHETICAL PROTEIN
ST1444

(Sulfurisphaera
tokodaii) 		PF01870
(Hjc) 		4 LYS A  83
ALA A  82
GLY A  77
LEU A  56
 None
 0.68A 4po0A-2eo0A:
undetectable		 4po0A-2eo0A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ALA A 239
LEU A 131
LEU A 133
GLU A 110
 None
 0.89A 4po0A-2ewnA:
undetectable		 4po0A-2ewnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 4 LYS A  54
ALA A  55
LEU A  59
LEU A   6
 None
 0.51A 4po0A-2f06A:
undetectable		 4po0A-2f06A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		4 ALA A 126
GLY A 133
LEU A 132
LEU A 119
 None
 0.89A 4po0A-2f2bA:
undetectable		 4po0A-2f2bA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ful EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		5 LYS A 386
ALA A 385
LEU A 343
LEU A 347
GLU A 329
 None
 1.42A 4po0A-2fulA:
undetectable		 4po0A-2fulA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ARG A 296
ALA A 292
LEU A 289
LEU A 258
 None
 0.77A 4po0A-2fuqA:
undetectable		 4po0A-2fuqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ALA A 241
GLY A 248
LEU A 246
LEU A 166
 None
 0.88A 4po0A-2gepA:
undetectable		 4po0A-2gepA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 LYS A 363
ALA A 364
LEU A 302
LEU A 286
 None
 0.86A 4po0A-2hekA:
undetectable		 4po0A-2hekA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		4 ALA A 125
GLY A  88
LEU A 123
LYS A 172
 None
 0.88A 4po0A-2hxsA:
undetectable		 4po0A-2hxsA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ALA A 114
GLY A  29
LEU A  30
LEU A  64
 None
 0.80A 4po0A-2hyjA:
4.3		 4po0A-2hyjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Homo sapiens) 		PF01923
(Cob_adeno_trans) 		4 ALA A  85
GLY A 125
LEU A 128
LEU A 199
 None
 0.75A 4po0A-2idxA:
3.5		 4po0A-2idxA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		5 LYS A 166
ALA A 167
GLY A 160
LEU A 159
LEU A 193
 None
 1.29A 4po0A-2is3A:
undetectable		 4po0A-2is3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ARG A  23
ALA A  22
GLY A  17
LEU A  18
LEU A  10
 None
 1.25A 4po0A-2iu3A:
undetectable		 4po0A-2iu3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ARG A  23
ALA A  22
GLY A  17
LEU A  18
LEU A  42
 None
 1.21A 4po0A-2iu3A:
undetectable		 4po0A-2iu3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Chlamydia
trachomatis) 		PF00132
(Hexapep)
PF04613
(LpxD) 		4 ALA A  12
GLY A  23
LEU A   8
LEU A  79
 None
 0.84A 4po0A-2iu8A:
undetectable		 4po0A-2iu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		5 ARG A 219
ALA A 199
GLY A 204
LEU A 203
LEU A 153
 None
 1.17A 4po0A-2j1oA:
3.3		 4po0A-2j1oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 ALA A  57
GLY A   6
LEU A  68
LEU A  83
 None
 0.89A 4po0A-2jfqA:
undetectable		 4po0A-2jfqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzc UNCHARACTERIZED
PROTEIN

(Jannaschia sp.
CCS1) 		PF07345
(DUF1476) 		4 LYS A  78
ALA A  77
GLY A  72
LEU A  13
 None
 0.88A 4po0A-2kzcA:
undetectable		 4po0A-2kzcA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljr GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LYS A  22
GLY A 202
LEU A 201
LEU A 167
 None
 0.84A 4po0A-2ljrA:
undetectable		 4po0A-2ljrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lva UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 28

(Homo sapiens) 		no annotation 4 ALA A  54
GLY A  49
LEU A  44
LEU A  28
 None
 0.87A 4po0A-2lvaA:
undetectable		 4po0A-2lvaA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 LYS A  73
ALA A  74
LEU A  78
LEU A 259
 None
 0.85A 4po0A-2nmpA:
undetectable		 4po0A-2nmpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LYS A 362
ALA A 361
LEU A 453
LYS A 382
 None
None
None
CME  A 381 ( 3.4A)
 0.72A 4po0A-2ocfA:
undetectable		 4po0A-2ocfA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 471
LEU A 467
LEU A 117
GLU A 125
 None
 0.76A 4po0A-2pajA:
undetectable		 4po0A-2pajA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF

(Bacillus
subtilis) 		PF00448
(SRP54) 		4 LYS A 114
ALA A 115
LEU A 119
LEU A 133
 None
 0.66A 4po0A-2px0A:
4.1		 4po0A-2px0A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 ALA A 323
GLY A 354
LEU A 325
GLU A 101
 FAD  A 401 ( 4.1A)
None
None
BEZ  A 501 ( 2.6A)
 0.86A 4po0A-2q6uA:
undetectable		 4po0A-2q6uA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A 279
ALA A 280
LEU A 284
LEU A 312
 None
 0.83A 4po0A-2qdeA:
undetectable		 4po0A-2qdeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN
SMALL CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 ALA B 577
GLY B 573
LEU B 572
GLU A 533
 None
 0.63A 4po0A-2qqpB:
2.3		 4po0A-2qqpB:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LYS A  23
ALA A  24
LEU A  28
LEU A  58
 None
 0.72A 4po0A-2r3sA:
undetectable		 4po0A-2r3sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5s UNCHARACTERIZED
PROTEIN VP0806

(Vibrio
parahaemolyticus) 		PF14559
(TPR_19)
PF14561
(TPR_20) 		4 LYS A 154
ALA A 155
LEU A 159
LEU A 186
 None
 0.77A 4po0A-2r5sA:
undetectable		 4po0A-2r5sA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ALA A 295
GLY A 482
LEU A 292
LEU A 273
 None
 0.89A 4po0A-2rjqA:
undetectable		 4po0A-2rjqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 ALA A 218
GLY A 237
LEU A 241
GLU A 155
 PG4  A1443 (-4.4A)
PG4  A1443 (-3.6A)
PG4  A1443 ( 4.9A)
None
 0.83A 4po0A-2veoA:
undetectable		 4po0A-2veoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 LYS A 127
ALA A 126
GLY A 122
LEU A 148
 None
None
None
PLM  A1278 (-4.2A)
 0.86A 4po0A-2w3yA:
undetectable		 4po0A-2w3yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 LEU A 607
LEU A 623
LYS A 627
GLU A 630
 None
 0.62A 4po0A-2wb7A:
3.8		 4po0A-2wb7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbr GW182

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 LYS A1167
ALA A1168
LEU A1172
LEU A1119
 None
 0.82A 4po0A-2wbrA:
undetectable		 4po0A-2wbrA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 ARG A 223
GLY A 230
LEU A 231
LEU A 108
 None
None
HEM  A1398 ( 4.6A)
None
 0.81A 4po0A-2x9pA:
3.8		 4po0A-2x9pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 LYS A 632
ALA A 631
GLY A 621
LEU A 627
LEU A 127
 None
 1.49A 4po0A-2yiaA:
undetectable		 4po0A-2yiaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 LYS D 632
ALA D 631
GLY D 621
LEU D 627
LEU D 127
 None
 1.46A 4po0A-2yibD:
undetectable		 4po0A-2yibD:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		5 LYS A  69
ALA A  68
GLY A  63
LEU A  64
LEU A  83
 None
 1.48A 4po0A-2yrfA:
2.9		 4po0A-2yrfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 ALA A 211
GLY A 209
LEU A 205
LEU A  35
 None
 0.89A 4po0A-2z2zA:
undetectable		 4po0A-2z2zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4r CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Thermotoga
maritima) 		PF00308
(Bac_DnaA) 		4 ALA A 325
LEU A 328
LEU A 309
LYS A 313
 None
 0.86A 4po0A-2z4rA:
2.0		 4po0A-2z4rA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 ARG A 324
ALA A 322
GLY A 326
LEU A 351
LEU A 401
 None
 1.32A 4po0A-2zukA:
undetectable		 4po0A-2zukA:
22.75